Mycotic Mastitis in Three Dogs Due to Blastomyces dermatitidis

2011 ◽  
Vol 47 (5) ◽  
pp. 356-358 ◽  
Author(s):  
Heidi Ditmyer ◽  
Linden Craig

Canine blastomycosis is a common systemic fungal infection within the Ohio and Mississippi River valleys and typically presents as pneumonia, lymphadenitis, or endophthalmitis. This report describes three cases in which mammary tissue samples were submitted to the Department of Pathobiology, University of Tennessee, College of Veterinary Medicine with clinical suspicion of neoplasia or postpartum bacterial mastitis. Pyogranulomatous to granulomatous mastitis and dermatitis with intralesional yeast consistent with Blastomyces dermatitidis were diagnosed. Two of the three dogs also had lymph node and pulmonary involvement. Mycotic mastitis due to Blastomyces dermatitidis is rarely reported and blastomycosis should be considered in the differential diagnosis of dogs with mammary lesions from endemic areas.

2015 ◽  
Vol 59 (2) ◽  
pp. 255-261
Author(s):  
Gulbin Sennazli ◽  
Funda Yildirim ◽  
Seckin Serdar Arun ◽  
Aydin Gurel ◽  
Kivilcim Sonmez

Abstract The objective of this study was to investigate the correlation between different histological types and grades of canine malignant mammary tumours, tumour cell proliferation and their angiogenic activity using immunohistochemical markers. Mammary tissue samples from 47 bitches with mammary cancer were evaluated. The expression of cellular proliferation marker Ki-67 and endothelial marker Von Willebrand’s factor (vWF) were immunohistochemically demonstrated. The tumours with the highest Ki-67 and vWF expressions were found to share similar histomorphological features. Simple solid carcinoma had the highest levels of Ki-67, vWF, and higher histological grade while complex carcinomas, osteosarcomas, and carcinosarcomas had the lowest ones. The differences between the expressions of Ki-67 and vWF in different tumour types were considered to be of great importance in determination of biological behaviour and prognosis of these tumours. This study is one of the few studies that evaluate these differences among the subtypes of malignant canine mammary tumours


Author(s):  
James Hudnut-Beumler

Of all European faiths transplanted to what became the U.S. southern states, Roman Catholicism came first. Southern Catholicism was mostly confined to the Atlantic and Gulf coasts and the Ohio and Mississippi river valleys, leading a Glenmary priest to dub the interior “No Priest Land.” This chapter depicts the Catholic filling of the southern interior in four waves: first, select immigrant towns were established like Cullman, Alabama in the 19th century, home to a Benedictine monastery; a second wave came in the early and mid-20th century with the Glenmary Home Missioners and a colorful nun named Mother Angelica, determined in different ways to evangelize and serve the South; the third wave came from rustbelt transplant Catholics moving south for jobs, especially with the auto industry in the 1980s forward; finally, the fourth and largest wave is composed of Hispanic Catholics helping making the South’s states the fastest growing in Hispanic population 2000-2010. This chapter features visits to two fast growing Hispanic congregations, one largely Mexican in ethnicity, the other pan-Central American. The principal emerging religious feature for Catholicism in the South that it has quickly become the most immigrant-embracing form of Christianity in the region.


1973 ◽  
Vol 10 (1) ◽  
pp. 1-11 ◽  
Author(s):  
R. W. Wilson ◽  
A. A. van Dreumel ◽  
J. N. R. Henry

Four cases of canine blastomycosis are described. Biopsy specimens were examined in two of the cases. Typical granulomas and microabscesses containing yeast forms of Blastomyces dermatitidis were seen in the testicle, prostate, kidney and bladder. Complete necropsies are described in two dogs with granulomas in the lung, eyes, prostate, testicle and meninges. The distribution of the lesions indicates a systemic infection.


