Effectiveness of leukotriene receptor antagonists in the treatment for atopic pathology in children

Objective: to study the effectiveness of leukotriene receptor antagonists in the treatment foratopic pathology in children.Material and methods. 224 children with allergic diseases were prescribed to take montelucast for 3– 6 months.Results. Taking montelucast has lead to positive clinical dynamics in 75 % of the cases.A significant reduction of the eosinophil count was achieved on days 10–15 of the therapy. The Cys-LTC4/D4/E4 indices came to normal after a one-month course of montelucast therapy in 40.3 % of cases in children with bronchial asthma, in 63.3 % of cases in children with allergic rhinitis and in 60.5 % of cases in children with atopic dermatitis.Conclusions. The use of montelucast has significantly enhanced the control incidencerate ofallergic diseases in children.

APPLICATION OF VITAMIN D IN DIFFERENT DOSAGE TO TREAT CHILDREN WITH ALLERGIC DISEASES

Wiadomości Lekarskie ◽

10.36740/wlek202007114 ◽

2020 ◽

Vol 73 (7) ◽

pp. 1377-1383

Author(s):

Olexandra V. Tiazhka ◽

Zoriana V. Selska

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Blood Serum ◽

Bronchial Asthma ◽

Vitamin D3 ◽

Allergic Diseases ◽

Acute Disease ◽

Disease Remission ◽

Significant Difference ◽

Different Doses

The aim: To study the dynamics of the level of 25(ОН)D, ІL-4, ІL-10, and IgG in the blood serum of children with allergic diseases and to study the clinical effect of vitamin D3 administration n different dosage in this category of patients. Materials and methods: 153 children aged 3-16 with such allergic diseases as bronchial asthma, atopic dermatitis and allergic rhinitis have been examined. The level of 25(ОН) D was determined using the electrochemiluminescence method, while the levels of ІL-4, ІL-10 and IgG were assessed using enzyme-linked immunoassay. Results: In the contrasting of the initial level of 25(ОН)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higher doses (4,000–5,000 IU) over 2 months, significant difference was established between the indicators by the Friedman criterion (λ2 = 41.211; P < 0.05). In the similar contrasting of ІL-4 indicators, a significant difference between them was traced (P < 0.05) in the period of acute disease as well as the downward tendency in the period of remission. In the similar contrasting of ІL-10 indicators, a significant difference between them was traced (P < 0.05) in the acute period and in the period of disease remission. In the similar contrasting of IgG indicators, a downward tendency was traced in the period of acute disease and significant decrease (P < 0.05) – in the period of disease remission. In the contrasting of 25(ОН)D and ІL-4, ІL-10 figures a strong reverse correlation relationship was traced. The therapeutic effect of the administration of vitamin D3 medication in different doses in children with allergic diseases was traced. Conclusions: The data obtained shows that in the treatment of children with bronchial asthma, allergic rhinitis and atopic dermatitis the complex therapy should include vitamin D3 medications in different doses within a long-term course of treatment.

Leukotriene receptor antagonists are not as effective as intranasal corticosteroids for managing nighttime symptoms of allergic rhinitis

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2005.03.045 ◽

2005 ◽

Vol 116 (2) ◽

pp. 463-464 ◽

Cited By ~ 2

Author(s):

Robert A. Nathan

Keyword(s):

Allergic Rhinitis ◽

Receptor Antagonists ◽

Intranasal Corticosteroids ◽

Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis

Clinical & Experimental Allergy ◽

10.1111/j.1365-2222.2001.00964.x ◽

2001 ◽

Vol 31 (1) ◽

pp. 61-68 ◽

Cited By ~ 58

Author(s):

A. M. Wilson ◽

L. C. Orr ◽

E. J. Sims ◽

B. J. Lipworth

Keyword(s):

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Receptor Antagonists ◽

Topical steroids are better than leukotriene receptor antagonists at relieving nasal symptoms of seasonal allergic rhinitis

BMJ ◽

10.1136/bmj.333.7561.0-e ◽

2006 ◽

Vol 333 (7561) ◽

Keyword(s):

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Topical Steroids ◽

Receptor Antagonists ◽

Nasal Symptoms ◽

Leukotriene Receptor ◽

Better Than

Correlation between Total Serum Immunoglobulin E (IgE) and Absolute Eosinophil Count (AEC) in Allergic Diseases In Children

VIMS Health Science Journal ◽

10.46858/vimshsj.7102 ◽

2020 ◽

Vol 7 (1) ◽

pp. 5-9

Author(s):

Dr. Mayank Surana ◽

Dr. Vineeta Pande ◽

Dr. Sharad Agarkhedkar ◽

Dr. Ajit Teegala

Keyword(s):

