Clinical characteristics, laboratory findings and outcomes of Toxoplasma gondii infection in HIV/AIDS patients at Bach Mai Hospital

2021 ◽  
Vol 07.en ◽  
Keyword(s):  
Toxoplasma Gondii ◽  
Clinical Characteristics ◽  
Aids Patients ◽  
Laboratory Findings ◽  
Toxoplasma Gondii Infection ◽  
Hiv Aids

scholarly journals Sero-Molecular Detection of Toxoplasma Gondii Infection among HIV-Positive Patients in Khartoum : A Cross Sectional Study

2021 ◽  
pp. 125-131
Author(s):  
Elghazali Mohammed ◽  
Mustafa Yassin ◽  
Khalid Anan ◽  
Awadalkareem Omer ◽  
Mutaz A. Elsir ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Blood Donors ◽  
Demographic Data ◽  
Clinical Stage ◽  
Hiv Positive ◽  
Aids Patients ◽  
Cross Sectional ◽  
Igm Antibodies ◽  
Toxoplasma Gondii Infection ◽  
Hiv Aids

Background and Aim : Toxoplasmosis is one of the most common comorbidities in HIV-positive patients with CD4+ T lymphocytes below 200 cells/μl. Toxoplasmosis with encephalitis may affect HIV infection, in particular in patients with developing AIDS. Early diagnosis and treatment of toxoplasmosis reduces the mortality rate in HIV-positive people. The aim of this study was to estimate the seroprevalence of Toxoplasma gondii infection in HIV-positive patients in Khartoum, Sudan using serological and molecular methods. Methods : This was a descriptive cross sectional, hospital based study, blood sample were collected from 100 participants; out of them were 50 HIV/AIDS patients and 50 were healthy Blood donors attending HIV Center -Omdurman Hospital, and Sudan Heart Center blood bank respectively. Socio- demographic data were collected by structured questionnaire. Of the 50 HIV/AIDS patients, 25 (50%) were from each gender, their age ranged between 22 and 62 with mean of 39.5+10.69. They were classified into two age groups; from 22 to 42 years, and from 43 to 62 years, and their distribution was 29 (58%), and 21 (42%) respectively. According to the clinical stage they were classified into the four clinical-stage groups and their distribution was as following: 06 (12.0%) in stage 1, 02 (04%) in stage 2, 40 (80.0%) in stage 3, and 02 (04.0%) in stage 4. Twelve of them (22%) were under ART treatments. The 50 blood donors on their hand were all males, their age was ranged between 18 and 42 years old. Regarding their educatio, 15 (30%) were educated, while the remaining 35 (70%) were none educated. Mentioning their marital status 10 (20%) were married, while 40 (80%) were single. Regarding the contact with cats 25 (50%) has contact with cats. All samples collected were tested for anti-Toxoplasma IgG and IgM antibodies by ELISA, and by PCR for detection of Toxoplasma DNA.. Results: Out of the 50 HIV/AIDS patients; Anti-Toxoplasma IgM was detected in two patients (04%), while IgG was detected in 08 (16%) patients, the Toxoplasma DNA was detected in three (06%) patients.Regarding the blood donors group; all studied blood donors showed negative results for anti-toxoplasma IgM, while 16 (32%) showed positive anti-Toxoplasma IgG.No blood donors sample was detected positive for Toxoplasma DNA with PCR. There were no significant differences in comparison between the blood donors and the HIV/AIDS patients regarding serological and molecular toxoplasma test results. Conclusion : The current study showed a relatively high seroprevalance of anti-T.gondii IgG and low IgM antibodies in HIV-positive patients in comparison with previous studies in Sudan. Considering the relatively high seroprevalance rate of toxoplasma infection in blood donors reported in this study, toxoplasmosis should be considered as a significant transfusion risk.

scholarly journals Sero–Prevalence, and Associated Risk Factors of Toxoplasma gondii Infection in Pregnant Women and HIV/AIDS Patients in Selected Cities of Ethiopia

