scholarly journals AST to platelets ratio (APRI) as a Biomarker of liver fibrosis status in patients of chronic Hepatitis B and Hepatitis C in comparison with Fibroscan

2021 ◽  
Vol 15 (8) ◽  
pp. 2448-2450
Author(s):  
Farrukh Saleem ◽  
Saima Ameer ◽  
Nighat Haroon ◽  
Saira Bilal ◽  
Wajid Ali ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
General Hospital ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Test Results ◽  
Pearson Correlation Test ◽  
Hep B ◽  
Pacs System

Objective: The aim of the study is to correlate the AST to platelets ratio (APRI) with different stages of liver fibrosis measured by the fibroscan. Methods: The study included 40 patients. The study was conducted in outpatient clinic of Lahore General Hospital. The study duration was from November-2020 to January-2021. Their fibroscan data was collected from hepatic clinic of general hospital OPD and their AST and Platelets values were obtained retrogradely from the PACS system of hospital. Correlation between the APRI and fibroscan values was done by linear Pearson correlation test. Results: APRI values showed moderately positive correlation with increased kpa values and different stages of fibrosis (r=0.55). Similarly, the correlation coefficient of AST also shown to be moderately positive correlated with kpa values and stages of fibrosis however this correlation was slightly weak as compared to APRI values (r=0.49). The correlation coefficient (r) for platelets showed moderately negative correlation with liver fibrosis stages (r=-0.43). Conclusions: APRI levels increased as the degree of fibrosis and inflammation increased in patients suffering from chronic hep B and hep C. So, our data showed the clinical significance of APRI levels in diagnosing extent of liver fibrosis and cirrhosis. Keywords: AST, Platelets, APRI, fibroscan, chronic hepatitis

Decrease in liver fibrosis after achieving SVR in patients with chronic Hepatitis C infection

2015 ◽  
Vol 53 (05) ◽  
Author(s):  
K Kozbial ◽  
S Beinhardt ◽  
C Freissmuth ◽  
A Stättermayer ◽  
R Stern ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Hepatitis C Infection

Impact of high serum glucose on liver fibrosis in chronic hepatitis C (CHC)

2001 ◽  
Vol 34 ◽  
pp. 163-164 ◽  
Author(s):  
V.D. Ratziu ◽  
M. Munteanu ◽  
L. Bonyhay ◽  
F. Charlotte ◽  
P. Opolon ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Serum Glucose ◽  
High Serum

scholarly journals Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Mostafa M. Sira ◽  
Behairy E. Behairy ◽  
Azza M. Abd-Elaziz ◽  
Sameh A. Abd Elnaby ◽  
Ehab E. Eltahan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Heavy Chain ◽  
Trypsin Inhibitor ◽  
Clinical Laboratory ◽  
Treatment Naïve ◽  
Liver Fibrogenesis ◽  
Chronic Hcv

Liver fibrosis and viremia are determinant factors for the treatment policy and its outcome in chronic hepatitis C virus (HCV) infection. We aimed to investigate serum level of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and its relation to liver fibrosis and viremia in children with chronic HCV. ITIH4 was measured by ELISA in 33 treatment-naive children with proved chronic HCV and compared according to different clinical, laboratory and histopathological parameters. Liver histopathological changes were assessed using Ishak score and compared with aspartate transaminase-to-platelet ratio (APRI) and FIB-4 indices as simple noninvasive markers of fibrosis. ITIH4 was measured in a group of 30 age- and sex-matched healthy controls. ITIH4 was significantly higher in patients than in controls (54.2±30.78 pg/mL versus 37.21±5.39 pg/mL; P=0.021). ITIH4, but not APRI or FIB-4, had a significant direct correlation with fibrosis stage (P=0.015, 0.961, and 0.389, resp.), whereas, the negative correlation of ITIH4 with HCV viremia was of marginal significance (P=0.071). In conclusion, ITIH4 significantly correlated with higher stages of fibrosis indicating a possible relation to liver fibrogenesis. The trend of higher ITIH4 with lower viremia points out a potential antiviral properties and further studies in this regard are worthwhile.

Large-scale multicentre comparison of three algorithms combining serum non-invasive markers for liver fibrosis in chronic hepatitis C

2008 ◽  
Vol 40 (10) ◽  
pp. A119-A120
Author(s):  
G. Sebastiani ◽  
P. Halfon ◽  
L. Castera ◽  
A. Mangia ◽  
V. Di Marco ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Large Scale ◽  
Non Invasive

scholarly journals Comparison of FIB-4 and transient elastography in evaluating liver fibrosis of chronic hepatitis C subjects in community

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206947 ◽  
Author(s):  
Pin-Nan Cheng ◽  
Hung-Chih Chiu ◽  
Yen-Cheng Chiu ◽  
Shu-Chuan Chen ◽  
Yi Chen
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Transient Elastography

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus

2018 ◽  
Vol 67 (3) ◽  
pp. 681-685 ◽  
Author(s):  
Ali Sobhy ◽  
Mohammed Fakhry M. ◽  
Haitham A Azeem ◽  
Ahmed M Ashmawy ◽  
Hamed Omar Khalifa
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Non Invasive ◽  
B Virus

Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p<0.001), but the level was not different between the CHC group and the controls (p<0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p<0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p<0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p<0.001) and CHC (r=0.59; p<0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.

scholarly journals High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

2012 ◽  
Vol 73 (4) ◽  
pp. 382-388 ◽  
Author(s):  
Christopher Sjöwall ◽  
Kristina Cardell ◽  
Elisabeth A. Boström ◽  
Maria I. Bokarewa ◽  
Helena Enocsson ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
C Reactive Protein ◽  
Hepatitis C Infection ◽  
Reactive Protein ◽  
High Prevalence
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