Folic Acid from Fortified Foods and/or Supplements during Pregnancy and Lactation and Health Outcomes: A Systematic Review

Abstract Objectives To inform the Dietary Guidelines for Americans, 2020–2025, USDA and HHS identified the following important public health question for the 2020 Dietary Guidelines Advisory Committee to answer with support from USDA's Nutrition Evidence Systematic Review (NESR) team: What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and lactation and health outcomes? Methods The Committee developed protocols to describe how they would use NESR's systematic review methodology to examine the evidence. NESR conducted a literature search and dual-screened the results using pre-defined inclusion and exclusion criteria for articles published between 1980 and 2019. NESR extracted data and assessed risk of bias of included studies. The Committee synthesized the evidence, developed conclusion statements, and graded the strength of the evidence underlying the conclusion statements. Results This systematic review included 30 articles, most of which were well-designed RCTs. Observational studies had risk of bias concerns. The study populations did not fully represent the diversity of the U.S. population. Conclusions Strong evidence indicates that folic acid supplements consumed before and/or during pregnancy are positively associated with folate status. Moderate evidence indicates that folic acid supplements consumed during lactation are positively associated with folate status. Limited evidence suggests that folic acid supplements consumed during early pregnancy may have a beneficial effect on reducing the risk of hypertensive disorders during pregnancy among women at high-risk versus no supplementation. Moderate evidence indicates that higher versus lower levels of folic acid supplements consumed during pregnancy does not affect the risk of hypertensive disorders during pregnancy among women at low-risk. Moderate evidence indicates that folic acid supplements consumed during lactation does not influence folate levels in human milk. Insufficient or no evidence was available to examine folic acid and gestational diabetes or child developmental, or folic acid from fortified foods and any outcome. Funding Sources USDA, Food and Nutrition Service, Center for Nutrition Policy and Promotion.

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How Does Mindfulness Affect Cognition? A Reflection on Confounding Issues Surrounding Mindfulness-based Intervention Research Targeting Cognitive Outcomes

10.31231/osf.io/86hrv ◽

2018 ◽

Author(s):

David R Vago ◽

Resh Gupta ◽

Sara Lazar

Keyword(s):

Systematic Review ◽

Health Outcomes ◽

Cognitive Functioning ◽

Cognitive Processes ◽

Methodological Quality ◽

Cognitive Outcomes ◽

Controlled Trials ◽

Randomized Controlled ◽

Existing Data

One potential pathway by which mindfulness-based meditation improves health outcomes is through changes in cognitive functioning. A systematic review of randomized controlled trials of mindfulness-based interventions (MBIs) was conducted with a focus on assessing the state of the evidence for effects on cognitive processes and associated assays. Here, we comment on confounding issues surrounding the reporting of these and related findings, including 1) criteria that appropriately define an MBI; 2) limitations of assays used to measure cognition; and 3) methodological quality of MBI trials and reporting of findings. Because these issues contribute to potentially distorted interpretations of existing data, we offer constructive means for interpretation and recommendations for moving the field of mindfulness research forward regarding the effects on cognition.

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Mental Health Outcomes Among Healthcare Workers Dealing with COVID-19/ SARS-CoV-2 Pandemic: A Systematic Review and Meta-Analysis

SSRN Electronic Journal ◽

10.2139/ssrn.3633225 ◽

2020 ◽

Author(s):

Abhijit Dutta ◽

Avinash Sharma ◽

Rodrigo Torres-Castro ◽

Hariom Pachori ◽

SukhDev Mishra

Keyword(s):

Mental Health ◽

Systematic Review ◽

Health Outcomes ◽

Healthcare Workers ◽

Meta Analysis ◽

Mental Health Outcomes

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A systematic review of the use of prazosin in pregnancy and lactation

General Hospital Psychiatry ◽

10.1016/j.genhosppsych.2021.03.012 ◽

2021 ◽

Author(s):

Ashley D. Davidson ◽

Amritha Bhat ◽

Frances Chu ◽

Jessie N. Rice ◽

N. Aba Nduom ◽

...

Keyword(s):

Systematic Review ◽

Pregnancy And Lactation ◽

In Pregnancy

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Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis

Obesity Surgery ◽

10.1007/s11695-021-05311-2 ◽

2021 ◽

Cited By ~ 1

Author(s):

Wen Zhang ◽

◽

Meiling Fan ◽

Cunchuan Wang ◽

Kamal Mahawar ◽

...

