What are the significant factors associated with adjacent segment disease in short-segment lumbar spinal fusion? A retrospective cohort analysis of cases with at least 2 years of follow-up at a single center, 2005–2015

Background: Anterior cervical discectomy and fusion (ACDF) has been widely performed to treat cervical generative diseases. Cage subsidence is a complication after ACDF. Although it is known that segmental kyphosis, acceleration of adjacent segmental disease, and restenosis may occur due to cages subsidence; however detailed research comparing zero-profile cages (ROI-C) and conventional plate and cage construct (CPC) on cage subsidence has been lacking.Objective: The objectives of this study was to compare the rate of postoperative cage subsidence between zero profile anchored spacer (ROI-C) and conventional cage and plate construct (CPC) and investigate the risk factors associated with cage subsidence following ACDF.Methods: Seventy-four patients with ACDF who received either ROI-C or CPC treatment from October 2013 to August 2018 were included in this retrospective cohort study. Clinical and radiological outcomes and the incidence of cage subsidence at final follow up-were compared between groups. All patients were further categorized into the cage subsidence (CS) and non-cage subsidence (NCS) groups for subgroup analysis.Results: The overall subsidence rate was higher in the ROI-C group than in the CPC group (66.67 vs. 38.46%, P = 0.006). The incidence of cage subsidence was significantly different between groups for multiple-segment surgeries (75 vs. 34.6%, P = 0.003), but not for single-segment surgeries (54.55 vs. 42.30%, P = 0.563). Male sex, operation in multiple segments, using an ROI-C, and over-distraction increased the risk of subsidence. Clinical outcomes and fusion rates were not affected by cage subsidence.Conclusion: ROI-C use resulted in a higher subsidence rate than CPC use in multi-segment ACDF procedures. The male sex, the use of ROI-C, operation in multiple segments, and over-distraction were the most significant factors associated with an increase in the risk of cage subsidence.

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Risk Factors Associated with Default from Multi- and Extensively Drug-Resistant Tuberculosis Treatment, Uzbekistan: A Retrospective Cohort Analysis

PLoS ONE ◽

10.1371/journal.pone.0078364 ◽

2013 ◽

Vol 8 (11) ◽

pp. e78364 ◽

Cited By ~ 12

Author(s):

Maeve K. Lalor ◽

Jane Greig ◽

Sholpan Allamuratova ◽

Sandy Althomsons ◽

Zinaida Tigay ◽

...

Keyword(s):

Risk Factors ◽

Retrospective Cohort ◽

Cohort Analysis ◽

Tuberculosis Treatment ◽

Drug Resistant ◽

Drug Resistant Tuberculosis ◽

Factors Associated ◽

Resistant Tuberculosis ◽

Extensively Drug Resistant ◽

Retrospective Cohort Analysis

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Case Report and Cohort Analysis of Drug-Induced Liver Injury Associated with Daptomycin

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.03157-14 ◽

2014 ◽

Vol 58 (8) ◽

pp. 4902-4903 ◽

Cited By ~ 8

Author(s):

Nicole Bohm ◽

Charles Makowski ◽

Mario Machado ◽

Adam Davie ◽

Nelson Seabrook ◽

...

Keyword(s):

Case Report ◽

Liver Injury ◽

Retrospective Cohort ◽

Cohort Analysis ◽

Single Center ◽

Drug Induced ◽

Drug Induced Liver Injury ◽

Retrospective Cohort Analysis ◽

Creatinine Kinase Level

ABSTRACTA patient receiving daptomycin developed asymptomatic transaminitis and hyperbilirubinemia without concurrent multiorgan dysfunction or elevation of his creatinine kinase level. After ruling out other etiologies, the liver injury was attributed to daptomycin and was subsequently resolved. A single-center retrospective cohort analysis of baseline and follow-up liver function panels (n= 614) from all admissions from 2008 to 2013 during which daptomycin was administered did not reveal any other cases of probable or definite drug-induced liver injury associated with daptomycin.

