Phage therapy is an important replacement for the antibiotic resistance

2021 ◽  
Vol 15 (5) ◽  
pp. 1236-1240
Author(s):  
P. Farmehr
Keyword(s):  
Antibiotic Resistance ◽  
Phage Therapy ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Bacterial Disease ◽  
Advantages And Disadvantages ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant ◽  
History Of ◽  
Alternative Antibiotic

Antibiotic resistance has become a significant and growing threat to public and environmental health. The emergence of multiple drug-resistant bacteria has prompted interest in alternatives to conventional antimicrobial. One of the possible replacement options for antibiotics is the use of bacteriophages as antimicrobial. We were forced to look for a new approach in treatment. Phage therapy is an important alternative antibiotic in the current of drug-resistance pathogens. In this way, poisoning bacteria bacteriophage bacteria infect and replicate in bacteria, in this therapy, identify the type of virus per person and can be targeted manipulation of harmful bacteria and then returned the person and invented phage therapy. We discuss the advantages and disadvantages of bacteriophages as therapeutic agents in this regard. And so describe a brief history of bacteriophages and clinical studies on their use in bacterial disease. Much hope is placed in genetic modifications of bacteriophages prevents the development of phage-resistant bacteria. Keywords: antibiotic resistance‚ bacteriophage, phage therapy

scholarly journals Bacteriophage therapy: a potential solution for the antibiotic resistance crisis

2014 ◽  
Vol 8 (02) ◽  
pp. 129-136 ◽  
Author(s):  
Zhabiz Golkar ◽  
Omar Bagasra ◽  
Donald Gene Pace
Keyword(s):  
Antimicrobial Agents ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Bacterial Disease ◽  
Drug Resistant ◽  
Bacteriophage Therapy ◽  
Advantages And Disadvantages ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant ◽  
History Of

The emergence of multiple drug-resistant bacteria has prompted interest in alternatives to conventional antimicrobials. One of the possible replacement options for antibiotics is the use of bacteriophages as antimicrobial agents. Phage therapy is an important alternative to antibiotics in the current era of drug-resistant pathogens. Bacteriophages have played an important role in the expansion of molecular biology and have been used as antibacterial agents since 1966. In this review, we describe a brief history of bacteriophages and clinical studies on their use in bacterial disease prophylaxis and therapy. We discuss the advantages and disadvantages of bacteriophages as therapeutic agents in this regard.

Efficacy of experimental phage therapies in livestock

2020 ◽  
Vol 21 (1) ◽  
pp. 69-83 ◽  
Author(s):  
Marta Dec ◽  
Andrzej Wernicki ◽  
Renata Urban-Chmiel
Keyword(s):  
Bacterial Infections ◽  
Phage Therapy ◽  
Resistant Bacteria ◽  
Form Of Life ◽  
Drug Resistant Bacteria ◽  
Experimental Therapies ◽  
History Of ◽  
Experimental Treatments ◽  
Human Infections ◽  
Life On Earth

AbstractBacteriophages are the most abundant form of life on earth and are present everywhere. The total number of bacteriophages has been estimated to be 1032 virions. The main division of bacteriophages is based on the type of nucleic acid (DNA or RNA) and on the structure of the capsid. Due to the significant increase in the number of multi-drug-resistant bacteria, bacteriophages could be a useful tool as an alternative to antibiotics in experimental therapies to prevent and to control bacterial infections in people and animals. The aim of this review was to discuss the history of phage therapy as a replacement for antibiotics, in response to EU regulations prohibiting the use of antibiotics in livestock, and to present current examples and results of experimental phage treatments in comparison to antibiotics. The use of bacteriophages to control human infections has had a high success rate, especially in mixed infections caused mainly by Staphylococcus, Pseudomonas, Enterobacter, and Enterococcus. Bacteriophages have also proven to be an effective tool in experimental treatments for combating diseases in livestock.

scholarly journals Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus

2012 ◽  
Vol 78 (8) ◽  
pp. 2768-2774 ◽  
Author(s):  
Ashley N. Brown ◽  
Kathryn Smith ◽  
Tova A. Samuels ◽  
Jiangrui Lu ◽  
Sherine O. Obare ◽  
...  
Keyword(s):  
Methicillin Resistant Staphylococcus Aureus ◽  
Enterobacter Aerogenes ◽  
Resistance Mechanisms ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Antibiotic Resistant ◽  
Gram Positive Bacteria ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

ABSTRACTWe show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.

scholarly journals A Simple Assay to Screen Antimicrobial Compounds Potentiating the Activity of Current Antibiotics

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Junaid Iqbal ◽  
Ruqaiyyah Siddiqui ◽  
Shahana Urooj Kazmi ◽  
Naveed Ahmed Khan
Keyword(s):  
Aqueous Extract ◽  
Bacterial Infections ◽  
Juglans Regia ◽  
Tree Bark ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Antimicrobial Compounds ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

Antibiotic resistance continues to pose a significant problem in the management of bacterial infections, despite advances in antimicrobial chemotherapy and supportive care. Here, we suggest a simple, inexpensive, and easy-to-perform assay to screen antimicrobial compounds from natural products or synthetic chemical libraries for their potential to work in tandem with the available antibiotics against multiple drug-resistant bacteria. The aqueous extract ofJuglans regiatree bark was tested against representative multiple drug-resistant bacteria in the aforementioned assay to determine whether it potentiates the activity of selected antibiotics. The aqueous extract ofJ. regiabark was added to Mueller-Hinton agar, followed by a lawn of multiple drug-resistant bacteria,Salmonella typhior enteropathogenicE. coli. Next, filter paper discs impregnated with different classes of antibiotics were placed on the agar surface. Bacteria incubated with extract or antibiotics alone were used as controls. The results showed a significant increase (>30%) in the zone of inhibition around the aztreonam, cefuroxime, and ampicillin discs compared with bacteria incubated with the antibiotics/extract alone. In conclusion, our assay is able to detect either synergistic or additive action ofJ. regiaextract against multiple drug-resistant bacteria when tested with a range of antibiotics.

scholarly journals Potential of Herbal Antibacterials as an Alternative to Antibiotics for Multiple Drug Resistant Bacteria: An Analysis

2019 ◽  
Vol 13 (1) ◽  
pp. 1-8
Author(s):  
Bhoj Raj Singh ◽  
Akanksha Yadav ◽  
Dharmendra Kumar Sinh ◽  
Obli Rajendran Vinodh Kum
Keyword(s):  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant
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