Prevalence of Hepatitis B in Patients with and without Liver Disease in Tertiary Care Hospital: A Study in Govt. Medical College, Thiruvananthapuram

Introduction: Hepatitis B virus infection is one among the principle causes of liver diseases and death, which has limited data on demographic and epidemiological characteristics. This study aims to determine the above characters in patients diagnosed with HBV, enrolled at saveetha medical college and hospital. Methods: Medical records of patients aged >18yrs and diagnosed with HBV infection from June 2018 to December 2018 were analysed for this study. Result: Among 79 patients taken for study, the male and female ratio is 55:24; mean age limit of HBV cases are between 40-48 years. Few cases were found to be co infected with HCVand 2-3 cases were medicated workers and 21 cases received tenofovir monotherapy. Conclusion: This study reviewed the epidemiological and demographic characteristics of HBV infected patients and revealed their role in HBV. New measures has to be implemented for curative and preventive measures to create awareness among patients. Aim :To determine the demographic and epidemiological characteristics of Hepatitis B infected patients in a tertiary care hospital

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"Genotypes and Markers of Hepatitis B and Antibodies to Hepatitis C virus in Patients with Chronic Liver Disease in a Tertiary Care Hospital in Puducherry"

International Journal of Current Research and Review ◽

10.7324/ijcrr.2017.9216 ◽

2017 ◽

Keyword(s):

Hepatitis C Virus ◽

Liver Disease ◽

Hepatitis C ◽

Hepatitis B ◽

Chronic Liver Disease ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Chronic Liver ◽

Care Hospital

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Sero-Occurrence of HBV/HCV Co-infection and Levels of Liver Enzymes among Patients at a Tertiary Care Hospital in Central India: a Pilot Study

Central Asian Journal of Global Health ◽

10.5195/cajgh.2019.313 ◽

2019 ◽

Vol 8 (1) ◽

Author(s):

Prabha Desikan ◽

Aseem Rangnekar ◽

Zeba Khan ◽

Nikita Panwalkar ◽

Protiti Bose ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Disease ◽

Hepatitis B ◽

Liver Function ◽

Liver Enzymes ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Central India ◽

Liver Function Tests ◽

Care Hospital

Introduction: Hepatitis B and C viral infections share common modes of transmission and account for a large proportion of liver disease burden across the globe. Patients with Hepatitis B (HBV) and Hepatitis C virus (HCV) co-infection may have more severe liver disease and are potentially at higher risk for developing hepatocellular carcinoma. The aim of this study was to assess the sero-occurrence of HBV/HCV co-infection by examining the medical records of tertiary care hospital patients in Central India and determine the extent of liver damage based on liver function tests (LFTs).Methods: Patients with a positive test for HBV surface antigen (HBsAg) over a period of 10 years were identified from laboratory records in a tertiary care facility in central India. Records of 51,075 consecutive non-duplicate blood samples were then screened for a positive HBV and HCV tests. LFT, liver enzymes, and bilirubin data were also extracted. Means and standard deviations were determined for continuous variables, and the difference in means was compared using a independent samples t-test. Associations between HBV/HCV co-infection status and demographic variables were calculated using Pearson’s Chi-squared test. A p-value less than 0.05 was considered statistically significant.Results: In this study, 1674 (3.27%) screened patients were positive for HBsAg and the sero-occurrence of co-infection with HCV in HBsAg positive patients was reported in 28 individuals (1.67%). There was no significant gender difference for HBV/HCV co-infection (p>0.05). HBV/HCV co-infection was observed more frequently in the 31-60 year old age group (p=0.001). HBV/HCV co-infected patients had significantly higher levels of liver enzymes and bilirubin than those with HBsAg mono-infection (p=0.001).Conclusion: Liver function tests are potentially important predictors for HBV/HCV coinfection. Screening for HCV co-infection in HBsAg-positive patients is recommended in India. Detection of co-infection may enable timely preventive/therapeutic interventions aimed at preventing progression to hepatocellular carcinoma.

