Transient Fanconi Syndrome After Treatment with Firocoxib, Cefadroxil, Tramadol, and Famotidine in a Maltese

ABSTRACT Fanconi syndrome is a renal proximal tubulopathy characterized by excessive urinary loss of glucose, amino acids, several electrolytes, and bicarbonate. Here, we report the case of transient Fanconi syndrome in a dog following administration of firocoxib, cefadroxil, tramadol, and famotidine. A 10 mo old Maltese was presented with lethargy, anorexia, vomiting, and weight loss. Transient Fanconi syndrome without azotemia was associated with firocoxib, cefadroxil, tramadol, and famotidine treatment. The dog received supportive care including IV fluids, gastroprotectants, and oral nutritional supplements. Two months after initial diagnosis and treatment, the dog showed complete resolution of glucosuria and aminoaciduria. The unique features of Fanconi syndrome in this case emphasize the potential renal tubular toxicity of this widely used multiple-drug combination.

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Fanconi Syndrome in Four Non–Basenji Dogs Exposed to Chicken Jerky Treats

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-5602 ◽

2011 ◽

Vol 47 (6) ◽

pp. e178-e187 ◽

Cited By ~ 9

Author(s):

Ashley N. Hooper ◽

Brian K. Roberts

Keyword(s):

Chronic Kidney Disease ◽

Urinary Tract Infection ◽

Complete Resolution ◽

Fanconi Syndrome ◽

Diagnostic Testing ◽

Clinical Signs ◽

Nutritional Supplements ◽

Rickettsial Disease ◽

Oral Nutritional Supplements ◽

The Face

Four small-breed dogs were diagnosed with acquired Fanconi syndrome. All dogs ate varying amounts of chicken jerky treats. All dogs were examined for similar clinical signs that included, but were not limited to, lethargy, vomiting, anorexia, diarrhea, and altered thirst and urination. The quantity of chicken jerky consumed could not be determined; however, based on the histories obtained, the chicken jerky treats were a significant part of the diet and were consumed daily by all dogs. Extensive diagnostic testing eliminated other causes of the observed clinical signs, such as urinary tract infection and rickettsial disease. Glucosuria in the face of euglycemia or hypoglycemia, aminoaciduria, and metabolic acidosis confirmed the diagnosis of Fanconi syndrome. All dogs received supportive care, including IV fluids, antibiotics, gastroprotectants, and oral nutritional supplements. Three dogs exhibited complete resolution of glucosuria, proteinuria, and the associated azotemia; however, one dog remained azotemic, resulting in a diagnosis of chronic kidney disease.

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ORAL NUTRITIONAL SUPPLEMENTS AND TASTE ADHERENCE IN MALNOURISHED ELDERLY ADULT’S OUTPATIENTS

Journal of Aging Research and Lifestyle ◽

10.14283/jarcp.2017.12 ◽

2017 ◽

pp. 1-5

Author(s):

D.A. de Luis ◽

O. Izaola ◽

A Castro ◽

J.J. Lopez ◽

B. Torres ◽

...

Keyword(s):

