scholarly journals The Correlation between Diffusion-Weighted Imaging and Histopathological Evaluation of 356 Prostate Biopsy Sites in Patients with Prostatic Diseases

ISRN Urology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
R. Kilinç ◽  
O. G. Doluoglu ◽  
B. Sakman ◽  
D. S. Ciliz ◽  
E. Yüksel ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Diffusion Weighted Imaging ◽  
Definitive Treatment ◽  
Apparent Diffusion Coefficients ◽  
Prostate Biopsies ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Adc Values ◽  
The Difference ◽  
Prostatic Diseases

Purpose. The aim of this study is to investigate the reliability of diffusion MRI for detection of cancer foci by comparing diffusion-weighted imaging (DWI) results and pathology results of prostate biopsy sites. Methods. Of the patients who applied with lower urinary tract symptoms, 36 patients who had suspected DRE and/or PSA ≥2.5 ng/mL were included in the study. Patients underwent DWI prior to 10 cores-prostate biopsy. 356 biopsy cores were obtained from the patients. Foci from the patients with prostate cancer were labeled as malignant or benign foci, likewise foci from the patients with benign pathology were grouped as BPH and inflammation foci. Apparent diffusion coefficients (ADCs) of biopsy groups were compared with each other in order to measure the reliability of DWI in detection of PCa foci. Results. When ADC values of adenocarcinoma foci and BPH foci were compared, a statistically significant difference was found (P<0.001). When ADC values obtained from adenocarcinoma foci and chronic inflammation foci are compared, the difference between two groups is statistically significant, too (P<0.001). Conclusions. Biopsies focused on suspected regions after formation of ADC maps by means of DWI would provide to start definitive treatment immediately as well as being beneficial to prevent morbidity related to repeated prostate biopsies.

scholarly journals Role of Quantitative Diffusion-Weighted Imaging in Differentiating Benign and Malignant Orbital Masses

2021 ◽  
Author(s):  
Preeti Mundhada ◽  
Sudarshan Rawat ◽  
Ullas Acharya ◽  
Dhananjay Raje
Keyword(s):  
Roc Curve ◽  
Diffusion Weighted Imaging ◽  
Care Hospital ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Orbital Masses ◽  
Adc Values ◽  
Orbital Lesions

Abstract Aim To determine the role of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) values in differentiating benign and malignant orbital masses. Materials and Methods After obtaining institutional ethical board approval and informed consent from all patients, an observational study was done for a period of 24 months in the radiology department of a tertiary care hospital in South India. Conventional magnetic resonance imaging and DWI using a 3T scanner was done for all patients with suspected orbital mass lesion. ADC value and clinicohistopathological correlation were studied for every patient. Chi-square test was used to compare the signal characteristics of DWI and ADC maps between benign and malignant lesions. A comparison of mean ADC values for benign and malignant masses was performed using Student’s t-test for independent samples. The cut-off value for ADC was obtained using the receiver operating characteristic (ROC) curve. Results Of 44 patients with orbital lesions, 70% were benign and 30% were malignant. There was a significant difference in the mean ADC values of benign and malignant orbital masses. Using ROC curve analysis, an optimal ADC threshold of 1.26 × 10−3 mm2/s was calculated for the prediction of malignancy with 100% sensitivity, 80.65% specificity, and 86.36% accuracy (95% confidence interval: 0.872, 1.00, p < 0.0001). Two ADC thresholds were used to characterize the orbital masses with more than 90% confidence. Conclusion Quantitative assessment of ADC is a useful noninvasive diagnostic tool for differentiating benign and malignant orbital masses. Malignant orbital lesions demonstrate significantly lower ADC values as compared with benign lesions.

scholarly journals PERBEDAAN INFORMASI CITRA ANATOMI SEKUEN DIFFUSION WEIGHTED IMAGING (DWI) ANTARA PENGGUNAAN PROPELLER DENGAN TANPA PROPELLER PADA PEMERIKSAAN MRI BRAIN DENGAN KASUS STROKE

