scholarly journals Salivary levels of uric acid, lactate dehydrogenase, and amylase in smokers versus non-smokers

2021 ◽  
Vol 6 (3) ◽  
pp. 19-24
Author(s):  
S lesan ◽  
M Khatibi ◽  
S Firoozan ◽  
◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactate Dehydrogenase

scholarly journals Prognosis of chronic lymphocytic leukemia: a multivariate regression analysis of 325 untreated patients

Blood ◽  
1987 ◽  
Vol 69 (3) ◽  
pp. 929-936 ◽  
Author(s):  
JS Lee ◽  
DO Dixon ◽  
HM Kantarjian ◽  
MJ Keating ◽  
M Talpaz
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Regression Analysis ◽  
Lactate Dehydrogenase ◽  
Chronic Lymphocytic Leukemia ◽  
Regression Model ◽  
Multivariate Regression ◽  
Risk Groups ◽  
Multivariate Regression Analysis ◽  
Lymphocytic Leukemia

Three hundred twenty-five previously untreated patients with chronic lymphocytic leukemia were analyzed to identify significant prognostic factors for survival. Univariate analysis identified the following characteristics associated with survival: (1) clinical characteristics: age, race, sex, performance status, lymphadenopathy, and hepatosplenomegaly; (2) hematologic parameters: WBC count, absolute lymphocyte and granulocyte counts, hemoglobin level, and platelet count; and (3) biochemical parameters: serum albumin, calcium, uric acid, lactate dehydrogenase, alkaline phosphatase, BUN, and creatinine. Multivariate regression analysis in a randomly selected training subset of 217 patients demonstrated that the combination of uric acid, alkaline phosphatase, lactate dehydrogenase, external lymphadenopathy, and age had the strongest predictive relation to survival time. The resulting model was validated in the remaining independent subset of 108 patients and led to classification of patients into low, intermediate, and high-risk groups with five-year survival rates of 75%, 59%, and 14%, respectively, and with distinctively different annual mortality rates (P less than .01). Both the regression model and Rai staging were highly effective in identifying risk groups among the entire patient population (P less than 0.001). Overall the regression model was superior to Rai staging in defining prognostic risk groups. In addition, it was able to separate patients into significantly different risk categories within each Rai stage, thus improving on the prognostic prediction of individual patients with chronic lymphocytic leukemia.

scholarly journals Prognosis of chronic lymphocytic leukemia: a multivariate regression analysis of 325 untreated patients

Blood ◽  
1987 ◽  
Vol 69 (3) ◽  
pp. 929-936 ◽  
Author(s):  
JS Lee ◽  
DO Dixon ◽  
HM Kantarjian ◽  
MJ Keating ◽  
M Talpaz
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Regression Analysis ◽  
Lactate Dehydrogenase ◽  
Chronic Lymphocytic Leukemia ◽  
Regression Model ◽  
Multivariate Regression ◽  
Risk Groups ◽  
Multivariate Regression Analysis ◽  
Lymphocytic Leukemia

Abstract Three hundred twenty-five previously untreated patients with chronic lymphocytic leukemia were analyzed to identify significant prognostic factors for survival. Univariate analysis identified the following characteristics associated with survival: (1) clinical characteristics: age, race, sex, performance status, lymphadenopathy, and hepatosplenomegaly; (2) hematologic parameters: WBC count, absolute lymphocyte and granulocyte counts, hemoglobin level, and platelet count; and (3) biochemical parameters: serum albumin, calcium, uric acid, lactate dehydrogenase, alkaline phosphatase, BUN, and creatinine. Multivariate regression analysis in a randomly selected training subset of 217 patients demonstrated that the combination of uric acid, alkaline phosphatase, lactate dehydrogenase, external lymphadenopathy, and age had the strongest predictive relation to survival time. The resulting model was validated in the remaining independent subset of 108 patients and led to classification of patients into low, intermediate, and high-risk groups with five-year survival rates of 75%, 59%, and 14%, respectively, and with distinctively different annual mortality rates (P less than .01). Both the regression model and Rai staging were highly effective in identifying risk groups among the entire patient population (P less than 0.001). Overall the regression model was superior to Rai staging in defining prognostic risk groups. In addition, it was able to separate patients into significantly different risk categories within each Rai stage, thus improving on the prognostic prediction of individual patients with chronic lymphocytic leukemia.

