Nanosuspension a Promising Tool for Solubility Enhancement: A Review

2021 ◽  
pp. 252-258
Author(s):  
Dode Raj H. ◽  
Mogal Prasad S. ◽  
Pagar Ujwala N. ◽  
Pansare Jagruti J. ◽  
Surawase Rajendra K.
Keyword(s):  
Solubility Enhancement ◽  
Atomic Level ◽  
Length Scale ◽  
Hydrophobic Drugs ◽  
Survey Article ◽  
Promising Tool ◽  
Scale Size ◽  
Vehicle Size

Nanotechnology is the science that manages the interaction that happens at sub-atomic level and of nano length scale size. Nano alludes to the molecule size in between of 1-1000nm. Nanosuspensions are going under nanotechnology. A drug Nanosuspension is characterized as finely colloid, biphasic, scattered strong medication particles in a fluid vehicle, size under 1 μm settled by surfactants and polymers arranged by reasonable techniques for drug conveyance applications. It gives effective conveyance of hydrophobic drugs and expands the bioavailability. Nanosuspension is an alluring and promising innovation to improve helpless solvency and bioavailability of the drugs. This survey article depicts the strategies for development, techniques and stability related study of nanosuspensions in the field of drug sciences.

On the breakup of Taylor length scale size bubbles and droplets in turbulent dispersions

2020 ◽  
Vol 386 ◽  
pp. 121826
Author(s):  
Yongjie Chen ◽  
Jue Ding ◽  
Peifen Weng ◽  
Xiaoquan Yang ◽  
Wenjun Wu
Keyword(s):  
Length Scale ◽  
Scale Size ◽  
Turbulent Dispersions

Modulation of isotropic turbulence by particles of Taylor length-scale size

2010 ◽  
Vol 650 ◽  
pp. 5-55 ◽  
Author(s):  
FRANCESCO LUCCI ◽  
ANTONINO FERRANTE ◽  
SAID ELGHOBASHI
Keyword(s):  
Isotropic Turbulence ◽  
Volume Fraction ◽  
Density Ratio ◽  
Particle Diameter ◽  
Finite Size ◽  
Rate Of Change ◽  
Spherical Particles ◽  
Length Scale ◽  
Frequency Spectra ◽  
Scale Size

This study investigates the two-way coupling effects of finite-size solid spherical particles on decaying isotropic turbulence using direct numerical simulation with an immersed boundary method. We fully resolve all the relevant scales of turbulence around freely moving particles of the Taylor length-scale size, 1.2≤d/λ≤2.6. The particle diameter and Stokes number in terms of Kolmogorov length- and time scales are 16≤d/η≤35 and 38≤τp/τk≤178, respectively, at the time the particles are released in the flow. The particles mass fraction range is 0.026≤φm≤1.0, corresponding to a volume fraction of 0.01≤φv≤0.1 and density ratio of 2.56≤ρp/ρf≤10. The maximum number of dispersed particles is 6400 for φv=0.1. The typical particle Reynolds number is of O(10). The effects of the particles on the temporal development of turbulence kinetic energy E(t), its dissipation rate (t), its two-way coupling rate of change Ψp(t) and frequency spectra E(ω) are discussed.In contrast to particles with d < η, the effect of the particles in this study, with d > η, is that E(t) is always smaller than that of the single-phase flow. In addition, Ψp(t) is always positive for particles with d > η, whereas it can be positive or negative for particles with d < η.

Is Stokes number an appropriate indicator for turbulence modulation by particles of Taylor-length-scale size?

2011 ◽  
Vol 23 (2) ◽  
pp. 025101 ◽  
Author(s):  
Francesco Lucci ◽  
Antonino Ferrante ◽  
Said Elghobashi
Keyword(s):  
Stokes Number ◽  
Length Scale ◽  
Turbulence Modulation ◽  
Scale Size

An experimental study of the effect of uniform strain on thermal fluctuations in grid-generated turbulence

1980 ◽  
Vol 99 (3) ◽  
pp. 545-573 ◽  
Author(s):  
Z. Warhaft
Keyword(s):  
Heat Flux ◽  
Decay Rate ◽  
Time Scale ◽  
Cross Correlation ◽  
Thermal Fluctuation ◽  
Thermal Fluctuations ◽  
Length Scale ◽  
Scale Size ◽  
Velocity Scale ◽  
Scale Ratio