2020 ◽  
Vol 6 (1) ◽  
pp. 36-43
Author(s):  
Yeti Kartikasari ◽  
M. Irwan Kartili ◽  
Dwi Rochmayanti ◽  
Nindya Aprilia
Keyword(s):  
Diffusion Weighted Imaging ◽  
Quantitative Research ◽  
Wilcoxon Test ◽  
Image Information ◽  
Mri Brain ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Anatomical Image ◽  
The Difference

Background: Stroke is a brain disease where an acute nerve function is occurred due to the cerebral vascular disorders. To establish a diagnosis the stroke, it can be identified by employing the Diffusion Weighted Imaging (DWI) sequence in the MRI examination. Artifacts still exist on the MRI image which in turn reduce the resolution when using the DWI sequence. Adding the PROPELLER data acquisition method in the DWI sequence possibly improves the quality of brain images. The purpose of this study is to know the difference on the quality of anatomical image information between the DWI sequences with PROPELLER and without PROPELLER methods, and to determine adequate anatomical image appearance that created in amongst of the two methods, specifically for the stroke disease.Methods: this research is quantitative research with experimental approach. This study was conducted using MRI 1.5 T at Bethesda Hospital Yogyakarta. Data were 16 images from 8 patients using DWI sequences using PROPELLER without PROPELLER on MRI Brain examination with stroke. The results of the image were evaluated on 7 criteria: cortex cerebri, basal ganglia, thalamus, pons, cerebellum, stroke (infarction) and artifacts using questionnaires given to 3 respondents. Data analysis was done by Wilcoxon test to know the difference of anatomical image information on DWI sequence using PROPELLER without PROPELLER and to know better anatomical image information from both sequences seen from mean rank value.Results: The results shown, there is a significant difference on the quality of anatomical image information and the artifacts between the use of DWI sequence with and without PROPELLER methods ( 0.05). Based on the mean rank results, the DWI PROPELLER sequence has a higher mean rank value 4.50 compared to the DWI sequence without PROPELLER 0.00.Conclusions: The DWI PROPELLER sequence has better image results compared to the DWI sequence without PROPELLER.

scholarly journals The Influence of Bowel Preparation on ADC Measurements: Comparison between Conventional DWI and DWIBS Sequences

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 394
Author(s):  
Ilze Apine ◽  
Monta Baduna ◽  
Reinis Pitura ◽  
Juris Pokrotnieks ◽  
Gaida Krumina
Keyword(s):  
Bowel Preparation ◽  
Diffusion Weighted Imaging ◽  
Mr Enterography ◽  
High Signal ◽  
Diffusion Weighted ◽  
Signal Suppression ◽  
Significant Difference ◽  
Before And After ◽  
Apparent Diffusion ◽  
Adc Values

Background and objectives: The aim of the study was to assess whether there were differences between apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI) and diffusion-weighted imaging with background body signal suppression (DWIBS) sequences in non-prepared and prepared bowels before and after preparation with an enteric hyperosmolar agent, to assess whether ADC measurements have the potential to avoid bowel preparation and whether ADC-DWIBS has advantages over ADC-DWI. Materials and Methods: 106 adult patients without evidence of inflammatory bowel disease (IBD) underwent magnetic resonance (MR) enterography before and after bowel preparation. ADC-DWI and ADC-DWIBS values were measured in the intestinal and colonic walls demonstrating high signal intensity (SI) at DWI tracking images of b = 800 s/mm2 before and after preparation. Results: There were significant difference (p < 0.0001) in both ADC-DWI and ADC-DWIBS results between non-prepared and prepared jejunum for DWI being 1.09 × 10−3 mm2/s and 1.76 × 10−3 mm2/s, respectively, and for DWIBS being 0.91 × 10−3 mm2/s and 1.75 × 10−3 mm2/s, respectively. Both ADC-DWI and DWIBS also showed significant difference between non-prepared and prepared colon (p < 0.0001), with DWI values 1.41 × 10−3 mm2/s and 2.13 × 10−3 mm2/s, and DWIBS—1.01 × 10−3 mm2/s and 2.04 × 10−3 mm2/s, respectively. No significant difference between ADC-DWI and ADC-DWIBS was found in prepared jejunum (p = 0.84) and prepared colon (p = 0.58), whereas a significant difference was found in non-prepared jejunum and non-prepared colon (p = 0.0001 in both samples). Conclusions: ADC between DWI and DWIBS does not differ in prepared bowel walls but demonstrates a difference in non-prepared bowel. ADC in non-prepared bowel is lower than in prepared bowel and possible overlap with the ADC range of IBD is possible in non-prepared bowel. ADC-DWIBS has no advantage over ADC-DWI in regard to IBD assessment.

