Synthesis, Characterization, Antimicrobial Activity and Theoretical Studies of  New Polymeric Schiff-base

A novel Schiff-base compound was synthesized by condensation of 4-hydroxybenzaldehyde and 4-aminoazobenzene. The prepared Schiff-base was converted to a polymer by reaction with formaldehyde and resorcinol. The two types of the prepared compounds were characterized with spectral techniques (FT-IR and 1H-NMR). The biological activity as antibacterial and antifungal was tested using the cork well diffusion method against some standard microorganisms, which indicate that these compounds showed good antimicrobial activity. HyperChem-8 program has been used to determine total energy, LUMO-HOMO, bond length and angles.

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Synthesis, characterization, crystal structure, and theoretical studies on Schiff-base compound 6-[(5-Bromopyridin-2-yl)iminomethyl]phenol

Structural Chemistry ◽

10.1007/s11224-009-9554-5 ◽

2009 ◽

Vol 21 (1) ◽

pp. 153-157 ◽

Cited By ~ 21

Author(s):

Aliakbar Dehno Khalaji ◽

Alireza Najafi Chermahini ◽

Karla Fejfarova ◽

Michal Dusek

Keyword(s):

Crystal Structure ◽

Schiff Base ◽

Theoretical Studies ◽

Schiff Base Compound ◽

Base Compound

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A new Schiff base compound N,N′-(2,2-dimetylpropane)-bis(dihydroxylacetophenone): Synthesis, experimental and theoretical studies on its crystal structure, FTIR, UV–visible, 1H NMR and 13C NMR spectra

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2011.05.080 ◽

2011 ◽

Vol 81 (1) ◽

pp. 144-150 ◽

Cited By ~ 20

Author(s):

Vahid Saheb ◽

Iran Sheikhshoaie

Keyword(s):

Crystal Structure ◽

Schiff Base ◽

13C Nmr ◽

Nmr Spectra ◽

Theoretical Studies ◽

13C Nmr Spectra ◽

Uv Visible ◽

Schiff Base Compound ◽

Experimental And Theoretical Studies ◽

Base Compound

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Synthesis, Characterization, X-Ray, HOMO-LUMO, MEP, FT-IR, NLO, Hirshfeld surface, ADMET, Boiled-Egg Model Properties and Molecular Docking Studies with Human Cyclophilin D (CypD) of a Schiff Base Compound: (E)-1-(5-nitro-2-(piperidin-1-yl)phenyl)-N-(3-nitrophenyl)methanimine

Polyhedron ◽

10.1016/j.poly.2021.115320 ◽

2021 ◽

pp. 115320

Author(s):

Songül Şahin ◽

Necmi Dege

Keyword(s):

Schiff Base ◽

Molecular Docking ◽

Docking Studies ◽

Hirshfeld Surface ◽

Cyclophilin D ◽

X Ray ◽

Ft Ir ◽

Schiff Base Compound ◽

Homo Lumo ◽

Base Compound

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Antimicrobial Activity of 2-Nitro-6-[(4-Phenyl-Benzo[4,5]imidazo[1,2-a] Pyrimidin-2-ylimino)-Methyl]-Phenol: A Novel Schiff Base Compound

Nov. 27-28, 2017 South Africa ASETWM-17, RCABES-17 & EBHSSS-17 ◽

10.17758/eares.eap517211 ◽

2017 ◽

Keyword(s):

Antimicrobial Activity ◽

Schiff Base ◽

Schiff Base Compound ◽

Base Compound

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SYNTHESIS AND STRUCTURAL ELUCIDATION OF AMINO ACETYLENIC AND THIOCARBAMATES DERIVATIVES FOR 2-MERCAPTOBENZOTHIAZOLE AS ANTIMICROBIAL AGENTS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i2.15760 ◽

2017 ◽

Vol 9 (2) ◽

pp. 192

Author(s):

Aseel Alsarahni ◽

Zuhair Muhi Eldeen ◽

Elham Al-kaissi ◽

Ibrahim Al- Adham ◽

Najah Al-muhtaseb

Keyword(s):

