scholarly journals A case of idiopathic nephrotic syndrome treated with the homeopathic therapeutic

2021 ◽  
Vol 8 (26) ◽  
pp. 26-32
Author(s):  
Luiz Figueira Pinto
Keyword(s):  
Nephrotic Syndrome ◽  
White Woman ◽  
Idiopathic Nephrotic Syndrome ◽  
Valuable Resource ◽  
Clinical Protocol ◽  
High Dilution ◽  
Dialysis Treatment ◽  
Palabras Clave ◽  
Apis Mellifica ◽  
Renal Ablation

Nephrotic syndrome is a chronic clinical condition and drugs used in its treatment may result in severe side-effects. Renal transplantation or renal ablation and subsequent chronic dialysis treatment may be the only feasible way to patients. The present article reports the case of a 23-years-old white woman that presented nephrotic syndrome and was successfully treated with homeopathic medicines. Six kind of homeopathic diagnoses were made to build the clinical homeopathic picture of the patient and to determine the appropriate medicines, according to the clinical protocol used. Apis mellifica was the main medicine used to treat the diathesis sycosis. The satisfactory treatment outcome shows that the judicious homeopathic therapeutic may be a valuable resource in the treatment of nephrotic syndrome. Keywords: Nephrotic syndrome; Clinical protocol; Diathesis; Sycosis; Homeopathy   Um caso de síndrome nefrótica idiopática tratada com terapéutica homeopática. Resumo A síndrome nefrótica é uma condição clínica crônica. Os fármacos utilizados em seu tratamento podem produzir severos efeitos colaterais. O transplante ou a ablação renal, com a necessidade posterior de diálise, as vezes é a única alternativa real de tratamento. Este artigo descreve o caso de um paciente de 23 anos de idade portador de síndrome nefrótica. Foram realizados 6 diagnósticos homeopáticos para construir um quadro clínico homeopático do paciente e determinar os medicamentos homeopáticos, bem como o protocolo terapéutico. Apis mellifica foi o principal medicamento utilizado para tratar a diástesis sicótica. Os resultados terapéuticos foram satisfatórios e indicam que uma terapéutica homeopática racional pode ser um valioso recurso no tratamento da síndrome nefrótica. Palavras-chave: Síndrome nefrótica; Protocolo clínico; Diatese; Sicose; Homeopatia.   Un caso de síndrome nefrotico idiopatico tratado con terapeutica homeopatica Resumen El síndrome nefrótico es una condición clínica crónica; los fármacos utilizados en su tratamiento pueden producir severos efectos colaterales. El trasplante o ablación renal, con la necesidad posterior de diálisis, a veces es la única alternativa real de tratamiento. Este artículo describe el caso de una paciente de 23 años de edad portadora de síndrome nefrótico; 6 diagnósticos homeopáticos fueron realizados para construir el cuadro clínico homeopático de la paciente y determinar los medicamentos homeopáticos, como prescripto por el protocolo terapéutico utilizado. Apis mellifica fue el principal medicamento utilizado para tratar la diátesis sicótica. Los resultados terapéuticos favorables muestran que una terapéutica homeopática racional puede ser un recurso valioso en el tratamiento del síndrome nefrótico. Palabras-clave: Síndrome nefrótico; Protocolo clínico; Diatese; Sicose; Homeopatia   Correspondence author: Luiz Figueira Pinto, [email protected] How to cite this article: Pinto LF. A case of idiopathic nephrotic syndrome treated with the homeopathic therapeutic. Int J High Dilution Res [online]. 2009 [cited YYYY Mmm dd]; 8(26):26-32. Available from: http://journal.giri-society.org/index.php/ijhdr/article/view/302/382.  