Weight Loss ◽

Daily Intake ◽

Nutritional Supplements ◽

Nutritional Supplement ◽

Taste Preferences ◽

Oral Nutrition ◽

Oral Nutritional Supplement ◽

Nutrition Supplement ◽

Significant Difference ◽

Oral Nutritional Supplements

Abstract: The aim of our study was to evaluate a hypercaloric sweet milkbased oral nutrition supplement in a prospective 3 day-study designed to assess the taste preferences of this oral nutritional supplement (ONS) in elderly malnourished out-patients and the influence on adherence in daily intake during two months.A total of 28 out-patients with recent weight loss were included in this study. One flavour (chocolate, vanilla or strawberry) was administered each day in a random way during three consecutive days. In the first three days, patients were asked to fulfill two questionnaires in order to reflect ONS tolerance and acceptance. Sweet and aftertaste were better for chocolate flavour than for vanilla or strawberry flavours. Patients who chose vainilla took a total of 96.3+7.4 average bricks during outpatient followup (1.60+0.3 per day), patients who chose chocolate took 76.8+15.0 bricks (1.28+0.8 per day) and patients who chose strawberry bricks taken 60.3+19.5 bricks (1.10+0.7 per day), with a significant difference with vainilla flavour (p <0.01). The improvement of weight (vanilla +1.0+0.8 kg vs chocolate +0.5+0.8 kg vs 0.6+1.0 kg:p=0.03), tricipital skinfols (vanilla +1.5+0.3 mm vs chocolate +1.1+0.4 mm vs 0.7+0.3 mm:p=0.03), prealbumin levels (vanilla +4.2+0.8 mg/dl vs chocolate +3.9+0.7 mg/dl vs +3.6+1.0 mg/dl:p=0.01) and transferrin levels (vanilla +100.0+21.8 mg/dl vs chocolate +75.5+18.8 mg/dl vs 63.8+14.1 mg/dl:p=0.03) was higher in patients treated with vanilla ONS than chocolate or strawberry ONS. The three flavoured ONS taste preferences are similar although the consumption is high in vanilla flavoured ONS.

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Taste Perception of Nutrients Found in Nutritional Supplements: A Review

Nutrients ◽

10.3390/nu11092050 ◽

2019 ◽

Vol 11 (9) ◽

pp. 2050 ◽

Cited By ~ 7

Author(s):

Thomas Delompré ◽

Elisabeth Guichard ◽

Loïc Briand ◽

Christian Salles

Keyword(s):

Amino Acids ◽

Fatty Acids ◽

Nutritional Status ◽

Nutritional Supplements ◽

Good Health ◽

Sensory Attributes ◽

Taste Perception ◽

Potential Influence ◽

Oral Nutritional Supplements ◽

Industrial Level

Nutritional supplements are prescribed when one’s nutritional status is not conducive to good health. These foodstuffs constitute concentrated sources of nutrients such as vitamins, minerals, amino acids, and fatty acids. For nutritional supplements to be effective, patients must consume the amount that has been prescribed for the recommended period of time. Therefore, special attention must be given to the sensory attributes of these products. Indeed, the presence of active compounds can cause an off-taste or aftertaste. These negative sensations can lead to a reduction in the consumption of nutritional supplements and reduce the effectiveness of the treatment. In this manuscript, we provide an overview of the sensory characteristics and the sensing receptor mechanism of the main compounds present in oral nutritional supplements, such as amino acids, minerals, fatty acids, and vitamins. Part of this article is devoted to the development of new masking strategies and the corresponding potential influence at the industrial level.

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Oral Nutritional Supplements and Taste Adherence in Malnourished Adults Inpatients, Effect on Adhesion during Hospital Stance

Annals of Nutrition and Metabolism ◽

10.1159/000440684 ◽

2015 ◽

Vol 67 (4) ◽

pp. 205-209 ◽

Cited By ~ 3

Author(s):

Daniel Antonio de Luis ◽

Olatz Izaola ◽

Juan Jose Lopez ◽

Beatriz Torres ◽

Emilia Gomez Hoyos

Keyword(s):

Weight Loss ◽

Daily Intake ◽

Nutritional Supplements ◽

Nutritional Supplement ◽

Taste Preferences ◽

Oral Nutrition ◽

Oral Nutritional Supplement ◽

Nutrition Supplement ◽

Oral Nutritional Supplements ◽

Strawberry Flavor

Aim: The aim of our study was to evaluate a hypercaloric sweet milk-based oral nutrition supplement in a prospective 3-day study designed to assess the taste preferences of this oral nutritional supplement (ONS) in malnourished inpatients and the influence on adherence in daily intake. Methods: A total of 46 in patients with recent weight loss were included in this study. One flavor (chocolate, vanilla or strawberry) was administered each day in a random way to each patient during 3 consecutive days. In the first 3 days, patients were asked to fill 2 questionnaires intended for reflecting ONS tolerance and acceptance. Results: Sweet was better for chocolate flavor (3.9 ± 2.4 points) than for vanilla flavor (2.7 ± 2.3 points; p < 0.02) and strawberry flavor (3.1 ± 2.3 points; p < 0.01). Chocolate flavored ONSs were rated as having more aftertaste (3.4 ± 2.1 points) than vanilla (2.4 ± 2.1 points; p < 0.01) and strawberry (2.6 ± 1.5 points; p < 0.03). Patients who chose chocolate took a total of 20.7 ± 20.9 average bricks during hospitalization (1.95 ± 0.2 per day), patients who chose vanilla took 18.6 ± 21.0 bricks (1.90 ± 0.7 per day) and finally patients who chose strawberry took 14.5 ± 13.5 bricks during admission (1.78 ± 0.1 per day; p < 0.01). Conclusions: The taste preferences of all the ONSs are similar although the consumption is high in chocolate flavored ONS during hospitalization. Sweetness may have influenced this finding.