Keyword(s):

Systematic Review ◽

Bariatric Surgery ◽

Folic Acid ◽

Hair Loss ◽

Meta Analysis ◽

Serum Zinc ◽

Serum Levels ◽

Mean Difference ◽

Younger Women ◽

Metabolic And Bariatric Surgery

Abstract Background Hair loss is a common complication after metabolic and bariatric surgery (MBS). There is a lack of published systematic review in the scientific literature on this topic. The aim of this study was to perform a systematic review and meta-analysis on hair loss after MBS in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. Methods PubMed, CINAHL, EMBASE, Web of Science, SCOPUS, and four Chinese databases were searched. Data were pooled using Review Manager 5.3 and Stata 12.0, and subgroups were performed if necessary and feasible. Results A total of 18 studies (n = 2538) were included. The pooled results showed that the incidence of hair loss after MBS was 57% (95% CI 42–71%). It decreased with longer follow-up times. Hair loss was significantly more common in younger (mean difference (MD), − 2.45; 95% CI, − 4.26 to − 0.64; p = 0.008) women (OR, 3.87; 95% CI, 0.59 to 17.59; p = 0.08). Serum zinc (standardized mean difference (SMD), − 1.13; 95% CI, − 2.27 to 0.01, p = 0.05), folic acid (SMD = − 0.88, 95% CI − 1.29 to − 0.46, p < 0.0001), and ferritin levels (SMD, − 0.22; 95% CI, − 0.38 to − 0.05; p = 0.01), but not serum iron and vitamin B12, were associated with hair loss following MBS. Conclusions Hair loss is common after MBS especially in younger women, and those with low serum levels of zinc, folic acid, and ferritin. Prospective studies on larger cohorts are needed.

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Interventions directed at men for preventing intimate partner violence: a systematic review protocol

Systematic Reviews ◽

10.1186/s13643-021-01712-7 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Dina Idriss-Wheeler ◽

Julia Hajjar ◽

Sanni Yaya

Keyword(s):

Systematic Review ◽

Intimate Partner Violence ◽

Health Outcomes ◽

Partner Violence ◽

Intimate Partner ◽

Cochrane Central Register ◽

Female Partners ◽

Key Characteristics ◽

Unpublished Manuscripts ◽

The Impact

Abstract Background Intimate partner violence (IPV) is a population health problem linked to a myriad of negative psychological, physical, emotional, sexual and reproductive health outcomes for women. The movement towards working with boys and men over the past couple of decades has increased the number of interventions specifically directed at men who perpetrate violence against a female partner. There is little evidence-based research on key characteristics of effective interventions directed at men to reduce or prevent IPV against female partners. The objective of this systematic review is to identify interventions specifically directed at males , as the perpetrators of violence against women, that have proven to be effective in preventing or reducing intimate partner violence. Methods The following electronic databases will be used to search for peer-reviewed studies: MEDLINE (OVID), Embase (OVID), PsycInfo (OVID), CINAHL (EBSCO), Global Health (EBSCO), Gender Watch (ProQuest), Web of Science (Web of Knowledge), PROSPERO, Cochrane Central Register of Controlled Trials Database (Ovid) and SCOPUS. We will include randomized control trials, non-randomized studies of interventions published in peer-reviewed journals and relevant unpublished manuscripts, books/chapters and clinical or programme study reports. Studies have to demonstrate direction of effect (i.e. pre-post intervention/difference between groups) in terms of prevention or reduction in the outlined outcomes. Primary outcomes include change in behaviour and knowledge of male perpetrator regarding the impact of IPV on women as well as women’s experience of IPV. Secondary outcomes include change in behaviours around substance use and social activities, decrease in negative mental health outcomes and interactions with law enforcement. Studies will be screened, appraised and extracted by two reviewers; any conflicts will be resolved through discussion. Narrative synthesis will be used to analyse and present findings. If sufficient and comparable data is available, a meta-analysis will be conducted. Discussion This review will provide synthesized evidence on interventions directed at males to reduce or prevent their perpetration of intimate partner violence against female partners. Implications for practice will include key characteristics of interventions proven to be effective based on evidence synthesis and certainty of findings. Recommendations for further research will also be considered. Systematic review registration This protocol was submitted for registration in the International Prospective Register of Systematic Reviews (PROSPERO) on September 4, 2020.

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