scholarly journals Olfactory neuroblastoma

2020 ◽  
Vol 55 (1) ◽  
pp. 33-35
Author(s):  
B. B. ZHETPISBAEV ◽  
E. B. SATBAEVA ◽  
N. A. RYSKELDIEV ◽  
N. N. ASHIROV ◽  
E. S. GORSHKOVA
Keyword(s):  
Nasal Cavity ◽  
Olfactory Neuroblastoma ◽  
City Hospital ◽  
Differentiation Markers ◽  
Typical Structure ◽  
Clinical Observations ◽  
Tumor Diagnostics ◽  
Degree Of Malignancy ◽  
The Right ◽  
Ethmoid Sinuses

The article describes a classic case of olfactory neuroblastoma in a 33-year-old female patient diagnosed with «nasal cavity neoplasm (polyp?)» who was referred to the National Centre for Neurosurgery JSC from the ENT Department of the City Hospital No. 1. The first symptoms of the tumor occurred during her pregnancy. The aggressive tumor has invaded the anterior cranial fossa and spread into the right half of the ethmoid sinuses and the orbit. The tumor diagnostics was complicated by the prevalence of symptoms of a nasal cavity neoplasm. The “olfactory neuroblastoma” diagnosis was verified by clinical observations, MRI, and pathomorphological studies. Histological examination of the tumor showed a typical structure of olfactory neuroblastoma. IHC examination showed an expression of neuronal differentiation markers. The degree of malignancy was determined by Hyams grading.

scholarly journals Olfactory neuroblastoma

2020 ◽  
Vol 55 (1) ◽  
pp. 39-42
Author(s):  
B. B. Zhetpisbaev ◽  
E. B. Satbaeva ◽  
N. A. Ryskeldiev ◽  
N. N. Ashirov ◽  
E. S. Gorshkova
Keyword(s):  
Nasal Cavity ◽  
Classical Case ◽  
Olfactory Neuroblastoma ◽  
City Hospital ◽  
Differentiation Markers ◽  
Typical Structure ◽  
Tumor Diagnostics ◽  
Degree Of Malignancy ◽  
The Right ◽  
Ethmoid Sinuses

The article describes a classical case of olfactory neuroblastoma in a 33-year-old female patient diagnosed with «nasal cavity neoplasm (polyp?)» who was referred to the National Centre for Neurosurgery JSC from the ENT Department of the City Hospital No. 1. The first symptoms of the tumor occurred during her pregnancy. The aggressive tumor has invaded the anterior cranial fossa and spread into the right half of the ethmoid sinuses and the orbit. The tumor diagnostics was complicated by the prevalence of symptoms of a nasal cavity neoplasm. The “olfactory neuroblastoma” diagnosis was verified by clinical observations, MRI, and pathomorphological studies. Histological examination of the tumor showed a typical structure of olfactory neuroblastoma. IHC examination showed an expression of neuronal differentiation markers. The degree of malignancy was determined by Hyams grade

scholarly journals Olfactory Neuroblastoma: The Adjunctive Role of Somatostatin Agonists After Surgery

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A595-A595
Author(s):  
Fernando Pazos Toral ◽  
Maria Martino ◽  
David Lobo Duro ◽  
Isabel Martinez Rodriguez
Keyword(s):  
Local Recurrence ◽  
Nasal Cavity ◽  
Residual Disease ◽  
Somatostatin Analogs ◽  
Olfactory Neuroblastoma ◽  
Purulent Discharge ◽  
Low Grade ◽  
Maxillary Artery ◽  
Octreotide Scan ◽  
The Right

