scholarly journals Lifetime Risk of Radiation Induced Severe Hereditary Stochastic (SHS) Effects in Medical Radiation Personnel

2021 ◽  
Vol 15 (5) ◽  
pp. 1105-1107
Author(s):  
Saman Shahid ◽  
Asma Majeed ◽  
Rana Aatif Siddique ◽  
Khalid Masood ◽  
Shahid Ali
Keyword(s):  
Radiation Effects ◽  
Genetic Diseases ◽  
Radiation Risk ◽  
Lifetime Risk ◽  
Dose Assessment ◽  
Risk Assessments ◽  
Whole Body ◽  
Medical Radiation ◽  
Effective Doses ◽  
Hereditary Effects

Background: Hereditary risk assessments in medical radiation workers must be accentuated as a precaution against genetic diseases. Ionizing radiations can induce hereditary or genetic radiation effects. Aim: To evaluate the lifetime risk of severe hereditary stochastic (SHS) effects in INMOL’s medical radiation personnel. Methods: The determination of the ‘whole-body’ effective doses was performed by ‘dose assessment algorithm’. We adopted the procedure described by ICRP for the assessment of lifetime severe hereditary annual risks by using ‘nominal probability coefficient’. Results: The AAEDs were between 1.41-1.79 mSv (in NM), 1.07-1.43 mSv (in RT) and 1.21-1.70 mSv (in RD) during 2014-2018. A declining trend is observed in AAED values in five consecutive years, due to improvements in radiation protection and safety measures. The risks of severe hereditary effects were also decreased from 2014-2018. The SHS risk was decreased from 5.012×10-4 to 3.948 ×10-4 in NM, 4.004×10-4 to 2.996×10-4 in RT and 4.76×10-4 to 3.388×10-4 in DR department. Conclusion: This study is emphasizing towards evaluating risks of hereditary effects from chronic exposure of radiations in occupational workers to avoid further late genetic complications. Such quantitative indicators would be useful in comparing other lifetime death risks from other harmful substances. Keywords: Hereditary Stochastic Effects; Annual Average Effective Doses; Nominal Probability Coefficient; Medical Radiation; Occupational Radiation Risk Assessments

scholarly journals Internal dose assessment of 148Gd using isotope ratios of gamma-emitting 146Gd or 153Gd in accidently released spallation target particles

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
C. Rääf ◽  
V. Barkauskas ◽  
K. Eriksson Stenström ◽  
C. Bernhardsson ◽  
H. B. L. Pettersson
Keyword(s):  
Operation Time ◽  
Isotope Ratios ◽  
Dose Assessment ◽  
Sensitive Indicator ◽  
Whole Body ◽  
Internal Dose ◽  
Tungsten Target ◽  
Alpha Emitter ◽  
Spallation Source ◽  
Effective Doses

AbstractThe pure alpha emitter 148Gd may have a significant radiological impact in terms of internal dose to exposed humans in case of accidental releases from a spallation source using a tungsten target, such as the one to be used in the European Spallation Source (ESS). In this work we aim to present an approach to indirectly estimate the whole-body burden of 148Gd and the associated committed effective dose in exposed humans, by means of high-resolution gamma spectrometry of the gamma-emitting radiogadolinium isotopes 146Gd and 153Gd that are accompanied by 148Gd generated from the operation of the tungsten target. Theoretical minimum detectable whole-body activity (MDA) and associated internal doses from 148Gd are calculated using a combination of existing biokinetic models and recent computer simulation studies on the generated isotope ratios of 146Gd/148Gd and 153Gd/148Gd in the ESS target. Of the two gamma-emitting gadolinium isotopes, 146Gd is initially the most sensitive indicator of the presence of 148Gd if whole-body counting is performed within a month after the release, using the twin photo peaks of 146Gd centered at 115.4 keV (MDA < 1 Bq for ingested 148Gd, and < 25 Bq for inhaled 148Gd). The corresponding minimum detectable committed effective doses will be less than 1 µSv for ingested 148Gd, but substantially higher for inhaled 148Gd (up to 0.3 mSv), depending on operation time of the target prior to the release. However, a few months after an atmospheric release, 153Gd becomes a much more sensitive indicator of body burdens of 148Gd, with a minimum detectable committed effective doses ranging from 18 to 77 µSv for chronic ingestion and between 0.65 to 2.7 mSv for acute inhalation in connection to the release. The main issue with this indirect method for 148Gd internal dose estimation, is whether the primary photon peaks from 146 and 153Gd can be detected undisturbed. Preliminary simulations show that nuclides such as 182Ta may potentially create perturbations that could impair this evaluation method, and which impact needs to be further studied in future safety assessments of accidental target releases.

