SURVEY ON THE USE OF CARBAPENEM ANTIBIOTICS AT CAN THO CHILDREN’S HOSPITAL

2021 ◽  
Vol 62 (6) ◽  
Author(s):  
Bui Dang Lan Huong ◽  
Bui Dang Minh Tri ◽  
Le Thi Kim Ngan

Objective: To survey the use of carbapenem antibiotics at Can Tho Children’s Hospital. Objects and methods: Retrospective-descriptive study on 140 medical records of patients being treated at departments of Can Tho Children’s Hospital during the period from June 1st, 2020 to December 31st, 2020. Results: 26.43% of carbapenems were indicated empirically initiate, 73.57% of carbapenem was indicated in alternative regimens as the presence of microbiological results or worsened or impaired patient status. Carbapenem was mainly used in combination regimens. The proportion of the combination in the initiation regimen was 100%. In which, the proportion of combination regimen between carbapenem and an antibiotic (or vancomycin or gentamicin) was mainly. The rate of combination of three antibiotics was 18.9%. In the replacement regimen, the proportion of combination regimen was 79.6%. Of these, 57.3% of the carbapenem was combined with another antibiotic, most of which was combined with vancomycin. Combination regimen of three or four antibiotics accounted for a low percentage. Conclusion: 26.43% of carbapenem was indicated empirically initiate, 73.57% of carbapenem was indicated in an alternative regimen in the presence of microbiological results or worsened or impaired patient status. Carbapenem was mainly used in combination regimens.

2021 ◽  
Vol 62 (4) ◽  
Author(s):  
Nguyen Viet Dang ◽  
Tri Kim Ngoc ◽  
Bui Tung Hiep ◽  
Bui Dang Minh Tri

Objective: To investigate the reasonableness of using drugs to treat pneumonia at Can Tho Children’s Hospital. Subjects and methods: a retrospective-descriptive study on 384 inpatient medical records at Can Tho Children’s Hospital from January 2019 to December 2019 was diagnosed pneumonia. Results: The percentage of the initial treatment regimen that was not reasonable with the recommended antibiotic regimen was relatively high at 84.11%. The proportion of antibiotics with inappropriate dose was only 1.71% of the total number of surveyed cases. The appropriate rate of antibiotic dose was 98.29%. The proportion of adjuvants with high appropriate doses such as Salbutamol, Hydrocortison and Prednisolon accounted for 100%. The rate of taking antibiotics in accordance with recommendations accounted for 94.67%. The rate of adjuvanvt drug delivery was very high, there were only a few cases that did not comply with recommendations such as Ibuprofen with 14 cases, accounting for 37.84%, Acetylcysteine ​​and Hydrocortison accounted for 14.58% with 7 cases, and Prednisolon and Budesonid accounted for the very low percentage. Conclusion: The proportion of the initial treatment regimen that was not compatible with the antibiotic regimen was relatively high. The appropriate rate of antibiotic dose was high. The proportion of adjuvants with suitable doses was high such as Salbutamol, Hydrocortison and Prednisolon. The antibiotic delivery rate was consistent with recommendations. The rate of adjuvant delivery was very high.


2021 ◽  
Vol 62 (6) ◽  
Author(s):  
Dinh Nguyen Tuong ◽  
Bui Tung Hiep ◽  
Do Van Mai ◽  
Nguyen Huu Phuc

Objective: To investigate the situation of antibiotic use in the treatment of community pneumonia in children at Can Tho Children’s Hospital. Subjects and methods: Retrospective-descriptive study on 140 children diagnosed with community pneumonia, hospitalized for treatment at Can Tho Children’s Hospital from October 2020 to December 2020. Results: 55.71% of patients were taking antibiotics before hospitalization. Antibiotics used the most to treat pneumonia at hospital were penicillins/betalactamse inhibitors, accounting for 44.44%. For pneumonia patients, the rate of choosing the single regimen for initial treatment was 89.47% and the combination regimen was 10.53%. For patients with severe pneumonia, the rate of choosing of single regimen had decreased to 74.14%, while the choice of combination regimen had increased to 25.83%. The average number of regimen changes during treatment was 1.43 ± 056 times. The main reason for the change in the regimen was improved clinical symptoms (43.75%). The average duration of treatment with antibiotics was 6.48 ± 0.71 days. The duration of treatment as well as the duration of antibiotic use increased with the severity of the disease. Conclusion: The most commonly used antibiotics for treating commnity pneumonia at hospital were penicillins/betalactamse inhibitors. For pneumonia patients, a single regimen (89.47%) and a combination regimen (10.53%) was chosen. For patients with severe pneumonia, the choice of the single regimen decreased to 74.14%, the combination regimen increased to 25.83%. The main reason for the modification of the regimen was the improvement of clinical symptoms. The duration of treatment as well as the duration of antibiotic use increased with the severity of the disease.


