Effects of Aqueous Root Extract of Jatropha curcas on Hyperglycaemic and Haematological Indices in Alloxan-induced Diabetic Rats

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
R A Aladodo
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Cell ◽  
Jatropha Curcas ◽  
Diabetic Rats ◽  
Haematological Parameters ◽  
Root Extract ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Aqueous Root Extract

Hypoglycaemic potentials of aqueous root extract of Jatropha curcas (250 and 450 mg/kg body weight of rats) was investigated in alloxan-induced diabetic rats. Effect of the extract on some haematological parameters was also investigated. Thirty albino rats (Rattus norvegicus) of mean weight 165.0 ± 2.50 g were randomly selected into normal and diabetic groups, each with six rats. Diabetic treated rats were placed on 14.2 mg/kg body weight glucophage (reference drug), 250 mg/kg and 450 mg/kg body weight of extract. All treatments were administered orally, once daily for fifteen days. The blood glucose levels were monitored and the haematological parameters like haemoglobin (Hgb), red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume (PCV), percentage lymphocytes (LYM) and neutrophils (NEUT) were also analyzed. A significant (p<0.05) reduction in fasting Blood Glucose Levels (BGL) was observed in alloxan-induced diabetic rats treated with the extract. There was a significant (p<0.05) reduction in Hgb, PCV, RBC and WBC and its differentials of the diabetic untreated rats while administration of glucophage, 250 and 450 mg/kg body weight of the aqueous extract (Jc250 and Jc450) to diabetic rats significantly (p<0.05) increase all these parameters. These results suggested that the aqueous root extract of Jatropha curcas possesses hypoglycaemic activity and also improved the aberrations in the blood parameters of alloxan-induced diabetic rat.

Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Mohamed Eddouks ◽  
Farid Khallouki ◽  
Robert W. Owen ◽  
Morad Hebi ◽  
Remy Burcelin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Oral Administration ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

scholarly journals HYPOGLYCEMIC ACTIVITY OF A NOVEL POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A THERAPEUTIC STUDY

2019 ◽  
pp. 218-223
Author(s):  
PULAK MAJUMDER ◽  
PARIDHAVI M
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Beta Cells ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Polyherbal Formulation ◽  
Blood Glucose Levels ◽  
Therapeutic Study ◽  
Glutamyl Transferase

Objective: The concept of the synergistic effect of poly-herbalism was as old as medicine history. Present novel polyherbal formulation (PHF) composed of five different herbs. The present investigation aimed to evaluate the synergistic therapeutic hypoglycemic potential of PHF against streptozotocin (STZ) (60 mg/kg b.w, ip)-induced diabetic rats. Methods: For this therapeutic study, the dose was framed orally once a day to the test objects after STZ dosing at 500 mg/kg/5 ml dosage levels for 21 days. The transformation of body weight and blood glucose level was examined, and the histopathological changes of beta cells of the pancreas, cellular architectures of liver and kidney were also perceived after scarification of the objects. Results: The outcomes were compared to that of glibenclamide (5 mg/kg) treated group. Declines of body weight and blood glucose levels were perceived in STZ-induced diabetic animals very significantly (p<0.01 or p<0.05). However, these diabetic changes were significantly (p<0.01 or p<0.05) decreased in PHF-dosing groups revealed more encouraging effects compared to that of glibenclamide. In the other hand, various liver function and enzymes test (creatinine, urea, total bilirubin, total albumin, alkaline phosphatase, gamma-glutamyl transferase, aspartate transaminases, and alanine transaminases) and lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, total protein, low-density lipoprotein [LDL], and very LDL) studies strongly indicate the potential action of this novel formulation. Conclusions: It is deliberated that PHF has the favorable effect to normalize the blood glucose levels, and also rejuvenation and reproduction of beta cells lead a better futuristic ant diabetic therapy for diabetic management.

scholarly journals Antidiabetic activity of curry leaves Murraya koenigii on glucose level, kidney and islets of langerhans in streptozotocin induced diabetes in rats

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Imad M. Al-Ani ◽  
Rahajoe I. Santosa ◽  
Muhammad H. Yankuzo
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Aqueous Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Murraya Koenigii ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Curry Leaves ◽  
Aqueous Leaf Extract

Introduction: This study examined the antihyperglycemic effect of curry leaves, Murraya koenigii “MK” aqueous extract, and to examine its possible protective effects on the Islets of Langerhans and kidneys in streptozotocin (STZ) induced diabetic rats.  Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with “MK” control, diabetic control (non-treated with “MK”), diabetic treated with 200mg/kg MK aqueous leaf extract and diabetic treated with 400mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic control group significantly (p<0.001) showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with aqueous extract showed significant (p<0.001) improvement in blood glucose levels and body weight gain.  The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and endocrine pancreas.  Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats.

