The Effect of Working-based Individual Protective Behaviors (WIPB) on COVID-19 Mortality in North-West of Iran: A Case-Control Study

SummaryCalpain 10 (CAPN10) variants have been associated with the genetic susceptibility to type 2 diabetes (T2D). In the present case-control study, we analysed the distribution of SNP-19 insertion/deletion (I/D) polymorphism in a total of 607 samples (103 T2D cases and 102 healthy controls) from Brahmin; (100 T2D cases and 100 healthy controls) from Bania and (100 T2D cases and 102 healthy controls) from Jat Sikh ethnic groups of the North-West Indian population. Increased frequency of I allele and II genotype was found in T2D in Brahmin ethnic group [P = 0·003, OR = 2·83 (1·43–5·61 at 95% CI)]. Significant correlation between II genotype and body mass index (BMI) was also observed [P = 0·003, OR = 3·31 (1·52–7·20 at 95% CI)]. No association for the genotypes and alleles was seen in Banias and Jat Sikhs. Our data suggests that SNP-19 I/D variation in the CAPN10 gene is modulated by ethnicity and influences the susceptibility to T2D in the North-West Indian population. We also performed a meta-analysis of relevant studies to assess the validity of this association. Data from 13 case-control studies with 15 760 samples comprising of 8395 T2D cases and 7365 controls were finally analysed. Significant heterogeneity between individual studies was evident in dominant and codominant models. The results of present meta-analysis indicate an association of T2D with carriers of DD genotype of CAPN10 I/D polymorphism. However, further analyses on a larger sample size are required to establish a conclusive association in meta-analysis.

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Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study

Iranian Red Crescent Medical Journal ◽

10.5812/ircmj.26874 ◽

2016 ◽

Vol 18 (12) ◽

Cited By ~ 1

Author(s):

Neda Ghamarzad Shishavan ◽

Saeed Pirouzpanah ◽

Mehrzad Hajialilo ◽

Alireza Khabbazi ◽

Farnaz Jafarpour ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Case Control Study ◽

Case Control ◽

North West ◽

Rheumatoid Arthritis Development ◽

Control Study

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Association of genetic variants in INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) with type 2 diabetes (T2D): a case–control study in three ethnic groups from North-West India

Molecular Genetics and Genomics ◽

10.1007/s00438-015-1099-2 ◽

2015 ◽

Vol 291 (1) ◽

pp. 205-216 ◽

Cited By ~ 10

Author(s):

Jasmine Sokhi ◽

Ruhi Sikka ◽

Priyanka Raina ◽

Ramandeep Kaur ◽

Kawaljit Matharoo ◽

...

Keyword(s):

Type 2 Diabetes ◽

Ethnic Groups ◽

Genetic Variants ◽

Case Control Study ◽

Case Control ◽

North West ◽

Control Study

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Associated Factors and Outcome of Uterine Rupture at Suhul General Hospital, Shire Town, North West Tigray, Ethiopia 2016: A Case-Control Study

Obstetrics and Gynecology International ◽

10.1155/2017/8272786 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Tefera Marie Bereka ◽

Amlaku Mulat Aweke ◽

Tewodrose Eshetie Wondie

Keyword(s):

General Hospital ◽

Uterine Rupture ◽

Associated Factors ◽

Case Control Study ◽

Perinatal Death ◽

Case Control ◽

Uterine Wall ◽

Obstructed Labor ◽

North West ◽

Control Study

Background. Uterine rupture is tearing of the uterine wall during pregnancy or delivery. It may extend to partial or whole thickness of the uterine wall. It is usually a case where obstetric care is poor. In extensive damage, death of the baby and sometimes even maternal death are evident.Objective. This study assesses associated factors and outcome of uterine rupture at Suhul General Hospital, Tigray Region, Ethiopia, 2016.Methodology. A case-control study was conducted by review of data from September 2012 to August 2016. A total of 336 samples were studied after calculating by EPI-INFO using proportion of multiparity (53%) and ratio of 1 : 2 for cases and controls, respectively. Analysis was done using SPSS version 20. Bivariate and multivariate logistic regression was applied withp<0.05.Result. ANC, grand multiparity, malpresentation, and obstructed labor had association, but previous cesarean delivery was not significant. Perinatal mortality was 105 (93%) versus 13 (5.8%) in cases and controls, respectively. Anemia was highest for both groups (53.7% versus 32.1%).Conclusion. Majority of uterine rupture is attributed to prolonged or obstructed labor. Cases of uterine rupture had prompt management preventing maternal mortality, but burden of perinatal death is still high.

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