scholarly journals APPLICATION OF VITAMIN D IN DIFFERENT DOSAGE TO TREAT CHILDREN WITH ALLERGIC DISEASES

2020 ◽  
Vol 73 (7) ◽  
pp. 1377-1383
Author(s):  
Olexandra V. Tiazhka ◽  
Zoriana V. Selska
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Vitamin D3 ◽  
Allergic Diseases ◽  
Acute Disease ◽  
Disease Remission ◽  
Significant Difference ◽  
Different Doses

The aim: To study the dynamics of the level of 25(ОН)D, ІL-4, ІL-10, and IgG in the blood serum of children with allergic diseases and to study the clinical effect of vitamin D3 administration n different dosage in this category of patients. Materials and methods: 153 children aged 3-16 with such allergic diseases as bronchial asthma, atopic dermatitis and allergic rhinitis have been examined. The level of 25(ОН) D was determined using the electrochemiluminescence method, while the levels of ІL-4, ІL-10 and IgG were assessed using enzyme-linked immunoassay. Results: In the contrasting of the initial level of 25(ОН)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higher doses (4,000–5,000 IU) over 2 months, significant difference was established between the indicators by the Friedman criterion (λ2 = 41.211; P < 0.05). In the similar contrasting of ІL-4 indicators, a significant difference between them was traced (P < 0.05) in the period of acute disease as well as the downward tendency in the period of remission. In the similar contrasting of ІL-10 indicators, a significant difference between them was traced (P < 0.05) in the acute period and in the period of disease remission. In the similar contrasting of IgG indicators, a downward tendency was traced in the period of acute disease and significant decrease (P < 0.05) – in the period of disease remission. In the contrasting of 25(ОН)D and ІL-4, ІL-10 figures a strong reverse correlation relationship was traced. The therapeutic effect of the administration of vitamin D3 medication in different doses in children with allergic diseases was traced. Conclusions: The data obtained shows that in the treatment of children with bronchial asthma, allergic rhinitis and atopic dermatitis the complex therapy should include vitamin D3 medications in different doses within a long-term course of treatment.

scholarly journals The Role of Interleukin-37 in the Pathogenesis of Allergic Diseases

Acta Naturae ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 54-64
Author(s):  
I. P. Shilovskiy ◽  
M. E. Dyneva ◽  
O. M. Kurbacheva ◽  
D. A. Kudlay ◽  
M. R. Khaitov
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Interleukin 1 ◽  
Allergic Diseases ◽  
Biological Properties ◽  
Negative Regulator ◽  
Cellular Mechanisms ◽  
Wide Range

Cytokines of the interleukin-1 (IL-1) family play an important role in the realization of the protective functions of innate immunity and are the key mediators involved in the pathogenesis of a wide range of diseases, including various manifestations of allergy. The IL-1 family includes more than 11 members. However, the functions of many of them remain to be elucidated. Recently, new members of the IL-1 family have been discovered. In 2000, several independent research groups reported the discovery of a new interleukin of this family, which was named IL-37, or IL-1F7 (according to the new nomenclature). IL-37 was assigned to the IL-1 family based on its structural similarity with other members of this family. The study of its biological properties showed that its activity changes in inflammatory diseases, such as rheumatoid arthritis, psoriasis, as well as allergic diseases (allergic rhinitis, bronchial asthma, and atopic dermatitis). However, unlike most members of the IL-1 family, IL-37 acts as a negative regulator of inflammation. Activation of IL-37 suppresses inflammation, resulting in the suppression of inflammatory cytokines and chemokines, which in turn prevents infiltration of pro-inflammatory cells, mainly eosinophils and neutrophils. The exact molecular and cellular mechanisms of the anti-inflammatory effect of IL-37 in the development of allergic diseases (AD) have not been fully studied. This review summarizes and analyzes the accumulated experimental data on the role of IL-37 in the pathogenesis of AD, such as allergic rhinitis, bronchial asthma, and atopic dermatitis.

scholarly journals Effectiveness of leukotriene receptor antagonists in the treatment for atopic pathology in children

2020 ◽  
pp. 38-42
Author(s):  
A. I. Zariankina ◽  
M. Kh. Mirrakhimova ◽  
E. R. Shamsieva
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Eosinophil Count ◽  
Allergic Diseases ◽  
Receptor Antagonists ◽  
Leukotriene Receptor Antagonists ◽  
Leukotriene Receptor