2014 ◽  
Vol V (10) ◽  
pp. 17-29 ◽  
Author(s):  
Anteneh HAILU HAILU ◽  
Kassahun NEGASHE NEGASHE ◽  
Aweke TASE TASEW ◽  
Medhint GETACH GETACHEW ◽  
Tesfaye SISAY SISAY ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Aids Patients ◽  
Women And Hiv ◽  
Toxoplasma Gondii Infection ◽  
Associated Risk Factors ◽  
Hiv Aids

scholarly journals Toxoplasma gondii Infection and Clinical Characteristics of Patients With Schizophrenia: A Systematic Review and Meta-analysis

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Arjen L Sutterland ◽  
David A Mounir ◽  
Juul J Ribbens ◽  
Bouke Kuiper ◽  
Tom van Gool ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Publication Bias ◽  
Clinical Characteristics ◽  
Negative Symptoms ◽  
Age Of Onset ◽  
Meta Analysis ◽  
Random Effects Models ◽  
Duration Of Illness ◽  
Toxoplasma Gondii Infection

Abstract Schizophrenia is associated with an increased prevalence of IgG antibodies against Toxoplasma gondii (T. gondii seropositivity), whereby the infection seems to precede the disorder. However, it remains unclear whether a T. gondii infection affects clinical characteristics of schizophrenia. Therefore, a systematic review and meta-analysis was conducted following PRISMA guidelines examining the association between T. gondii seropositivity and severity of total, positive, or negative symptoms or age of onset in schizophrenia. PubMed, Embase, and PsycInfo were systematically searched up to June 23, 2019 (PROSPERO #CRD42018087766). Random-effects models were used for analysis. Furthermore, the influence of potential moderators was analyzed. Indications for publication bias were examined. From a total of 934 reports, 13 studies were included. No overall effect on severity of total, positive, or negative symptoms was found. However, in patients with a shorter duration of illness T. gondii seropositivity was associated with more severe positive symptoms (standardized mean difference [SMD] = 0.32; P < .001). Similar but smaller effects were seen for total symptoms, while it was absent for negative symptoms. Additionally, a significantly higher age of onset was found in those with T. gondii seropositivity (1.8 y, P = .015), although this last finding was probably influenced by publication bias and study quality. Taken together, these findings indicate that T. gondii infection has a modest effect on the severity of positive and total symptoms in schizophrenia among those in the early stages of the disorder. This supports the hypothesis that T. gondii infection is causally related to schizophrenia, although more research remains necessary.

CEREBRAL TOXOPLASMA GONDII INFECTION AMONG NORWEGIAN AIDS PATIENTS. INDICATION FOR PROPHYLAXIS?

AIDS ◽  
1994 ◽  
Vol 8 (Supplement 4) ◽  
pp. S39
Author(s):  
O Dunlop ◽  
V Rootwelt ◽  
M Sannes ◽  
J Mahlen ◽  
K Skaug ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Aids Patients ◽  
Toxoplasma Gondii Infection

scholarly journals Disseminated toxoplasmosis presenting as sepsis in two AIDS patients

2007 ◽  
Vol 49 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Carlos José Dornas Gonçalves Barbosa ◽  
Rodrigo Juliano Molina ◽  
Murilo Barcelos de Souza ◽  
Ana Cristina A. Silva ◽  
Adilha Rua Micheletti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Toxoplasma Gondii ◽  
Inflammatory Reaction ◽  
Acquired Immunodeficiency Syndrome ◽  
Aids Patients ◽  
Laboratory Findings ◽  
Opportunistic Disease ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

This report describes two patients who presented acute disseminated and severe toxoplasmosis as the first opportunistic disease related to acquired immunodeficiency syndrome. At admission, clinical and laboratory findings were similar to sepsis or septic shock and a fast evolutive course to death occurred in both cases. At necropsy, an inflammatory reaction and presence of a great number of Toxoplasma gondii cysts and tachyzoites were observed in most organs examined.

scholarly journals Molecular diagnosis of Toxoplasma gondii infection in cerebrospinal fluid from AIDS patients

2009 ◽  
Vol 6 (1) ◽  
pp. 2 ◽  
Author(s):  
Yenisey Alfonso ◽  
Jorge Fraga ◽  
Carlos Fonseca ◽  
Narciso Jiménez ◽  
Taimy Pinillos ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Toxoplasma Gondii ◽  
Molecular Diagnosis ◽  
Aids Patients ◽  
Toxoplasma Gondii Infection