Radiation risk issues in recurrent imaging

2021 ◽  
pp. 20210389
Author(s):  
Charles Brower ◽  
Madan M Rehani
Keyword(s):  
Radiation Effects ◽  
Radiation Risk ◽  
Clinical Decision ◽  
Imaging Modalities ◽  
Imaging Device ◽  
Positron Emission ◽  
Time Period ◽  
Pet Ct ◽  
Effective Doses ◽  
High Doses

Millions of patients benefit from medical imaging every single day. However, we have entered an unprecedented era in imaging practices wherein 1 out of 125 patients can be exposed to effective dose >50 mSv from a single CT exam and 3 out of 10,000 patients undergoing CT exams could potentially receive cumulative effective doses > 100 mSv in a single day. Recurrent imaging with CT, fluoroscopically guided interventions, and hybrid imaging modalities such as positron emission tomography/computed tomography (PET/CT) is more prevalent today than ever before. Presently, we do not know the cumulative doses that patients may be receiving across all imaging modalities combined. Furthermore, patients with diseases with longer life expectancies are being exposed to high doses of radiation enabling radiation effects to manifest over a longer time period. The emphasis in the past on improving justification of imaging and optimization of technique and practice has proved useful. While that must continue, the current situation requires imaging device manufacturers to urgently develop imaging technologies that are safer for patients as high doses have been observed in patients where imaging has been justified through clinical decision-support and optimized by keeping doses below the national benchmark doses. There is a need to have a critical look at the fundamental principles of radiation protection as cumulative doses are likely to increase in the coming years.

Nuclear-medical irradiation during pregnancy

2009 ◽  
Vol 48 (01) ◽  
pp. 10-16 ◽  
Author(s):  
E.A. Nekolla ◽  
D. Noßke ◽  
J. Griebel ◽  
G. Brix ◽  
V. Minkov
Keyword(s):  
Nuclear Medicine ◽  
Radiation Effects ◽  
Radiation Risk ◽  
Diagnostic Procedures ◽  
Excess Risk ◽  
Individual Risk ◽  
Reference Levels ◽  
Diagnostic Nuclear Medicine ◽  
Hereditary Effects ◽  
Individual Risk Assessment

Summary Aim: To estimate and evaluate the risks for the offspring due to the administration of radiopharmaceuticals to women during the first pregnancy weeks after conception (weeks p.c.). Methods: The in-utero exposition of the embryo due to diagnostic nuclear medicine procedures, for which diagnostic reference levels (DRL) are specified, as well as due to radio iodine therapy (RIT) was determined. To this end, it is assumed that the activity of the diagnostic radiopharmaceuticals administered to the mother corresponds with the DRL and amounts to 600 MBq or 4 GBq 131I for RIT of benign or malignant thyroid disease, respectively. Based on these data, the radiation risk for the offspring was assessed and compared with the spontaneous risks (R0). Results: The dose for the offspring does not exceed 7.8 mSv for the diagnostic procedures considered, resulting in an excess risk for the offspring of less than 0.12% (R0 ~ 25%) to die from cancer during life, of less than 0.07% (R0 ~ 0.2%) to develop cancer up to the age of 15 years, and of less than 0.16% (R0 ~ 2%) for hereditary effects. RIT during the first 8 weeks p.c. results in doses for the offspring of about 100–460 mSv, resulting in an excess risk for malformations of the child of 3.4%–22% (R0 ~6%). Conclusions: The risk of stochastic radiation effects for the offspring due to a diagnostic nuclear medicine procedure of the mother during the first 8 weeks p.c. is – compared with the spontaneous risks – very small; deterministic effects are unlikely. In contrast, deterministic effects for the offspring may occur following RIT. In order to decide on a possibly indicated abortion after RIT, an individual risk assessment is mandatory.