Potent Antihyperglycemic Effects of an Endemic Plant from Morocco (Matthiola maroccana Coss.) in Normal and Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Ayoub Amssayef ◽  
Nadia Lahrach ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Body Weight ◽  
Blood Glucose ◽  
Aqueous Extract ◽  
Histopathological Examination ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Endemic Plant ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aims: The study aims to evaluate the antidiabetic effect of Matthiola maroccana (Coss.). Background: Matthiola maroccana (Coss.) belongs to Brassicaceae family is an endemic plant from Morocco. Objective: The objective of the study was to evaluate the effect of its aqueous extract on blood glucose levels in normal and diabetic rats. Method: Single dose (6 hours) and daily oral administration for seven days of the Aerial Part Aqueous Extract (A.P.A.E) of Matthiola maroccana (Coss.) (M. maroccana) at a dose of 20 mg/kg body weight on blood glucose levels both in normal and streptozotocin(STZ)-induced diabetic rats. Furthermore, body weight, oral glucose tolerance test, liver histopathological examination, phytochemical screening, and in vitro antioxidant activity of A.P.A.E were performed in this study. Results: The results showed that M. maroccana A.P.A.E exerts potent hypoglycemic and antihyperglycemic effects in normal and STZ-induced diabetic rats (p<0.0001). Also, it was able to restore body weight in diabetic rats (p<0.05). Furthermore, the aqueous extract has been shown to regenerate hepatic tissues in diabetic rats. In addition, A.P.A.E revealed the presence of several phytochemical constituents (polyphenols, flavonoids, tannins, saponins, alkaloids, sterols and terpenoids), and possessed an antioxidant activity. Conclusion: In conclusion, our findings showed that A.P.A.E of M. maroccana (A.P.A.E MM) possesses a significant antihyperglycemic and hypoglycemic activity.

scholarly journals Antidiabetic and antihyperlipidemic activities of extracts of Barleria cuspidata Heyne ex Nees on streptozotocin induced diabetic rats

2021 ◽  
Vol 12 (1) ◽  
pp. 643-652
Author(s):  
Manohar Reddy ◽  
Raja Sundararajan
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Serum Triglycerides ◽  
Methanol Extracts ◽  
Glucose Levels ◽  
Blood Glucose Levels

Traditionally, Barleria cuspidata Heyne ex Nees is utilized for antidiabetic action with the absence of logical investigation. Thus, the current examination was attempted to explore for its antidiabetic and antihyperlipidemic movement in streptozotocin instigated diabetic animal models. Blood glucose levels were estimated in normoglycemic rats at initial, 60th and 120th minutes intervals and in glucose feed hyperglycemic rats at initial, 30, 60, 90 and 120 minutes after a solitary portion of streptozotocin at 55 mg/kg body weight intraperitoneal were made diabetic in albino rats. Blood glucose levels were estimated at week by week spans after everyday administration of chloroform and methanol extracts of Barleria cuspidata at dosages of 250 and 500 mg/kg body weight. Other biochemical boundaries of serum triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, total protein, albumin, globulin, uric acid, creatinine, urea, transaminases, alkaline phosphatase, alanine aminotransaminase, insulin and glycosylated hemoglobin were likewise estimated toward the finish of the investigation. Chloroform and methanol extracts of Barleria cuspidata by an oral organization for 21 days altogether (P<0.001) decreases the elevated blood glucose extents in diabetic rats whereas in normoglycemic rats it doesn't adjust the blood glucose amounts altogether and in glucose feed hyperglycemic rats significantly decreases the raised blood glucose levels. Likewise, the chloroform and methanol extracts of Barleria cuspidata improved other biochemical boundaries related to diabetes. Moreover, the extracts of Barleria cuspidata favourable affect the histopathological changes of pancreas in streptozotocin initiated diabetic rats. Delayed consequences legitimize the traditional utilization of Barleria cuspidata for its anti-diabetic action.

scholarly journals Effect of Sorghum-tigernut Ibyer (A Traditional Gruel) on the Fasting Blood Glucose Levels of Alloxan-induced Diabetic Rats

2019 ◽  
pp. 260-268
Author(s):  
Shalem Shiekuma ◽  
Moses Ukeyima ◽  
Msendoo, Janet Ahuah ◽  
Idoko Blessing ◽  
Terzungwe Tughgba
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Saline Water ◽  
Fasting Blood Glucose ◽  
Sensory Attributes ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Sorghum Flour ◽  
Blood Glucose Levels ◽  
Alloxan Monohydrate

Background: There is growing interest in the use of natural foods in the management of chronic diseases like diabetes. Ibyer is a fibre rich gruel consumed amongst the Tiv people of Benue State made from whole sorghum or millet flours. Aim: The aim of the study was to evaluate the effect of sorghum-tigernut ibyer on the fasting blood glucose levels and body weight of alloxan monohydrate-induced diabetic rats. Methods: Sorghum flour (SF) and tigernut flour (TNF) were blended at different proportions (100:00; 90:10; 80:20; 70:30) for the purpose of ibyer production. The flour samples were subjected to proximate analysis using standard analytical procedures, the sensory attributes of ibyer produced from the different flour samples was evaluated on a 9-point hedonic scale. Thirty (30) male Wistar rats (100–180 g body weight) were grouped into five (1-5) each group containing six rats. They were induced with diabetes by injecting them with 150ml/kg of body weight with alloxan monohydrate dissolved in saline water (0.9% NaCl) except for group 1. Blood samples were collected from the tail of the rats, prior to induction, 48hrs after induction and 72 hrs after three days of continuous feeding with test diet. Fasting blood glucose was measured using a standard glucometer and test strips. Results: The sensory attributes indicated that ibyer produced from the flour samples were generally acceptable. Fasting blood glucose levels after 72 hrs of feeding were found to be lowered more in groups giving flours with a higher proportion of Tigernut. Conclusion: The results indicated that sorghum-tigernut ibyer exerted hypoglycaemic effect on the experimental animals.