Abstract Clinical Case: A 54 years old woman who had a right-sided nasal obstruction, rhinorrhea, and sometimes purulent discharge in 2016. In 2002 she had hyperthyroidism by Graves disease and treated for two years with remission after that. The examination of the nose revealed a dark red bleeding mass filling the area from the right nasal cavity to the nasopharynx. The biochemical and serum hormonal values were in a normal range. Urine 5 -HIIAA was 2,5 mg/24h. MRI T1 and T2-weighted images revealed a mass of 4,1 x 4,2 cm, slightly higher signal in T2 and isointense in T1, that extended into the right nasal cavity and ethmoidal sinus. A biopsy was performed, which revealed neuroendocrine characteristics. Octreotide scan with SPECT showed an intense nasal uptake. Right internal maxillary artery embolization was performed. In the next two days, the tumor was resected through a right lateral rhinotomy. Histopathological examination revealed olfactory neuroblastoma, score low grade, ki67<2%. Positive immunohistochemical staining to CD56, synaptophysin, NSE, GFAP, calretinin, S-100 and chromogranin A, and negative staining to cytokeratins (CKs) (CKAPM, CKBPM, CK8/18), CD99 and Bcl-2. The resection was almost total, with no octreotide scan uptake. The post-MRI revealed a minimal residual lesion. Lanreotide treatment was introduced after surgery; the dose was 120 mg every four weeks the first year and every 8 weeks after that. No secondary effects or biochemical alterations were observed. In 2020 the octreotide scan again revealed nasal uptake showing local recurrence. This local recurrence was treated with surgery, followed by lanreotide 120 mg every 4 weeks. No residual disease has been found afterward. Discussion: A limited number of cases have been reported, but none of them were treated with somatostatin agonists. As in our case, the majority of the ON is slow-progressive and non-secreting. The patients mainly complain of local symptoms such as nasal congestion. Surgery is considered to be the first-line treatment for localized disease. In the case of a close margin of the lesion or a residual tumor, the recommendation was radiotherapy or chemotherapy for more advanced disease. We confirmed that the tumor expressed somatostatin receptors. The octreotide scan has been found helpful in the diagnosis and follow-up. We treated the patient with lanreotide with no progression of the disease for three years. Local recurrence could be treated with surgery, following by lanreotide treatment, no residual disease has been found to date. The somatostatin analogs may be a useful adjuvant therapy for stable disease without evident residual disease after surgery.

scholarly journals Olfactory Neuroblastoma of the Sinonasal Tract with Prominent Orbital Protrusion: A Case Report and Literature Review

2021 ◽  
Author(s):  
Lin Chen ◽  
Jingxin Wang ◽  
Zhigang Yang ◽  
Yingkun Guo
Keyword(s):  
Nasal Cavity ◽  
Nasal Congestion ◽  
Tumor Grade ◽  
Olfactory Neuroblastoma ◽  
Who Grade ◽  
Therapeutic Decisions ◽  
Nasopharyngeal Biopsy ◽  
Chief Complaints ◽  
The Right ◽  
Unilateral Proptosis

AbstractOlfactory neuroblastoma (ONB) is a rare malignant neuroectodermal tumor of the nasal cavity. Olfactory neuroblastoma centered in the posterior right orbit with prominent orbital protrusion is even rare. Grading ONB is extremely important as individualized treatment plans must be formulated according to tumor grade. We report the case of a 67-year-old female who presented with the chief complaints of persistent nasal congestion with intermittent epistaxis and unilateral proptosis over the past five years. Radiological imaging was suggestive of a large heterogeneous mass in the right superior nasal cavity with extensions into the right medial orbit, nasopharynx, the right maxillary sinus, the anterior cranial fossa, right ethmoidal, frontal and bilateral sphenoidal sinuses, as well as into the right frontal lobe. Assessment of the radiologic features revealed the diagnostic possibility of olfactory neuroblastoma. A nasopharyngeal biopsy confirmed an olfactory neuroblastoma. Frontal osteoplastic craniotomy and excision of the intracranial part of the tumor from above and transnasal endoscopic removal of the mass in the nasal cavities, paranasal sinuses and right medial orbit from below was done. Evaluation of histopathological characteristics and immunohistochemical findings revealed a diagnosis of WHO grade IV olfactory neuroblastoma. Because of poor economic condition, the patient did not take adjuvant radiotherapy and chemoradiation and post-operative examination. We report a huge ONB centered in the posterior right orbit with prominent orbital protrusion. Magnetic resonance image and computed tomography are helpful for evaluating the appearance and the extent of ONB, as well as grading this tumor, which may aid therapeutic decisions and improve survival.

scholarly journals Primary mucosal malignant melanoma of the nasal cavity

2020 ◽  
Vol 6 (5) ◽  
pp. 988
Author(s):  
Subrata Mukhopadhyay ◽  
Misbahul Haque
Keyword(s):  
Computed Tomography ◽  
Malignant Melanoma ◽  
Nasal Cavity ◽  
Maxillary Antrum ◽  
Positron Emission ◽  
Recurrent Epistaxis ◽  
Mucosal Malignant Melanoma ◽  
The Right ◽  
Primary Mucosal Malignant Melanoma ◽  
Enhanced Computed Tomography