scholarly journals Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats

2017 ◽  
Vol 6 (2) ◽  
pp. 149-155
Author(s):  
Parveen Kumar Goyal ◽  
◽  
Santosh Kumar Verma ◽  
Anil Kumar Sharma ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Ethylene Glycol ◽  
Calcium Oxalate ◽  
Creatinine Clearance ◽  
Ammonium Chloride ◽  
Biochemical Parameters ◽  
Calcium Phosphorus ◽  
Calcium Oxalate Calculi ◽  
Vernonia Cinerea

Objectives: The present manuscript was focused on evaluating the antilithiatic potential of Vernonia cinerea extract (VCE) against calcium oxalate calculi using experimental model. Methods: The drinking water containing ethylene glycol (0.75% v/v) and ammonium chloride (1% w/v) was used to induce hyperoxaluria in Wistar rats. Thirty-six rats, divided into following six groups (each containing six animals), were treated with vehicle (normal control), ethylene glycol and ammonium chloride (urolithic), Neeri (standard), 100, 300 and 500 mg/kg, VCE (tests). The experimental protocol involved the estimation of different biochemical parameters in urine, serum, kidney homogenates, and histopathological examinations of the kidney. Results: The urolithic rats showed the presence of oxalate crystals in renal tubules and significant changes in biochemical parameters like decreased creatinine clearance, increased urinary levels of oxalates, urea, calcium, phosphorus, uric acid, proteins, decreased urinary magnesium levels; increased serum levels of urea nitrogen, uric acid, calcium, phosphorus, lactate dehydrogenase; increased calcium, phosphorus, and oxalate contents in kidney homogenates. It altered the renal architecture and impaired the functions. The extract significantly (p< 0.05) reversed the biochemical changes in urine, serum and kidney homogenates in a dose-dependent manner. It improved the renal functions as indicated by improved creatinine clearance, reduced lactate dehydrogenase activity and restoration of renal architecture towards normal. Conclusions: Vernonia cinerea showed significant antilithiatic potential against oxalate calculi in glycolated rats.

Correlation of Selected Serum Constituents: 1. Inter-Individual Variation and Analytical Error

1975 ◽  
Vol 21 (11) ◽  
pp. 1592-1600 ◽  
Author(s):  
Per Winkel ◽  
Bernard E Statland ◽  
Henning Bokelund ◽  
Eugene A Johnson
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Aspartate Aminotransferase ◽  
Correlation Coefficients ◽  
Serum Samples ◽  
Significant Component ◽  
Healthy Men ◽  
Analytical Error ◽  
Analytical Errors

Abstract The intra-subject correlations of three clinically meaningful combinations of serum constituents—(a) potassium, calcium, and albumin; (b) urea, creatinine, and uric acid; and (c) aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase—were studied in 11 healthy men. Duplicate serum samples were obtained at 800 h, 1100 h, and 1400 h on five different days. All assays were performed on the AutoChemist Multichannel Analyzer. Correlation coefficients differed significantly among the subjects for the following six pairs of serum constituents: urea and creatinine, urea and uric acid, creatinine and uric acid, aspartate aminotransferase and lactate dehydrogenase, aspartate aminotransferase and alkaline phosphatase, and lactate dehydrogenase and alkaline phosphatase. Nonbiological positive correlation between analytical errors (i.e., errors of two different assays performed on the same specimen) was demonstrated for two of the pairs: potassium and calcium, and aspartate aminotransferase and lactate dehydrogenase. The error correlations of these two pairs of constituents comprised a significant component of the observed intra-subject correlations. Probable reasons for these analytical error correlations are discussed

Correlation of selected serum constitutents: 2. Consistency of intra-individual correlation values, means, and variances during four months.

