Differential regulation of brown adipose tissue physiology by orexin A and orexin B

2013 ◽  
pp. BIOP 049
Author(s):  
Manjunath Ramanjaneya
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Differential Regulation ◽  
Orexin A ◽  
Brown Adipose

scholarly journals Dual Regulatory Effects of Orexins on Sympathetic Nerve Activity Innervating Brown Adipose Tissue in Rats

Endocrinology ◽  
2005 ◽  
Vol 146 (6) ◽  
pp. 2744-2748 ◽  
Author(s):  
Tohru Yasuda ◽  
Takayuki Masaki ◽  
Tetsuya Kakuma ◽  
Masahide Hara ◽  
Tomoko Nawata ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Histidine Decarboxylase ◽  
Cerebral Ventricle ◽  
Induced Response ◽  
Nerve Activity ◽  
Orexin A ◽  
Brown Adipose

Abstract This study examined how orexin regulates the activity of the sympathetic nerves that innervate brown adipose tissue (BAT) in rats. Infusion of orexin A at a dose of 0.3 nmol into the third cerebral ventricle decreased BAT sympathetic nerve activity, compared with the effect of PBS (P < 0.05), whereas infusion of orexin B at the same dose caused a significant increase (P < 0.05). Pretreatment with a third cerebral ventricle injection of 2.24 μmol/kg α-fluoromethylhistidine, an irreversible inhibitor of the histamine-synthesizing enzyme histidine decarboxylase, attenuated the orexin B-induced response of BAT sympathetic nerve activity, but not that induced by orexin A. These results indicate that orexins may regulate both BAT energy expenditure and thermogenesis through their dual effects on sympathetic nerve activity. In particular, orexin B regulates BAT sympathetic nerve activity via neuronal histamine in the hypothalamus.

scholarly journals Differential Regulation of Brown Adipose Tissue Activation by PDE3 and PDE4

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Stephen M. Kraynik ◽  
Thomas R. Hinds ◽  
Joseph A. Beavo
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Differential Regulation ◽  
Brown Adipose

Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue

2017 ◽  
Vol 41 (11) ◽  
pp. 1646-1653 ◽  
Author(s):  
M F Pino ◽  
A Divoux ◽  
A V Simmonds ◽  
S R Smith ◽  
L M Sparks
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Orexin A ◽  
Brown Adipose

Differential regulation of Na(+)-K(+)-ATPase in the obese Zucker rat

1996 ◽  
Vol 271 (5) ◽  
pp. R1123-R1129 ◽  
Author(s):  
A. Ferrer-Martinez ◽  
A. Felipe ◽  
E. J. Casado ◽  
M. Pastor-Anglada
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Intestinal Mucosa ◽  
Sodium Pump ◽  
Differential Regulation ◽  
Zucker Rats ◽  
Mrna Levels ◽  
Subunit Protein ◽  
Brown Adipose ◽  
Subunit Expression

Expression of Na(+)-K(+)-adenosinetriphosphatase (ATPase) in tissues from obese and lean Zucker rats was monitored. The phosphatase activity of the sodium pump was increased in liver and intestinal mucosa from obese animals but was unaltered in skeletal muscle, brown adipose tissue, kidney, and heart. Induction of Na(+)-K(+)-ATPase activity was correlated with increased alpha 1-subunit protein amounts in liver and intestinal mucosa, although alpha 1-subunit mRNA levels were increased only in liver tissue. Neither protein nor mRNA amounts for both subunits were significantly altered in the other tissues analyzed. The only exception was a decrease in the amount of beta 1-protein in kidney from obese rats. alpha 2-Subunit protein and alpha 2- and beta 2-mRNA levels were not altered in brown adipose tissue, heart, and soleus. In summary, this study shows that in obese Zucker rats the expression of the sodium pump is enhanced in tissues that are directly involved in nutrient uptake and processing. This adaptation may be related to the ongoing hyperphagia and to tissue hypertrophia but develops in a different manner in each tissue, suggesting differential regulation of alpha 1-subunit expression.

scholarly journals Differential regulation of the expression of α1-adrenergic receptor subtype genes in brown adipose tissue

1997 ◽  
Vol 322 (2) ◽  
pp. 417-424 ◽  
Author(s):  
Kazue KIKUCHI-UTSUMI ◽  
Miwa KIKUCHI-UTSUMI ◽  
Barbara CANNON ◽  
Jan NEDERGAARD
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Receptor Gene ◽  
Differential Regulation ◽  
Receptor Subtype ◽  
Physiological Control ◽  
Brown Adipose ◽  
Enhanced Expression ◽  
Receptor Gene Expression

The physiological control of the expression of the genes for the α1-adrenoceptor subtypes was examined in rat brown adipose tissue by analysing Northern blots of poly(A)-enriched RNA with oligonucleotide probes. In control rats, α1B-receptor gene expression was much lower in brown adipose tissue than in liver, but the expression of both α1A and α1D was higher than in the heart, making brown adipose tissue one of the mammalian tissues with the highest expression of these subtypes. During acute exposure to cold, α1B-receptor gene expression was essentially unchanged, α1A-receptor gene expression was increased and α1D-receptor gene expression was transiently decreased. Noradrenaline injection could mimic these effects of acute cold exposure, indicating that the physiologically induced up- and down-regulations were due to the interaction of noradrenaline with cells within the tissue. In chronically cold-acclimated animals, α1B-receptor gene expression was decreased but that of the α1A-receptor gene remained at a level twice that of controls. α1D-Receptor gene expression was also somewhat decreased. It is suggested that the enhanced expression of the α1A-receptor gene explains the increased α1-receptor density in recruited brown adipose tissue reported previously. The intricate and differential regulation of α1-receptor gene expression and the markedly enhanced expression of the α1A-receptor may imply that α1-receptors are important for the recruitment process or for maintenance of the recruited state in this tissue.

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