<p>Primary mucosal melanoma of the nasal cavity and paranasal sinuses is a very aggressive and rare disease with only about 0.5 % of malignant melanoma arising from the nasal cavity. There are only few reports from India. We report a rare case of sino-nasal mucosal malignant melanoma in a 58 years old female who presented with blackish coloured sino-nasal mass involving right nasal cavity, spontaneous and recurrent epistaxis and obliteration of the right naso-labial fold with occasional pain in the past 10 months. Contrast enhanced computed tomography scan showed a heterogenous mass involving right nasal cavity, right maxillary antrum and right ethmoidal area. A positron emission tomography computed tomography was also done which showed increased uptake in the region mentioned above. Initial biopsy, the mass was diagnosed as malignant melanoma. Total maxillectomy was performed with plan of post-operative radiotherapy.</p>

scholarly journals T-cell Lymphoma in the Nasal Cavity in Goat

2021 ◽  
Vol 49 ◽  
Author(s):  
Millena Oliveira Firmino ◽  
Ismael Lira Borges ◽  
Gian Libânio Da Silveira ◽  
Mikael Leandro Duarte De Lima Tolentino ◽  
Erika de Lourdes Gomes Queiroz ◽  
...  
Keyword(s):  
T Cell ◽  
Nasal Cavity ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
Clinical Signs ◽  
T Cell Lymphoma ◽  
Differential Diagnoses ◽  
Farm Animals ◽  
Ocular Involvement ◽  
The Right

Background: Lymphomas are considered uncommon in goats, being the multicentric form with the highest number of cases for the species. Primary intranasal lymphomas are often diagnosed in dogs, cats, and humans. In the literature, there is only a description of a multicentric case involving the frontal sinuses and mucosa of the nasal cavity in a goat; therefore, it is important to describe unusual cases of this disease for the inclusion of new clinical and pathological characteristics in the ruminant clinic medicine. The objective of this work is to describe a case of T-cell lymphoma in the nasal cavity of a young goat.Case: The animal had dyspnea and respiratory noise for 15 days. Clinical examination showed nodulation in the right nasal cavity associated with serosanguinous secretion. Tracheostomy was performed; however, after 30 days the animal was euthanized. A sagittal plane of the head showed a pinkish-gray mass in the right and left nasal cavity, with a smooth, multilobulated surface, smooth adhering to the rostral portion of the dorsal concha and occluding the dorsal nasal meatus. Submandibular lymph nodes were slightly enlarged. Histopathological examination of the nasal cavity revealed a non-encapsulated, poorly delimited and ulcerated tumor composed of round cells arranged in a mantle supported by a discrete fibrovascular stroma extending the mucosa and lamina propria. Cells were round with sparse, eosinophilic and poorly delimited cytoplasm. Nuclei varied from round to elongated with condensed chromatin and evident nucleoli. Occasionally, aberrant nuclei, reniform shape and multinucleated cells were seen. Pleomorphism was moderate characterized by anisocytosis and anisocariosis. Typical and atypical mitosis were frequent (0-4 per field of highest magnification [400x]). Amidst the neoplasm, there were multifocal areas of necrosis and hemorrhage associated with a mild lymphocytic inflammatory infiltrate. Immunohistochemistry showed positive immunostaining for Vimentin antibodies and CD3, and negative for pan CK and CD20.Discussion: The lymphomas immunophenotyping is little used when it comes to farm animals, and there are few studies that use this technique for the definitive diagnosis of these neoplasms for small ruminants. The use of this technique must be considered in each case, in order to determine the pathogenesis, the accurate diagnosis and the origin of the neoplastic lymphocytes. In goats, T-cell lymphomas are the most diagnosed, although cases of multicentric B-cell lymphomas with ocular involvement have been diagnosed. In view of the clinical picture of the case described, infectious rhinitis already described in goats, such as aspergillosis and protothecosis, should be included as differential diagnoses. However, the anatomopathological findings facilitate the direction of the diagnosis, since infectious rhinitis presents as nodules / ulcerated masses or focal areas of necrosis associated with purulent secretion and in the histopathological examination it is possible to observe the intralesional etiological agents. In addition, the enzootic ethmoidal tumor must be included, as it has similar clinical signs and affects young animals, but they are adenomas/adenocarcinomas that affect the ethmoidal nasal shells induced by a retrovirus. Lymphomas in the caprine species are rare in the Northeastern semi-arid, but that in the present diagnostic routine occasionally occurs, being important the first description of its nasal shape for its inclusion in the differential diagnoses of diseases that present with clinical obstruction and dyspnea for the species. Keywords: hematopoietic neoplasia, immunophenotyping, lymphocytes, dyspnea.Descritores: neoplasia hematopoietica, imunofenotipagem, linfócitos, dispneia.Título: Linfoma de células T na cavidade nasal de caprino. 