Author(s):  
Jeffery S. Girard

Dr. Montroville Wilson Dickeson, born in Philadelphia in 1810, was a medical doctor, taxidermist and avid collector of fossils. Between 1837 and 1844 he pursued another interest—excavating Indian burial mounds in the Ohio and Mississippi River valleys. He claimed to have “opened up” more than a thousand mounds and collected more than 40,000 objects. He also made drawings of the mounds and later provided these to an artist by the name of John J. Egan, who, about 1850, converted the drawings into a series of large paintings on huge canvases. Dickeson toured the country in 1852 allowing the public to view the canvasses and his artifact collections for a fee of 25 cents. The panorama, titled “Monumental Grandeur of the Mississippi Valley”, was nine feet high, 400 feet long, and consisted of 27 scenes. The canvasses later were curated at the University Museum, University of Pennsylvania until 1953 when purchased by the St. Louis Art Museum where they remain today. Dickeson’s lecture notes refer to Scene 21 as follows: “The following picture shows a group of connected mounds in Caddo Parish, in Northwestern Louisiana, with some of the aboriginal inhabitants of the region . . .” The scene depicts a cluster of nine mounds, some of which are connected by low earthen walls. In the background are mountains, and a group of Indians with elaborate headdresses are shown in front of tents. Similar mountains and the same Indian scene appear in other segments of the Mississippi Panorama and are understandable in light of the Romantic artistic style of the times, as well as the fact that the panorama was part of a show intended to evoke wonder and awe in its audience. Today we know of only one place in Caddo Parish where there is a cluster of at least nine mounds. Located on the western side of the Red River, north of the present city of Shreveport, is the Mounds Plantation Site (16CD12), the single largest Caddo ceremonial center in northwestern Louisiana. It seems fitting that the earliest reference that we have to a prehistoric site in northwest Louisiana likely pertains to Mounds Plantation, a place of primary importance to its ancient Caddo inhabitants, as well as to modern archaeological research.


2019 ◽  
Vol 34 (6) ◽  
pp. 1605-1631 ◽  
Author(s):  
Walker S. Ashley ◽  
Alex M. Haberlie ◽  
Jacob Strohm

Abstract This research uses image classification and machine learning methods on radar reflectivity mosaics to segment, classify, and track quasi-linear convective systems (QLCSs) in the United States for a 22-yr period. An algorithm is trained and validated using radar-derived spatial and intensity information from thousands of manually labeled QLCS and non-QLCS event slices. The algorithm is then used to automate the identification and tracking of over 3000 QLCSs with high accuracy, affording the first, systematic, long-term climatology of QLCSs. Convective regions determined by the procedure to be QLCSs are used as foci for spatiotemporal filtering of observed severe thunderstorm reports; this permits an estimation of the number of severe storm hazards due to this morphology. Results reveal that nearly 32% of MCSs are classified as QLCSs. On average, 139 QLCSs occur annually, with most of these events clustered from April through August in the eastern Great Plains and central/lower Mississippi and Ohio River Valleys. QLCSs are responsible for a spatiotemporally variable proportion of severe hazard reports, with a maximum in QLCS-report attribution (30%–42%) in the western Ohio and central Mississippi River Valleys. Over 21% of tornadoes, 28% of severe winds, and 10% of severe hail reports are due to QLCSs across the central and eastern United States. The proportion of QLCS-affiliated tornado and severe wind reports maximize during the overnight and cool season, with more than 50% of tornadoes and wind reports in some locations due to QLCSs. This research illustrates the utility of automated storm-mode classification systems in generating extensive, systematic climatologies of phenomena, reducing the need for time-consuming and spatiotemporal-limiting methods where investigators manually assign morphological classifications.


1993 ◽  
Vol 129 (5) ◽  
pp. 453-457 ◽  
Author(s):  
M Klempt ◽  
BH Breier ◽  
SH Min ◽  
DDS MacKenzie ◽  
SN McCutcheon ◽  
...  