2013 ◽  
Vol 19 (4) ◽  
pp. 459-465
Author(s):  
Vytautas Usonis ◽  
Irena Narkevičiūtė ◽  
Vilija Guntaitė

Background. Oseltamivir is recommended for treatment of pandemic influenza in children. The therapy should be started as soon as possible, however, data on the effectiveness of such a treatment is rather limited. This study was accomplished in order to evaluate the effectiveness of oseltamivir depending on the time of the beginning of treatment. Materials and methods. Medical records of 72 children hospitalised to the Vilnius University Children’s Hospital (VUCH) because of laboratory confirmed pandemic influenza during November–December 2009 were analysed retrospectively. Duration of fever and frequency of complications in children treated with oseltamivir starting on days 1–2 and those who were started to treat ≥day 3 from the beginning of flu symptoms were compared to those who did not receive oseltamivir. Results. 40 patients were treated with oseltamivir: 20 children were commenced on treatment within 48 hours of their illness and the other 20 were started on oseltamivir on day 3 or later. 32 children were not treated with oseltamivir. Fever lasted 2.1 ± 0.8 days if the treatment with oseltamivir was started within 48 hours of illness and 4.1 ± 1.9 days if the treatment was started later (p 


Author(s):  
Hong Tu Nguyen ◽  
Thi Thuy Ha Dang ◽  
Bich Ngoc Hoang ◽  
Thi Luong Nguyen

Purpose: To describe some subclinical characteristics of Shigella dysentery in children of the Gastroenterology Department at the Vietnam National Children’s Hospital in 2019 and review the results of treatment in these patients. Methods: A cross-sectional descriptive study was conducted on patients under 15 years of age admitted to the Gastroenterology Department at Vietnam National Children's Hospital. Results: The CRP index increased to 81.8%, of which the increase was mainly in the S.sonnei group. The rate of the most common bacteria strain is S.sonnei accounting for 87.1%, followed by S.fexneri 11.8%, S.dysenteriae encountered a case of 1.1%. No cases of stool culture resulted in S.boydii. The cure rate with Ciprofloxacin is 89.5%. The recovery rate is quite high, 93.3%, the percentage of patients who are also significantly better at 6.7% and there is no case of treatment failure. Conclusions: The number of leukocytes and CRP in the peripheral blood is increased in most cases. The main antibiotic used is Ciprofloxacin, the treatment effectiveness with Ciprofloxacin antibiotic is 89.5%, the cure rate is high and there is no case of treatment failure.


2014 ◽  
Vol 186 (2) ◽  
pp. 676
Author(s):  
H.O. Berdel ◽  
F. Davis ◽  
D. Moore ◽  
A. Qadeer ◽  
S. Gurley ◽  
...  

2021 ◽  
pp. 112067212199473
Author(s):  
David Gildea ◽  
Reinold Goetz ◽  
Richard Drew ◽  
Sarah Chamney

Objectives: The purpose of this study was to examine the aetiology, investigation and management of ophthalmia neonatorum (ON) presenting to a tertiary referral children’s hospital over 5 years. Methods: The eye swab data of all neonates presenting to Children’s Health Ireland at Temple Street (Dublin, Ireland) between 1st January 2013 and 3rd September 2018 was analysed. The medical records of all patients with positive eye swab results were retrospectively reviewed. Results: A total of 157 neonates had positive eye swab results. 54 cases were identified as ON. Chlamydia trachomatis (20.4%) was the most common organism identified, followed by Staphylococcus aureus (18.5%), Haemophilus influenzae (14.8%), Moraxella catarrhalis (7.4%), Streptococcus pneumoniae (5.6%), Escherischia coli (3.7%), Klebsiella pneumoniae (1.9%) and Pseudomonas aeruginosa (1.9%). A bacterial culture swab was tested in all cases (100%), a C. trachomatis/N. gonorrhoeae PCR swab in 70.4% and a viral PCR swab in 35.2%. On subanalysis of the cases that had C. trachomatis/N. gonorrhoeae PCR testing, C. trachomatis was responsible for 28.9% of cases. 50% of cases were hospitalised, intravenous antibiotics were administered in 46.3% and macrolide therapy was prescribed in 38.9%. Conclusions: C. trachomatis was the most common cause of ON in this study and may be responsible for an even higher proportion of cases due to incomplete testing. In keeping with studies in different populations, S. aureus, H. influenzae and S. pneumoniae were also common. As a result, an improved management algorithm for cases of ON has been introduced in this centre.


Objective: To assess the efficacy and duration of propranolol therapy in pediatric patients with parotid hemangiomas, and compare the results with the efficacy and duration of propranolol therapy in patients with infantile hemangiomas in other anatomic locations. Methods: In this retrospective review, we analyzed the electronic medical records of 21 patients with parotid hemangiomas seen at the Children’s Hospital of Orange County’s Vascular Anomalies Clinic between 2009 and 2015. We compared the duration of propranolol therapy and rate of re-growth after completion of therapy with established data for these parameters in the literature for patients with other infantile hemangiomas. Results: In our cohort, 13 of the 21 patients had completed therapy, with a mean duration of 26 months of propranolol therapy. Eighteen patients (85.7%) were treated with the goal dose of propranolol (2 mg/kg/day). Three patients required a higher dose in order to achieve significant improvement in the size of the hemangioma. All patients had some response to propranolol. Eight of the 13 patients (61.5%) who completed propranolol therapy saw regrowth once initial propranolol therapy was either weaned or stopped. Conclusion: Pediatric patients with parotid hemangiomas require longer duration of propranolol therapy than patients with other infantile hemangiomas, and a greater percentage may have regrowth after completion of therapy.


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