Objective: to study the effectiveness of leukotriene receptor antagonists in the treatment foratopic pathology in children.Material and methods. 224 children with allergic diseases were prescribed to take montelucast for 3– 6 months.Results. Taking montelucast has lead to positive clinical dynamics in 75 % of the cases.A significant reduction of the eosinophil count was achieved on days 10–15 of the therapy. The Cys-LTC4/D4/E4 indices came to normal after a one-month course of montelucast therapy in 40.3 % of cases in children with bronchial asthma, in 63.3 % of cases in children with allergic rhinitis and in 60.5 % of cases in children with atopic dermatitis.Conclusions. The use of montelucast has significantly enhanced the control incidencerate ofallergic diseases in children.

scholarly journals Features of sensitization to widespread allergens in residents of St. Petersburg and the Leningrad region with common allergic deseases

2013 ◽  
Vol 10 (4) ◽  
pp. 74-80
Author(s):  
O V Aak ◽  
A V Sobolev
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Leningrad Region ◽  
Food Allergens ◽  
Significant Similarity ◽  
High Degree

Background. To identify differences in sensitization to widespread allergens in patients with common allergic diseases: allergic rhinitis, bronchial asthma, angioedema, allergic urticaria and atopic dermatitis. Materials and methods. Determination of sIgE in serum using commercial and domestic reagent kits («AllergoI-FA-specific IgE» and biotinylated allergens of «Alcor Bio», St. Petersburg) was conducted in patients with allergic rhinitis, bronchial asthma, angioedema, allergic urticaria and atopic dermatitis. Results. There was a significant similarity between the spectrum of sensitization in patients with allergic rhinitis and asthma In atopic dermatitis patients the increasing of frequency of food and especially mold sensitization was estimated. The high degree of correlation between the moulds, plants and food allergens in atopic dermatitis was observed. Conclusion. The results obtained in the study can be interesting for physicians in allergological examination and for the researchers to identify new cross-reactive allergens.

scholarly journals Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

2018 ◽  
Vol 17 (2) ◽  
pp. 114-120
Author(s):  
E. E. Varlamov ◽  
A. N. Pampura ◽  
A. N. Asmanov
Keyword(s):  
Allergic Rhinitis ◽  
Early Childhood ◽  
Atopic Dermatitis ◽  
Primary Prevention ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
The State ◽  
Older Age ◽  
Epidermal Barrier ◽  
Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

scholarly journals Allergic march in children of Ukraine

2021 ◽  
Vol 26 (4) ◽  
pp. 181-188
Author(s):  
О.P. Volosovets  ◽  
Yu.K. Bolbot ◽  
G.V. Beketova ◽  
V.S. Berezenko ◽  
T.R. Umanets ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
School Age Children ◽  
Steady Increase ◽  
The Past ◽  
Number Of Factors ◽  
Allergic March ◽  
Analyze Data

Allergic diseases, which have a certain stage in their development from food allergy to bronchial asthma / allergic rhinitis, are much more common in children than in adults. The aim of this study was to analyze data on the prevalence and incidence of atopic dermatitis, bronchial asthma and allergic rhinitis as components of the allergic march, in children of Ukraine from 1994 to 2017 to determine the possible impact of adverse environmental factors on their development. During the same period, due to the influence of a number of factors, in particular environmental, there were significant changes in the structure of allergic diseases making up the stages of the allergic march due to an increase in the proportion of allergic rhinitis with the reduced one of asthma and atopic dermatitis. Within 24 years, the incidence of atopic dermatitis in children aged 0-6 years including, increased by 27.6%, in adolescents - by 40.5% and significantly decreased by 39.5% in children aged 7-14 years including. Most cases of allergic rhinitis and bronchial asthma were observed in schoolchildren (47.6 and 54.0%, respectively) with a slight decrease compared to 1994. In general, allergic diseases in recent years have become more common in children from 0 to 6 years and their detection has decreased in school-age children and adolescents. Over the past 24 years, in children of Ukraine a steady increase in the incidence and prevalence of allergic diseases that form an allergic march has been noted: the prevalence of bronchial asthma has increased by 69.3% and the incidence has increased by 22.9%; the prevalence of atopic dermatitis increased by 43.9% and the incidence increased by 8.3%; the prevalence of allergic rhinitis increased by 488.3% and the incidence of allergic rhinitis increased by 380.3%, with a predominance of detection of this pathology in children from regions with developed infrastructure and industry, where there are significant emissions of pollutants into the atmosphere, that have a direct moderate effect on the increase in the prevalence of bronchial asthma, the incidence and prevalence of allergic rhinitis in children.

