Seminal Plasma Calcium in Normal and Infertile Patients

2016 ◽  
Vol 84 (1) ◽  
pp. 35-37 ◽  
Author(s):  
Kalanghot P. Skandhan ◽  
Birendranath Mazumdar ◽  
Balakrishnan Sumangala ◽  
Vasudevan Jaya
Keyword(s):  
Seminal Plasma ◽  
Calcium Level ◽  
Plasma Calcium ◽  
Normal Men ◽  
Infertile Patients

Introduction In this study an attempt is made to find out the level of calcium in seminal plasma of normal and infertile patients. Materials and Methods Semen samples are collected from 34 normal men and 112 infertile patients. After semen evaluation seminal plasma was separated and calcium level was measured in it. Results Calcium level in mg% is recorded in each group as follows; in normozospermia (n34) 20.14 ± 1.25 (±SE), oligozoospermia (n26) 9.76 ± 1.17, azoospermia (n33) 14.65 ± 2.63, oligoasthenozoosperma (n28) 20.91 ± 1.94 and in asthenozoospermia (n25) 11.56 ± 1.68. Statistically highly significant reduction in calcium is seen in Oligozoospermia and asthenozoospermia. Conclusions The probable reasons for these two conditions are discussed.

Determination of Interleukin-11 in Seminal Plasma and Elevated Il-11 in Seminal Plasma of Infertile Patients with Urogenital Infection

1998 ◽  
Vol 41 (3) ◽  
pp. 177-183 ◽  
Author(s):  
I. Matalliotakis ◽  
A. Goumenou ◽  
E. Koumantakis ◽  
D. Kyriakou ◽  
Y. Fragouli ◽  
...  
Keyword(s):  
Seminal Plasma ◽  
Urogenital Infection ◽  
Interleukin 11 ◽  
Infertile Patients

scholarly journals SEMINAL PLASMA MELATONIN AND GONADAL STEROIDS CONCENTRATIONS IN NORMAL MEN

2002 ◽  
Vol 48 (3) ◽  
pp. 225-232 ◽  
Author(s):  
R. Luboshitzky ◽  
Z. Shen-Orr ◽  
P. Herer
Keyword(s):  
Seminal Plasma ◽  
Gonadal Steroids ◽  
Plasma Melatonin ◽  
Normal Men

scholarly journals Human seminal plasma contains somatostatin-64

1994 ◽  
Vol 303 (1) ◽  
pp. 263-268 ◽  
Author(s):  
L Odum ◽  
A H Johnsen
Keyword(s):  
Seminal Plasma ◽  
Biologically Active ◽  
Gel Chromatography ◽  
Human Seminal Plasma ◽  
Active Peptides ◽  
Accessory Sex Glands ◽  
Biologically Active Peptides ◽  
Terminal Amino ◽  
High Concentrations ◽  
Normal Men

Prosomatostatin is processed into two biologically active peptides, somatostatin (SS)-14 and SS-28. SS-14 is found in many tissues, whereas SS-28 is most prominent in the intestine. Human seminal plasma contained high concentrations (median = 3 nmol/l, range 0.6-76 nmol/l, n = 17) of SS with a higher M(r) than that of SS-28 as determined by gel chromatography. After isolation the SS immunoreactivity was identified as SS-64 based on the N-terminal amino acid sequence Leu-Ala-Glu-Leu-Leu-Ser-Glu-Pro-Asn-Gln-, and M(r) of 7242 determined by m.s. and on reactivity with two antibodies raised against SS-14. SS-64 displaced the binding of [125I-Tyr1]SS-14 to rat cerebrocortical membranes as effectively as SS-14 (IC50 = 1.6 mol/l). The concentration of SS-64 in seminal plasma from vasectomized men was significant higher (P < 0.005) than in normal men (median = 25.4 nmol/l, range 1.5-156 nmol/l, n = 21), suggesting that the synthesis of SS-64 takes place in the male accessory sex glands.

scholarly journals Decreased piRNAs in Infertile Semen Are Related to Downregulation of Sperm MitoPLD Expression