scholarly journals Rhinolith causing unilateral chronic rhinosinusitis: a case report

2020 ◽  
Vol 6 (2) ◽  
pp. 414
Author(s):  
Sumit Prinja ◽  
Garima Bansal ◽  
Jailal Davessar ◽  
Simmi Jindal ◽  
Suchina Parmar
Keyword(s):  
Nasal Cavity ◽  
Nasal Obstruction ◽  
Maxillary Sinusitis ◽  
Nasal Discharge ◽  
Endonasal Approach ◽  
Review Of Literature ◽  
Medical College ◽  
Uncommon Disease ◽  
Chronic Maxillary Sinusitis ◽  
The Right

<p class="abstract">Rhinolith or nasal stone is formed by mineralization within nasal cavity. They are calcareous concretions that are formed by the deposition of salts on an intranasal foreign body. It is an uncommon disease that may present asymptomatically or cause symptoms like nasal obstruction, consecutive sinusitis with or without purulent rhinitis, post nasal discharge, epistaxis, anosmia, nasal malodour and headache. They are usually diagnosed incidentally on radiographic examinations or depending on the symptoms. In this paper we report a 28-year-old woman admitted in the ENT department of GGS Medical College and Hospital, Faridkot with a calcified mass in the right nasal cavity causing long standing unilateral nasal obstruction for 3 years, rhinorrhoea (usually malodourous foetid), post nasal discharge and headache for 1 year. The calcified mass was thought to contain the air cell and removed by endonasal approach. The aim of this study is to report a case of rhinolith with chronic maxillary sinusitis along with a review of literature.</p>

The nasal cavity and paranasal sinuses

2013 ◽  
Author(s):  
Martin E. Atkinson
Keyword(s):  
Nasal Cavity ◽  
Nasal Septum ◽  
Goblet Cells ◽  
Septal Cartilage ◽  
Olfactory Mucosa ◽  
Nasal Cartilages ◽  
Orbital Roof ◽  
External Nose ◽  
The Right ◽  
Lateral Walls

The nasal cavity is the entrance to the respiratory tract. Its functions are to clean, warm, and humidify air as it is inhaled. Respiratory mucosa covered by pseudostratified ciliated epithelium and goblet cells, as described in Chapter 5 and illustrated in Figure 5.2B, lines the majority of the nasal cavity. The cilia and mucus trap particles, thus cleaning the air; the mucus also humidifies the air and warming is achieved through heat exchange from blood in the very vascular mucosa. The efficiency of all these processes is increased by expanding the surface of the nasal cavity by folds of bone. The nasal cavity also houses the olfactory mucosa for the special sense of olfaction although the olfactory mucosa occupies a very small proportion of the surface of the nasal cavity. The nasal cavity extends from the nostrils on the lower aspect of the external nose to the two posterior nasal apertures between the medial pterygoid plates where it is in continuation with the nasopharynx. Bear in mind that in dried or model skulls, the nasal cavity is smaller from front to back and the anterior nasal apertures seem extremely large because the cartilaginous skeleton of the external nose is lost during preparation of dried skulls. As you can see in Figure 27.1 , the nasal cavity extends vertically from the cribriform plate of the ethmoid at about the level of the orbital roof above to the palate, separating it from the oral cavity below. Figure 27.1 also shows that the nasal cavity is relatively narrow from side to side, especially in its upper part between the two orbits and widens where it sits between the right and left sides of the upper jaw below the orbits. The nasal cavity is completely divided into right and left compartments by the nasal septum . From the anterior view seen in Figure 27.1 , you can see that the surface area of lateral walls of the nasal cavity are extended by the three folds of bone, the nasal conchae. The skeleton of the external nose shown in Figure 27.2 comprises the nasal bones, the upper and lower nasal cartilages, the septal cartilage, and the cartilaginous part of the nasal septum.

scholarly journals Pleomorphic Adenoma Presenting as an Atypical Nasal Mass in a 26-Year-Old Female

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Racheal Hapunda ◽  
Chibamba Mumba ◽  
Owen Ngalamika
Keyword(s):  
Nasal Cavity ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumor ◽  
Rare Entity ◽  
Gland Tumor ◽  
Diagnostic Dilemma ◽  
Nasal Blockage ◽  
History Of ◽  
The Right ◽  
Radiological Image

Pleomorphic adenoma (PA) is a salivary gland tumor that may rarely occur in the nasal cavity. It can be a clinical diagnostic dilemma in many instances due to many possible differential diagnoses. We report the case of a 26-year-old female who presented with a 3-year history of a right nasal growth associated with ipsilateral nasal blockage, nasal pain, and rhinorrhea. Radiological image showed a mild enhancing lesion in the right nasal cavity. The patient underwent a lateral rhinotomy with wide excision of the mass. Histopathological exam was consistent with PA. Nasal PA is a rare entity and should be suspected as a diagnosis for intranasal tumors.

