Pityriasis rosea revealing a viral Hepatitis B

Pityriasis rosea, described by Gibert in 1860, is a frequent, benign, transient dermatosis, with unknown etiology that affects especially young adults. It is believed to be a consequence of a viral infection, but this argument is not convincing. We report a case of Pityriasis Rosea from Gilbert (PRG) revealing viral hepatitis B. Observation: This was a 47-year-old adult from Diago (commune of Kati), with no known medical and surgical history, who was seen for pink spots scattered throughout the trunk associated with pruritus in which the retained diagnosis was PRG. He have given vaseline with urea 5%, and Mequitazine10mg as treatment. Facing the persistence of this pruritus despite this treatment, a biological investigation was done to look for probable etiology was requested and this led to the diagnosis of an infection with the hepatitis B virus. Conclusion: this observation should lead dermatologists to systematically search for hepatitis B viral infection when facing a PRGs that are very pruriginous and resistant to the usual treatments.Mots clés : Pityriasis rosea, Viral hepatis B

Download Full-text

LETHALITY OF TB PATIENTS, COMBINED WITH THE VIRAL HEPATITIS AND HIV INFECTION IN SAINT-PETERSBURG

HIV Infection and Immunosuppressive Disorders ◽

10.22328/2077-9828-2019-11-2-42-47 ◽

2019 ◽

Vol 11 (2) ◽

pp. 42-47

Author(s):

A. K. Ivanov ◽

V. V. Nechaev ◽

L. N. Pozhidayeva ◽

V. B. Musatov ◽

V. S. Belyakov ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Hiv Infection ◽

Viral Hepatitis ◽

Fatal Outcome ◽

Chronic Viral Hepatitis ◽

Unknown Etiology ◽

Saint Petersburg ◽

Viral Hepatitis B ◽

High Level

Сombination of tuberculosis and viral hepatitis have been registered 2525 newly identified patients in Saint-Petersburg for the period 2006–2017. Some of these patients have been infected with HIV. Fatal outcome in 625 (24,7%) was noted. Patients with tuberculosis and chronic viral hepatitis have had a combination of viral hepatitis B and C in 36% of cases. Patients with combination tuberculosis and chronic hepatitis of unknown etiology experienced a more frequent death (60%) than patients with combination tuberculosis and other chronic viral hepatitis. In patients with concurrent tuberculosis, chronic viral hepatitis and HIV infection, patients infected viral hepatitis B and C were 31,6%. In 160 patients with fatal outcomes had a combination of infections (tuberculosis, viral hepatitis and HIV infection), the mortality rate of persons with hepatitis of unknown etiology was the lowest (42%), compared with a group of individuals affected by viral hepatitis B and C simultaneously (83%). Among patients with tuberculosis, chronic hepatitis and HIV infection, the highest incidence of tuberculosis of the intrathoracic lymph nodes and disseminated pulmonary tuberculosis was registered. Lethal outcomes most often occur in individuals with advanced tuberculosis, in whom the secretion of mycobacteria tuberculosis into the external environment has not been established. Given the high level of mortality in patients with simultaneous defeat of tuberculosis, viral hepatitis and HIV infection, it is necessary to establish their centralized registration in order to study the epidemiological patterns and clinical features of co-infections.

Download Full-text

Possibilities of the use of shear wave elastography of the liver in pregnant women infected with viral hepatitis B and C

Kazan medical journal ◽

10.17816/kmj2019-345 ◽

2019 ◽

Vol 100 (2) ◽

pp. 345-350

Author(s):

E G Saryeva

Keyword(s):

