scholarly journals Sero-Occurrence of HBV/HCV Co-infection and Levels of Liver Enzymes among Patients at a Tertiary Care Hospital in Central India: a Pilot Study

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Prabha Desikan ◽  
Aseem Rangnekar ◽  
Zeba Khan ◽  
Nikita Panwalkar ◽  
Protiti Bose ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Hepatitis B ◽  
Liver Function ◽  
Liver Enzymes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Central India ◽  
Liver Function Tests ◽  
Care Hospital

Introduction: Hepatitis B and C viral infections share common modes of transmission and account for a large proportion of liver disease burden across the globe. Patients with Hepatitis B (HBV) and Hepatitis C virus (HCV) co-infection may have more severe liver disease and are potentially at higher risk for developing hepatocellular carcinoma. The aim of this study was to assess the sero-occurrence of HBV/HCV co-infection by examining the medical records of tertiary care hospital patients in Central India and determine the extent of liver damage based on liver function tests (LFTs).Methods: Patients with a positive test for HBV surface antigen (HBsAg) over a period of 10 years were identified from laboratory records in a tertiary care facility in central India. Records of 51,075 consecutive non-duplicate blood samples were then screened for a positive HBV and HCV tests. LFT, liver enzymes, and bilirubin data were also extracted. Means and standard deviations were determined for continuous variables, and the difference in means was compared using a independent samples t-test. Associations between HBV/HCV co-infection status and demographic variables were calculated using Pearson’s Chi-squared test. A p-value less than 0.05 was considered statistically significant.Results: In this study, 1674 (3.27%) screened patients were positive for HBsAg and the sero-occurrence of co-infection with HCV in HBsAg positive patients was reported in 28 individuals (1.67%). There was no significant gender difference for HBV/HCV co-infection (p>0.05). HBV/HCV co-infection was observed more frequently in the 31-60 year old age group (p=0.001). HBV/HCV co-infected patients had significantly higher levels of liver enzymes and bilirubin than those with HBsAg mono-infection (p=0.001).Conclusion: Liver function tests are potentially important predictors for HBV/HCV coinfection. Screening for HCV co-infection in HBsAg-positive patients is recommended in India. Detection of co-infection may enable timely preventive/therapeutic interventions aimed at preventing progression to hepatocellular carcinoma.

scholarly journals Prevelence of Hepatitis B and C virus Co-infection in HIV positive patients in Tertiary Care Hospital of Central India

2021 ◽  
Vol 39 ◽  
pp. S132
Author(s):  
Ranjna Dehariya ◽  
Bharat Singh ◽  
Dharmendra Rajput ◽  
Sadhana Sodani
Keyword(s):  
Hepatitis B ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Central India ◽  
Hiv Positive ◽  
Care Hospital

scholarly journals Frequency of severe liver cirrhosis and hepatocellular carcinoma caused by hepatitis B and C in a tertiary care hospital.

2021 ◽  
Vol 28 (10) ◽  
pp. 1452-1456
Author(s):  
M. Umer Bin Arshad ◽  
Naveed Asghar ◽  
Talha Shamshad
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Severe Liver ◽  
Cross Sectional ◽  
Class C

Objective: Liver cirrhosis is one of the most widespread diseases in underdeveloped countries. Study Design: Cross Sectional Study. Setting: Nishtar Hospital Multan. Period: January 2020 to March 2020. Material & Methods: Three hundred and ninety seven of admitted patients were included and patients falling in class C of child Turcotte Pugh classification of liver cirrhosis were determined. Prevalence of hepatocellular carcinoma and cause of cirrhosis in these patients was also determined. Statistical Package for Social Sciences (SPSS 23.0) was used for analysis. Results: Out of 397 patients included in the study 25.4 % or 101 had class C cirrhosis, out of these 5.94% or 6 also had hepatocellular carcinoma. With respect to age of initial diagnosis of the illness 25.7% or 26 were in age interval 31-40yrs, 24.8% or 25 in interval 41-50yrs, 20.8% or 21 in interval 51-60 yrs. Hepatitis C (67.3%) comes out to be the commonest of all causes of chronic liver disease, followed by other causes (18.8%), then both hepatitis C and B (7.9%) and hepatitis B alone (5.9%). Conclusion: Our study concluded that approximately 1 in every 4 patients admitted in medical wards of a tertiary care hospital have severe liver cirrhosis caused most commonly by hepatitis C with most common age of presentation being 30-60 years. Approximately 6 out of 100 of these patients also had hepatocellular carcinoma.