The effect of homogeneous strain on passive scalar fluctuations, and the resultant evolution of the scalar field when the strain is removed, is experimentally studied by passing thermal fluctuations in decaying grid turbulence through a four-to-one axisymmetric contraction. Using amandoline(Warhaft & Lumley 1978a) to vary the scale size of the initial thermal fluctuations and hence the pre-contraction mechanical/thermal time-scale ratio,r, it is shown, for values ofrgreater than unity, that asris increased so is the post-contraction thermal decay rate, i.e. the contraction does not cause the thermal-fluctuation decay rate to equilibrate to a constant value. In these experiments the post-contraction thermal decay rate is always greater than the pre-contraction decay rate, i.e. the contraction accelerates the thermal-fluctuation decay. Moreover, the mechanical/thermal time-scale ratio in the post-contraction region is driven further from unity. In terms of scale size the uniform strain has the effect of increasing the thermal length scale by an amount equal in value to the contraction ratio if the pre-contraction thermal length scale is comparable to that of the pre-contraction velocity scale. However, if the pre-contraction thermal length scale is smaller than the pre-contraction velocity scale then the effect of the contraction on the thermal scale is less marked. The contraction induces significant negative cross-correlation ρuθbetween the longitudinal velocityuand thermal fluctuations θ even if the pre-contraction cross-correlation is close to zero. The magnitude of ρuθand hence the post-contraction heat flux is varied and the coherence structure is studied. It is shown that the thermal-fluctuation decay rate is insensitive to the magnitude of the heat flux, the latter of which decays rapidly compared to the relatively slow decay of turbulence energy in the post-contraction region. It is also shown that ρuθtends towards zero in this axisymmetric homogeneous flow at a faster rate than in isotropic turbulence. In accord with previous investigations, the return toward isotropy of the velocity field is very slow.

scholarly journals Buckling Analysis of CNTRC Curved Sandwich Nanobeams in Thermal Environment

2021 ◽  
Vol 11 (7) ◽  
pp. 3250
Author(s):  
Ahmed Amine Daikh ◽  
Mohammed Sid Ahmed Houari ◽  
Behrouz Karami ◽  
Mohamed A. Eltaher ◽  
Rossana Dimitri ◽  
...  
Keyword(s):  
Thermal Environment ◽  
Numerical Study ◽  
Slenderness Ratio ◽  
Higher Order ◽  
Strain Gradient Theory ◽  
Gradient Theory ◽  
Length Scale ◽  
Scale Size ◽  
Proposed Model ◽  
Reinforcement Material

This paper presents a mathematical continuum model to investigate the static stability buckling of cross-ply single-walled (SW) carbon nanotube reinforced composite (CNTRC) curved sandwich nanobeams in thermal environment, based on a novel quasi-3D higher-order shear deformation theory. The study considers possible nano-scale size effects in agreement with a nonlocal strain gradient theory, including a higher-order nonlocal parameter (material scale) and gradient length scale (size scale), to account for size-dependent properties. Several types of reinforcement material distributions are assumed, namely a uniform distribution (UD) as well as X- and O- functionally graded (FG) distributions. The material properties are also assumed to be temperature-dependent in agreement with the Touloukian principle. The problem is solved in closed form by applying the Galerkin method, where a numerical study is performed systematically to validate the proposed model, and check for the effects of several factors on the buckling response of CNTRC curved sandwich nanobeams, including the reinforcement material distributions, boundary conditions, length scale and nonlocal parameters, together with some geometry properties, such as the opening angle and slenderness ratio. The proposed model is verified to be an effective theoretical tool to treat the thermal buckling response of curved CNTRC sandwich nanobeams, ranging from macroscale to nanoscale, whose examples could be of great interest for the design of many nanostructural components in different engineering applications.

Direct particle–fluid simulation of Kolmogorov-length-scale size particles in decaying isotropic turbulence

2017 ◽  
Vol 819 ◽  
pp. 188-227 ◽  
Author(s):  
Lennart Schneiders ◽  
Matthias Meinke ◽  
Wolfgang Schröder
Keyword(s):  
Kinetic Energy ◽  
Strain Rate ◽  
Viscous Dissipation ◽  
Dissipation Rate ◽  
Isotropic Turbulence ◽  
Bulk Flow ◽  
Small Scale ◽  
Length Scale ◽  
Kolmogorov Length Scale ◽  
Scale Size

The modulation of decaying isotropic turbulence by 45 000 spherical particles of Kolmogorov-length-scale size is studied using direct particle–fluid simulations, i.e. the flow field over each particle is fully resolved by direct numerical simulations of the conservation equations. A Cartesian cut-cell method is used by which the exchange of momentum and energy at the fluid–particle interfaces is strictly conserved. It is shown that the particles absorb energy from the large scales of the carrier flow while the small-scale turbulent motion is determined by the inertial particle dynamics. Whereas the viscous dissipation rate of the bulk flow is attenuated, the particles locally increase the level of dissipation due to the intense strain rate generated near the particle surfaces due to the crossing-trajectory effect. Analogously, the rotational motion of the particles decouples from the local fluid vorticity and strain-rate field at increasing particle inertia. The high level of dissipation is partially compensated by the transfer of momentum to the fluid via forces acting at the particle surfaces. The spectral analysis of the kinetic energy budget is supported by the average flow pattern about the particles showing a nearly universal strain-rate distribution. An analytical expression for the instantaneous rate of viscous dissipation induced by each particle is derived and subsequently verified numerically. Using this equation, the local balance of fluid kinetic energy around a particle of arbitrary shape can be precisely determined. It follows that two-way coupled point-particle models implicitly account for the particle-induced dissipation rate via the momentum-coupling terms; however, they disregard the actual length scales of the interaction. Finally, an analysis of the small-scale flow topology shows that the strength of vortex stretching in the bulk flow is mitigated due to the presence of the particles. This effect is associated with the energy conversion at small wavenumbers and the reduced level of dissipation at intermediate wavenumbers. Consequently, it damps the spectral flux of energy to the small scales.

