Etiology of Juandice and Associated Liver Diseases Among Hiv Patients

2021 ◽  
Vol 15 (10) ◽  
pp. 3366-3369
Author(s):  
Syed Shah Gul ◽  
Muhammad Abdul Quddus ◽  
Jahangir Zaib ◽  
Tahir Iqbal ◽  
Wajid Hussain ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Liver Disease ◽  
Cross Sectional Study ◽  
Drug Induced ◽  
Abdominal Ultrasonography ◽  
Cross Sectional ◽  
Term Survival ◽  
Immunodeficiency Virus ◽  
Fundamental Cause ◽  
Immunodeficiency Syndrome

Background and Aim: Jaundice and associated liver disease are frequently diagnosed in patients with acquired immunodeficiency syndrome (AIDS). The assessment of jaundice causes, etiology, and outcomes in human immunodeficiency virus (HIV)-infected patients with liver disease have not been addressed. The present study aimed to evaluate jaundice and associated liver disease in human immunodeficiency virus (HIV)-infected patients. Materials and Methods: This cross-sectional study was conducted on 272 human immunodeficiency virus(HIV)-infected patients with liver disease at the Department of Gastroenterology AK CMH/ Sheikh Khalifa bin Zayad Al Nahyan Hospital Rawalakot, Medicine Medical Unit A, Hayatabad Medical Complex, Peshawar and department of Medicine, Fauji Foundation Hospital Rawalpindi for duration between 5th January 2020 and 5th December 2020. Jaundice was defined as a serum bilirubin concentration of 3 mg/dL or higher. The etiology of jaundice was determined using a pattern of liver disease biochemistry test, radiographic studies, liver biopsy and clinical follow-up. Results: About 272 HIV-infected patients were evaluated liver disease; the prevalence of jaundice was 46 (16.9%). Drug-induced hepatitis was the more prevalent cause in Jaundice 19 (41.3%) followed by neoplasms in 14 (30.4%) patients. Out of 14 neoplasms, the extrahepatic and intrahepatic disease was present in 8 and 6 patients respectively. Alcoholic liver disease was present in 5 (10.9%). Various potential causes were present in three patients. The use of abdominal ultrasonography and CT was beneficial in determining the fundamental cause of the infection. five of these patients died as a result of liver disease. Conclusion: Jaundice is rare and can be caused by a number of opportunistic and non-opportunistic etiologies in AIDS. The most common cause is drug-induced hepatitis, which can be fatal. Long-term survival was dismal. Keywords: Jaundice, Liver Disease, Human immunodeficiency virus (HIV)

scholarly journals Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Abebe Zeleke ◽  
Bethelihem Misiker ◽  
Teshager Aklilu Yesuf
Keyword(s):  
Body Mass Index ◽  
Human Immunodeficiency Virus ◽  
Body Mass ◽  
Statistical Significance ◽  
Extrapulmonary Tuberculosis ◽  
Cross Sectional Study ◽  
Referral Hospital ◽  
Drug Induced ◽  
Cross Sectional ◽  
Immunodeficiency Virus

Abstract Objectives Anti-tuberculosis drug-induced hepatotoxicity is a common serious adverse drug reaction. This study intended to determine the prevalence and associated factors of drug-induced hepatotoxicity among tuberculosis and human immunodeficiency virus co-infected patients in Dessie referral hospital northeast Ethiopia. Results In this cross-sectional study 84 patients were enrolled retrospectively. Data from September 1/2015 to August 30/2018 were extracted from March 1/2019 to April 1/2019. Association between dependent and independent variables was determined using the odds ratio and a P value of < 0.05 was considered as statistical significance. Out of 84 patients, 17 patients developed drug-induced hepatotoxicity which makes the prevalence of drug-induced hepatotoxicity 20.2%. The result revealed that the presence of disseminated or extrapulmonary tuberculosis [(AOR: 7.728, 95% CI (1.516–39.404)] and/or body mass index less than 18.5 kg/m2 [(AOR = 5.593, 95% CI (1.180–26.519)] were a risk factor for drug-induced hepatotoxicity. Tuberculosis and human immunodeficiency virus co-infected patients with extra- pulmonary tuberculosis and/or body mass index less than 18.5 kg/m2 should be closely followed and supervised for the development of hepatotoxicity.

