scholarly journals Growth, Nutrition and Economy

2021 ◽  
Vol 1 ◽  
Author(s):  
Michael Hermanussen ◽  
Christiane Scheffler ◽  
Lidia Martin ◽  
Detlef Groth ◽  
James G. Waxmonsky ◽  
...  
Keyword(s):  
Parental Education ◽  
Hormone Secretion ◽  
Body Height ◽  
Growth Hormone Secretion ◽  
Child Growth ◽  
Socioeconomic Indicators ◽  
Reverse Causality ◽  
Pituitary Development ◽  
Delayed Motherhood ◽  
The Impact

Twenty-three scientists met at Krobielowice, Poland to discuss the role of growth, nutrition and economy on body size. Contrasting prevailing concepts, re-analyses of studies in Indonesian and Guatemalan school children with high prevalence of stunting failed to provide evidence for an association between nutritional status and body height. Direct effects of parental education on growth that were not transmitted via nutrition were shown in Indian datasets using network analysis and novel statistical methods (St. Nicolas House Analysis) that translate correlation matrices into network graphs. Data on Polish children suggest significant impact of socioeconomic sensitivity on child growth, with no effect of maternal money satisfaction. Height and maturation tempo affect the position of a child among its peers. Correlations also exist between mood disorders and height. Secular changes in height and weight varied across decades independent of population size. Historic and recent Russian data showed that height of persons whose fathers performed manual work were on average four cm shorter than persons whose fathers were high-degree specialists. Body height, menarcheal age, and body proportions are sensitive to socioeconomic variables. Additional topics included delayed motherhood and its associations with newborn size; geographic and socioeconomic indicators related to low birth weight, prematurity and stillbirth rate; data on anthropometric history of Brazil, 1850-1950; the impact of central nervous system stimulants on the growth of children with attention-deficit/hyperactivity disorder; and pituitary development and growth hormone secretion. Final discussions debated on reverse causality interfering between social position, and adolescent growth and developmental tempo.

scholarly journals Body Image Disturbance in Acromegaly Patients Compared to Nonfunctioning Pituitary Adenoma Patients and Controls

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Helen M. Conaglen ◽  
Dennis de Jong ◽  
Veronica Crawford ◽  
Marianne S. Elston ◽  
John V. Conaglen
Keyword(s):  
Growth Hormone ◽  
Body Image ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Primary Diagnosis ◽  
Body Image Disturbance ◽  
Separate Analysis ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
The Impact

Purpose. Excess growth hormone secretion in adults results in acromegaly, a condition in which multiple physical changes occur including bony and soft tissue overgrowth. Over time these changes can markedly alter a person’s appearance. The aim of this study was to compare body image disturbance in patients with acromegaly to those with nonfunctioning pituitary adenomas (NFAs) and controls and assess the impact of obesity in these groups.Methods. A cross-sectional survey including quality of life, body image disturbance, anxiety and depression measures, growth hormone, and BMI measurement was carried out.Results. The groups did not differ with respect to body image disturbance. However separate analysis of obese participants demonstrated relationships between mood scales, body image disturbance, and pain issues, particularly for acromegaly patients.Conclusions. While the primary hypothesis that acromegaly might be associated with body image disturbance was not borne out, we have shown that obesity together with acromegaly and NFA can be associated with body image issues, suggesting that BMI rather than primary diagnosis might better indicate whether patients might experience body image disturbance problems.

Serious Late Complications After Hematopoietic Stem Cell Transplantation (HSCT) Following Myeloablative Conditioining (MAC) In Infants.

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4501-4501
Author(s):  
Masahiro Yasui ◽  
Kayo Yamada ◽  
Osamu Kondo ◽  
Maho Sato ◽  
Akihisa Sawada ◽  
...  
Keyword(s):  
Conflicts Of Interest ◽  
Lymphoblastic Leukemia ◽  
Hormone Secretion ◽  
Body Height ◽  
Growth Hormone Secretion ◽  
Late Complications ◽  
Myelogenous Leukemia ◽  
Endocrine Disorders ◽  
Hematopoietic Stem ◽  
Secondary Cancers