Antimicrobial Activity ◽

Elemental Analysis ◽

Antimicrobial Agents ◽

Diffusion Method ◽

Benzothiazole Derivatives ◽

H Nmr ◽

Ft Ir ◽

Potential Antimicrobial Activity ◽

C Nmr

Objective: To design and synthesize amino acetylenic and thiocarbonate of 2-mercapto-1,3-benthiazoles as potential antimicrobial agents.Methods: A new series of 2-{[4-(t-amino-1-yl) but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole derivatives (AZ1-AZ6), and S-1,3-benzothiazol-2-yl-O-alkyl carbonothioate derivatives were synthesised, with the aim that the target compounds show new and potential antimicrobial activity. The elemental analysis was indicated by the EuroEA elemental analyzer, and biological characterization was via IR, 1H-NMR, [13]C-NMR, DSC were determined with the aid of Bruker FT-IR and Varian 300 MHz spectrometer using DMSO-d6 as a solvent. In vitro antimicrobial activity, evaluation was done for the synthesised compounds, by agar diffusion method and broth dilution test. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. Results: The IR, 1H-NMR, 13C-NMR, DSC and elemental analysis were consistent with the assigned structures. Compound of 2-{[4-(4-methylpiperazin-1-yl)but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole (AZ1), 2-{[4-(2-methylpiperidin-1-yl)but-2-yn-1-yl]sulfanyl}-1,3-benzothiazole (AZ2), 2-{[4-(piperidin-1-yl) but-2-yn-1-yl]sulfanyl}-1, 3-benzothiazole (AZ6), S-1,3-benzothiazol-2-yl-O-ethyl carbonothioate (AZ7), and S-1,3-benzothiazol-2-yl-O-(2-methylpropyl) carbonothioate (AZ9) showed the highest antimicrobial activity against Pseudomonas aeruginosa (P. aeruginosa), AZ-9 demonstrated the highest antifungal activity against Candida albicans (C. albicans), with MIC of 31.25 µg/ml.Conclusion: These promising results promoted our interest to investigate other structural analogues for their antimicrobial activity further.

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Phytochemical investigation and in vitro antimicrobial activity of Richardia scabra

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v11i2.24666 ◽

2016 ◽

Vol 11 (2) ◽

pp. 248 ◽

Cited By ~ 1

Author(s):

Kathirvel Poonkodi ◽

Subban Ravi

Keyword(s):

Antimicrobial Activity ◽

Diffusion Method ◽

Bacterial Strains ◽

Weed Species ◽

Antibacterial And Antifungal Activities ◽

Agar Plug ◽

Phytochemical Investigation ◽

Antibacterial And Antifungal ◽

Simple Sugar

The present study was aimed to evaluate the phytochemical screening and antimicrobial activity of the petroleum ether and methanol extracts from the mature leaves of Richardia scabra from India. Disc diffusion method was used to determine the zone inhibition of the tested samples for antibacterial and agar plug method was used to determine the antifungal activity, while the microtube-dilution technique was used to determine the minimum inhibitory concentration. Both extracts showed significant antibacterial and antifungal activities when tested against 10 bacterial and four fungal strains. The minimum inhibitory concentrations of the methanol extract of R. scabra ranged between 12.5–100 μg/mL for bacterial strains. Alkaloids, steroids, flavonoids, fatty acids, terpenoids and simple sugar were detected as phytoconstituents of extracts. To the best of our knowledge, this is the first report against antimicrobial activity of common weed species R. scabra found in India.

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Combined experimental and theoretical studies on the X-ray crystal structure, FT-IR, 1H NMR, 13C NMR, UV–Vis spectra, NLO behavior and antimicrobial activity of 2-hydroxyacetophenone benzoylhydrazone

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2014.01.043 ◽

2014 ◽

Vol 124 ◽

pp. 548-555 ◽

Cited By ~ 26

Author(s):

Iran Sheikhshoaie ◽

S. Yousef Ebrahimipour ◽

Mahdeyeh Sheikhshoaie ◽

Hadi Amiri Rudbari ◽

Moj Khaleghi ◽

...

Keyword(s):

Crystal Structure ◽

Antimicrobial Activity ◽

1H Nmr ◽

13C Nmr ◽

Theoretical Studies ◽

X Ray ◽

Ft Ir ◽

Experimental And Theoretical Studies

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Computational and Spectral Discussion of Some Substituted Chalcone Derivatives

Biointerface Research in Applied Chemistry ◽

10.33263/briac126.71597176 ◽

2021 ◽

Vol 12 (6) ◽

pp. 7159-7176

Keyword(s):

Geometry Optimization ◽

Spectroscopic Characterization ◽

Diffusion Method ◽

Geometrical Parameters ◽

1H And 13C Nmr ◽

Chalcone Derivatives ◽

Ft Ir ◽

Experimental Values ◽

Antibacterial And Antifungal ◽

Homo Lumo

The substituted chalcone derivatives 1–7 have been synthesized, and spectroscopic characterization were done as done using the experimental FT-IR, UV-Vis, GC-MS, 1D NMR spectroscopy. The favored conformation of substituted chalcone 3 was predicted theoretically by geometry optimization structure selected geometrical parameters and molecular properties such as NBO, AIM, HOMO-LUMO, MEP surface, and atomic charges were derived from optimized structures. The 1H and 13C NMR spectral data had been additionally computed using the Gaussian-09 package and compared with the experimental values. The antibacterial and antifungal activity was derived by the disc diffusion method.

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