scholarly journals Social Support and Depression in Patients with Human Immunodeficiency Virus Attending a General Hospital in South-South,Nigeria

2021 ◽  
Vol 6 (1) ◽  
Keyword(s):  
Social Support ◽  
Human Immunodeficiency Virus ◽  
General Hospital ◽  
Cross Sectional Study ◽  
Health Issues ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Received Social Support ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Background: Depression is one of the commonest psychiatric disorders seen among Human immunodeficiency virus/Acquired immunodeficiency syndrome (HIV/AIDS) individuals and these two conditions are significant public health issues. Also, lack of social support increases the risk of depression among them. Aim: To determine the extent and type of social support and correlates of depression among HIV/AIDS patients attending General Hospital in south-south, Nigeria. Setting: The research was conducted in the HIV/AIDS outpatient clinic of the General hospital in south-south, Nigeria. Methods: A cross-sectional study design was carried out on three hundred and twenty-three patients living with HIV/AIDS from June to October 2016. The instruments used were Socio-demographic questionnaire, Mini international neuropsychiatric interview M.I.N.I (A1-A6 module, English version 6.0), and OSLO-3 items social support scale. Results: Majority (95.7%) of the respondents received social support and more than half (53.6%) of the respondents have strong social support. There was a significant association between social support and depression (X2 =18.38, df =1, p=0.001). The majority (83.3%) of the respondents were females and depression was significantly associated with marital status (X2=7.36, df=2, p=0.03).Also, there was a significant association between monthly income and depression(X2=9.31, df=2, p=0.01). In multivariate regression, absence of social support (B=2.120, p=0.001, OR=8.327) was the most significant predictor for depression Conclusion: This finding implies that depression is one of the mental health issues that affect HIV/AIDS infected individuals in Nigeria and lack of social support increases the risk of depression among them.

scholarly journals Low Cluster of Differentiation 4+ T Cell Count in People Living with HIV/AIDS Undergoing Antiretroviral Therapy Visiting a Reference Laboratory: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (237) ◽  
Author(s):  
Samikshya Kandel ◽  
Sundar Khadka ◽  
Mahesh Lamsal ◽  
Bimlesh Jha ◽  
Sunil Paudyal ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Cell Count ◽  
Acquired Immunodeficiency Syndrome ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Cluster Of Differentiation

Introduction: Human Immunodeficiency Virus is a lentivirus that causes human immunodeficiency virus infection and over time, acquired immunodeficiency syndrome. Cluster of Differentiation 4+ T cell count of people living with this infection play a vital role to determine infection progression and necessary treatment changes. This study was conducted to find out the prevalence of low Cluster of Differentiation 4+ T Cell Count in the People Living with human immunodeficiency virus/ acquired immunodeficiency syndrome. Methods: A descriptive cross-sectional study was conducted between June to August 2018 in the Human Immunodeficiency virus and Hepatitis Reference Unit of National Public Health Laboratory, Ministry of Health and Population Teku. Ethical approval was taken (Reference Number 2912) and a total of 550 seropositive cases of Human Immunodeficiency Virus-1 undergoing antiretroviral therapy were studied. Convenient sampling technique was used. Data was analysed by Statistical Package for the Social Sciences. Results: Seventeen (3.1%) of patients had Cluster of Differentiation 4+ T cell counts below 100 cells/mm3 of blood. The mean Cluster of Differentiation 4+ T cell count was 509.3 cells/mm3 of blood. Of the total samples, 280 (50.9%) were males, 268 (48.7%) were females, and the rest 2 (0.4%) were of other gender. Conclusions: Majority of people living with human immunodeficiency virus/ acquired immunodeficiency syndrome were found immune-competent.

scholarly journals Prevalence of significant liver disease in human immunodeficiency virus-infected patients exposed to Didanosine: A cross sectional study

2016 ◽  
Vol 8 (36) ◽  
pp. 1623 ◽  
Author(s):  
Sarah Logan ◽  
Alison Rodger ◽  
Laura Maynard-Smith ◽  
James O’Beirne ◽  
Thomas Fernandez ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Liver Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Immunodeficiency Virus
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