scholarly journals Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata

2017 ◽  
Vol 5 (3) ◽  
pp. 305-309 ◽  
Author(s):  
Javad Ghaffari ◽  
Ghasem Rahmatpour Rokni ◽  
Armaghan Kazeminejad ◽  
Hosein Abedi
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Alopecia Areata ◽  
Allergic Diseases ◽  
Control Group ◽  
Case Group ◽  
Control Groups ◽  
Significant Difference ◽  
History Of ◽  
And Control

BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals.METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group. Participants filled the questionnaires, and necessary tests were performed.RESULTS: In this study, the mean age of the participants was 2.55 ± 14.26 and 3.19 ± 11.92 in the case and control groups, respectively. Prevalence of asthma was 22% in the case group and 12.5% in control group (P = 0.109). Also, allergic rhinitis and eczema were observed in 20% and 22% of the subjects of the case group, whereas they were reported to be 8% and 10% in the control group (PV = 0.03 and 0.175, respectively). Moreover, 28% and 8% of the participants in the case and control groups had a family history of atopy and allergic disorders, respectively (P = 0.046). A significant difference was observed between the two groups regarding gender, type of delivery and contact with animals.CONCLUSIONS: According to the results of this study, a significant association was observed between the prevalence of alopecia areata and atopic conditions, such as allergic rhinitis and history of atopic dermatitis.

scholarly journals Asthma, Allergic Rhinitis, and Atopic Dermatitis Incidence in Korean Adolescents before and after COVID-19

2021 ◽  
Vol 10 (15) ◽  
pp. 3446
Author(s):  
Hyo Geun Choi ◽  
Il Gyu Kong
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Economic Status ◽  
Allergic Diseases ◽  
P Value ◽  
Adolescent Risk Behavior ◽  
Adolescent Risk ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
Before And After

With changes in personal habits (masks and handwashing) during the COVID-19 outbreak, the study analyzed the reporting of physician-diagnosed cases (incidence) of allergic diseases (asthma, allergic rhinitis, and atopic dermatitis) using the data for years 2019 and 2020 from the Korean adolescent risk behavior web-based survey (KYRBWS-15 and 16). Altogether, 92,659 adolescents (48,443 in 2019 and 44,216 in 2020) were enrolled. The crude and adjusted odd ratios (ORs) were calculated for each disease in 2020 compared to that in 2019 using multiple logistic regression. Subgroup analyses were performed according to sex and economic status. The incidence of asthma decreased from 1.5% in 2019 to 1.0% 2020 (p < 0.001). The incidence of allergic rhinitis in 2019 and 2020 was 19.5% and 16.3%, respectively (p < 0.001). Compared with 2019, the adjusted OR (aOR) in 2020 was 0.68 (95% CI = 0.66–0.77, p value < 0.001) for asthma and 0.82 (95% CI = 0.78–0.85, p < 0.001) for allergic rhinitis. In contrast, there was no statistically significant difference between the incidence of atopic dermatitis in 2019 and that in 2020 (6.4%, vs. 6.4%, p > 0.05, respectively). Subgroup analyses results were consistent. In conclusion, there was decrease in the incidence of asthma and allergic rhinitis but not in that of atopic dermatitis from 2019 to 2020.

scholarly journals PREVALENCE OF ALLERGIC DISEASES SYMPTOMS AMONG CHILDREN OF THE GRODNO REGION (REPUBLIC OF BELARUS)

2014 ◽  
Vol 11 (5) ◽  
pp. 46-50
Author(s):  
R N Khokha
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
International Study ◽  
Allergic Diseases ◽  
School Students ◽  
Russian Version ◽  
Childhood Program ◽  
Asthma And Allergy

