Follow-Up Study Results of Patients of a Cigarette Cessation Clinic and Factors Affecting These Results

BACKGROUND Rasburicase (recombinant urate oxidase) has been proven to be an effective therapy for prevention of tumour lysis syndrome (TLS). The recommended daily dosing regimen of rasburicase is 0.2 mg/kg/day for 5 days which is expensive and unaffordable to many patients in the developing countries. The purpose of the present study was to evaluate the effect of single 1.5 mg dose rasburicase in the management of tumour lysis syndrome. METHODS This is a follow-up study done at our institute. Fifty (50) patients with tumour lysis syndrome who received rasburicase from August 2015 to January 2020 were enrolled in this study RESULTS Single dose of rasburicase is effective in decreasing serum uric acid level in significant number (N = 41) of patients. Percentage of patients having uric acid less than 7 mg after single dose of rasburicase in 48 hours - 82.9 % (N = 34) while 17 % (N = 7) were found to have uric acid levels of more than 7 mg/dl. The percentage of patients with uric acid levels more than 7 mg/dl reduced from 36.5 % after 24 hours to 17 % after 48 hours. This indicates that the uric acid levels show a declining trend even after 24 hours without giving an additional dose of rasburicase. There was no relationship between uric acid levels at 24 hours and percentage change in creatinine level from baseline to 24 hours (correlation coefficient (r) = -0.047, P = 0.770. Patients who required additional dose (N = 9) had high base line value of uric acid and their high value was maintained over the follow up period of three days. Patients with pre exiting kidney disease and high level of baseline uric acid also needed dialysis (N = 3). CONCLUSIONS In majority of patients, a single 1.5 mg dose of rasburicase is an effective way to reduce raised uric acid in appropriate circumstances. KEYWORDS Single Dose, Recombinant Urate Oxidase, Uric Acid, Leukemia, Tumour Lysis Syndrome, Rasburicase

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An empirical investigation of physical literacy-based adolescent health promotion

Applied Mathematics and Nonlinear Sciences ◽

10.2478/amns.2021.2.00010 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Minmin Du ◽

Yimin Liu ◽

Lei Li

Keyword(s):

Health Promotion ◽

Adolescent Health ◽

Panel Survey ◽

Physical Literacy ◽

Factors Affecting ◽

Training Models ◽

Study Results ◽

Main Factors ◽

Physical Elements

Abstract A reexamination of the health problems of Chinese adolescents based on the concept of physical literacy (PL) was necessary. Through the use of follow-up data collected from the China Education Panel Survey 2014–2015, the main factors affecting the health of adolescents were identified, and possible explanations were investigated after cluster and inductive analyses were conducted. The results showed that (1) the 10 main factors identified as affecting adolescent health promotion are in line with the four main elements of PL (emotional, cognitive, social and physical elements) and (2) the three major categories of influencing factors identified through a cluster analysis were aligned with the three main factors of PL (endogeneity, fundamentality and permeability). These findings suggest that the factors influencing adolescent health promotion are closely associated with PL. The study results can provide empirical evidence for adolescent health promotion research and a reference for the development of evidence-based PL training models.

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Topical Ethanol Therapy for Human Papillomavirus in Atheroma

Acupuncture & Electro-Therapeutics Research ◽

10.3727/036012921x16264625521763 ◽

2021 ◽

Author(s):

Etsuo Murata ◽

Kazutaka Tokita ◽

Shigeyuki Tsurusaki ◽

Hidetaka Murata

Keyword(s):

Human Papillomavirus ◽

Side Effects ◽

Simple Procedure ◽

Ring Test ◽

Pathological Examination ◽

Open Drainage ◽

Hpv 16 ◽

Follow Up Study ◽

Study Results

We have developed ethanol therapy for infectious atheroma based on the experience of two cases in which ethanol was injected into the liver cyst and the cyst shrank. For 64 infectious atheromas, atheroma contents were excreted and the cyst wall was contacted with 76% ethanol gauze for 5 minutes. Postoperatively, the cyst was washed daily as an open drainage. All cases were cured 10 days postoperatively, and no side effects. Postoperative follow up study results in 36 cases showed no recurrence in an average of 5 years. Pathological examination revealed koilocytosis in 14 of 25 cases (56%), which is considered to be an in direct finding of viral infection. The changes in human papillomavirus (HPV 16) before and after ethanol therapy in 25 cases using the Bi Digital O Ring Test (BDORT) decreased significantly from 10 26 ng (BDORT units) preoperatively to 1.6 ng (BDORT units) postoperatively. In also 12 cases follow up study without microscopy HPV 16 same decreased from 1064ng to 1.2 ng (BDORT unit) using BDORT with atheroma photographs. In total, HPV 16 could be demonstrated in 37 of 64 cases (57.8%) using BDOR T. Temporal changes of HPV 16 used for BDORT in 7 cases after contact with ethanol were inactivated after 3 minutes 30 seconds. The involvement of HPV 16 is suggested as the cause of atheroma. It is speculated that ethanol inactivated HPV 16 of atheroma, which stopped the turnover of the squamous epithelium and prevented recurrence. Ethanol therapy for infectious atheroma is useful as an original new one stage surgery because it is a simple procedure and has no side effects or recurrence.

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