2021 ◽  
Vol 12 ◽  
Author(s):  
Yeting Hong ◽  
Yanqian Wu ◽  
Jianbin Zhang ◽  
Chong Yu ◽  
Lu Shen ◽  
...  
Keyword(s):  
Male Infertility ◽  
Sperm Motility ◽  
Seminal Plasma ◽  
Molecular Mechanisms ◽  
Molecular Biomarkers ◽  
Loss Of Function ◽  
Human Seminal Plasma ◽  
High Concentrations ◽  
Tight Correlation ◽  
Infertile Patients

Currently, the molecular mechanisms underlining male infertility are still poorly understood. Our previous study has demonstrated that PIWI-interacting RNAs (piRNAs) are downregulated in seminal plasma of infertile patients and can serve as molecular biomarkers for male infertility. However, the source and mechanism for the dysregulation of piRNAs remain obscure. In this study, we found that exosomes are present in high concentrations in human seminal plasma and confirmed that piRNAs are predominantly present in the exosomal fraction of seminal plasma. Moreover, we showed that piRNAs were significantly decreased in exosomes of asthenozoospermia patients compared with normozoospermic men. By systematically screening piRNA profiles in sperms of normozoospermic men and asthenozoospermia patients, we found that piRNAs were parallelly reduced during infertility. At last, we investigated the expression of some proteins that are essential for piRNAs biogenesis in sperms and therefore identified a tight correlation between the levels of spermatozoa piRNA and MitoPLD protein, suggesting that the loss-of-function of MitoPLD could cause a severe defect of piRNA accumulation in sperms. In summary, this study identified a parallel reduction of piRNAs and MitoPLD protein in sperms of asthenozoospermia patients, which may provide pathophysiological clues about sperm motility.

scholarly journals 1,25(OH)2D3 Induced Alterations in Plasma Calcium, Inorganic Phosphate, Ultimobranhial Gland and Parathyroid Gland of the Garden Lizard, Calotes Versicolor

2008 ◽  
Vol 53 (1-4) ◽  
pp. 5-18
Author(s):  
Bhawna Srivastava ◽  
Diwakar Mishra ◽  
Sunil Srivastav ◽  
Nobuo Suzuki ◽  
Ajai Srivastav
Keyword(s):  
Parathyroid Gland ◽  
Calcium Level ◽  
Inorganic Phosphate ◽  
Plasma Calcium ◽  
Nuclear Volume ◽  
Progressive Decrease ◽  
Weak Staining ◽  
Calotes Versicolor ◽  
Plasma Calcium Level ◽  
Ultimobranchial Gland

1,25(OH)2D3Induced Alterations in Plasma Calcium, Inorganic Phosphate, Ultimobranhial Gland and Parathyroid Gland of the Garden Lizard,Calotes VersicolorGarden lizardsCalotes versicolorwere procured and given daily intraperitoneal injections of 30 pmol of 1,25(OH)2D3/50 g body wt for 30 days. Lizards were sacrificed on the 1st, 3rd, 5th, 10th, 15thand 30thday of the experiment. The plasma calcium levels ofC. versicolorremain unaffected after day 1 following 1,25(OH)2D3treatment. After day 3 the levels increase significantly which progresses up to day 10. Thereafter, the plasma calcium level tends to decrease on day 15 and the levels become normal at day 30. In 1,25(OH)2D3injected lizards the plasma inorganic phosphate levels remain unaltered up to day 3. After day 5, the value increases significantly. This increase progresses up to day 15. On day 30, the levels become almost normal. The ultimobranchial gland exhibits hyperactivity following 5 day 1,25(OH)2D3treatment which is expressed by an increase in the nuclear volume and weak staining response of the cytoplasm of ultimobranchial cells. After day 10, the nuclear volume is further increased and some of the cells are exhausted. Following 15 days 1,25(OH)2D3treatment the nuclear volume records an increase and many degenerating cells are discerned. After day 30, the nuclear volume is almost normal, most cells seem to be recovered and only a few degenerating cells are noticed. After day 10 and day 15 following 1,25(OH)2D3treatment, the parathyroid glands ofC. versicolorshow reduced chromaticity of nuclei and a progressive decrease in the nuclear volume of parathyroidal cells. On day 30, the nuclear volume tends to become normal and a few degenerating cells are observed.

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