Atopic Dermatitis ◽

Bronchial Asthma ◽

Eosinophil Count ◽

Immunoglobulin E ◽

Allergic Diseases ◽

Total Ige ◽

Serum Ige ◽

Absolute Eosinophil Count ◽

Serum Total Ige ◽

Total Immunoglobulin

Allergy, is a clinical expression of soluble factors like IgE, histamine or eosinophils found in serum or plasma of such patients. The products that are responsible for allergy are called as Allergens. Allergens normally induce IgE production which leads to type 1 hypersensitivity response on subsequent exposure to the same allergen. The target organs are mostly nose, lung, skin and gastrointestinal tract. Atopy is also considered as a triad of Atopic dermatitis, allergic rhinitis and bronchial asthma. Raised serum IgE and AEC are proven indicators of allergic phenomenon. Various studies show relationship between serum Immunoglobulin E level and total eosinophil count in population suffering from allergic diseases. Serum total Immunoglobulin E, total eosinophil count and specific IgE are all helpful for the diagnosis and treatment of allergic diseases. Objectives: 1.To Evaluate Serum Total IgE level in Children with allergic diseases.2. To Evaluate Absolute Eosinophil Count (AEC) in children with allergic diseases.3. To Correlate Serum Total Immunoglobulin E Level and Absolute Eosinophil Count (AEC) with allergic diseases. Methodology: Cross sectional study with 100 children in the age group 2-12 years with nasopharyngeal allergies (like bronchial asthma and atopic rhinitis) and skin allergies (like atopic dermatitis, urticaria) ,eye allergies were enrolled and serum IgE levels and AEC levels was done. Results: In present study Absolute eosinophil count was raised in 58% of cases Serum IgE was raised in 54% of cases. In present study, of 58% cases with raised Absolute eosinophil count 81% (47 cases) showed raised serum IgE levels. Conclusion: Absolute eosinophil count and serum Total IgE has been considered as a significant marker of allergic state and can be used as a marker of allergic response in atopic individuals. Raised serum IgE and AEC are more in nasobronchial allergy as compare to other systemic allergies. The elevated level of serum Total IgE and Absolute Eosinophil Count both shows Significant Correlation thus can be considered as a dependable laboratory investigation in diagnosing and categorizing allergic diseases.

Exploring the role of leukotriene receptor antagonists in the management of allergic rhinitis and comorbid asthma

Clinical & Experimental Allergy Reviews ◽

10.1046/j.1472-9725.2003.00017.x ◽

2003 ◽

Vol 3 (2) ◽

pp. 74-80 ◽

Cited By ~ 7

Author(s):

R. Pawankar

Keyword(s):

Allergic Rhinitis ◽

Receptor Antagonists ◽

The Role of Interleukin-37 in the Pathogenesis of Allergic Diseases

Acta Naturae ◽

10.32607/20758251-2019-11-4-54-64 ◽

2019 ◽

Vol 11 (4) ◽

pp. 54-64

Author(s):

I. P. Shilovskiy ◽

M. E. Dyneva ◽

O. M. Kurbacheva ◽

D. A. Kudlay ◽

M. R. Khaitov

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

Interleukin 1 ◽

Allergic Diseases ◽

Biological Properties ◽

Negative Regulator ◽

Cellular Mechanisms ◽

Wide Range

Cytokines of the interleukin-1 (IL-1) family play an important role in the realization of the protective functions of innate immunity and are the key mediators involved in the pathogenesis of a wide range of diseases, including various manifestations of allergy. The IL-1 family includes more than 11 members. However, the functions of many of them remain to be elucidated. Recently, new members of the IL-1 family have been discovered. In 2000, several independent research groups reported the discovery of a new interleukin of this family, which was named IL-37, or IL-1F7 (according to the new nomenclature). IL-37 was assigned to the IL-1 family based on its structural similarity with other members of this family. The study of its biological properties showed that its activity changes in inflammatory diseases, such as rheumatoid arthritis, psoriasis, as well as allergic diseases (allergic rhinitis, bronchial asthma, and atopic dermatitis). However, unlike most members of the IL-1 family, IL-37 acts as a negative regulator of inflammation. Activation of IL-37 suppresses inflammation, resulting in the suppression of inflammatory cytokines and chemokines, which in turn prevents infiltration of pro-inflammatory cells, mainly eosinophils and neutrophils. The exact molecular and cellular mechanisms of the anti-inflammatory effect of IL-37 in the development of allergic diseases (AD) have not been fully studied. This review summarizes and analyzes the accumulated experimental data on the role of IL-37 in the pathogenesis of AD, such as allergic rhinitis, bronchial asthma, and atopic dermatitis.