scholarly journals Diffusion-weighted imaging for identifying patients at high risk of tumor recurrence following liver transplantation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yi-Hsuan Chuang ◽  
Hsin-You Ou ◽  
Chun-Yen Yu ◽  
Chao-Long Chen ◽  
Ching-Chun Weng ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Diffusion Weighted Imaging ◽  
Tumor Recurrence ◽  
Survival Rates ◽  
Prognostic Indicator ◽  
Imaging Data ◽  
Donor Liver Transplantation ◽  
Apparent Diffusion Coefficients ◽  
Diffusion Weighted ◽  
Significant Difference

Abstract Background Tumor recurrence is the major risk factor affecting post-transplant survival. In this retrospective study, we evaluate the prognostic values of magnetic resonance (MR) diffusion-weighted imaging (DWI) in liver transplantation for hepatocellular carcinoma (HCC). Methods From April 2014 to September 2016, 106 HCC patients receiving living donor liver transplantation (LDLT) were enrolled. Nine patients were excluded due to postoperative death within 3 months and incomplete imaging data. The association between tumor recurrence, explant pathologic findings, and DWI parameters was analyzed (tumor-to-liver diffusion weighted imaging ratio, DWIT/L; apparent diffusion coefficients, ADC). The survival probability was calculated using the Kaplan–Meier method. Results Sixteen of 97 patients (16%) developed tumor recurrence during the follow-up period (median of 40.9 months; range 5.2–56.5). In those with no viable tumor (n = 65) on pretransplant imaging, recurrence occurred only in 5 (7.6%) patients. Low minimum ADC values (p = 0.001), unfavorable tumor histopathology (p <  0.001) and the presence of microvascular invasion (p <  0.001) were risk factors for tumor recurrence, while ADCmean (p = 0.111) and DWIT/L (p = 0.093) showed no significant difference between the groups. An ADCmin ≤ 0.88 × 10− 3 mm2/s was an independent factor associated with worse three-year recurrence-free survival (94.4% vs. 23.8%) and overall survival rates (100% vs. 38.6%). Conclusions Quantitative measurement of ADCmin is a promising prognostic indicator for predicting tumor recurrence after liver transplantation.

scholarly journals Feasibility and possible value of quantitative semi-automated diffusion weighted imaging volumetry of neuroblastic tumors

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sebastian Gassenmaier ◽  
Ilias Tsiflikas ◽  
Jörg Fuchs ◽  
Robert Grimm ◽  
Cristian Urla ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Tumor Volume ◽  
Integrated Analysis ◽  
Volume Comparison ◽  
Total Tumor Volume ◽  
Diffusion Weighted ◽  
Parametric Data ◽  
Significant Difference ◽  
Neuroblastic Tumors ◽  
Adc Values

Abstract Background To assess the feasibility and possible value of semi-automated diffusion weighted imaging (DWI) volumetry of whole neuroblastic tumors with apparent diffusion coefficient (ADC) map evaluation after neoadjuvant chemotherapy. Methods Pediatric patients who underwent surgical resection of neuroblastic tumors at our institution from 2013 to 2019 and who received a preoperative MRI scan with DWI after chemotherapy were included. Tumor volume was assessed with a semi-automated approach in DWI using a dedicated software prototype. Quantitative ADC values were calculated automatically of the total tumor volume after manual exclusion of necrosis. Manual segmentation in T1 weighted and T2 weighted sequences was used as reference standard for tumor volume comparison. The Student’s t test was used for parametric data while the Wilcoxon rank sum test and the Kruskal-Wallis test were applied for non-parametric data. Results Twenty seven patients with 28 lesions (neuroblastoma (NB): n = 19, ganglioneuroblastoma (GNB): n = 7, ganglioneuroma (GN): n = 2) could be evaluated. Mean patient age was 4.5 ± 3.2 years. Median volume of standard volumetry (T1w or T2w) was 50.2 ml (interquartile range (IQR): 91.9 ml) vs. 45.1 ml (IQR: 98.4 ml) of DWI (p = 0.145). Mean ADC values (× 10− 6 mm2/s) of the total tumor volume (without necrosis) were 1187 ± 301 in NB vs. 1552 ± 114 in GNB/GN (p = 0.037). The 5th percentile of ADC values of NB (614 ± 275) and GNB/GN (1053 ± 362) provided the most significant difference (p = 0.007) with an area under the curve of 0.848 (p < 0.001). Conclusions Quantitative semi-automated DWI volumetry is feasible in neuroblastic tumors with integrated analysis of tissue characteristics by providing automatically calculated ADC values of the whole tumor as well as an ADC heatmap. The 5th percentile of the ADC values of the whole tumor volume proved to be the most significant parameter for differentiation of the histopathological subtypes in our patient cohort and further investigation seems to be worthwhile.