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SEROPREVALENCE OF HIV AND HBsAg AMONGST BLOOD DONORS IN A TERTIARY CARE HOSPITAL, CHHATTISGARH.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i8.495 ◽

2019 ◽

Vol 3 (8) ◽

Author(s):

Anusha P ◽

Bankar Nandkishor J ◽

Karan Jain ◽

Ramdas Brahmane ◽

Dhrubha Hari Chandi

Keyword(s):

Hepatitis B ◽

Blood Donors ◽

Hepatitis B Surface Antigen ◽

Tertiary Care ◽

Laboratory Diagnosis ◽

Blood Bank ◽

Care Hospital ◽

Medical College ◽

The World ◽

First Time

INTRODUCTION: India being the second highly populated nation in the world. HIV/AIDS has acquired pandemic proportion in the world. Estimate by WHO for current infection rate in Asia. India has the third largest HIV epidemic in the world. HIV prevalence in the age group 15-49 yrs was an estimate of 0.2%. India has been classified as an intermediate in the Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone with the second largest global pool of chronic HBV infections. Safety assessment of the blood supply, the quality of screening measures and the risk of transfusion transmitted infectious diseases (TTIs) in any country can be estimated by scrutinizing the files of blood donors. After the introduction of the blood banks and improved storage facilities, it became more extensively used. Blood is one of the major sources of TTIs like hepatitis B, hepatitis C, HIV, syphilis, and many other blood borne diseases. Disclosure of these threats brought a dramatic change in attitude of physicians and patients about blood transfusion. The objective of this study is to determine the seroprevalence of transfusion transmitted infections amidst voluntary blood donors at a rural tertiary healthcare teaching hospital in Chhattisgarh. MATERIAL AND METHODS: This retrospective study was carried out in Chandulal Chandrakar Memorial Medical College, Kachandur, Durg. Blood donors were volunteers, or and commercial donors who donated the blood and paid by patients, their families, or friends to replace blood used or expected to be used for patients from the blood bank of the hospital. After proper donation of blood routine screening of blood was carried out according to standard protocol. Laboratory diagnosis of HIV 1 and HIV 2 was carried out by ELISA test. Hepatitis B surface antigen was screened by using ELISA. RESULTS: A total of 1915 consecutive blood donors’ sera were screened at Chandulal Chandrakar Memorial Medical College, blood bank during study period. Of these 1914 were male and 1 female. The mean age of patients was found to be 29.34 years with standard deviation (SD) of 11.65 Years. Among all blood donors in present study, 759(39.63%) were first time donors and 1156(60.37%) were repeated donors. 1 patient was HIV positive in first donation group while 3 (75%) were positive in repeat donation group. 7 (38.9%) were HBsAg positive in in first donation group while 11(61.1%) were positive in repeat donation group. Two patients in first donation group had dual infection of HIV and HBsAg. CONCLUSION: Seropositivity was high in repeated donors as compared to first time donors. The incidence of HIV is observed to be 0.2% and that of HBsAg is 0.94%. Strict selection of blood donors should be done to avoid transfusion-transmissible infections during the window period.

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Clinical profile of tetanus in children admitted in tertiary care hospital, BJ Medical College, Ahmedabad, Gujrat

MedPulse International Journal of Pediatrics ◽

10.26611/10141223 ◽

2019 ◽

Vol 12 (2) ◽

pp. 29-33

Author(s):

Manisha Ghoniya ◽

Keyword(s):

Tertiary Care Hospital ◽

Tertiary Care ◽

Clinical Profile ◽

Care Hospital ◽

Medical College

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SOCIODEMOGRAPHIC AND ANTHROPOMETRIC PROFILE OF DIABETIC PATIENTS ATTENDING IN A DIABETIC CLINIC IN A TERTIARY MEDICAL COLLEGE AND HOSPITAL, WEST BENGAL

10.36106/9100420 ◽

2021 ◽

pp. 12-15

Author(s):

Smarajit Banik ◽

Sandip Saha ◽

Sudipan Mitra ◽

Ujjwal Pattanayak ◽

Rajib Sikder ◽

...

