Validation of Chinese Version of Positive and Negative Syndrome Scale-6 in Clinical Setting: A Preliminary Study

Objetivo: Ainda não está claro quais são os fatores de risco para a esquizofrenia resistente ao tratamento (ERT) em primeiro episódio psicótico (PEP). O objetivo deste trabalho é investigar indicadores de risco para ERT em PEP. Métodos: Foram selecionados 53 pacientes em primeiro episódio psicótico, com diagnóstico de esquizofrenia, que deram entrada à enfermaria de psiquiatria do Hospital das Clínicas Luzia de Pinho Melo entre 2011 e 2015. Ao ser admitido na enfermaria, o paciente era avaliado com a Escala de Sintomas para as Síndromes Positiva e Negativa (Positive and Negative Syndrome Scale – PANSS) e recebia tratamento inicial por 4 semanas. Caso sua resposta fosse inferior a 40% de redução na PANSS, o antipsicótico era trocado, e as escalas eram aplicadas novamente após mais 4 semanas. Após a falha com dois antipsicóticos, em doses plenas, por 4 semanas cada, a clozapina era introduzida, e o paciente era considerado ERT. Uma regressão logística foi aplicada onde sexo, idade de início, tempo de doença não tratada, uso de substâncias, avaliação global do funcionamento inicial e PANSS inicial total foram inseridos como variáveis independentes, e ERT foi inserida como variável dependente. Resultados: Tempo de doença não tratada apresentou significância de p = 0,038 e Exp (B) = 4,29, enquanto que PANSS total apresentou p = 0,012 e Exp (B) = 1,06. Conclusão: Identificar os fatores associados à resistência precoce ao tratamento poderia permitir aos clínicos evitar o atraso na introdução da clozapina e prevenir um pior prognóstico para esses pacientes.

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Obtaining employment as an anchor for estimating the minimum clinically important difference on the Positive and Negative Syndrome Scale (PANSS) in schizophrenia

Psychiatry Research ◽

10.1016/j.psychres.2016.02.018 ◽

2016 ◽

Vol 238 ◽

pp. 304-309 ◽

Cited By ~ 4

Author(s):

Meaghan A. Leddy-Stacy ◽

Robert Rosenheck

Keyword(s):

Minimum Clinically Important Difference ◽

Clinically Important Difference ◽

Syndrome Scale ◽

Negative Syndrome

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Standardized training in the rating of the six-item Positive And Negative Syndrome Scale (PANSS-6)

Schizophrenia Research ◽

10.1016/j.schres.2020.12.044 ◽

2021 ◽

Vol 228 ◽

pp. 438-446

Author(s):

Pernille Kølbæk ◽

David Dines ◽

Johanna Hansen ◽

Mark Opler ◽

Christoph U. Correll ◽

...

Keyword(s):

Syndrome Scale ◽

Negative Syndrome

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Amusia and protolanguage impairments in schizophrenia

Psychological Medicine ◽

10.1017/s0033291714000373 ◽

2014 ◽

Vol 44 (13) ◽

pp. 2739-2748 ◽

Cited By ~ 13

Author(s):

J. T. Kantrowitz ◽

N. Scaramello ◽

A. Jakubovitz ◽

J. M. Lehrfeld ◽

P. Laukka ◽

...

Keyword(s):