Prevalence of Toxoplasmosis among HIV/AIDS Patients and Correlation of Radiological Investigations with Laboratory Findings

2019 ◽  
Vol 26 (3) ◽  
pp. 1-10
Author(s):  
Siddharth Pimpalkar ◽  
Meena Mishra ◽  
Arvind Kurhade ◽  
Chandrashekhar Unakal ◽  
Geeta Kurhade ◽  
...  
Keyword(s):  
Aids Patients ◽  
Laboratory Findings ◽  
Hiv Aids

scholarly journals Toxoplasmosis in Pregnant Women and HIV/AIDS Patients in Ethiopia: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Daniel Getacher Feleke ◽  
Angesom Gebreweld ◽  
Gashaw Zewde
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Group Analysis ◽  
Aids Patients ◽  
Pooled Prevalence ◽  
Women And Hiv ◽  
And Control ◽  
Hiv Aids

Background. Although Toxoplasma gondii infection in immune-competent individuals is usually asymptomatic or causes a mild flu-like illness, it may become severe and can occasionally be fatal in immune-compromised people, such as AIDS patients or pregnant women. Method. Electronic English databases (Pubmed, Google Scholar, Science Direct, and Scopus), parasitology congresses, and theses of Ethiopian medical universities, were systematically searched (published or unpublished data). Full-length articles and abstracts were collected using keywords such as Toxoplasma gondii, Toxoplasmosis, pregnant women, HIV/AIDS, and Ethiopia. Results. Analysis of seroprevalence estimates was pooled using a random effects meta-analysis. Seventeen studies were included in the present systematic review and meta-analysis. One of these studies reported seroprevalence of T. gondii in HIV/AIDS patients and pregnant women. In this review, a total of 4,030 individuals were included and analyzed. The pooled prevalence of T. gondii in this review was 81.00% (95% CI = 69.10–89.78). Sub-group analysis showed that 2,557 pregnant women were evaluated. In pregnant women, the pooled sero-prevalence was 71.2 (95% CI = [51.9%, 87.1%]. In HIV/AIDS patients, 1,473 individuals were evaluated and the pooled seroprevalence was 88.45 (95% CI = 80.87%–94.31%). Conclusion. This systematic review and meta-analysis identified a high seroprevalence of Toxoplasma infection of 81% among immunocompromised patients. Scaling up prevention and control methods mainly strengthening educational efforts are necessary to avoid reactivation and to stop the spread of T. gondii infection.

STUDY OF TOXOPLASMA GONDII INFECTION IN EPILEPTIC CHILDREN

2014 ◽  
pp. 63-67
Author(s):  
Thi Hong Duc Nguyen ◽  
Nu Van Anh Ton
Keyword(s):  
Toxoplasma Gondii ◽  
Clinical Characteristics ◽  
Pediatric Patients ◽  
Igg Antibodies ◽  
Key Words Epilepsy ◽  
Epileptic Children ◽  
Center Hospital ◽  
Toxoplasma Gondii Infection ◽  
Acquired Epilepsy ◽  
Pediatric Center

Objective: Epilepsy is a chronic neurological disorder that affects many people of all ages. Some recent studies showed that cerebral toxoplasmosis is one of the causes’ acquired epilepsy in developing countries. In this study, we investigated the frequency of Toxoplasma gondii infection in epileptic children and some clinical characteristics difference with between seropositive and seronegative of T.gondii. Material and methods: We selected 62 pediatric patients with epilepsies that were treatment at Pediatric center (Hue Center Hospital) and tested them for evidence of T. gondii IgM, IgG antibodies by the enzyme-linked immunesorbent assay (ELISA). We studied some clinical characteristics differences between T.gondii seropositive and seronegative groups. Results: The seropositive proportion of antibodies to Toxoplasma gondii in epileptic children was 25.8% (25% IgM(+)IgG(-), 56,25% IgG(+)IgM(-) and 18.75% IgM(+)IgG(+)) and the over 10 age group accounted for the highest percentage of T.gondii positive (43.8%). The seropositive group had a significant different than seronegative group about ages, frequency of seizures and period of disease. There had no significant different between two groups about sex, residency and the type of seizures. Conclusion: Toxoplasma gondii had a high proportion in epileptic children. Key words: Epilepsy, Toxoplasma gondii

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