1976 ◽  
Vol 22 (11) ◽  
pp. 1855-1861 ◽  
Author(s):  
P Winkel ◽  
B E Statland
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Individual Differences ◽  
Lactate Dehydrogenase ◽  
Aspartate Aminotransferase ◽  
Covariance Structure ◽  
Correlation Coefficients ◽  
Nonprotein Nitrogen ◽  
Protein Nitrogen ◽  
Mean Values

Abstract We examined whether inter-individual differences in correlation coefficients previously found among subjects truly reflect consistent inter-individual differences or are time-related within an individual. The consitutents studied in this investigation were (a) the enzmes aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase; and (b) the non=protein nitrogen-containing constituents urea, uric acid, and creatinine. Ten healthy women were each subjected to 15 venipunctures over a five-week period (Series I), and, after a two-month interval, were again subjected to 15 venipunctures over a second five-week period (Series II). Before statistical analysis, the data were corrected for the batch-to-batch (day-to-day) arnalytical variation. There was a signiificant (P less than .05) change in the covariance structure (variances or correlation coefficients, or both) between the two series in four of the 10 subjects for the combination of enzymes, and in three other subjects for the combination of nonprotein nitrogen constitutents. Although we found a significant (P lees than .05) average intra-individual variation in the mean values from series to series in the cases of the three enzymes and urea, the magnitude of the inter-series variation in means was relatively small. CV's were: alkaline phosphatase, 3.4%; lactate dehydrogenase, 2.3+; aspartate aminotransferase, 3.3%; urea, 5.0%; uric acid, 1.0%; and creatinine, 1.2%.

Single 6-mg dose of rasburicase: The experience in a large academic medical center

2018 ◽  
Vol 25 (6) ◽  
pp. 1349-1356 ◽  
Author(s):  
Mary Nauffal ◽  
Robert Redd ◽  
Jian Ni ◽  
Richard M Stone ◽  
Daniel J DeAngelo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Serum Creatinine ◽  
Medical Center ◽  
Academic Medical Center ◽  
Tumor Lysis Syndrome ◽  
Urate Oxidase ◽  
Baseline Serum ◽  
Tumor Lysis ◽  
Blood Ph

Background Tumor lysis syndrome is an oncologic emergency due to the release of tumor cell contents, leading to metabolic derangements. Rasburicase, a recombinant urate oxidase, catabolizes uric acid. At our institution, we administer a single 6-mg dose of rasburicase to patients who are at risk for tumor lysis syndrome. We aimed to assess the efficacy of single 6-mg dose of rasburicase and explore risk factors associated with rasburicase failure. Methods We report results in 92 adult patients who had a baseline uric acid greater than 7.5 mg/dL and received a single 6-mg dose of rasburicase for the management of tumor lysis syndrome. Responders were defined as those whose uric acid was less than or equal to 7.5 mg/dL within 24–36 h of rasburicase administration. The primary end point was response based on uric acid level. Secondary end points included response to rasburicase in association with lactate dehydrogenase, serum creatinine, calcium, phosphorus, blood pH, and oncologic diagnosis. Results Median age was 65 years and 70% were men. Most patients had leukemia (32%) or lymphoma (40%). Eighty-seven of 92 patients (95%), who received single 6-mg dose of rasburicase, achieved a uric acid less than 7.5 mg/dL within 24–36h of dosing. Body mass index was similar between responders and non-responders: 28.6 kg/m2 vs. 26.6 kg/m2, respectively, p = 0.6. Baseline lactate dehydrogenase levels were similar between the groups: 756 U/L vs. 892 U/L, respectively, p = 0.33. Blood pH values documented within 24 h of first dose of rasburicase were also similar between the two groups (n = 30; 7.33 vs. 7.34 respectively, p = 0.6). However, median baseline uric acid was lower in responders than non-responders: 12.3 mg/dL vs. 17.3 mg/dL, respectively, p = 0.012. Baseline serum creatinine and creatinine clearance were similar between responders and non-responders (2.2 mg/dL vs. 3.95 mg/dL; p = 0.12 and 29 mL/min vs. 16 mL/min; p = 0.11, respectively). Conclusions Higher baseline uric acid levels were observed in patients who did not respond to the first rasburicase dose. In our study, uric acid levels normalized in 95% of patients after a single 6-mg dose of rasburicase indicating that a single 6-mg dose of rasburicase may be sufficient to manage tumor lysis syndrome, for most patients.

scholarly journals Partial plasma exchange using albumin replacement: removal and recovery of normal plasma constituents