Cognitive Remediation ◽

Thought Disorder ◽

Musical Ability ◽

Group Status ◽

Treatment Development ◽

Discrimination Ability ◽

Syndrome Scale ◽

Language And Music ◽

Auditory Tasks ◽

Negative Syndrome

BackgroundBoth language and music are thought to have evolved from a musical protolanguage that communicated social information, including emotion. Individuals with perceptual music disorders (amusia) show deficits in auditory emotion recognition (AER). Although auditory perceptual deficits have been studied in schizophrenia, their relationship with musical/protolinguistic competence has not previously been assessed.MethodMusical ability was assessed in 31 schizophrenia/schizo-affective patients and 44 healthy controls using the Montreal Battery for Evaluation of Amusia (MBEA). AER was assessed using a novel battery in which actors provided portrayals of five separate emotions. The Disorganization factor of the Positive and Negative Syndrome Scale (PANSS) was used as a proxy for language/thought disorder and the MATRICS Consensus Cognitive Battery (MCCB) was used to assess cognition.ResultsHighly significant deficits were seen between patients and controls across auditory tasks (p < 0.001). Moreover, significant differences were seen in AER between the amusia and intact music-perceiving groups, which remained significant after controlling for group status and education. Correlations with AER were specific to the melody domain, and correlations between protolanguage (melody domain) and language were independent of overall cognition.DiscussionThis is the first study to document a specific relationship between amusia, AER and thought disorder, suggesting a shared linguistic/protolinguistic impairment. Once amusia was considered, other cognitive factors were no longer significant predictors of AER, suggesting that musical ability in general and melodic discrimination ability in particular may be crucial targets for treatment development and cognitive remediation in schizophrenia.

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Decision making under ambiguity and risk in adolescent-onset schizophrenia

BMC Psychiatry ◽

10.1186/s12888-021-03230-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Dandan Li ◽

Fengyan Zhang ◽

Lu Wang ◽

Yifan Zhang ◽

Tingting Yang ◽

...

Keyword(s):

Decision Making ◽

Executive Function ◽

Iowa Gambling Task ◽

Clinical Symptoms ◽

Healthy Controls ◽

Syndrome Scale ◽

Significant Difference ◽

Abnormal Pattern ◽

Negative Syndrome ◽

The Relationship

Abstract Objective Numerous studies have identified impaired decision making (DM) under both ambiguity and risk in adult patients with schizophrenia. However, the assessment of DM in patients with adolescent-onset schizophrenia (AOS) has been challenging as a result of the instability and heterogeneity of manifestations. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT), which are frequently used to evaluate DM respectively under ambiguity and risk, are sensitive to adolescents and neuropsychiatric patients. Our research intended to examine the performance of DM in a relatively large sample of patients with AOS using the above-mentioned two tasks. We also aimed to take a closer look at the relationship between DM and symptom severity of schizophrenia. Methods We compared the performance of DM in 71 patients with AOS and 53 well-matched healthy controls using IGT for DM under ambiguity and GDT for DM under risk through net scores, total scores and feedback ration. Neuropsychological tests were conducted in all participants. Clinical symptoms were evaluated by using Positive and Negative Syndrome Scale (PANSS) in 71 patients with AOS. Pearson’s correlation revealed the relationship among total score of DM and clinical and neuropsychological data. Results Compared to healthy controls, patients with AOS failed to show learning effect and had a significant difference on the 5th block in IGT and conducted more disadvantageous choices as well as exhibited worse negative feedback rate in GDT. Apart from DM impairment under risk, diminished DM abilities under ambiguity were found related to poor executive function in AOS in the present study. Conclusions Our findings unveiled the abnormal pattern of DM in AOS, mainly reflected under the risky condition, extending the knowledge on the performance of DM under ambiguity and risk in AOS. Inefficient DM under risk may account for the lagging impulse control and the combined effects of developmental disease. In addition, our study demonstrated that the performance on IGT was related to executive function in AOS.