Sero-Prevalence of Parvovirus B 19 Infection Among HIV Positive Patients Attending Tertiary Care Hospital in Central India

2017 ◽  
Vol 01 (04) ◽  
pp. 127-132
Author(s):  
Bhushan Shrikhande ◽  
Meena Mishra ◽  
Mohiuddin Qazi ◽  
Arvind Kurhade ◽  
Chandrashekhar Unakal ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Central India ◽  
Hiv Positive ◽  
Care Hospital ◽  
Parvovirus B 19

SCCA-IgM in hepatocellular carcinoma patients treated with transarterial chemoembolization: gender-related differences

2020 ◽  
Vol 14 (10) ◽  
pp. 855-867
Author(s):  
Filippo Pelizzaro ◽  
Federica Soldà ◽  
Romilda Cardin ◽  
Angela Imondi ◽  
Anna Sartori ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Immunoglobulin M ◽  
Care Hospital ◽  
Squamous Cell Carcinoma Antigen ◽  
Preclinical Models ◽  
Relevant Variable ◽  
Gender Specific

Aim: Squamous cell carcinoma antigen immune complexed with immunoglobulin M (SCCA-IgM) is a useful but not completely satisfactory biomarker of hepatocellular carcinoma (HCC). Considering its gender-specific behavior in preclinical models, we investigated gender-related differences of SCCA-IgM as a prognostic marker in HCC. Patients & methods: Two hundred and eight prospectively recruited patients treated with transarterial chemoembolization in a single tertiary care hospital were retrospectively evaluated. Correlations between SCCA-IgM levels, clinical characteristics and survival were assessed according to gender. Results: When the disease was advanced, SCCA-IgM was higher in males and lower in females. Levels below 130 AU/ml predicted a significantly longer survival in males (p = 0.007) and a shorter survival in females (p = 0.01). Conclusion: In predicting the prognosis of HCC patients, the interpretation of SCCA-IgM should consider gender as a relevant variable.

CLINICAL PROFILE AND THE CIRCULATING GENOTYPES OF HEPATITIS C VIRUS IN A TERTIARY CARE HOSPITAL IN WEST BENGAL

2021 ◽  
pp. 165-167
Author(s):  
Kumkum Sarkar ◽  
Rupak Chatterjee ◽  
Sumanta Sinha ◽  
Netai Pramanik
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Hcv Rna ◽  
Care Hospital ◽  
Patient Department

Background and objectives- Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, with majority of the patients being asymptomatic and when they present to clinicians, they have already advanced liver disease in form of cirrhosis or hepatocellular carcinoma. Data from developing countries on this evolving global health problem are sparse. Hence this study was planned with the aim to determine the HCV genotypes prevalant in patients attending a tertiary care hospital with their clinical prole. Materials and Methods- Detailed history taking and clinical examination were done of consecutive 30 patients who attended out-patient department or admitted at in- patient department of Tropical Medicine with chronic hepatitis C. Laboratory investigations like LFT, viral serology (HBsAg, AntiHCV, HIV), prothrombin time, ultrasonography of upper abdomen, HCV- RNA Quantative assay with genotyping were done. Data were collected and then analysed using standard statistical methods. Result- Of proposed 30 sample size, complete data could be collected of 28 patients and accordingly, analysis was done. Of the 28 HCV seroreactive individuals, majority (20) were males. The mode of transmission was unknown in 19 patients, blood transfusion in 5 patients who were thalassemic and hemodialysis in remaining 4 patients. Most of the patients (18/28) were asymptomatic even if their viral load was high. Most common presenting symptom was dyspepsia. LFT showed signicant transaminitis in 50% of the patients. Of the 28 seroreactive patients, 15 (53.57%) were HCV RNA positive based on RT-PCR. HCV rNA was below detectable level in 13 patients. HCV genotype 3 was the predominant genotype found in 11 individuals followed by genotype 1 found in 3 and genotype 2 was seen in one individual. Conclusion- Community screening specially among high risk individuals is needed for early diagnosis and prompt treatment of chronic hepatitis C to prevent its several complications and also to prevent community spread.

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