RNA expression as a prognostic tool in idiopathic nephrotic syndrome

2007 ◽  
Vol 148 (23) ◽  
pp. 1067-1075
Author(s):  
Krisztina Fischer ◽  
Orsolya Galamb ◽  
Béla Molnár ◽  
Zsolt Tulassay ◽  
András Szabó
Keyword(s):  
Nephrotic Syndrome ◽  
Northern Blot ◽  
Idiopathic Nephrotic Syndrome ◽  
Minimal Change ◽  
Ribonuclease Protection Assay ◽  
Rna Expression ◽  
Rt Pcr ◽  
Protection Assay ◽  
Ribonuclease Protection

A gyermekkori nephrosis 90%-a idiopathiás nephrosis szindróma. Az idetartozó három kórkép, a minimal change betegség, a mesangialis proliferatio és a focalis sclerosis hasonló klinikai képpel jelentkező, eltérő prognózisú és terápiás válaszú betegség. Dolgozatunk célja az idiopathiás nephrosis szindrómába tartozó kórképek kialakulásával, progressziójával összefüggő genetikai ismeretek, génexpressziós változások áttekintése és funkcionális csoportosítása. A génexpressziós változások meghatározásának eszközeként, dolgozatunk röviden összefoglalja a northern blot, a ribonuclease protection assay, az in situ RNS-hibridizáció, a kvantitatív RT-PCR és a microarray módszerek lényegét. Az eddig elvégzett vizsgálatok a DNS-szintézis és repair gének, növekedési faktorok, extracelluláris mátrix, extracelluláris ligandreceptorok, extracelluláris jelátvitel zavarai mellett kiemelik a metabolikus és transzporter gének, illetve az immunszabályozó gének molekuláris eltéréseit, amelyek összefüggésben vannak az idiopathiás nephrosis szindróma eddig megismert molekuláris hátterével. A chiptechnológia fejlődésével és elterjedésével ezek a markerek és a hagyományos vizsgálati módszerek párhuzamos alkalmazása rutindiagnosztikai szempontból is fontossá válhat.

scholarly journals Reliability of generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome: a systematic review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ann E. Aronu ◽  
Samuel N. Uwaezuoke ◽  
Uzoamaka V. Muoneke
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Children And Adolescents ◽  
Idiopathic Nephrotic Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Generic Quality ◽  
Quality Of Life Instruments

Abstract Introduction Most of the studies reporting the negative impact of idiopathic nephrotic syndrome on health-related quality of life in children and adolescents were conducted with generic quality-of-life instruments rather than disease-specific instruments. The consistency of these studies' findings using these generic instruments is not well established. Aim This systematic review aims to determine the reliability of current generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome. Methods We searched the PubMed, MEDLINE, EMBASE, and Google Scholar databases for articles published between 2000 and 2020, using appropriate descriptors. We included primary studies that met the eligibility criteria, independently screened their titles and abstracts, and removed all duplicates during the study-selection process. We resolved disagreements until a consensus was reached on study selection. We independently retrieved relevant data, including the generic quality-of-life instruments and the subjects’ and controls’ aggregate health-related quality of life scores, using a preconceived data-extraction form. Results Ten original articles were selected for qualitative and quantitative analyses. Some of the studies reported the following significant findings. The mean health-related quality of life scores for children with prevalent and incident nephrotic syndrome were 68.6 (range, 52.6–84.6) and 73.7 (range, 55.9–91.5), respectively. Children with idiopathic nephrotic syndrome and their controls with other chronic diseases had median scores of 65 (interquartile range, 59–68.75) and 62.2 (interquartile range, 58.05–65.78). Patients on oral immunosuppressive drug and intravenous rituximab reportedly had median scores of 76.2 and 72.6 and mean scores of 71.4 (range, 55.4–87.4) and 61.6 (range, 42.1–81.1) respectively for quality-of-life assessment on the ‘school functioning domain.’ Conclusions The health-related quality of life scores in patients with idiopathic nephrotic syndrome are consistently low. Lower scores occur in prolonged disease duration and severe clinical phenotypes, whereas the scores are higher than the scores obtained in other chronic diseases. These consistent findings underscore the reliability of the current generic instruments in assessing health-related quality of life in patients with idiopathic nephrotic syndrome.

