scholarly journals CHEMICAL CONSTITUENTS AND ACETYLCHOLINESTERASE ACTIVITY FROM Polyalthia sumatrana (Miq.) Kurz

2022 ◽  
Vol 52 (1) ◽  
pp. 73-76
Author(s):  
Wan Mohd Nuzul Hakimi Wan Salleh ◽  
Natasa Mohd Shakri ◽  
Mohd Azlan Nafiah ◽  
Shamsul Khamis
Keyword(s):  
Cinnamic Acid ◽  
Vanillic Acid ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Acetylcholinesterase Activity ◽  
Isolation And Identification ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Reported Data

This study was carried out to investigate the phytochemicals from Polyalthia sumatrana and their acetylcholinesterase inhibitory activity. Fractionation and purification of the leaves of P. sumatrana led to the isolation and identification of five alkaloids; boldine (1), norboldine (2), liriodenine (3), predicentrine (4), laurotetanine (5) together with β-sitosterol (6), β-sitostenone (7), vanillin (8), vanillic acid (9) and cinnamic acid (10). The structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that all isolated alkaloids were found to inhibit AChE with percentage inhibition values ranged from 45.0 to 80.6%.

scholarly journals Chemical constituents and acetylcholinesterase inhibitory activity of Piper abbreviatum Opiz

2021 ◽  
Vol 34 (3) ◽  
pp. 625-632
Author(s):  
W. M. N. H. W. Salleh ◽  
M. A. Nafiah ◽  
K. H. Yen ◽  
H. Kassim ◽  
A. Tawang
Keyword(s):  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Isolation And Identification ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Aerial Parts ◽  
The World ◽  
Chemotaxonomic Markers ◽  
Reported Data ◽  
Physiologically Active Compounds

Plants of the genus Piper have long been used as medicinal herbs. The chemistry of Piper species has been widely investigated and phytochemical investigations conducted in all parts of the world have led to the isolation of a number of physiologically active compounds. Thus, this study was carried out to investigate the phytochemicals from Piper abbreviatum and their acetylcholinesterase inhibitory activity, which has not been previously investigated. Fractionation and purification of the aerial parts of P. abbreviatum led to the isolation and identification of five methoxylated flavonoids, namely 5,7-dimethoxyflavone, 4ʹ,5,7-trimethoxyflavone, 3',4',5,7-tetramethoxyflavone, 5-hydroxy-7-methoxyflavone, 5-hydroxy-4ʹ,7-dimethoxyflavone, together with lupeol, lupenone, β-sitosterol, and β-sitostenone. The structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that all isolated flavones were found to inhibit AChE with percentage inhibition values ranged from 24.2 to 58.2%. This is the first report on the isolation of methoxylated flavonoid from P. abbreviatum. The high variants of flavonoid compounds from this species may be used as chemotaxonomic markers for this Piper species.                     KEY WORDS: Piperaceae, Piper, Piper abbreviatum, Flavonoid, Acetylcholinesterase   Bull. Chem. Soc. Ethiop. 2020, 34(3), 625-632. DOI: https://dx.doi.org/10.4314/bcse.v34i3.17

scholarly journals Two new α-Methoxy-γ-Pyrones From the Mangrove Sediment-Derived Streptomyces psammoticus SCSIO NS126

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110414
Author(s):  
Kunlong Li ◽  
Mengdie Zhou ◽  
Ziqi Su ◽  
Xiliang Yang ◽  
Xuefeng Zhou ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Spectroscopic Analysis ◽  
Mangrove Sediment ◽  
Natural Sources ◽  
Fermentation Conditions ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Actinomycete Strain

Two new α-methoxy- γ-pyrone analogs, 2-methoxy-3-methyl-5,6-diethyl- γ-pyrone (2) and 2-methoxy-3,5-dimethyl-6-propyl- γ-pyrone (3), together with 2-methoxy-3,5-dimethyl-6-ethyl- γ-pyrone (1), firstly isolated from natural sources, were obtained from the EtOAc-solube extract of the mangrove sediment-derived actinomycete strain Streptomyces psammoticus SCSIO NS126, under the optimized fermentation conditions. Their structures were elucidated by detailed spectroscopic analysis and by comparison of their spectroscopic data with those reported in the literature. Those α-methoxy-γ-pyrones were evaluated for their acetylcholinesterase inhibitory activity; however, none of them exhibited obvious activity. Moreover, their biosynthetic relationship with piericidins was also discussed.

scholarly journals Rotenoid Derivatives from Derris Trifoliata with Nitric Oxide Production Inhibitory Activity

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701
Author(s):  
Chihiro Ito ◽  
Tomiyasu Murata ◽  
Hugh T.-W. Tan ◽  
Norio Kaneda ◽  
Hiroshi Furukawa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inhibitory Activity ◽  
Chemical Constituents ◽  
Interferon Γ ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Murine Macrophage ◽  
Isolation And Identification ◽  
Oxide Production

Study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) collected in Singapore led to the isolation and identification of three known and two new rotenoid derivatives. The new derivatives, named derrisfolin A (1) and B (2), inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ and lipopolysaccharide.

