scholarly journals Testicular Cancer - An Unexpected Course of the Disease

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Marija Gamulin
Keyword(s):  
Lymph Nodes ◽  
Testicular Cancer ◽  
Unusual Case ◽  
Neuroendocrine Differentiation ◽  
Germ Cell Tumours ◽  
Testicular Seminoma ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Pure Seminoma ◽  
Histologic Types

There are two major histologic types of testicular cancer: pure seminoma and nonseminomatous germ cell tumours which include embryonic carcinoma, choriocarcinoma, yolc sac tumours and teratomas. Rarely, in 2% of cases, teratomas may contain elements of somatic cancer, such as sarcoma or adenocarcinoma and it is then referred to as a ''teratoma with somatic type malignancy''. The histology of somatic malignant elements most commonly includes adenocarcinoma and various types of sarcomas; however, so far as the primitive neuroectodermal tumors (PNETs) are concerned the experience is quite limited. Here we report an unusual case of a testicular seminoma that relapsed 6 months after surgery as a teratoma with somatic neuroendocrine differentiation situated in retroperitoneal lymph nodes.

scholarly journals Unusual case of classic testicular seminoma in a 90-year-old patient: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ahmad Al-Mousa ◽  
Mohammad Nour Shashaa ◽  
Mohamad Shadi Alkarrash ◽  
Mohamad Alkhamis ◽  
Lina Ghabreau ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Elderly Patients ◽  
Unusual Case ◽  
Medical Literature ◽  
Testicular Tumor ◽  
Testicular Seminoma ◽  
Case Presentation ◽  
History Of ◽  
Pure Seminoma

Abstract Background Seminoma is the most common subtype of testicular cancer and occurs most commonly in patients aged 30–49 years, but decreases to a very low level in men in their 60s or older. Case presentation A 90-year-old Syrian man with a 6-year history of an increase in size of his right scrotum, presented to the urological clinic and, on clinical examination, the findings suggested testicular tumor. After orchiectomy and histology results based on microscopic and immunohistochemical examinations, a pure seminoma was diagnosed, so we describe in this case report the second-oldest patient with classical seminoma in the medical literature. Conclusion This case report has been written to focus on the probability of any type of testicular tumor occurring at any age or decade; urologists should consider seminoma as a differential diagnosis with any testicular swelling even in elderly patients.

Testis

2013 ◽  
Author(s):  
Peter Hoskin
Keyword(s):  
Lymph Nodes ◽  
Testicular Cancer ◽  
Metastatic Disease ◽  
Combination Chemotherapy ◽  
Palliative Treatment ◽  
Stage I ◽  
Testicular Seminoma ◽  
Resistant Disease

Chapter 8c discusses the role of radiotherapy in testicular cancer and how it is becoming less prominent. The mainstay of treatment is radical orchidectomy and, where there is a risk of metastatic disease, combination chemotherapy. Radiotherapy may be indicated in the following situations: 1) Stage I testicular seminoma delivering prophylactic para-aortic lymph nodes irradiation, and 2) Palliative treatment in the management of chemotherapy resistant disease.

Testis

2019 ◽  
pp. 279-281
Author(s):  
Peter Hoskin
Keyword(s):  
Lymph Nodes ◽  
Testicular Cancer ◽  
Metastatic Disease ◽  
Combination Chemotherapy ◽  
Palliative Treatment ◽  
Stage I ◽  
Testicular Seminoma ◽  
Resistant Disease

Chapter 12 discusses the role of radiotherapy in testicular cancer and how it is becoming less prominent. The mainstay of treatment is radical orchidectomy and, where there is a risk of metastatic disease, combination chemotherapy. Radiotherapy may be indicated in the following situations: 1) stage I and IIa testicular seminoma delivering prophylactic para-aortic lymph nodes irradiation, and 2) palliative treatment in the management of chemotherapy resistant disease.

Late recurrence of testicular cancer.

1988 ◽  
Vol 6 (8) ◽  
pp. 1248-1253 ◽  
Author(s):  
N Borge ◽  
S D Fosså ◽  
S Ous ◽  
A E Stenwig ◽  
H H Lien
Keyword(s):  
Lymph Nodes ◽  
Testicular Cancer ◽  
Mature Teratoma ◽  
Signs And Symptoms ◽  
Late Recurrence ◽  
Primary Treatment ◽  
Good Prognosis ◽  
Observation Time ◽  
Recurrent Tumor ◽  
Pure Seminoma

The aim of this study is to draw attention to important points concerning the clinical management of late relapses in testicular cancer. From 1972 to 1982 The Norwegian Radium Hospital (NRH) has treated 1,008 patients with testicular cancer. Fifteen (1.5%) of these patients relapsed 36 months or more after their primary treatment. The patients' medical records were reviewed in this retrospective study, and all available histological sections were reevaluated. Six patients had pure seminoma initially and relapsed after an average of 54.5 months. Five of them had subjective symptoms due to recurrent tumor. Four patients relapsing in the supradiaphragmatic lymph nodes only are alive with no evidence of disease after an observation time of 17 to 30 months after treatment. Nine nonseminoma patients relapsed after an average of 85 months (36 to 194 months). Eight of these were aware of subjective signs or symptoms due to recurrent tumor leading to the diagnosis of the relapse. Four of these patients are alive with no evidence of disease after an observation time of 4 to 46 months after treatment. Two of these patients relapsed with pure mature teratoma. Late relapses do occur although they are rare events. Seminoma patients relapsing in the lymph nodes only have a good prognosis, and nonseminoma patients have a slightly poorer prognosis. Active follow-up for relapse detection is not justified. All testicular cancer patients should instead be informed of typical signs and symptoms that can be related to a relapse and encouraged to seek medical help for further investigation.