DEVELOPMENT OF THE MONITORING (CONTROL) PROGRAM OF THE SAFETY OF NUCLEAR POWER PLANTS

2020 ◽  
Vol 2020 (2) ◽  
pp. 50-56
Author(s):  
Mariya Berberova ◽  
Vladislav Chuenko ◽  
Oleg Zolotarev ◽  
Olga Trefilova ◽  
Maksim Grudev ◽  
...  
Keyword(s):  
Nuclear Power ◽  
Power Plants ◽  
Nuclear Power Plants ◽  
Radiation Risk ◽  
Safety Data ◽  
Control Program ◽  
Data Sheet ◽  
Risk Assessments ◽  
Safety Data Sheet ◽  
Increased Risk

Nuclear power plants (NPP), being complex technological systems, represent a source of increased risk, in particular, a specific risk of radiation exposure. Obtaining quantitative assessments of radiation risk is critical for risk reduction and accident prevention. Existing methods for assessing radiation risk do not take into account the influence of external factors, such as population composition, geographical features, anthropogenic environmental changes, etc.[1]. Since 1997, in connection with changes in the norms and rules in the field of the use of atomic energy, it became necessary to perform a probabilistic safety analysis (PSA) at all nuclear power plants in Russia. Subsequently, a standard safety data sheet for a hazardous facility was developed. To fill out the second section of the safety data sheet, it is necessary to carry out a risk assessment of the objects in question. From this moment on, risk assessments were performed for all power units of all operating nuclear power plants in Russia. Today, in our country there are 14 nuclear power plants. On average, there are 3 power units per nuclear power plant. In order to systematize and centralize data on NPP risk assessments, it became necessary to develop a program for monitoring NPP safety. The aim of the work is to develop a monitoring (control) program for ensuring the safety of nuclear power plants, using modern technologies to systematize and group data on nuclear safety data sheets, as well as organize quick access to information.

scholarly journals Repeated Pelvic Radiographs in Infants, After Harness Treatment for Developmental Dysplasia of the Hip, Carry Very Low Radiation Risk

2021 ◽  
Author(s):  
Elizabeth Vogel ◽  
Thomas Leaver ◽  
Fiona Wall ◽  
Ben Johnson ◽  
Michael Uglow ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Radiation Risk ◽  
Low Risk ◽  
Lifetime Risk ◽  
Body Region ◽  
Pavlik Harness ◽  
Pelvic Radiographs ◽  
Risk Of Malignancy ◽  
The Mean

Abstract Objective There are no data on the effect of X-Ray irradiation to the vulnerable pelvic organs of babies during DDH follow-up. This study aims to calculate, for the first time, the radiation exposure to infants during follow-up for DDH harness treatment, and thus quantify the lifetime risk of malignancy. Methods Patients who had completed 5 years’ follow-up following successful Pavlik harness treatment were identified from the hospital DDH database. The radiation dose was extracted from the Computerised Radiology Information System database for every radiograph of every patient. The effective dose (ED) was calculated using conversion coefficients for age, sex and body region irradiated. Cumulative ED was compared to Health Protection Agency standards to calculate lifetime risk of malignancy from the radiographs. Results All radiographs of 40 infants, successfully treated in Pavlik harness for DDH, were assessed. The mean number of AP pelvis radiographs was 7.00 (range: 6–9, mode: 7). The mean cumulative ED was 0.25 mSv (Range: 0.11–0.46, SD: 0.07). This is far lower than the annual ‘safe’ limit for healthcare workers of 20 mSv and is categorised as “Very Low Risk”. Conclusion Clinicians involved in the treatment DDH can be re-assured that the cumulative radiation exposure from pelvic radiographs following Pavlik harness treatment is “Very Low Risk”. Whilst being mindful of any radiation exposure in children, this study provides a scientific answer that help addresses parental concerns.