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The relationship of insight with psychopathological dimensions in patients with schizophrenia

Journal of Experimental Psychopathology ◽

10.1177/20438087211019932 ◽

2021 ◽

Vol 12 (2) ◽

pp. 204380872110199

Author(s):

Si-Sheng Huang ◽

Cheng-Chen Chang

Keyword(s):

Medical Center ◽

Self Report ◽

Psychiatric Ward ◽

Neurocognitive Functions ◽

Bivariate Correlation ◽

Syndrome Scale ◽

Acute Psychiatric Ward ◽

Negative Syndrome ◽

Relationship Of ◽

The Relationship

Impaired insight in patients with schizophrenia results in less satisfactory clinical outcomes. This study was conducted to investigate the relationship between insight and individual psychopathological dimensions in inpatients with schizophrenia using a self-report questionnaire. In this study, 90 patients with schizophrenia aged 18–75 years admitted in the acute psychiatric ward of a medical center in Taiwan were enrolled. Patient insight was measured using the Self-Appraisal of Illness Questionnaire (SAIQ), and psychopathological dimensions were measured using the Positive and Negative Syndrome Scale (PANSS) and its five-factor structure model. A higher SAIQ score indicates greater insight. In bivariate correlation analyses, statistically significant correlations were observed between age, single marital status, educational level, and positive, excited, and depressed symptom factor of the PANSS and SAIQ score. In regression analyses, age and excited and depressed symptom factors were significantly associated with SAIQ score. No significant association was observed between insight and neurocognitive functions. Considering demographic characteristics, psychopathology, and neurocognition, in the acute phase of schizophrenia, younger patients with less severe excited symptoms and more severe depressive symptoms had greater insight.

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SA56. New Approaches to Evaluate Dimensions on the Positive and Negative Syndrome Scale

Schizophrenia Bulletin ◽

10.1093/schbul/sbx023.055 ◽

2017 ◽

Vol 43 (suppl_1) ◽

pp. S133-S133

Author(s):

Cinthia Higuchi ◽

Hugo Cogo-Moreira ◽

Bruno Ortiz ◽

Cristiano Noto ◽

Quirino Cordeiro ◽

...

Keyword(s):

New Approaches ◽

Syndrome Scale ◽

Negative Syndrome

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Positive and negative syndrome scale (PANSS) in geriatric schizophrenic inpatients

Biological Psychiatry ◽

10.1016/0006-3223(91)91039-t ◽

1991 ◽

Vol 29 (9) ◽

pp. 76 ◽

Cited By ~ 1

Keyword(s):

Syndrome Scale ◽

Negative Syndrome

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Sinistrality in subtypes of schizophrenia

European Psychiatry ◽

10.1016/s0924-9338(02)00677-6 ◽

2002 ◽

Vol 17 (5) ◽

pp. 272-277 ◽

Cited By ~ 15

Author(s):

Sonia Dollfus ◽

Jacqueline A. Buijsrogge ◽

Karim Benali ◽

Pascal Delamillieure ◽

Perrine Brazo

Keyword(s):

Negative Correlation ◽

Language Disorders ◽

Normal Process ◽

Deficit Syndrome ◽

Syndrome Scale ◽

Schizophrenic Patients ◽

Dsm Iv ◽

Negative Syndrome ◽

Hemisphere Specialization

SummarySinistrality, characterized by an excess of non-right-handedness, has been reported in schizophrenic patients, but the findings are controversial.Aim.As sinistrality could be linked to a failure of hemisphere specialization in schizophrenia that would translate into language disorders, sinistrality was found out in disorganized and positive schizophrenic patients characterized by language disorders.Methods.Seventy-three schizophrenic patients (DSM IV) and 81 controls were evaluated with the Edinburgh Handedness Inventory (EHI). Patients were evaluated and classified into five subtypes (deficit, positive, disorganized, mixed and residual) with the Positive and Negative Syndrome Scale and the Schedule for the Deficit Syndrome.Results.Disorganized patients had a significantly more severe sinistrality in comparison to the deficit, residual and mixed subtypes and controls. A negative correlation was found between the disorganization and the EHI scores (r = – 0.34; P < 0.01). A significantly more severe sinistrality was also observed in the positive subtype in comparison to controls, but there was no correlation between hallucinatory and EHI scores (r = 0.06).Conclusion.The findings provided further evidence that the defects in the normal process of lateralization observed in schizophrenia affects primarily disorganized patients.

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