Chemical constituents and acetylcholinesterase inhibitory activity from the stems of Bauhinia pentandra

2020 ◽  
pp. 1-5
Author(s):  
Horlando C. da Silva ◽  
Francisco das Chagas L. Pinto ◽  
Anderson F. de Sousa ◽  
Otília Deusdenia L. Pessoa ◽  
Maria Teresa Salles Trevisan ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Chemical Constituents ◽  
Acetylcholinesterase Inhibitory Activity

scholarly journals Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii

2018 ◽  
Vol 23 ◽  
pp. 33-37 ◽  
Author(s):  
Thanika Promchai ◽  
Tongchai Saesong ◽  
Kornkanok Ingkaninan ◽  
Surat Laphookhieo ◽  
Stephen G. Pyne ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Chemical Constituents ◽  
Acetylcholinesterase Inhibitory Activity

scholarly journals Chemical composition and acetylcholinesterase inhibitory activity of essential oil from rhizomes of Distichochlamys benenica

2021 ◽  
Vol 129 (1D) ◽  
pp. 43-49
Author(s):  
Hanh Thi Nhu Hoang ◽  
Thanh Thu Thi Dinh ◽  
Ty Viet Pham ◽  
Hien Bich Thi Le ◽  
Duc Viet Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Inhibitory Activity ◽  
Acetylcholinesterase Activity ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Ic50 Value

Twenty-seven constituents were identified by using GC/MS, representing 99.57% of the rhizome oil of Distichochlamys benenica. The major constituents of the essential oil are 1,8-cineole (54.39%), β-pinene (7.50%), (E)-citral (7.26%), and (Z)-citral (6.79%). The rhizome essential oil has anti-acetylcholinesterase activity with an IC50 value of 136.63 ± 2.70 mg/mL.

Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria

2016 ◽  
Vol 71 (1-2) ◽  
pp. 9-14 ◽  
Author(s):  
Radka Z. Vrancheva ◽  
Ivan G. Ivanov ◽  
Ina Y. Aneva ◽  
Ivayla N. Dincheva ◽  
Ilian K. Badjakov ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Hplc Analysis ◽  
Acetylcholinesterase Activity ◽  
Isoquinoline Alkaloids ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Ms Analysis ◽  
Inhibitory Activities ◽  
Alkaloid Extracts ◽  
Alkaloid Profiles

Abstract GC-MS analysis of alkaloid profiles of five Fumaria species, naturally grown in Bulgaria (F. officinalis, F. thuretii, F. kralikii, F. rostellata and F. schrammii) and analysis of acetylcholinesterase inhibitory activity of alkaloid extracts were performed. Fourteen isoquinoline alkaloids were identified, with the principle ones being protopine, cryptopine, sinactine, parfumine, fumariline, fumarophycine, and fumaritine. Protopine contents, defined by HPLC analysis varied between 210.6 ± 8.8 μg/g DW (F. schrammii) and 334.5 ± 7.1 μg/g DW. (F. rostellata). While all of the investigated alkaloid extracts significantly inhibited acetylcholinesterase activity, the F. kralikii demonstrated the highest level of inhibition (IC50 0.13 ± 0.01 mg extract/mL).

scholarly journals Lignans and Terpenoids From the Fruits of Vitex kwangsiensia and Their Inhibitory Activity on Nitric Oxide Production in Macrophages

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984817
Author(s):  
Tong Shen ◽  
Yongdong Wang ◽  
Zhiming Zhu ◽  
Xiujie Wang ◽  
Tian Tian
Keyword(s):  
Nitric Oxide ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Spectroscopic Methods ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Raw264.7 Macrophages ◽  
Phytochemical Investigation ◽  
Reported Data ◽  
First Time

Phytochemical investigation of the fruits from Vitex kwangsiensia led to the isolation of 18 constituents, including 6 lignans (1-6), 3 diterpenoids (7-9), 2 sesquiterpenoids (10, 11), 2 triterpenoids (16, 17), and 5 other compounds. Their structures were identified by spectroscopic methods (mass spectroscopy, infrared, UV, 1-dimensional and 2-dimensional nuclear magnetic resonance) and comparison with reported data in the literatures. Among these constituents, compound 1 was a new lignan and named as vitekwangin A. The spectroscopic data of 2 was reported herein for the first time, and given a trivial name vitekwangin B. The isolated lignans, diterpenoids, and sesquiterpenoids were evaluated for their inhibitory activity to prevent nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophages.

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