MEASUREMENT OF THE ACTIVITY CONCENTRATIONS OF GAMMA EMITTING RADIONUCLIDES IN TOOTHPASTE SAMPLES AND ASSESSMENT OF THE CORRESPONDING ANNUAL EFFECTIVE DOSES

2021 ◽  
Author(s):  
Anas M Ababneh ◽  
Qutad M Samarah
Keyword(s):  
Effective Dose ◽  
Oral Hygiene ◽  
Annual Effective Dose ◽  
Daily Basis ◽  
Dose Assessment ◽  
Accidental Ingestion ◽  
Activity Concentrations ◽  
Effective Doses

Abstract It is inevitable that we are exposed to radiation daily from various sources and products that we consume on daily basis. The use of toothpaste for oral hygiene is one of the most common daily practices by humans and yet very little data are available regarding its radiation content. In this work, we investigated the concentrations of gamma emitting radionuclides in toothpaste samples consumed in Jordan. 40K and 226Ra were detected in almost one-third of the samples, whereas 228Ra was detected in nearly half of them. The corresponding activity concentrations in the detected samples were in the ranges of 68.7–154.2, 4.6–14.1 and 1.3–10.0 Bq/kg, respectively. Dose assessment of accidental ingestion of toothpaste for children and adults was made, and its contribution to the annual effective dose was found to be very minimal with maximum doses of ~2.9 and 1.3 μSv for children and adults, respectively.

PRELIMINARY EVALUATION OF PATIENT RADIATION DOSES DURING RADIONUCLIDE DIAGNOSTIC WITH MONOCLONAL ANTIBODIES LABELED WITH 89Zr

2021 ◽  
Author(s):  
Larisa A. Chipiga ◽  
Anna E. Petrova ◽  
Artem A. Mosunov ◽  
Laura T. Naurzbaeva ◽  
Stanislaus M. Kushnarenko ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Dose Assessment ◽  
Published Data ◽  
Radiation Doses ◽  
Preliminary Evaluation ◽  
Software Products ◽  
Absorbed Doses ◽  
Order Of Magnitude ◽  
Effective Doses

In connection with the constantly increasing use of monoclonal antibodies labeled with 89Zr, in clinical practice, it is urgent to study their pharmacokinetics with the determination, based on the data obtained, of absorbed doses in tumor foci, as well as intact organs and tissues, and effective doses of patients. To date, there are a limited number of studies that provide patient doses for diagnostic examinations using 89Zr-labeled monoclonal antibodies. In this regard, the purpose of this work was to assess the biodistribution of various monoclonal antibodies (ramucirumab, trastuzumab, atezolizumab) labeled with 89Zr, based on published data, with subsequent calculation of absorbed doses in radiosensitive organs and tissues and effective doses of patients. Based on the analysis of experimental data on the biodistribution of monoclonal antibodies labeled with 89Zr for the diagnosis of oncological diseases from the available literature sources and our own assessments, it has been concluded that the results of the determination of absorbed in organs and tissues and effective doses are inconsistent. The absorbed doses in organs, according to different literature sources, vary up to an order of magnitude within one organ and reach 440 mGy per examination, the effective dose varies from 3 to 112 mSv per examination. This may be due to differences in study design, radiometry and dose assessment methods. Comparison with doses obtained on the basis of a general model of biodistribution of monoclonal antibodies demonstrates the possibility of using this model for a rough estimate of internal doses of patients. However, for a more accurate assessment, it is necessary to standardize approaches to the determination of internal radiation doses using the most effective methodological solutions and software products.

