scholarly journals Chemical composition and acetylcholinesterase inhibitory activity of essential oil from rhizomes of Distichochlamys benenica

2021 ◽  
Vol 129 (1D) ◽  
pp. 43-49
Author(s):  
Hanh Thi Nhu Hoang ◽  
Thanh Thu Thi Dinh ◽  
Ty Viet Pham ◽  
Hien Bich Thi Le ◽  
Duc Viet Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Inhibitory Activity ◽  
Acetylcholinesterase Activity ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Ic50 Value

Twenty-seven constituents were identified by using GC/MS, representing 99.57% of the rhizome oil of Distichochlamys benenica. The major constituents of the essential oil are 1,8-cineole (54.39%), β-pinene (7.50%), (E)-citral (7.26%), and (Z)-citral (6.79%). The rhizome essential oil has anti-acetylcholinesterase activity with an IC50 value of 136.63 ± 2.70 mg/mL.

Chemical Constituents and Anti-Acetylcholinesterase Activities of Dolomiaea wardii

2013 ◽  
Vol 634-638 ◽  
pp. 901-904
Author(s):  
Chun Lei Li ◽  
Jie Sheng
Keyword(s):  
Chemical Composition ◽  
Ethyl Acetate ◽  
Betulinic Acid ◽  
Inhibitory Activity ◽  
Chemical Constituents ◽  
Acetylcholinesterase Activity ◽  
Ic50 Value ◽  
First Time

The chemical composition of the ethyl acetate and n-butanol extracts of Dolomiaea wardii has been reported for the first time in the present study and eight compounds were isolated and identified as corymbolone(1), encelin(2), 8-oxoargentone(3), betulinic acid(4), lupeol(5), 4-hydroxyacetophenone(6), sweroside(7), Laganoside(8). anti-acetylcholinesterase activity of 1-8 showed that compound 6 have weak inhibitory activity with IC50 value of 1.43 mM.

scholarly journals Chemical composition and antifungal activity of essential oils from four Asteraceae plants grown in Egypt

2018 ◽  
Vol 73 (7-8) ◽  
pp. 313-318 ◽  
Author(s):  
Rose Vanessa Bandeira Reidel ◽  
Simona Nardoni ◽  
Francesca Mancianti ◽  
Claudia Anedda ◽  
Abd El-Nasser G. El Gendy ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Antifungal Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibitory Activity ◽  
First Time

Abstract The objective of the present paper was the assessment of the chemical composition of the essential oils from four Asteraceae species with a considerable food, medicinal, and agricultural value, collected in Egypt, together with their in vitro inhibitory activity against molds and yeasts. The essential oil of Launaea cornuta flowers was also evaluated for the first time, but because of its very low yield (<0.01%), no antifungal test was performed.

scholarly journals Xanthine Oxidase Inhibitory Activity, Chemical Composition, Antioxidant Properties and GC-MS Analysis of Keladi Candik (Alocasia longiloba Miq)

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2658 ◽  
Author(s):  
Ferid Abdulhafiz ◽  
Arifullah Mohammed ◽  
Fatimah Kayat ◽  
Matcha Bhaskar ◽  
Zulhazman Hamzah ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Side Effects ◽  
Herbal Medicine ◽  
Xanthine Oxidase ◽  
Inhibitory Activity ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Fruit Extracts ◽  
Ms Analysis ◽  
Ic50 Value

Alocasia longiloba, locally known as ‘Keladi Candik’, has been used traditionally to treat wounds, furuncle and joint inflammations. A. longiloba can be a new source of herbal medicine against hyperuricemia by inhibiting the activity of xanthine oxidase enzyme, the enzyme which is responsible for the development of hyperuricemia in human. Existing xanthine oxidase inhibitors (XOI drugs) show several side effects on gout patients. Therefore, an alternative herbal medicine from plants, with high therapeutic property and free of side effects, are greatly needed. This study was conducted to evaluate XO inhibitory activity, chemical composition, antioxidant activity and GC-MS profile of A. longiloba. Our results showed that ethanolic petiole extract exhibited the highest XO inhibitory activity (70.40 ± 0.05%) with IC50 value of 42.71 μg/mL, followed by ethanolic fruit extracts (61.44 ± 1.24%) with the IC50 value of 51.32 μg/mL. In a parallel study, the phytochemical analysis showed the presence of alkaloid, flavonoid, terpenoids, glycoside and saponin in petiole and fruit extracts, as well as higher total phenolic and flavonoid contents and strong scavenging activity on DPPH and ABTS antioxidant assay. The GC-MS analysis of fruit and petiole extracts revealed the presence of various compounds belonging to different chemical nature, among them are limonen-6-ol, α-DGlucopyranoside, paromomycin, aziridine, phenol, Heptatriacotanol, Phen-1,2,3-dimethyl and Betulin found in ethanolic fruit extract, and Phen-1,4-diol,2,3-dimethyl-, 1-Ethynyl-3,trans(1,1-dimethylethyl), Phenol,2,6-dimethoxy-4-(2-propenyl)- and 7-Methyl-Z-tetradecen-1-olacetate found in ethanolic petiole extract. Some compounds were documented as potent anti-inflammatory and arthritis related diseases by other researchers. In this study, the efficiency of solvents to extract bioactives was found to be ethanol > water, methanol > hexane > chloroform. Together, our results suggest the prospective utilization of fruit and petiole of A. longiloba to inhibit the activity of XO enzyme.

