scholarly journals Disseminated toxoplasmosis presenting as sepsis in two AIDS patients

2007 ◽  
Vol 49 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Carlos José Dornas Gonçalves Barbosa ◽  
Rodrigo Juliano Molina ◽  
Murilo Barcelos de Souza ◽  
Ana Cristina A. Silva ◽  
Adilha Rua Micheletti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Toxoplasma Gondii ◽  
Inflammatory Reaction ◽  
Acquired Immunodeficiency Syndrome ◽  
Aids Patients ◽  
Laboratory Findings ◽  
Opportunistic Disease ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

This report describes two patients who presented acute disseminated and severe toxoplasmosis as the first opportunistic disease related to acquired immunodeficiency syndrome. At admission, clinical and laboratory findings were similar to sepsis or septic shock and a fast evolutive course to death occurred in both cases. At necropsy, an inflammatory reaction and presence of a great number of Toxoplasma gondii cysts and tachyzoites were observed in most organs examined.

scholarly journals Fungal Mastoiditis in AIDS Patients: Reported Cases

2011 ◽  
Vol 15 (02) ◽  
pp. 245-248
Author(s):  
Flavia Silveira ◽  
Gabriel Bijos Faidiga ◽  
Tassiana do Lago ◽  
Camila Carrara Yassuda ◽  
Eduardo Tanaka Massuda ◽  
...  
Keyword(s):  
Case Report ◽  
Facial Nerve ◽  
Antifungal Therapy ◽  
Acquired Immunodeficiency Syndrome ◽  
Aids Patients ◽  
Aspergillus Fumigates ◽  
Immunosuppressed Patients ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Fatal Complications

Summary Introduction: Fungal mastoidits by Aspergillus fumigates predominantly occurs in immunosuppressed patients. Diagnosis is usually hard and disease is potentially fatal. Treatment is comprised of antifungal therapy, surgical debridement and immunosuppression correction. Case Report: This article reports a case of fungal mastoiditis in a patient with acquired immunodeficiency syndrome (AIDS). The treatment performed was that of surgery associated with antifungal therapy. The patient's facial nerve was not affected, what does not exclude potentially fatal complications of mastoiditis.

Helicobacter pylori in Children With Acquired Immunodeficiency Syndrome

PEDIATRICS ◽  
1993 ◽  
Vol 91 (6) ◽  
pp. 1217-1217
Author(s):  
U. BLECKER ◽  
K. KEYMOLEN ◽  
H. SOUAYAH ◽  
J. LEVY ◽  
Y. VANDENPLAS
Keyword(s):  
Helicobacter Pylori ◽  
Acquired Immunodeficiency Syndrome ◽  
Ethnic Origin ◽  
Control Population ◽  
Aids Patients ◽  
Pediatric Aids ◽  
Acquired Immunodeficiency ◽  
H Pylori ◽  
Immunodeficiency Syndrome ◽  
Asymptomatic Control

To the Editor.— It has been demonstrated that the presence of Helicobacter pylori-associated gastritis is rare in adults with acquired immunodeficiency syndrome (AIDS).1 To investigate the prevalence of H pylori infection in pediatric AIDS patients, we examined 19 children, aged 1 to 14 years (mean age 5 years 11 months), of mainly central African ethnic origin. They were compared to an asymptomatic control population of comparable age (n = 52; mean age = 5 years, 10 months) and ethnic origin.

Septic shock in patients with the acquired immunodeficiency syndrome

1997 ◽  
Vol 23 (10) ◽  
pp. 1018-1023 ◽  
Author(s):  
M. Thyrault ◽  
B. Gachot ◽  
C. Chastang ◽  
B. Souweine ◽  
J. F. Timsit ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acquired Immunodeficiency Syndrome ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

scholarly journals Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS

Blood ◽  
1986 ◽  
Vol 67 (3) ◽  
pp. 831-834 ◽  
Author(s):  
DW Archibald ◽  
L Zon ◽  
JE Groopman ◽  
MF McLane ◽  
M Essex
Keyword(s):  
At Risk ◽  
Virus Type ◽  
Acquired Immunodeficiency Syndrome ◽  
Serum Antibodies ◽  
Aids Patients ◽  
T Lymphotropic Virus ◽  
Type Iii ◽  
Whole Saliva ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Abstract Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14 of 15 (93%) AIDS- related complex (ARC) patients had salivary antibodies that reacted with the virus-encoded glycoproteins gp160 and gp120 of HTLV-III infected cells. All of the AIDS and ARC patients had serum antibodies to the same antigens. Of 20 sex partners of AIDS/ARC patients, nine (45%) showed anti-HTLV-III antibodies, and four of 18 (22%) healthy homosexual males also were positive for such antibodies. Serum and salivary antibody status were the same in these groups. A minority of those patients positive for salivary antibodies to env gene-encoded gp160 and gp120 also had salivary antibodies to gag gene-encoded proteins of 55,000, 24,000, and/or 17,000 daltons. Immunoglobulin A (IgA) class antibodies comprised the majority of the salivary antibody response. The spectrum of HTLV-III proteins detected by the salivary and serum antibodies was similar. The possibility that secretory IgA from the gut-associated lymphoid system may play a role to restrict salivary transmission of HTLV-III should be considered.