scholarly journals BRAIN AND EYE AS POTENTIAL TARGETS FOR IONIZING RADIATION IMPACT. Part І. THE CONSEQUENCES OF IRRADIATION OF THE PARTICIPANTS OF THE LIQUIDATION OF THE CHORNOBYL ACCIDENT

2020 ◽  
Vol 25 ◽  
pp. 90-129
Author(s):  
K. Loganovsky ◽  
◽  
P. Fedirko ◽  
K. Kuts ◽  
D. Marazziti ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Neurodegenerative Diseases ◽  
Nuclear Power ◽  
Radiation Effects ◽  
Radiation Risk ◽  
International Studies ◽  
Neurocognitive Deficit ◽  
Radiation Induced ◽  
And Performance ◽  
Medical Radiology

Background.Exposure to ionizing radiation could affect the brain and eyes leading to cognitive and vision impairment, behavior disorders and performance decrement during professional irradiation at medical radiology, including interventional radiological procedures, long-term space flights, and radiation accidents. Objective. The objective was to analyze the current experimental, epidemiological, and clinical data on the radiation cerebro-ophthalmic effects. Materials and methods. In our analytical review peer-reviewed publications via the bibliographic and scientometric bases PubMed / MEDLINE, Scopus, Web of Science, and selected papers from the library catalog of NRCRM – the leading institution in the field of studying the medical effects of ionizing radiation – were used. Results. The probable radiation-induced cerebro-ophthalmic effects in human adults comprise radiation cataracts, radiation glaucoma, radiation-induced optic neuropathy, retinopathies, angiopathies as well as specific neurocognitive deficit in the various neuropsychiatric pathology including cerebrovascular pathology and neurodegenerative diseases. Specific attention is paid to the likely stochastic nature of many of those effects. Those prenatally and in childhood exposed are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases. Conclusions. The experimental, clinical, epidemiological, anatomical and pathophysiological rationale for visual system and central nervous system (CNS) radiosensitivity is given. The necessity for further international studies with adequate dosimetric support and the follow-up medical and biophysical monitoring of high radiation risk cohorts is justified. The first part of the study currently being published presents the results of the study of the effects of irradiation in the participants of emergency works at the Chornobyl Nuclear Power Plant (ChNPP). Key words: ionizing radiation, cerebroophthalmic effects, neurocognitive deficit, radiation accident, radiation cataracts, macular degeneration.

scholarly journals Patient radiation dose assessment system for diagnostic nuclear medicine procedures: Implementation and first results

2020 ◽  
Vol 35 (4) ◽  
pp. 380-385
Author(s):  
Dea Dundara-Debeljuh ◽  
Slaven Jurkovic ◽  
Ivan Pribanic ◽  
Neva Girotto ◽  
Svjetlana Grbac-Ivankovic ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Radiation Dose ◽  
Radiation Risk ◽  
Assessment System ◽  
Dose Assessment ◽  
Medical Documentation ◽  
Diagnostic Nuclear Medicine ◽  
Nuclear Medicine Procedures ◽  
Radiation Dose Assessment ◽  
Patient Radiation Dose

Dose assessment of diagnostic nuclear medicine procedures is necessary to further optimize respective procedure, estimate radiation risk, improve radiation safety and verify compliance of local practice with guidelines. In line with Council Directive 2013/59/EURATOM, patient medical documentation should include information related to radiation exposure. The aim of this work is to present the patient radiation dose assessment system designed for routine clinical use, that uses in-house designed worksheets for dose calculation based on relevant parameters introduced by the ICRP publications. Dose reports provide information about the absorbed dose delivered to the target and non-target organs of interest and the effective dose for each diagnostic procedure. The data from the dose reports was used to investigate average patient exposure levels during a one-year period and the results are presented. The implemented system has improved the quality of services provided and understanding of radiation risks. Moreover, the presented results have stimulated further optimization of nuclear medicine processes.

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