scholarly journals FUNCTIONAL CONNECTIVITY IN MILD GNITIVE IMPAIRMENT PATIENTS WITH PIB+ AND – BIOMARKERS

2021 ◽  
Author(s):  
Aline Gonçalves ◽  
Paulo Bazan ◽  
Maria da Graça Martins ◽  
Geraldo Busatto Filho ◽  
Artur Coutinho ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Temporal Region ◽  
Functional Compensation ◽  
Significant Difference ◽  
Left And Right ◽  
Protein Deposit ◽  
The Right

Background: According to the recent NIA-AA, a probable predictor of Alzheimer’s disease convertor in mild cognitive impairment (MCI) is the Aβ protein deposit in PET PIB exam. However, there is a lack of studies investigating functional connectivity in PIB +/- MCI patients. Objectives: to investigate differences in functional connectivity during resting state in MCI patients with PET PIB+ and - biomarkers. Methods: PET PIB+ (N=12 and PIB- (N=12) MCI patients underwent fMRI during resting state using 3 ROIS related to memory (posterior cingulate and bilateral hippocampus). Results: there were significant connectivity differences (p <0.05) between PIB+ and PIB- patients above 80% for right temporal region connectivity regarding left and right temporal region. Conclusions The results suggest that PET PIB+ MCI patients show significant difference in functional connectivity on the right temporal region in relation to left and right hippocampus ROI during the resting state possibly related to functional compensation.

Poorer Theory of Mind in Amnestic Mild Cognitive Impairment Is Associated with Decreased Functional Connectivity in the Default Mode Network

2021 ◽  
pp. 1-13
Author(s):  
Johannes C. Michaelian ◽  
Shantel L. Duffy ◽  
Loren Mowszowski ◽  
Adam J. Guastella ◽  
Donna McCade ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Theory Of Mind ◽  
Default Mode Network ◽  
Amnestic Mild Cognitive Impairment ◽  
Default Mode ◽  
Left And Right ◽  
The Right

Background: Older adults living with amnestic mild cognitive impairment (aMCI) not only demonstrate impairments in Theory of Mind (ToM), relative to adults with non-amnestic MCI (naMCI), but are also at a higher risk of developing dementia. Objective: Our primary objective was to ascertain whether default mode network (DMN) functional connectivity was differentially associated with ToM abilities between MCI subgroups. Methods: Using functional magnetic resonance imaging, we investigated alterations in resting-state functional connectivity within the brain’s DMN in a sample of 43 older adults with aMCI (n = 19) and naMCI (n = 24), previously reported to demonstrate poorer ToM abilities. Results: Compared to naMCI, the aMCI subgroup revealed a significant association between poorer ToM performance and reduced functional connectivity between the bilateral temporal pole (TempP) and the left lateral temporal cortex (LTC) (LTC_L-TempP_L: b = –0.06, t(33) = –3.53, p = 0.02; LTC_L-TempP_R: b = –0.07,t(33) = –3.20, p = 0.03); between the right TempP and the dorsal medial prefrontal cortex (dMPFC) (b = –0.04, t(33) = –3.02, p = 0.03) and between the left and right TempP (b = –0.05, t(33) = –3.26, p = 0.03). In the naMCI subgroup, the opposite relationship was present between the bilateral TempP and the left LTC (Combined correlation: r = –0.47, p = 0.02), however, not between the right TempP and the dMPFC (r = –0.14, p = 0.51) or the left and right TempP (r = –0.31, p = 0.14). Conclusion: Our findings suggest that alterations in functional connectivity within the DMN involving temporal and frontal lobe regions are associated with ToM deficits in aMCI.

scholarly journals Resting state functional connectivity associated with financial capacity in mild cognitive impairment

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Milap Nowrangi ◽  
Farah Naaz ◽  
Liuyi Chen ◽  
John D. Outen ◽  
Arnold Bakker ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Financial Capacity

scholarly journals Network change point detection in resting-state functional connectivity dynamics of mild cognitive impairment patients

2020 ◽  
Vol 20 (3) ◽  
pp. 200-212
Author(s):  
Núria Mancho-Fora ◽  
Marc Montalà-Flaquer ◽  
Laia Farràs-Permanyer ◽  
Daniel Zarabozo-Hurtado ◽  
Geisa Bearitz Gallardo-Moreno ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Change Point ◽  
Change Point Detection ◽  
Resting State Functional Connectivity ◽  
Network Change ◽  
Point Detection

scholarly journals Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Yuxia Li ◽  
Xiaoni Wang ◽  
Yongqiu Li ◽  
Yu Sun ◽  
Can Sheng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Angular Gyrus ◽  
Functional Connectivity Strength ◽  
Middle Occipital Gyrus ◽  
Left Angular Gyrus ◽  
Connectivity Strength

Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer’s disease (AD). However, little is known about functional characteristics of the conversion from MCI to AD. Resting-state functional magnetic resonance imaging was performed in 25 AD patients, 31 MCI patients, and 42 well-matched normal controls at baseline. Twenty-one of the 31 MCI patients converted to AD at approximately 24 months of follow-up. Functional connectivity strength (FCS) and seed-based functional connectivity analyses were used to assess the functional differences among the groups. Compared to controls, subjects with MCI and AD showed decreased FCS in the default-mode network and the occipital cortex. Importantly, the FCS of the left angular gyrus and middle occipital gyrus was significantly lower in MCI-converters as compared with MCI-nonconverters. Significantly decreased functional connectivity was found in MCI-converters compared to nonconverters between the left angular gyrus and bilateral inferior parietal lobules, dorsolateral prefrontal and lateral temporal cortices, and the left middle occipital gyrus and right middle occipital gyri. We demonstrated gradual but progressive functional changes during a median 2-year interval in patients converting from MCI to AD, which might serve as early indicators for the dysfunction and progression in the early stage of AD.

scholarly journals Resting state functional connectivity of financial capacity in mild cognitive impairment

2020 ◽  
Vol 16 (S1) ◽  
Author(s):  
Milap Nowrangi ◽  
Farah Naaz ◽  
Liuyi Chen ◽  
John D. Outen ◽  
Arnold Bakker ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Financial Capacity

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

2014 ◽  
Vol 4 (5) ◽  
pp. 361-370 ◽  
Author(s):  
Hongxiang Yao ◽  
Bo Zhou ◽  
Zengqiang Zhang ◽  
Pan Wang ◽  
Yan'e Guo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Fmri
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