Keyword(s):

West Bengal ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Care Hospital ◽

Diabetes Clinic ◽

Cross Sectional ◽

Medical College ◽

Study Participants

Background: Diabetes mellitus is one of the important causes of morbidity and mortality. With a rise in non communicable diseases in India, diabetes has become a modern epidemic showing a rising trend in West Bengal also. A large number of diabetes patients come to the diabetes clinic of our tertiary care hospital in North Bengal Medical College and Hospital, Darjeeling, West Bengal. The large proportion of patients presenting with this condition prompted us to study the Sociodemographic and Anthropometric Prole of such patients. Methods: This was a descriptive hospital based cross sectional study involving a total of 344 diabetic patients enrolled in the diabetes clinic of a tertiary care teaching hospital from December 2019 to February 2020. A self-administered questionnaire was used to collect data and was analyzed in Microsoft excel sheet and using SPSS 20.0 software. Results: Among the 344 study participants, we found that 220 (63.95%) were males and 124 (36.05%) were females. Diabetes was more common among those aged 51-60 years 108 (31.40%). Family history was present among 188 (54.65%) of the diabetic patients. Almost 160 (46.51%) patients have diabetes 1.1 – 5 years. Hypertension was present among 216 (62.79%) patients. Almost 218 (63.37%) of the patients were overweight and 84 (24.42%) were obese. Conclusions: The diabetic patients presenting to this tertiary care hospital belong lower socioeconomic strata and having limited education in their age group. There is high proportion of obesity and hypertension among them.

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CLINICAL PROFILE AND THE CIRCULATING GENOTYPES OF HEPATITIS C VIRUS IN A TERTIARY CARE HOSPITAL IN WEST BENGAL

10.36106/gjra/6811683 ◽

2021 ◽

pp. 165-167

Author(s):

Kumkum Sarkar ◽

Rupak Chatterjee ◽

Sumanta Sinha ◽

Netai Pramanik

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C Virus ◽

Liver Disease ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Hcv Rna ◽

Care Hospital ◽

Patient Department

Background and objectives- Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, with majority of the patients being asymptomatic and when they present to clinicians, they have already advanced liver disease in form of cirrhosis or hepatocellular carcinoma. Data from developing countries on this evolving global health problem are sparse. Hence this study was planned with the aim to determine the HCV genotypes prevalant in patients attending a tertiary care hospital with their clinical prole. Materials and Methods- Detailed history taking and clinical examination were done of consecutive 30 patients who attended out-patient department or admitted at in- patient department of Tropical Medicine with chronic hepatitis C. Laboratory investigations like LFT, viral serology (HBsAg, AntiHCV, HIV), prothrombin time, ultrasonography of upper abdomen, HCV- RNA Quantative assay with genotyping were done. Data were collected and then analysed using standard statistical methods. Result- Of proposed 30 sample size, complete data could be collected of 28 patients and accordingly, analysis was done. Of the 28 HCV seroreactive individuals, majority (20) were males. The mode of transmission was unknown in 19 patients, blood transfusion in 5 patients who were thalassemic and hemodialysis in remaining 4 patients. Most of the patients (18/28) were asymptomatic even if their viral load was high. Most common presenting symptom was dyspepsia. LFT showed signicant transaminitis in 50% of the patients. Of the 28 seroreactive patients, 15 (53.57%) were HCV RNA positive based on RT-PCR. HCV rNA was below detectable level in 13 patients. HCV genotype 3 was the predominant genotype found in 11 individuals followed by genotype 1 found in 3 and genotype 2 was seen in one individual. Conclusion- Community screening specially among high risk individuals is needed for early diagnosis and prompt treatment of chronic hepatitis C to prevent its several complications and also to prevent community spread.

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Cerebral malaria in children : an update

Northern International Medical College Journal ◽

10.3329/nimcj.v6i2.23168 ◽

2015 ◽

Vol 6 (2) ◽

pp. 45-47

Author(s):

Mirza Md Ziaul Islam ◽

M Mizanur Rahman

Keyword(s):

Cerebral Malaria ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Medical Emergency ◽

Care Hospital ◽

Medical College ◽

Antimalarial Therapy ◽

Neurological Presentation ◽

Supportive Management ◽

Prompt Diagnosis

Cerebral malaria (CM) is the most severe neurological presentation of acute falciparum malaria. It is a medical emergency, the hallmark of which is the presence of coma probably due to diffuse encephalopathy. A compromised microcirculation with sequestration of parasitized erythrocytes is central to the pathogenesis of cerebral malaria. The death is unacceptably high even with effective antimalarials in tertiary care hospital. The mainstay of treatment of cerebral malaria include prompt diagnosis and early institution of effective antimalarial therapy, recognition of complications, and appropriate supportive management in an ICU. Neurological sequlae are increasingly recognized, but further research on the pathogenesis of coma and neurological damage is required to develop other ancillary treatmentsNorthern International Medical College Journal Vol.6(2) 2015: 45-47

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