Background. To study the prevalence of symptoms of allergic diseases among school students of the Grodno region (Republic of Belarus). Methods. Researches conducted a questioning method by means of the Russian version of the standardized «International Study of Asthma and Allergy in Childhood» program (ISAAC). Results. Results of questioning of 1787 schoolchildren showed that the wheezing, within the last 12 months was registered in 9,3% of children of the first classes (DI: 7,5-11,5%) and in 9,1% of children of the eighth classes (DI: 7,5-11%), rhinitis symptoms without cold or flu - in 29,7% of children of the first classes (DI: 26,7-32,85%) and in 47,2% of children of the eighth classes (DI: 44-50%), symptoms of atopic dermatitis - in 8,2% of children of the first classes (DI: 6,6-10%) and in 1,9% of children of the eighth classes (DI: 1-2,97%). Frequency of clinically verified diagnosis of bronchial asthma at schoolchildren at the age of 6-7 y.o. and at the age of 13-14 y.o. was 3,9% (DI: 3-4,9%), allergic rhinitis - 5,6% (DI: 4,6-6,8%), atopic dermatitis - 6,2% (DI: 5,2-7%). Conclusion. Results of the study confirm the need of carrying out further epidemiological researches for the purpose of earlier identification of patients with allergic diseases.

scholarly journals Evolution of bronchial obstruction pattern in children of presсhool age

2021 ◽  
pp. 57-65
Author(s):  
A. I. Markovskaya ◽  
N. L. Potapova ◽  
I. N. Gaymolenko
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Bronchial Obstruction ◽  
Prediction Tool ◽  
Palatine Tonsils ◽  
One Year ◽  
Significant Factors

Introduction. The diagnosis of asthma presents objective difficulties in children aged less than 5 years. Not all children with recurrent virus-induced obstruction can further develop asthma.Aim. To assess the realization of different clinical and pathogenetic variants of bronchoobstructive syndrome in the child population.Materials and methods. Risk factors of 75 patients with bronchoobstructive syndrome in the first 5 years of life were retrospectively evaluated. 57 patients were surveyed using the “Asthma Prediction Tool” questionnaire. At the end of the follow-up period (one year), cases of bronchial asthma were evaluated.Results. A predictive contribution to the implementation of the recurrent variant of bronchoobstructive syndrome has a burdened hereditary allergic anamnesis (OR=5,4, CI 1,79-16,46, p<0,05) and the presence of atopic dermatitis (OR=7,7, CI 2,73-21,95, p><0,05). Symptoms of allergic rhinitis in combination with hypertrophy of the Palatine tonsils in 6,06 and 3,45 times, respectively, increase the risk of bronchial asthma (p><0.05). Conclusion. As a result of research, there are significant factors in the implementation of bronchial asthma such as concomitant allergic diseases in combination with a hereditary background and hypertrophy of the palatine tonsils. The>˂ 0,05) and the presence of atopic dermatitis (OR=7,7, CI 2,73-21,95, p˂ 0,05). Symptoms of allergic rhinitis in combination with hypertrophy of the Palatine tonsils in 6,06 and 3,45 times, respectively, increase the risk of bronchial asthma (p˂ 0.05).Conclusion. As a result of research, there are significant factors in the implementation of bronchial asthma such as concomitant allergic diseases in combination with a hereditary background and hypertrophy of the palatine tonsils. The “Asthma Prediction Tool” questionnaire allows you to predict the development of bronchial asthma in patients with episodic and recurrent bronchial obstruction. The article will be useful for both pediatricians and primary care professionals, as it allows to rationally influence the risks of bronchial asthma formation. 

scholarly journals Prevalence of bronchial asthma, allergic rhinitis, atopic dermatitis in children in Lesnoy area of Sverdlovsk region

2012 ◽  
Vol 9 (3) ◽  
pp. 14-17
Author(s):  
N A Volkova ◽  
E K Beltyukov
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Age Groups ◽  
International Study ◽  
Allergic Diseases ◽  
Preschool Age ◽  
Atopic Diseases ◽  
Younger Age ◽  
Further Development

A research of prevalence of allergic diseases in children from 0 to 6 years has been carried out using a standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC) in town Lesnoy in 2010. Background. To define the prevalence and structure of atopic diseases in different age groups in children of preschool age in town Lesnoy. Methods. Standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC). Results. Formation of atopic march is defined, in early age — atopic dermatitis and later respiratory form of allergy. Conclusion. Treatment of atopic dermatitis as risk factor of further development of allergic rhinitis and bronchial asthma can promote preventive maintenance of respiratory forms of allergy in children of younger age.

Sign in / Sign up

Export Citation Format

Share Document