Association of TNF-α Genetic Polymorphisms with Hepatocellular Carcinoma Susceptibility: A Case-Control Study in a Han Chinese Population

2011 ◽  
Vol 26 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Xiangmei Chen ◽  
Ling Zhang ◽  
Yibin Chang ◽  
Tao Shen ◽  
Ling Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Han Chinese Population ◽  
Direct Dna Sequencing ◽  
Tnf Α ◽  
Control Study

The single nucleotide polymorphisms (SNPs) within the tumor necrosis factor-α (TNF-α) gene promoter region have been reported to be associated with susceptibility to various types of cancers. A case-control study (126 hepatocellular carcinoma [HCC] patients and 126 normal controls) was conducted to elucidate their possible association with the risk of hepatitis B virus (HBV)-related HCC in a Han Chinese population. TNF-α polymorphisms -1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A were genotyped by polymerase chain reaction (PCR) and direct DNA sequencing. Disease associations were analyzed by the chi-square test or Fisher's exact test. When analyzed by overall groups, no significant differences in genotype and allele distributions were observed between the control and cases. However, stratified analysis according to sex showed that the frequency of the homozygous C allele of the -857 polymorphism was lower in female cases than in female controls (62.9% vs. 88.9%, p=0.026). In addition, further haplotype analysis revealed that the TCCGA (-1031/-863/-857/-308/-238) was more frequent in controls than cases (p=0.018; odds ratio = 0.266; 95% confidence interval, 0.083–0.857). These results indicated that the TNF-α-857C/T polymorphism may modify HBV-related HCC risk among women, and the haplotype TCCGA (-1031/-863/-857/-308/-238) may account for a decreased susceptibility to HCC development in the Han Chinese population. Additional studies in patients with different ethnic backgrounds are needed to validate these finding and to further explore the genetic pathogenesis of HBV-related HCC.

scholarly journals Association between Two Resistin Gene Polymorphisms and Metabolic Syndrome in Jilin, Northeast China: A Case-Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Yingli Fu ◽  
Yaqin Yu ◽  
Yanhua Wu ◽  
Yueyue You ◽  
Yangyu Zhang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
International Diabetes Federation ◽  
Case Control ◽  
Han Chinese ◽  
Jilin Province ◽  
Han Chinese Population ◽  
Control Study

Metabolic syndrome (MetS) is a significant health care problem worldwide and is characterized by increased fasting glucose and obesity. Resistin is a protein hormone produced both by adipocytes and immunocompetent cells, including those residing in adipose tissue, and is believed to modulate glucose tolerance and insulin action. This study examined the association of resistin gene polymorphisms, rs1862513 and rs3745368, and related haplotypes with the development of metabolic syndrome in a Han Chinese population. This case-control study was performed on 3792 subjects, including 1771 MetS cases and 2021 healthy controls from the Jilin province of China. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Logistic regression analysis was used to estimate the relationship between gene polymorphism and MetS. Our results showed that there were no significant associations between MetS and the genotype distributions in four kinds of inheritance models, allele frequencies, and related haplotypes of resistin gene polymorphisms rs1862513 and rs3745368 (allpvalues > 0.05). Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China.

A Case-Control Study of ABCB1, ABCB6, and ABCG1 Polymorphisms and Schizophrenia in a Han Chinese Population

2019 ◽  
Vol 78 (3) ◽  
pp. 113-117 ◽  
Author(s):  
Gaini Ma ◽  
Xiaoye Huang ◽  
Yan Bi ◽  
Fei Xu ◽  
Weibo Niu ◽  
...  
Keyword(s):  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Control Study

scholarly journals Genetic polymorphisms of NOS2 and predisposition to fracture non-union: A case control study based on Han Chinese population

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193673 ◽  
Author(s):  
Wei Huang ◽  
Kun Zhang ◽  
Yangjun Zhu ◽  
Zhan Wang ◽  
Zijun Li ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Non Union ◽  
Control Study

Association Between SLC1A1 Gene and Early-Onset OCD in the Han Chinese Population: A Case–Control Study

2013 ◽  
Vol 50 (2) ◽  
pp. 353-359 ◽  
Author(s):  
Haisu Wu ◽  
Xuemei Wang ◽  
Zeping Xiao ◽  
Shunying Yu ◽  
Liping Zhu ◽  
...  
Keyword(s):  
Early Onset ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Control Study

scholarly journals Association study between genetic variants and the risk of schizophrenia in the Chinese population based on GWAS-implicated 6p21.3–23.1 human genome region: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gangqin Li ◽  
Jie Dai ◽  
Hao Liu ◽  
Yushan Lin ◽  
Qiaoni Liu ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Chinese Population ◽  
Protective Factor ◽  
Case Control Study ◽  
Genetic Model ◽  
Disease Risk ◽  
Case Control ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Control Study

Abstract Background Schizophrenia is a polygenic disease; however, the specific risk genetic variants of schizophrenia are still largely unknown. Single nucleotide polymorphism (SNP) is important genetic factor for the susceptibility of schizophrenia. Investigating individual candidate gene contributing to disease risk remains important. Methods In a case-control study, five SNPs located in 6p21.3-p23.1 including rs2021722 in human leukocyte antigen (HLA) locus and rs107822, rs383711, rs439205 and rs421446 within the upstream of microRNA-219a-1 were genotyped in 454 schizophrenia patients and 445 healthy controls to investigate the possible association between the loci and schizophrenia in a Han Chinese population. Results Our results showed significant associations between the rs2021722 and schizophrenia in allele (A vs. G: adjusted OR = 1.661, 95%CI = 1.196–2.308), co-dominant (AG vs. GG: OR = 1.760, 95%CI = 1.234–2.510) and dominant genetic model (AG + AA vs. GG: OR = 1.756, 95%CI = 1.237–2.492), respectively. Haplotype analysis showed that TGGT and CAAC were protective factor for schizophrenia compared with TAAC haplotype (OR = 0.324, 95% CI = 0.157–0.672; OR = 0.423, 95% CI = 0.199–0.900). Conclusions These findings indicate that rs2021722 in HLA locus might be involved in pathogenesis of schizophrenia and that genotypes AG and allele A of the locus are risk factors for schizophrenia in the Han Chinese population, confirming the association between immune system and schizophrenia.

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