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EFFECTS ON ADJACENT SEGMENT AFTER MINIMUM FIVE-YEARS FOLLOWING INSTRUMENTED LUMBAR SPINAL FUSION IN INDIAN POPULATION

10.36106/gjra/6811205 ◽

2020 ◽

pp. 132-135

Author(s):

Yogesh Kishorkant Pithwa

Keyword(s):

Spinal Fusion ◽

Lumbar Lordosis ◽

Indian Population ◽

Lower Limbs ◽

Walking Distance ◽

Adjacent Segment ◽

Lumbar Spinal Fusion ◽

Time Of Surgery ◽

Lumbar Spinal

Adjacent segment degeneration [ASD] after instrumented lumbar spinal fusion has been studied extensively in non-Indian population. Present study attempts to evaluate incidence of and factors predisposing to ASD in the Indian population. This was a retrospective study with the inclusion criteria being: patients who underwent lumbar spinal fusion for spondylolisthesis, trauma, infection or deformity with a minimum five-year follow-up. Exclusion criteria: postoperative iatrogenic surgical-site infections, revision surgeries, postoperative implant failure and pseudarthrosis. Radiographs reviewed immediate postoperatively, and at final follow-up. Global lumbar lordosis from L1-S1; and angulation and translation of spinal motion segment immediately adjacent [cranial and caudal] to fused segment were studied. ASD was defined using White and Panjabi’s criteria. At final follow-up, VAS for lower back as well as lower limbs was noted separately along with walking distance. Twenty patients [49.4+17.4years] included [six males, fourteen females]. ASD was seen in 13 of 20 [65%] patients. Age>50years at the time of surgery and global lumbar lordosis <40° in the immediate postoperative period were identified as significant risk factors for ASD [p=0.02 and 0.03, respectively]. However, no significant correlation was noted between development of ASD and extension of fusion to sacrum. Nor was there any correlation between ASD and gender or length of fusion. It was also notable that no significant differences were identified in VAS scores and walking distance between patients with and without ASD. To conclude, among the various factors studied, age>50years at the time of surgery and immediate postoperative global lumbar lordosis <400 were significantly associated with development of ASD after a minimum follow-up of five years.

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High risk of loss to follow-up among South African children on ART during transfer, a retrospective cohort analysis with community tracing

Journal of the International AIDS Society ◽

10.7448/ias.20.1.21748 ◽

2017 ◽

Vol 20 (1) ◽

pp. 21748 ◽

Cited By ~ 5

Author(s):

Chloe A. Teasdale ◽

Nonzwakazi Sogaula ◽

Katharine A. Yuengling ◽

Zachary J. Peters ◽

Anthony Mutiti ◽

...

Keyword(s):

High Risk ◽

South African ◽

Retrospective Cohort ◽

Cohort Analysis ◽

Loss To Follow Up ◽

African Children ◽

Retrospective Cohort Analysis ◽

South African Children

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Characterising double frequent users in an emergency department

Journal of Hospital Administration ◽

10.5430/jha.v7n3p35 ◽

2018 ◽

Vol 7 (3) ◽

pp. 35 ◽

Cited By ~ 3

Author(s):

Annelie Raidla ◽

Katrin Dárro ◽

Tobias Carlson ◽

Eric Carlström

Keyword(s):

Mental Health ◽

Alcohol Abuse ◽

Retrospective Cohort ◽

Primary Outcome ◽

Cohort Analysis ◽

Health Conditions ◽

Frequent Users ◽

Mental Health Conditions ◽

Retrospective Cohort Analysis

Visits by frequent users (FUs) has been suggested as one reason for crowding in emergency departments (EDs). In this article, we identified the characteristics of double frequent users (DFUs), ≥ 8 visits during 12 months in an ED during a period of six years, in one ED in Western Sweden. The primary outcome was to characterise DFUs and find common reasons for repeatedly visiting the ED. We conducted a retrospective cohort analysis on register data covering six years of all visits. The DFUs share of all visitors to the ED was not more than 0.03% (144 individuals), but their share of visits was 2.4% (1,017 visits/year). Chest pain and abdominal pain were the most common complaints. A typical DFU is male, around 50-year-old, unemployed, non-immigrant, suffering from alcohol abuse and/or mental health conditions. The results point to the need for changing strategies in ED services towards DFUs suffering from alcohol abuse and/or mental health conditions. The ED prioritises the severely ill but lacks resources and continuity for handling chronic diseases and follow-up routines.

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