Atomic-level imaging of the surface structure of Ag2O

1984 ◽  
Vol 42 ◽  
pp. 656-657
Author(s):  
William Krakow
Keyword(s):  
High Vacuum ◽  
Atomic Level ◽  
Ultra High Vacuum ◽  
Research Groups ◽  
Resolution Electron ◽  
Surface Reconstructions ◽  
Order Of Magnitude ◽  
High Resolution Electron Microscope ◽  
Saturated Structure ◽  
Transmission And Reflection

In recent years electron microscopy has been used to image surfaces in both the transmission and reflection modes by many research groups. Some of this work has been performed under ultra high vacuum conditions (UHV) and apparent surface reconstructions observed. The level of resolution generally has been at least an order of magnitude worse than is necessary to visualize atoms directly and therefore the detailed atomic rearrangements of the surface are not known. The present author has achieved atomic level resolution under normal vacuum conditions of various Au surfaces. Unfortunately these samples were exposed to atmosphere and could not be cleaned in a standard high resolution electron microscope. The result obtained surfaces which were impurity stabilized and reveal the bulk lattice (1x1) type surface structures also encountered by other surface physics techniques under impure or overlayer contaminant conditions. It was therefore decided to study a system where exposure to air was unimportant by using a oxygen saturated structure, Ag2O, and seeking to find surface reconstructions, which will now be described.

Biomimetic materials: An introduction

1992 ◽  
Vol 50 (2) ◽  
pp. 1020-1021 ◽  
Author(s):  
M. Sarikaya ◽  
J. T. Staley ◽  
I. A. Aksay
Keyword(s):  
Self Assembly ◽  
Structural Control ◽  
Hierarchical Structures ◽  
Ceramic Composites ◽  
Advanced Materials ◽  
Length Scale ◽  
Spider Webs ◽  
Biomimetic Materials ◽  
Synthetic Materials ◽  
All Ceramic

Biomimetics is an area of research in which the analysis of structures and functions of natural materials provide a source of inspiration for design and processing concepts for novel synthetic materials. Through biomimetics, it may be possible to establish structural control on a continuous length scale, resulting in superior structures able to withstand the requirements placed upon advanced materials. It is well recognized that biological systems efficiently produce complex and hierarchical structures on the molecular, micrometer, and macro scales with unique properties, and with greater structural control than is possible with synthetic materials. The dynamism of these systems allows the collection and transport of constituents; the nucleation, configuration, and growth of new structures by self-assembly; and the repair and replacement of old and damaged components. These materials include all-organic components such as spider webs and insect cuticles (Fig. 1); inorganic-organic composites, such as seashells (Fig. 2) and bones; all-ceramic composites, such as sea urchin teeth, spines, and other skeletal units (Fig. 3); and inorganic ultrafine magnetic and semiconducting particles produced by bacteria and algae, respectively (Fig. 4).

Facet Topography and Dislocation Structure as a Possible Source for Electrical Heterogeneity in [001] TILT Bicrystals of YBa2Cu3O7-δ

1996 ◽  
Vol 54 ◽  
pp. 338-339
Author(s):  
I-Fei Tsu ◽  
D.L. Kaiser ◽  
S.E. Babcock
Keyword(s):  
Grain Boundary ◽  
Critical Current Density ◽  
Critical Current ◽  
Current Density ◽  
Electromagnetic Properties ◽  
Length Scale ◽  
Density Values ◽  
Current Densities ◽  
Applied Fields ◽  
A Current

A current theme in the study of the critical current density behavior of YBa2Cu3O7-δ (YBCO) grain boundaries is that their electromagnetic properties are heterogeneous on various length scales ranging from 10s of microns to ˜ 1 Å. Recently, combined electromagnetic and TEM studies on four flux-grown bicrystals have demonstrated a direct correlation between the length scale of the boundaries’ saw-tooth facet configurations and the apparent length scale of the electrical heterogeneity. In that work, enhanced critical current densities are observed at applied fields where the facet period is commensurate with the spacing of the Abrikosov flux vortices which must be pinned if higher critical current density values are recorded. To understand the microstructural origin of the flux pinning, the grain boundary topography and grain boundary dislocation (GBD) network structure of [001] tilt YBCO bicrystals were studied by TEM and HRTEM.

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