Hepatitis B ◽

Viral Infection ◽

Pregnant Women ◽

Viral Hepatitis ◽

Shear Wave ◽

Clinical Medicine ◽

Shear Wave Elastography ◽

Average Density ◽

Viral Hepatitis B ◽

Medical University

Aim. To determine the diagnostic possibilities of using liver shear wave elastography in pregnant women with hepatitis B and C viral infection. Methods. The study included 87 women with hepatitis B and C viral infections admitted to the Center of Clinical Medicine №1 and Educational and Therapeutic Clinic of Azerbaijan Medical University (basis of the department of obstetrics and gynecology 2 of Azerbaijan Medical University) in 2016 to 2017 aged 18-45 (average age 31.4±7.1 years), and 50 uninfected women with physiological pregnancy matched by the age (average age 30.6±6.8 years). Infected women were divided into two groups: 70 pregnant women (group 1) and 17 women (group 2), who were non-pregnant at the time of the study (average age 29.8±7.2 and 30.9±6.7 years, respectively). Women with physiological course of pregnancy were included into group 3 (average age 30.6±6.8 years). Groups of pregnant patients were matched by age, gestation age and parity (p ˃0.05). All patients underwent clinical and biochemical analyses and shear wave elastography of the liver. The obtained data were processed using the methods of variation statistics with calculation of mean and standard error (M±m), Mann-Whitney U-test, Spearman's rank correlation coefficient. Results. In 52.9±6% of the examined pregnant women with viral hepatitis, hepatitis B was identified, in 47.1±6% - hepatitis C. According to the results of shear wave elastography, the average density of the liver in these patients was 7.2±1.0 kPa. An increase in liver density in pregnant women with viral hepatitis was not accompanied by changes in the size of the liver (only 1 patient had hepatomegaly). In 71.4±5.4% of the patients, F1 degree was revealed, in 20.0±4.8% - F2, in 5.7±2.8% - F3, in 2.9±2.0% - F4. İn comparison with infected patients without pregnancy, pregnant women with viral hepatitis B and C had more severe degree of fibrosis [F1 was significantly less frequent (p ˂0.05), and F2 was significantly more frequent (p ˂0.05)], and also had F4 degree, which was not observed in non-pregnant. In infected pregnant women, there was a positive correlation between liver echogenicity and density of its tissues (p=0.495; p <0.001). Conclusion. In pregnant women with hepatitis B and C viral infection, the use of shear wave elastography allows detecting various degrees of liver fibrosis by a non-invasive method in the early stages, even in the absence of marked clinical and laboratory changes.

Download Full-text

CLINICALAND LABORATORY CНARACTERISTICS OF NEWBORNS FROM MOTHERS WITH ACUTE VIRAL HEPATITIS В AND FEATURES REНABILITATION

Herald of physiotherapy and health resort therapy ◽

10.37279/2413-0478-2020-26-3-110-113 ◽

2020 ◽

Vol 26 (3) ◽

pp. 110-113

Author(s):

А. I. Bobrovitskaya ◽

В. А. Bezkaravaynyy ◽

L. А, Zakharova

Keyword(s):

Hepatitis B ◽

Viral Infection ◽

Cord Blood ◽

Viral Hepatitis ◽

Acute Viral Hepatitis ◽

Objective Assessment ◽

Third Trimester ◽

Pregnancy And Childbirth ◽

The Third ◽

Viral Hepatitis B

Relevance. Viral hepatitis in women during pregnancy is characterized by etiological diversity and has the entire spectrum of manifestations characteristic of HB infections. In the structure of viral hepatitis in pregnant women, viral hepatitis B accounts for up to 70 %. In case of a woman's illness, infection of newborns during pregnancy is a leading factor for the development of HB and HC - a viral infection in children. At the same time, the nature of specific immunological markers in the blood of the mother and child is of particular importance for the development of neonatal NV or HC-viral infection. Objective: assessment of the rehabilitation of children from mothers with acute viral hepatitis B at various stages of pregnancy based on the study of the clinical and laboratory characteristics of this infection. Materials and methods.The study included 45 children whose mothers suffered from acute viral hepatitis during pregnancy. The diagnosis was verified in all children according to the data of clinical and laboratory studies with the determination of HBsAg, HBeAg, DNA, RNA of viral hepatitis. Results. The first group consisted of 16 (35.5%) children whose mothers had HBsAg in their blood. HB viral infection developed in the third trimester of pregnancy, childbirth took place in the acute period of the disease at the end of the third week of the icteric period. The second group – 19 (42.3 %) newborns, whose mothers also fell ill in the third trimester of pregnancy, but childbirth took place later on the third week of the icteric period 15 (33.3 %) or in the period of early convalescence 4 (8.8 %). At the same time, HBsAg in the blood of all mothers continued to be determined during the early and late period of convalescence. Unlike the newborns of the first group, only 2 (4.4 %) children in the second group had HBsantigenemia at the 2nd week of life. In 2/3 of the examined newborns, antibodies to HBsAg were detected in cord blood or in serum taken in the first days of life. At the same time, the mothers had no antibodies, despite the presence of HBsAg. It is necessary to pay special attention to the fact that in the presence of antibodies to HBsAg in the umbilical cord blood in these children of HBsAg, there was no antigenemia during the follow-up during the year. Antibodies to HBsAg were re-detected at the age of 5-6 months and only in 3 (6.6 %) children at the age of 12 months. Mothers of 10 (22.2 %) newborns of the 3rd group were ill with HBV infection in the 2nd trimester of pregnancy and childbirth took place during the period of convalescence, after 6-7 months after clinical recovery and release from HBsantigenemia. However, these infants had anti-HBs in the absence of HBsAg, which persisted for 3-6 months after birth. Conclusion: the above requires rehabilitation measures in newborns from mothers who have had acute viral hepatitis B during pregnancy in order to prevent the development of complications and chronicity of the process.

Download Full-text