scholarly journals Anisocoria, An Unusual Physical Exam Finding Leading to a Concurrent Diagnosis of Cerebral Toxoplasmosis and HIV/AIDS

2021 ◽  
pp. 1-4
Author(s):  
Ivanka Vante ◽  
◽  
Melissa Matheus ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Toxoplasma Gondii ◽  
Hiv Infection ◽  
Acquired Immunodeficiency Syndrome ◽  
Cns Infection ◽  
Cerebral Toxoplasmosis ◽  
Acquired Immunodeficiency ◽  
Physical Exam Finding ◽  
Immunodeficiency Syndrome

Cerebral toxoplasmosis is the most common opportunistic central nervous system (CNS) infection, affecting patients with advanced/untreated acquired immunodeficiency syndrome (AIDS). Cerebral toxoplasmosis is caused by the parasite Toxoplasma gondii typically and it usually occurs in immunecompromised patients with a CD4 count below 100cell/microL [1,2]. Left untreated, symptomatic patients can progress to coma within days to weeks, significantly increasing rates of this population’s morbidity and mortality. Cerebral toxoplasmosis is rarely encountered before the diagnosis of HIV infection is established, which is why seemingly benign neurological complaints can be easily overlooked.

scholarly journals Sonographic detection of abdominal pathologies in human immunodeficiency virus/acquired immunodeficiency syndrome patients and its correlation with CD4 counts – A prospective analysis

2020 ◽  
Vol 0 ◽  
pp. 1-8
Author(s):  
Tejas Kanthrao Mankeshwar ◽  
Ashok Kumar Sharma
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Nodes ◽  
Acquired Immunodeficiency Syndrome ◽  
Cd4 Count ◽  
Aids Patients ◽  
Cd4 Counts ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Objectives: Abdominal pathologies are the second most common after pulmonary diseases in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Ultrasonography (USG) is a vital imaging technique for the evaluation of abdominal pathologies. This study was aimed at evaluating the abdominal pathologies using USG in HIV/AIDS and further analysis of its correlation with CD4 count. Material and Methods: The present study was carried out on 392 HIV-positive patients with abnormal abdominal sonographic findings. All data were analyzed by Chi-square test and one-way analysis of variance using SPSS 16.0 software. Results: Of these 392 patients, 66.3% were males, the mean age was 35.7 years, (range 7–64 years) and most of them were in 4th decade. On ultrasonographic evaluation, spleen was involved in 45.2% patients and liver as well as lymph nodes each was involved in 43.6% patients. Other cases displayed ascites and bowel thickening in 5.3% and 3.8% patients, respectively. Less involvement of kidney (2.3%), pancreas (1.5%), and biliary system (1.3%) was observed. In addition, pathologies such as hepatomegaly, splenomegaly, splenic microabscess, focal pancreatic lesion, mesenteric, and periportal lymphadenopathy showed significant correlation with CD4 counts. Lymphoma was found in 1% of patients, involving liver, pancreas, and retroperitoneal lymph nodes. Conclusion: Our study highlights the clinical utility of abdominal USG in HIV/AIDS patients. CD4 counts largely affect the differential diagnosis in HIV/AIDS patients. USG findings interpreted in the context of CD4 count may help in guiding the exact diagnosis.

Activation of monocyte-mediated tumoricidal activity in patients with acquired immunodeficiency syndrome.

1985 ◽  
Vol 3 (7) ◽  
pp. 1005-1012 ◽  
Author(s):  
E S Kleinerman ◽  
L M Ceccorulli ◽  
L A Zwelling ◽  
T Twilley ◽  
R B Herberman ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Mononuclear Cells ◽  
Human Tumor ◽  
Target Cells ◽  
Aids Patients ◽  
Tumoricidal Activity ◽  
Ifn Gamma ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

The purpose of these studies was to determine whether peripheral blood monocytes from acquired immunodeficiency syndrome (AIDS) patients with Kaposi's sarcoma could be activated to lyse human tumor target cells in vitro. Monocytes were isolated and incubated for 24 hours in vitro with either medium (control), a crude mitogen-induced lymphokine preparation (MAF), or endotoxin before the addition of [125I]IUdR-labeled A375 melanoma target cells. Cytolysis was determined 72 hours later. Twelve (100%) of 12 patients tested had monocyte-mediated cytotoxicity values that were comparable to those of normal individuals. Recombinant human gamma interferon (IFN gamma) activated both normal and AIDS monocyte-mediated tumoricidal function only when combined with lypopolysaccharide (LPS). In addition, mononuclear cells from ten AIDS patients were also tested for their ability to secrete MAF and IFN gamma in response to a mitogenic stimulus. Lymphokines generated from all ten patients contained substantial amounts of IFN gamma (100 to 2,500 U/mL); however, three of these ten lymphokine preparations failed to activate normal monocytes to lyse tumor cells. These results suggest that monocyte-mediated tumoricidal function of AIDS patients is intact and thus suggest new approaches for the therapy of AIDS.

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