Chemical composition and α-amylase inhibitory activity of the essential oil from Sabina chinensis cv. Kaizuca leaves

2017 ◽  
Vol 32 (6) ◽  
pp. 711-713 ◽  
Author(s):  
Dongyu Gu ◽  
Chen Fang ◽  
Jiao Yang ◽  
Minjing Li ◽  
Hengming Liu ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Inhibitory Activity

scholarly journals Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil

2013 ◽  
Vol 54 (1) ◽  
pp. 10 ◽  
Author(s):  
Chen-Tien Chang ◽  
Wen-Lun Chang ◽  
Jaw-Cherng Hsu ◽  
Ying Shih ◽  
Su-Tze Chou
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Inhibitory Activity ◽  
Tyrosinase Inhibitory Activity ◽  
Cinnamomum Cassia

scholarly journals Chemical Composition andα-Glucosidase Inhibitory Activity of VietnameseCitrusPeels Essential Oils

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Nguyen Hai Dang ◽  
Pham Huong Nhung ◽  
Bui Thi Mai Anh ◽  
Dinh Thi Thu Thuy ◽  
Chau Van Minh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibitory Activity ◽  
Inhibitory Effect ◽  
Potential Use

Background. Inhibition ofα-glucosidase is an important factor to control postprandial hyperglycemia in type 2 diabetes mellitus.Citrusessential oils (CEO) are among the most widely used essential oils, and some of them exhibited promising antidiabetic effect. However, theα-glucosidase inhibition of CEO has not been investigated so far. The present work aims to evaluate theα-glucosidase inhibition of essential oils from six VietnameseCitruspeels.Methods. The chemical composition of essential oils obtained by hydrodistillation from sixCitruspeels was analyzed by GC-MS. All essential oils were tested for their inhibitory activity onα-glucosidase usingp-nitrophenyl-α-D-glucopyranoside as substrate.Results. In Buddha’s hand and lime peels, the major components were limonene (59.0–61.31%) andγ-terpinene (13.98–23.84%) while limonene (90.95–95.74%) was most abundant in pomelo, orange, tangerine, and calamondin peels. Among the essential oils, the Buddha’s hand oil showed the most significantα-glucosidase inhibitory effect with the IC50value of 412.2 μg/mL. The combination of the Buddha’s hand essential oil and the antidiabetic drug acarbose increased the inhibitory effect.Conclusions. The results suggested the potential use of Buddha’s hand essential oil as an alternative in treatment of type 2 diabetes mellitus.

scholarly journals Chemical Composition and Lipoxygenase Inhibitory Activity of the Essential Oil of Alstonia Angustiloba

2021 ◽  
Author(s):  
Wan Mohd Nuzul Hakimi Wan Salleh ◽  
Muhammad Helmi Nadri ◽  
Shamsul Khamis
Keyword(s):  
Gas Chromatography ◽  
Essential Oil ◽  
Inhibitory Activity ◽  
Mass Spectrometry Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Chemical Components ◽  
Moderate Activity ◽  
Spectrometry Analysis ◽  
Ic50 Value ◽  
Total Oil

This study was aimed to investigate the chemica l compositions and lipoxygenase inhibitory activity of the essential oil from Alstonia angustiloba growing in Malaysia. The essential oils were obtained by hydrodistillation and fully characterized by gas chromatography and gas chromatography-mass spectrometry. Analysis of the A. angustiloba essential oil resulted in the identification of twenty-five chemical components, attributed 90.8% of the total oil. The most abundant components of A. angustiloba oil were linalool (21.2%), 1,8-cineole (16.8%), α-terpineol (9.5%), terpinene-4-ol (8.5%), β-caryophyllene (6.2%), and caryophyllene oxide (5.2%). The essential oil displayed moderate activity towards lipoxygenase activity with IC50 value of 45.8 μg/mL.

Chemical composition and in vitro anticholinesterase inhibitory activity of Citrus medica L. cv. Diamante essential oil

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
F Menichini ◽  
R Tundis ◽  
MR Loizzo ◽  
M Bonesi ◽  
F Conforti ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Inhibitory Activity ◽  
Citrus Medica

SEMI-SYNTHESIS AND EVALUATION OF HESPERETIN DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS7

2018 ◽  
Vol 8 (4) ◽  
pp. 7-12
Author(s):  
Huan Tran The ◽  
Dao Tran Thanh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Key Words ◽  
Inhibitory Activity ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Ic50 Value ◽  
Ellman’S Method ◽  
Further Development ◽  
Derivatives Of

Background: Inhibition of acetylcholinesterase are regarded as one of promising approach to treat Alzheimer’s disease. Hesperetin is a potential flavonoid for further development in this direction. Objectives: Semi-synthesized and assayed for hesperetin derivatives’s acetylcholinesterase inhibitory activity in vitro. Materials and methods: Ester and ether derivatives of hesperetin were semi-synthesized. The semi-synthesis compounds were tested for acetylcholinesterase inhibitory activity in vitro according to the Ellman’s method. Results: Hesperetin is obtained by hydrolysing hesperidin. Then, two ester and two ether derivatives were semi-synthesized from hesperetin. The results showed that some of the semi-synthesis hesperetin derivatives displayed stronger acetylcholinesterase inhibitory activity than hesperetin. Among them, derivative 1 has the best activity with an IC50 value of 43.50 μM. Conclusions: Four hesperetin derivatives were semi-synthesized and investigated their acetylcholinesterase inhibitory activity, some of which showed improvement in activity. Key words: Hesperetin, semi-synthesis, inhibit, enzyme, acetylcholinesterase

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