scholarly journals Acute and subchronic oral toxicities of “Da day An Chau” tablets in experimental animals

2021 ◽  
Vol 141 (5) ◽  
pp. 1-9
Author(s):  
Tran Thanh Tung ◽  
Dao Viet Hoang ◽  
Pham Thi Van Anh ◽  
Dang Thi Thu Hien
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
World Health Organization ◽  
Biochemical Parameters ◽  
Maximum Dose ◽  
Toxicity Study ◽  
World Health ◽  
Subchronic Toxicity ◽  
Experimental Animals ◽  
Health Organization

In this study, the toxicities of “Da day An Chau” tablets (DDAC) were assessed on experimental animals. To evaluate the acute toxicity on Swiss mice according to World Health Organization Guidance and to determine LD50 refer to the method of Litchfield – Wilcoxon. The subchronic toxicity study of DDAC at two doses (0.58 g/kg/day and 1.74 g/kg/day) was conducted in rats for four consecutive weeks. Evaluation of general conditions and weight of rats during the study period. Rat’s blood was taken for hematological and biochemical evaluations. The livers and kidneys microscopes were evaluated at the end of the experiment. The result revealed that mice were taken up to a maximum dose of 25.71 g/kg with no symptoms of acute toxicity; LD50 of DDAC has not been determined. At two doses, the subchronic toxicity study did not change rats’ body weight, hematological, biochemical parameters, and microscopic of the livers and kidneys during the study period.

Acute and sub-chronic oral toxicities of DA.AMLODEPON HVD hard capsule in experimental animals

2021 ◽  
Vol 148 (12) ◽  
pp. 58-67
Author(s):  
Pham Thi Van Anh ◽  
Nguyen Van Dam ◽  
Nguyen Van Dat ◽  
Pham Thanh Ky ◽  
Nguyen Trong Thong ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Chronic Toxicity ◽  
The Body ◽  
Toxicity Study ◽  
World Health ◽  
Histopathological Analysis ◽  
Experimental Animals ◽  
Health Organization ◽  
General Conditions

Assessment of toxicities of DA.AMLODEPON HVD hard capsule on experimental animals. The acute toxicity of DA.AMLODEPON HVD was assessed on Swiss mice according to World Health Organization Guidance, and LD50 determination according to the method of Litchfield – Wilcoxon. The sub-chronic toxicity study of DA.AMLODEPON HVD at two doses (0.42 g/kg/day and 1.26g/kg/day) was conducted in rats for four consecutive weeks. After administration, general conditions and the body weight of rats were evaluated. Blood samples were collected for analyzing serum parameters before treatment (T0), second week (T1), and fourth week (T2). Histopathological analysis of livers and kidneys was observed at the end of the experiment. The results revealed that mice were taken up to a maximum dose of 39.15 g/kg with no symptoms of acute toxicity, LD50 of DA.AMLODEPON HVD has not been determined. The sub-chronic toxicity study at two doses did not change the body weight of rats, general conditions. The parameters for structures and functions of livers and kidneys and microscopic of the livers and kidneys are in a normal range during the study period.

Daily Intakes of THbutyltin and THphenyltin Compounds from Meals

1995 ◽  
Vol 78 (4) ◽  
pp. 941-943 ◽  
Author(s):  
Taizo Tsuda ◽  
Tomohiro Inoue ◽  
Mihoko Kojima ◽  
Shigeru Aoki
Keyword(s):  
Body Weight ◽  
World Health Organization ◽  
World Health ◽  
Market Basket ◽  
Food And Agriculture ◽  
Food And Agriculture Organization ◽  
Duplicate Portion ◽  
Health Organization ◽  
Daily Intakes

Abstract Daily intakes of tributyltin (TBT) and triphenyltin (TPT) compounds from meals in Shiga Prefecture, Japan, were investigated by 2 methods. Daily intakes of TBT and TPT by the duplicate portion method were, respectively, 4.7 and 0.7 μg in 1991 and 2.2 and 0.7 μg in 1992. Those by the market basket method were, respectively, 6.9 and 5.4 μg in 1991 and 6.7 and 1.3 μg in 1992. Daily intakes of TBT and TPT by the market basket method were higher than those by the duplicate portion method. These values were considerably lower than acceptable daily intakes of 80 μg/50 kg body weight specified by the Welfare Ministry of Japan for bis(tri-n-butyltin) oxide and of 25 μg/50 kg body weight specified by the Food and Agriculture Organization/ World Health Organization for TPT.

scholarly journals Toxicity Study of 1-(2, 5-Dihidroxyphenil)-3-Pyridine-2-Il-Propenone In Adult Female Mice

2021 ◽  
Author(s):  
Ika Puspitasari ◽  
Ratna Asmah Susidarti
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Toxicity Test ◽  
Biochemical Parameters ◽  
Chronic Toxicity ◽  
Histological Analysis ◽  
Lymphocytic Infiltration ◽  
Experimental Animals ◽  
Female Mice ◽  
Chronic Toxicity Test

This research aimed to evaluate the toxicity of 1-(2, 5-dihidroxyphenil)-3-pyridine-2-il-propenone (DPP) after 24 hours and 90-day administration in female mice. Acute toxicity test was performed using the OECD 423 method, and DPP was administered once a day at doses of 300, 2000, and 5000 mg/kg body weight (BW). Toxic symptoms were observed after 24 hours of administration, and this continued until the 14th day. The experimental animals were dissected and examined for histological organs on the 15th day. The sub-chronic toxicity test was performed using the OECD 408 method, and DPP at 14, 28, and 56 mg/kg/day was administered for 90 days. Toxic symptoms were observed every day, and the amount of food and water intakes were also measured. Furthermore, statistical analysis was performed, and changes in body weight as well as routine blood checks and biochemistry were observed. At the end of the study, experimental animals were killed and the vital organs' weights were examined before their histological analysis. The results showed that DPP at 300-5000 mg/kg/day and 14-56 mg/kg/day for 90 days did not show any toxic symptom respectively. In the sub-chronic toxicity test, no change was observed in blood and urine biochemical parameters (p≥0.05). However, lymphocytic infiltration in the liver and congested vessel in the kidney occurred after administration at 56 mg/kg / day. The results showed that the acute toxicity of DPP is at category 5 according to Globally Harmonized Classification System and sub-chronic toxicity is at a dose below 56 mg/kg/day.

Effect of Body Weight and Age on the Pharmacokinetics of Dihydroartemisinin: Food and Drug Administration Basis for Dose Determination of Artesunate for Injection in Pediatric Patients With Severe Malaria

2021 ◽  
Author(s):  
Eliford Kitabi ◽  
Timothy J Bensman ◽  
Justin C Earp ◽  
Dakshina M Chilukuri ◽  
Heidi Smith ◽  
...  
Keyword(s):  
Body Weight ◽  
Literature Review ◽  
World Health Organization ◽  
Severe Malaria ◽  
Pediatric Patients ◽  
World Health ◽  
Dose Determination ◽  
The World ◽  
Health Organization

Abstract For treatment of severe malaria, the World Health Organization recommends 3 mg/kg intravenous artesunate in pediatric patients weighing less than 20 kg. Here we describe the Food and Drug Administration’s rationale for selecting 2.4 mg/kg in pediatric patients weighing less than 20 kg based on literature review and independent analyses.

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