Alternative EWS-FLI1 fusion gene and MIC2 expression in peripheral and central primitive neuroectodermal tumors

2001 ◽  
Vol 21 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Nobuaki Ishii ◽  
Hiroaki Hiraga ◽  
Yutaka Sawamura ◽  
Yumiko Shinohe ◽  
Kazuo Nagashima
Keyword(s):  
Fusion Gene ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors

Castleman's Disease Masquerading as Sigmoid Colon Tumor and Hodgkin Lymphoma

Swiss Surgery ◽  
2002 ◽  
Vol 8 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Altinli ◽  
Pekmezci ◽  
Balkan ◽  
Somay ◽  
M. Akif Buyukbese ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Sigmoid Colon ◽  
Castleman’S Disease ◽  
Malignant Potential ◽  
Colon Tumor ◽  
Rare Entity ◽  
Castleman's Disease ◽  
Mediastinal Lymph Nodes ◽  
Histologic Types

Castleman's disease is a benign lymphoid neoplasm first reported as hyperplasia of mediastinal lymph nodes. Some authors referred to the lesions as isolated tumors, described as a variant of Hodgkin's disease with a possibility of a malignant potential and others proposed that the lymphoid masses were of a hamartomatous nature. Three histologic variants and two clinical types of the disease have been described. The disease may occur in almost any area in which lymph nodes are normally found. The most common locations are thorax (63%), abdomen (11%) and axilla (4%). We report two separate histologic types of Castleman's disease which were rare in the literature, mimicking sigmoid colon tumor and Hodgkin lymphoma. The diagnostic and therapeutic aspects of this rare entity is discussed.

Aneurysm of the communicating vein between the left renal vein and left ascending lumbar vein mimicking a retroperitoneal lymphadenopathy: A case report

2020 ◽  
Vol 16 ◽  
Author(s):  
Sevtap Arslan ◽  
Yasin Sarıkaya ◽  
Musturay Karcaaltincaba ◽  
Ali Devrim Karaosmanoglu
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Testicular Cancer ◽  
Renal Vein ◽  
Medical Center ◽  
Left Renal Vein ◽  
Severe Bleeding ◽  
Lumbar Vein ◽  
Ascending Lumbar Vein ◽  
Communicating Vein

Introduction: Aneurysm of the communicating vein between the left renal vein and left ascending lumbar vein is extremely rare with only anecdotal reported cases. Unless detected and recognized promptly, this rare condition may give rise to severe bleeding in patients undergoing retroperitoneal surgery. It may also closely mimic enlarged retroperitoneal lymph nodes, paragangliomas, adrenal masses, or renal artery aneurysms. Case report: In this case study, we reported the imaging findings of this rare entity which was falsely diagnosed as enlarged retroperitoneal lymph node in an outside medical center, reported as to be consistent with metastatic disease, in a patient with newly diagnosed testicular cancer. Conclusion: The aneurysm of the communicating vein should be considered in the differential diagnosis in patients with testicular cancer and other disease processes where lymph nodes are commonly affected.

Analysis of Clinical, Imaging, and Pathologic Features of 36 Patients with Primary Intraspinal Primitive Neuroectodermal Tumors: A Case Series and Literature Review

2021 ◽  
Author(s):  
Xuefeng Wei ◽  
Xu Zhang ◽  
Zimu Song ◽  
Feng Wang
Keyword(s):  
Literature Review ◽  
Single Case ◽  
Case Reports ◽  
Case Series ◽  
Subtotal Resection ◽  
Study Cohort ◽  
Primitive Neuroectodermal Tumors ◽  
Pathologic Features ◽  
Neuroectodermal Tumors ◽  
The Mean

Abstract Background and Study Aims Primary intraspinal primitive neuroectodermal tumors (PNETs) account for ∼0.4% of all intraspinal tumors, but information about these tumors in the medical literature is limited to single case reports. We report four cases of primary intraspinal PNETs and present a systematic literature review of the reported cases. Materials and Methods We retrospectively reviewed and analyzed the clinical data of 4 patients with primary intraspinal PNETs who underwent neurosurgical treatment at our clinic between January 2013 and January 2020, and of 32 cases reported in the literature. Results The female-to-male ratio was 2.6:1. The mean patient age was 21.42 ± 15.76 years (range: 1–60 years), and patients <36 years of age accounted for 83.30% of the study cohort. Progressive limb weakness and numbness were the chief symptoms (accounting for ∼55.6%). The mean complaint duration was 0.89 ± 0.66 months for males and 2.72 ± 3.82 months for females (p = 0.028). Epidural (41.7%) was the most common site, and thoracic (47.3%) was the most frequent location. Most PNETs were peripheral, and magnetic resonance imaging (MRI) appearance was isointense or mildly hypointense on T1-weighted images and hyperintense on T2-weighted images. Homogeneous contrast enhancement was observed. The 1-year survival rate of patients who underwent chemoradiation after total or subtotal lesion resection was better compared with patients who did not undergo chemotherapy, radiotherapy, or total or subtotal resection. The modality of treatment was associated with survival time (p = 0.007). Conclusion Primary intraspinal PNETs mainly occur in young people with a female preponderance. In patients with a rapid loss of lower limb muscle strength and large intraspinal lesions on MRI, PNETs should be considered. Surgical resection and adjuvant radio chemotherapy are key prognostic factors.

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