Abstract Abstract 4501 Background: Recently, HSCT has been widely used as a curative therapy for refractory hematological/malignant diseases. However, late complications after HSCT such as endocrine disorders, infertility, short stature and secondary cancers have been recognized as serious problems in children. Late complications are assumed to be much more serious in younger children, especially in infants. Therefore, we retrospectively evaluated late complications among patients who underwent HSCT before one-year-old age in our institute to clarify this big issue. Methods and results: We performed HSCT in 530 children from 1993 to 2009. Among these 530 patients, 33 were infants (younger than 1- year - old) at HSCT. 23 infants with malignant disorders consisted of neuroblastoma 10, hepatoblastoma 2, rhabdomyosarcoma 1, retinoblastoma 1, acute lymphoblastic leukemia 5, myelodysplastic syndrome 2, acute myelogenous leukemia 2, and 10 infants with non-malignant disorders consisted of immunodeficiency 5, familial hemophagocytic lymphohistiocytosis/hemophagocytic syndrome 2, congenital metabolic disorder 1, severe aplastic anemia 1, pure red cell aplasia 1 were included. 9 infants underwent autologous HSCT and 24 underwent allogeneic HSCT. 22 infants received MAC and 11 received reduced-intensity conditioning (RIC). 26 out of 33 patients have been alive (MAC, 18/22 = 81.8 %; RIC, 8/11 = 72.7 %). Body height (BH) of 5 patients in RIC group who have been surviving longer than 5 years after HSCT is equal or taller than -2 standard deviation (SD) of BH. However, BH of 6 out of 13 evaluable patients in MAC group remains shorter than -2 SD (the shortest, -5.3 SD) of BH. All survivors in MAC group are suffering from one or more late complications such as growth hormone secretion insufficiency, premature puberty, hypothyroidism, gonadal failure and secondary cancers, therefore, they needs treatment and support for these late complications. Conclusions: The survival rate is similar (81.8 % versus 72.7 %) between MAC and RIC in infants, however, infants who underwent MAC-HSCT are suffering from late complications much more frequently and need treatment and support. These results suggest that less toxic conditioning should be adopted for infants who undergo HSCT to avoid serious late complications. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Effect of Octreotide Long-Acting Release on Tregs and MDSC Cells in Neuroendocrine Tumour Patients: A Pivotal Prospective Study

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2422
Author(s):  
Claudia von Arx ◽  
Giuseppina Rea ◽  
Maria Napolitano ◽  
Alessandro Ottaiano ◽  
Fabiana Tatangelo ◽  
...  
Keyword(s):  
Immune System ◽  
Prospective Study ◽  
Neuroendocrine Tumour ◽  
Hormone Secretion ◽  
Somatostatin Receptors ◽  
Growth Hormone Secretion ◽  
Suppressor Cells ◽  
Neuroendocrine Neoplasms ◽  
Long Acting ◽  
The Impact

Octreotide long-acting repeatable (LAR) is largely used to treat functional and/or metastatic neuroendocrine neoplasms (NENs). Its effect in controlling carcinoid syndrome and partially reduce tumour burden is attributable to the ability of octreotide to bind somatostatin receptors (SSTRs) on the tumour and metastasis, regulating growth hormone secretion and cell growth. Notably, SSTRs are also expressed, at different levels, on Tregs. Tregs, together with myeloid-derived suppressor cells (MDSCs), are key components in the anti-tumour immunoregulation. This is the first prospective study aimed to explore the impact of Octreotide (OCT) LAR on the immune system, with a particular focus on Tregs and MDSC cells. Here, we show that circulating Tregs are elevated in NENs patients compared to healthy donors and that treatment with OCT LAR significantly decrease the level of total Tregs and of the three functional Tregs populations: nTregs, eTregs and non-Tregs. Furthermore, OCT LAR treatment induces a functional impairment of the remaining circulating Tregs, significantly decreasing the expression of PD1, CTLA4 and ENTPD1. A trend in circulating MDSC cells is reported in patients treated with OCT LAR. The results reported here suggest that the effect of OCT LAR on Tregs could tip the balance of the patients’ immune-system towards a durable anti-tumour immunosurveillance with consequent long-term control of the NENs disease.

scholarly journals The impact of sex and exercise duration on growth hormone secretion

2006 ◽  
Vol 101 (6) ◽  
pp. 1641-1647 ◽  
Author(s):  
Laurie Wideman ◽  
Leslie Consitt ◽  
Jim Patrie ◽  
Brenda Swearingin ◽  
Richard Bloomer ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Exercise Duration ◽  
The Impact

THE EFFECT OF BETA-RECEPTOR BLOCKADE ON EXERCISE AND ARGININE-INDUCED GROWTH HORMONE SECRETION IN MAN

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S6 ◽  
Author(s):  
S. Raptis ◽  
H. Hirth-Schmidt ◽  
K. E. Schröder ◽  
E. F. Pfeiffer
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Receptor Blockade ◽  
Beta Receptor ◽  
Beta Receptor Blockade

Growth hormone secretion in children treated for medulloblastoma

2018 ◽  
Author(s):  
Alexey Kalinin ◽  
Natalia Strebkova ◽  
Olga Zheludkova ◽  
Maria Kareva
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion
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