scholarly journals Urinary Extracellular Vesicle Protein Profiles Discriminate Different Clinical Subgroups of Children with Idiopathic Nephrotic Syndrome

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 456
Author(s):  
Lucia Santorelli ◽  
William Morello ◽  
Elisa Barigazzi ◽  
Giulia Capitoli ◽  
Chiara Tamburello ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Protein Profile ◽  
Therapy Response ◽  
Extracellular Vesicle ◽  
Distinct Pattern ◽  
Specific Patient ◽  
Steroid Resistant ◽  
Primary Glomerular Disease ◽  
Disease Signature

Idiopathic nephrotic syndrome (INS) is the most frequent primary glomerular disease in children, displaying high grade proteinuria and oedema. The mainstay of therapy are steroids, and patients are usually classified according to the treatment response (sensitive vs. resistant). The mechanisms involved in INS pathogenesis and treatment responsiveness have not yet been identified. In this context, the analysis of urinary extracellular vesicles (UEv) is interesting, since they represent a molecular snapshot of the parental cells, offering a “fingerprint” for monitoring their status. Therefore, the aim of this study is to verify the feasibility of using UEv of INS patients as indicators of therapy response and its prediction. UEv were isolated from the urine of pediatric patients in remission after therapy; they showed characteristic electrophoresis profiles that matched specific patient subgroups. We then built a statistical model to interpret objectively each patient UEv protein profile: in particular, steroid-resistant patients cluster together with a very distinct pattern from other INS patients and controls. In conclusion, the evaluation of the UEv protein profile looks promising in the investigation of INS, showing a disease signature that might predict clinical evolution.

scholarly journals tRNA-Derived Fragments in Podocytes with Adriamycin-Induced Injury Reveal the Potential Mechanism of Idiopathic Nephrotic Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Shanwen Li ◽  
Yiwen Liu ◽  
Xiaowei He ◽  
Xiagang Luo ◽  
Huimin Shi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Signaling Pathway ◽  
Idiopathic Nephrotic Syndrome ◽  
Wnt Signaling Pathway ◽  
Differentially Expressed ◽  
Ras Signaling ◽  
Potential Mechanism ◽  
Significant Differential Expression ◽  
Podocyte Injury ◽  
Filtration Barrier

Idiopathic nephrotic syndrome (INS) is a disease involving injury to podocytes in the glomerular filtration barrier, and its specific causes have not been elucidated. Transfer RNA-derived fragments (tRFs), products of precise tRNA cleavage, have been indicated to play critical roles in various diseases. Currently, there is no relevant research on the role of tRFs in INS. This study intends to explore the changes in and importance of tRFs during podocyte injury in vitro and to further analyze the potential mechanism of INS. Differentially expressed tRFs in the adriamycin-treated group were identified by high-throughput sequencing and further verified by quantitative RT-PCR. In total, 203 tRFs with significant differential expression were identified, namely, 102 upregulated tRFs and 101 downregulated tRFs (q<0.05, ∣log2FC∣≥2). In particular, AS-tDR-008924, AS-tDR-011690, tDR-003634, AS-tDR-013354, tDR-011031, AS-tDR-001008, and AS-tDR-007319 were predicted to be involved in podocyte injury by targeting the Gpr, Wnt, Rac1, and other genes. Furthermore, gene ontology analysis showed that these differential tRFs were strongly associated with podocyte injury processes such as protein binding, cell adhesion, synapses, the actin cytoskeleton, and insulin-activate receptor activity. KEGG pathway analysis predicted that they participated in the PI3K-Akt signaling pathway, Wnt signaling pathway, and Ras signaling pathway. It was reported that these pathways contribute to podocyte injury. In conclusion, our study revealed that changes in the expression levels of tRFs might be involved in INS. Seven of the differentially expressed tRFs might play important roles in the process of podocyte injury and are worthy of further study.

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