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P132 PROTECTIVE EFFECT OF ORAL NUTRITIONAL SUPPLEMENTS ON TOTAL BODY WEIGHT LOSS IN AN ANIMAL MODEL OF FRACTIONATED-DOSE RADIOTHERAPY

Clinical Nutrition Supplements ◽

10.1016/s1744-1161(09)70182-6 ◽

2009 ◽

Vol 4 (2) ◽

pp. 81

Author(s):

Y.M. Dupertuis ◽

B. Robert ◽

C. Pichard ◽

P. Senesse

Keyword(s):

Weight Loss ◽

Animal Model ◽

Body Weight ◽

Protective Effect ◽

Body Weight Loss ◽

Nutritional Supplements ◽

Total Body Weight ◽

Oral Nutritional Supplements ◽

Total Body ◽

Total Body Weight Loss

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Oral nutritional supplements versus a regular diet alone for body weight loss after gastrectomy: a phase 3, multicenter, open-label randomized controlled trial

Gastric Cancer ◽

10.1007/s10120-021-01188-3 ◽

2021 ◽

Author(s):

Yasuhiro Miyazaki ◽

◽

Takeshi Omori ◽

Kazumasa Fujitani ◽

Junya Fujita ◽

...

Keyword(s):

Weight Loss ◽

Randomized Controlled Trial ◽

Body Weight ◽

Controlled Trial ◽

Body Weight Loss ◽

Nutritional Supplements ◽

Open Label ◽

Phase 3 ◽

Randomized Controlled ◽

Oral Nutritional Supplements

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The Weight Loss Effects of Branched Chain Amino Acids and Vitamin B6: A Randomized Controlled Trial on Obese and Overweight Women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000511 ◽

2018 ◽

Vol 88 (1-2) ◽

pp. 80-89 ◽

Cited By ~ 3

Author(s):

Zahra Shakibay Novin ◽

Saeed Ghavamzadeh ◽

Alireza Mehdizadeh

Keyword(s):

Amino Acids ◽

Weight Loss ◽

Body Composition ◽

Vitamin B6 ◽

Controlled Trial ◽

Density Lipoprotein ◽

Branched Chain Amino Acids ◽

Model Assessment ◽

Waist To Hip Ratio ◽

Branched Chain

Abstract. Branched chain amino acids (BCAA), with vitamin B6 have been reported to improve fat metabolism and muscle synthesis. We hypothesized that supplementation with BCAA and vitamin B6 would result in more weight loss and improve body composition and blood markers related to cardiovascular diseases. Our aim was to determine whether the mentioned supplementation would affect weight loss, body composition, and cardiovascular risk factors during weight loss intervention. To this end, we performed a placebo-controlled randomized clinical trial in 42 overweight and obese women (BMI = 25–34.9 kg/m2). Taking a four-week moderate deficit calorie diet (–500 kcal/day), participants were randomized to receive BCAA (6 g/day) with vitamin B6 (40 mg/day) or placebo. Body composition variables measured with the use of bioelectrical impedance analysis, homeostatic model assessment, and plasma insulin, Low density lipoprotein, High density lipoprotein, Total Cholesterol, Triglyceride, and fasting blood sugar were measured. The result indicated that, weight loss was not significantly affected by BCAA and vitamin B6 supplementation (–2.43 ± 1.02 kg) or placebo (–1.64 ± 1.48 kg). However, significant time × treatment interactions in waist to hip ratio (P = 0.005), left leg lean (P = 0.004) and right leg lean (P = 0.023) were observed. Overall, supplementation with BCAA and vitamin B6 could preserve legs lean and also attenuated waist to hip ratio.

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