Binding proteins for the insulin-like growth factors (IGFBPs) modulate the actions of IGF I and IGF II. IGFBP-2 is particularly high in plasma of pregnant and fetal animals and in milk. We investigated the peri-lactational control of IGFBP-2 expression and secretion. Fifteen singleton-bearing pregnant ewes at day 101 of gestation were injected sc twice daily for 8 days with bovine growth hormone (bGH) or ovine placental lactogen (oPL) both at 0.15 mg·kg−1·d−1 or saline. A further fifteen ewes at day 17 of lactation were injected sc twice daily for 5 days with bGH or oPL at 0.1 mg·kg−1·d−1 or saline. On the last day of injection blood samples were taken and the animals were sacrificed. Liver and mammary tissue samples were immediately frozen and subsequently extracted to provide total RNA for evaluation by Northern blot analysis using a rat IGFBP-2 cDNA probe. Plasma samples were analysed by Western ligand blotting for IGFBP-2. The comparison of the two saline-treated groups (pregnant vs lactating ewe) revealed no difference in the plasma concentrations of IGFBP-2. IGFBP-2 mRNA expression in the liver of the lactating ewes was markedly increased compared to that in the pregnant ewes. In contrast, in mammary tissue the expression was significantly lower in lactating than in pregnant sheep. In pregnant animals treatment with bGH, but not oPL, decreased the expression of IGFBP-2 in liver. There was a similar trend in the lactating ewe. GH treatment, but not PL treatment, moderately reduced IGFBP-2 levels in the lactating but not the pregnant ewes. bGH but not oPL induced hyperinsulinaemia. We conclude that GH has actions in pregnancy and lactation which are not mimicked by oPL. The regulation of hepatic IGFBP-2 expression by GH is similar in pregnant and postpartum animals. However, there are distinct differences in the tissue-specific regulation of IGFBP-2 between pregnancy and lactation. The liver might be the major source of circulating IGFBP-2.


2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Alex R. Boyd ◽  
Jamie L. VanDyke ◽  
Gene M. Scalarone

The systemic fungal infection, blastomycosis, which infects both humans and animals has presented a diagnostic challenge for clinicians for many years. The aim of this study was to evaluate the diagnostic sensitivity ofBlastomyces dermatitidisyeast lysate antigens with respect to antibody detection in dogs with blastomycosis. Lysate antigens were prepared fromB. dermatitidisisolates T-58 and T-66 (dogs, Tennessee) and WI-R and WI-J (dogs, Wisconsin). Based on results obtained from a preliminary comparative study, five combinations of these isolates and one individual isolate were tested against 92 serum specimens from dogs with culture-proven or histologically-confirmed blastomycosis, using the indirect enzyme-linked immunosorbent assay (ELISA). Mean absorbance values obtained from the sera ranged from 0.905 with the individual T-58 antigen to 1.760 using an antigen combination (T-58 + T-66 + WI-R). All of the 6 antigenic preparations were able to detect antibody in the serum specimens, but the antigen combinations detected antibody to a higher degree than the individual antigen. This study provides evidence that combinations of the yeast lysate reagents seem to be more efficacious for antibody detection in dog sera, but our laboratory is continuing to evaluate antigen lysate combinations for detection of antibodies in blastomycosis.


Author(s):  
Janis E Blair

Blastomyces dermatitidis is a fungus endemic in the central and eastern United States. It is coendemic with Histoplasma capsulatum in much of the central and southeastern United States, including the Mississippi and Ohio river valleys. Distribution of B dermatitidis extends farther north and west than H capsulatum and includes northern Wisconsin, Minnesota, Ontario, and Manitoba. Fungal growth occurs in nitrogen-rich soils close to streams, rivers, and lakes. Many outbreaks of blastomycosis occur within 100 meters of recreational water. Infection can be asymptomatic or can cause flulike symptoms, pneumonia, or skin, bone or CNS manifestations. Diagnosis and treatment are also reviewed.


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