Thymic Carcinoma Presenting as Cranial Metastasis with Intradural and Extracranial Extension: Case Report

Neurosurgery ◽  
2004 ◽  
Vol 54 (1) ◽  
pp. 209-212 ◽  
Author(s):  
Yoji Tamura ◽  
Toshihiko Kuroiwa ◽  
Atsushi Doi ◽  
Kyong-Yob Min
Keyword(s):  
Thymic Carcinoma ◽  
Delayed Diagnosis ◽  
Magnetic Resonance Images ◽  
Computed Tomographic ◽  
Multiple Cycle ◽  
Degree Of Malignancy ◽  
The Right ◽  
Cranial Metastasis ◽  
Upper Mediastinum ◽  
High Degree

Abstract OBJECTIVE AND IMPORTANCE Thymic carcinoma is an uncommon malignant tumor that is different from thymoma. Cranial and brain metastases from this tumor are extremely rare. We report a thymic carcinoma with cranial metastasis and discuss the behavior of this tumor. CLINICAL PRESENTATION A 50-year-old man presented with headache and a palpable scalp tumor. Computed tomographic scans and magnetic resonance images revealed an osteolytic tumor with intradural and extracranial extension in the right occipital bone. INTERVENTION After gross total resection and histological diagnosis, further investigation revealed a primary thymic tumor in the anterior upper mediastinum and liver metastases. The patient received multiple-cycle chemotherapy (cisplatin and gemcitabine) for primary and metastatic lesions. CONCLUSION Thymic carcinoma has a poor prognosis because of a high degree of malignancy, early metastasis, and delayed diagnosis. Thus, treatment of a patient with this tumor calls for prompt diagnosis, surgical treatment, and optimal adjuvant therapy.

scholarly journals Two Rhinoliths in a Single Nasal Cavity in an Elderly Patient Mimicking Fungal Sinusitis

2014 ◽  
Vol 7 (2) ◽  
pp. 76-79
Author(s):  
Vishal Prasad ◽  
Chandrakala Srinivas ◽  
Sheetal Krishnappa ◽  
Suresh T Narayan Rao ◽  
Harshitha T Rajanna
Keyword(s):  
Elderly Patient ◽  
Differential Diagnosis ◽  
Nasal Cavity ◽  
Histopathological Examination ◽  
Middle Turbinate ◽  
The Elderly ◽  
Nasal Discharge ◽  
Fungal Sinusitis ◽  
Nasal Mass ◽  
The Right

ABSTRACT Objective To highlight an interesting and a rare case of two rhinoliths in a single nasal cavity of an elderly male patient, mimicking fungal sinusitis or malignancy. To emphasize that rhinolith has to be considered in the differential diagnosis of unilateral nasal mass even in the elderly. Case report A 55-year-old man presented with a right-sided nasal obstruction, foul-smelling nasal discharge and a mass in the right nasal cavity of 6 months duration. Endoscopic examination revealed a gritty, blackish brown mass filling the entire right nasal cavity. A clinical differential diagnosis of malignancy or fungal sinusitis was made. CT scan of paranasal sinus was suggestive of fungal sinusitis following which patient was posted for biopsy. Intraoperatively, patient was found to have two separate masses in the right nasal cavity which were removed. We found a septal perforation adjoining the area where the rhinolith was impacted, with septum pushed laterally and adherent to middle turbinate. However, there were no features suggestive of malignancy. Histopathological examination also ruled out malignancy and confirmed a vegetable foreign body with calcification around an acellular material. Conclusion Rhinolith, though rare should be considered in the differential diagnosis of unilateral nasal mass in the elderly. How to cite this article Prasad V, Srinivas C, Krishnappa S, Rao STN, Rajanna HT. Two Rhinoliths in a single nasal Cavity in an Elderly Patient Mimicking fungal sinusitis. Clin Rhinol An Int J 2014;7(2):76-79.

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