Blood ◽  
1980 ◽  
Vol 56 (6) ◽  
pp. 1055-1059 ◽  
Author(s):  
JB Orlin ◽  
EM Berkman
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Plasma Exchange ◽  
Marked Reduction ◽  
Creatine Phosphokinase ◽  
Biologic Activity ◽  
Normal Plasma ◽  
The Mean ◽  
Removal And Recovery

Abstract Using albumin and crystalloid as the only replacement fluids, the effect of partial plasma exchange on the removal and recovery of normal plasma constituents was studied. The results of 30 procedures on 10 individuals were evaluated. Four patterns of removal are described: reduction in the concentration of fibrinogen and C3 were greater than would be expected based upon the extent of the exchange, while IgG, IgM, cholesterol, alkaline phosphatase and SGPT were removed as expected. Reduction of serum glutamicoxalacetic transaminase (SGOT), lactate dehydrogenase (LDH), amylase, and creatine phosphokinase (CPK) averaged 17% less, and uric acid, calcium and K+ averaged 53% less than expected. Concentrations of HCO-3 and glucose did not change. The mean recovery for all constituents except fibrinogen, C3, cholesterol. IgG and IgM was near 100% at 48–72 hr postpheresis. The 72-hr recovery of fibrinogen and complement was 66% and 60%, respectively. Cholesterol recovery was also slow, requiring a minimum of 1 wk to reach prepheresis levels. Measured at a time when quantitative IgM levels were still reduced, alloantibody agglutinating activity (anti-A and anti-B) in a postpheresis sample exceeded prepheresis agglutinating activity. These data demonstrated that, depending upon quantity and frequency of pheresis, partial plasma exchange using albumin replacement may cause progressive marked reduction in concentrations of immunoglobulin, complement, fibrinogen, and cholesterol. Furthermore, newly synthesized antibody may have increased biologic activity.

scholarly journals Blood plasma chemistry in White Sea bearded seals across different age groups

2019 ◽  
Vol 19 (4) ◽  
pp. 159-165
Author(s):  
IA Erokhina ◽  
NN Kavtsevich
Keyword(s):  
Alkaline Phosphatase ◽  
Creatine Kinase ◽  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
White Sea ◽  
Blood Chemistry ◽  
Total Lipids ◽  
Bearded Seal ◽  
Γ Globulins ◽  
Glutamyl Transferase

Blood chemistry values are reported for the bearded seal species (Erignathus barbatus barbatus Erxleben, 1777) from the White Sea. 27 blood plasma indices are used to describe the state of the metabolism of proteins, carbohydrates, lipids, minerals (total protein, albumin, α-, β-, γ-globulins, urea, creatinine, uric acid, glucose, lactic acid, total lipids, triglycerides, cholesterol, calcium, phosphorus, sodium, potassium, magnesium, iron, copper, chlorides, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase, creatine kinase, alkaline phosphatase, lactate dehydrogenase) in 3-, 5- and 10-year-old seals. The values of the studied parameters are similar to published data for bearded seal populations in other Arctic regions, as well as being in close agreement with indicators of other pinniped species of the same age. The plasma content of total protein, albumin, α-, β-, γ-globulins, urea, uric acid, total lipids, calcium, magnesium, sodium, and chlorides is invariable in animals of the studied ages. In common with other pinnipeds and land-based mammals, age-related changes in metabolic rates in the studied animal groups are most pronounced in the activity level of key metabolism enzymes. While aspartate aminotransferase, alanine aminotransferase and γ-glutamyl transferase activity is higher in adult seals than in immature animals, alkaline phosphatase, creatine kinase and lactate dehydrogenase activity is lower. Changes in biochemical parameters of bearded seal blood at the ages of 3, 5 and 10 years indicate a catabolic orientation in metabolism at all studied development stages. Although more research is needed to investigate the biological significance of a number of blood indices, the data presented in this study provide initial baseline blood chemistry parameters for use in assessing the condition of individual seals, as well as informing monitoring and management efforts for wild seal populations.

scholarly journals Correlation of serum lactate dehydrogenase and uric acid levels with severity parameters of preeclampsia

2019 ◽  
Vol 6 (3) ◽  
pp. 315-320
Author(s):  
Deena C Mendez ◽  
◽  
Mamatha Kunder ◽  
Shashidhar K N ◽  
Munikrishna M ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase
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