HYPOGLYCEMIC ACTIVITY OF ETHANOLIC EXTRACT OF SAURAUIA VULCANI KORTH. LEAVES

2018 ◽  
Vol 11 (13) ◽  
pp. 35 ◽  
Author(s):  
Panal Sitorus ◽  
Rosidah Rosidah ◽  
Rosidah Rosidah ◽  
Rosidah Rosidah ◽  
Denny Satria ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Leaf Powder

 Objective: The aim of this study was to investigate the hypoglycemic activity of ethanol extract of Saurauia vulcani Korth. leaves.Methods: S. vulcani Korth. leaf powder was extracted by maceration method with ethanol 96%. Hypoglycemic activity was examined on rats which is induced with streptozotocin 40 mg/Kg body weight (BW) at dose of 50; 100; and 200 mg/Kg BW.Results: Hypoglycemic activity of the extract in diabetic rats showed a significant reduction in blood glucose levels (p<0.001) at dosage 50 mg/Kg BW.Conclusion: The results reveal that ethanol extract of S. vulcani Korth. leaves has hypoglycemic activity. Our further study is to assess mechanism action as antidiabetic.

scholarly journals Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Il-Jun Kang ◽  
Soon Sung Lim
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Low Dose ◽  
Water Extract ◽  
Diabetic Rats ◽  
Control Group ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels

The objective of the present study was to evaluateα-glucosidase inhibitory and antidiabetic effects of Nopal water extract (NPWE) and Nopal dry power (NADP) in low-dose streptozotocin- (STZ-) induced diabetic rats fed a high-fat diet (HFD). The type 2 diabetic rat model was induced by HFD and low-dose STZ. The rats were divided into four groups as follows: (1) nondiabetic rats fed a regular diet (RD-Control); (2) low-dose STZ-induced diabetic rats fed HFD (HF-STZ-Control); (3) low-dose STZ-induced diabetic rats fed HFD and supplemented with NPWE (100 mg/kg body weight, HF-STZ-NPWE); and (4) low-dose STZ-induced diabetic rats fed HFD and supplemented with comparison medication (rosiglitazone, 10 mg/kg, body weight, HF-STZ-Rosiglitazone). In results, NPWE and NADP had IC50values of 67.33 and 86.68 μg/mL, both of which exhibit inhibitory activities but lower than that of acarbose (38.05 μg/mL) while NPWE group significantly decreased blood glucose levels compared to control and NPDP group on glucose tolerance in the high-fat diet fed rats model (P<0.05). Also, the blood glucose levels of HR-STZ-NPWE group were significantly lower (P<0.05) than HR-STZ-Control group on low-dose STZ-induced diabetic rats fed HFD. Based on these findings, we suggested that NPWE could be considered for the prevention and/or treatment of blood glucose and a potential use as a dietary supplement.

scholarly journals Phytochemical and Hypoglycemic Evaluation of Alangium Salviifolium Root Extract

2011 ◽  
Vol 3 (2) ◽  
pp. 393-402 ◽  
Author(s):  
Ahad H. A. ◽  
Padmaja B. S ◽  
Yesupadam P ◽  
Guruprakash P ◽  
Sravanthi M ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Control Group ◽  
Root Extract ◽  
Alcoholic Extract ◽  
Dependent Manner ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels

.The main purpose of present study was to perform phytochemical screening and explore the anti-hyperglycaemic properties of Alangium salvifolium root extract in normal and alloxan induced diabetic rats. A. salvifolium root gave maximum extractive values of 6.4 % w/w with Ethanol and other parameters were within limits. The extract gave positive tests for phytosterols, triterpenes, flavonoids, carbohydrates and alkaloids. The ethanolic extract of A. salvifolium was found to be nearly as potent as tolbutamide in decreasing the blood glucose levels in normal fasting rats. In normal control group the percent reduction in blood glucose indicated that the extract is fast acting. The extract showed significant decrease in blood glucose, when compared with tolbutamide. The evaluated blood glucose levels in alloxan induced diabetic rats were significantly decreased up to 24th h compared to tolbutamide. A single oral administration of alcoholic extract at doses 100, 250 and 500 mg per kg produced a significant blood glucose reduction in a dose dependent manner in normal and diabetic rats. These data confirm the hypoglycaemic and anti-hyperglycaemic effect of alcoholic extract of A. salvifolium root in normal and diabetic rats respectively when compared with standard drug tolbutamide.Keywords: Alangium salvifolium; Ethanolic extract; Alloxan induced; Hypoglycaemic action.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i2.7047                J. Sci. Res. 3 (2), 393-402 (2011)

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