scholarly journals Diagnostic value of Diffusion Weighted Imaging in assessment of malignant focal liver lesions

2009 ◽  
Vol 56 (4) ◽  
pp. 121-125 ◽  
Author(s):  
R.M. Maksimovic ◽  
M.S. Kratovac-Dunjic ◽  
G.B. Lilic ◽  
R.M. Milenkovic ◽  
D.M. Masulovic ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Diagnostic Value ◽  
Focal Liver Lesions ◽  
Cavernous Haemangioma ◽  
Liver Lesions ◽  
Secondary Tumors ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Adc Values ◽  
Hepatic Lesions

Introduction: The study was designed to determine if there was a difference between apparent diffusion coefficient (ADC) values using diffusion weighted imaging (DWI) MRI technique between different malignant focal liver lesions. Patients and methods: The study included 63 patients with focal hepatic lesions: fourteen patients (22.2%) with hepatocellular carcinoma (HCC), 16 patients (25.4%) with hepatic metastatic colorectal tumors, 17 patients (26.9%) with cavernous haemangioma and 16 patients (25.4%) with hepatic cysts. MRI was performed with 1.5T scanner, using EPI sequence with ADC values being determined for all lesions based on three b values. Results: ADC values were statistically different among the groups (F=70.7, p<0.01): HCC patients 1.11+0.29x10- 3 s/mm2, metastatic tumours 2.18+0.15x10-3 s/mm2, haemangioma 2.22+0.32x10-3 s/mm2, cysts 3.08+0.03 x10-3 s/mm2. Furthermore, there was statistically significant difference between benign lesions (haemangioma and cysts, 2.36+0.43x10-3 s/mm2), and malignant diseases (HCC and secondary tumors, 1.52+0.58x10-3 s/mm2), t=5,6, p<0.01. Conclusion: DWI technique could be helpful in defining the focal liver lesions.

scholarly journals Clinical Significance of Diffusion Weighted Magnetic Resonance Imaging on Treatment Efficacy in MS Patients with Acute Attacks

2021 ◽  
Author(s):  
Faezeh Asaadi ◽  
◽  
Fariborz Faeghi ◽  
Farzad Ashrafi ◽  
Morteza Sanei Taheri ◽  
...  
Keyword(s):  
White Matter ◽  
Treatment Efficacy ◽  
Imaging Techniques ◽  
Acute Attack ◽  
Normal Appearing White Matter ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Before And After ◽  
Adc Values ◽  
The Difference

Background: Despite the existence of various imaging methods, the accurate diagnosis of many neurodegenerative diseases is still controversial. The use of advanced imaging techniques, such as the diffusion weighted imaging can be help the early detection of MS and evaluation of the treatment efficacy in these patients. Materials and method: 24 MS patients with acute attack and thirty healthy subjects were considered in our study. In the patients' group, ROI was defined for acute and chronic plaques and normal appearing white matter (NAWM). In the normal group, ROI only was mapped in the white matter in the same regions of the patient. All MS patients were receiving Methylprednisolone for 3 to 5 days. The rate of clinical disability in these patients was also evaluated based on Expanded Disability Status Scale (EDSS) index. Finally evaluate changes of ADC values of plaques and NAWM before and after treatment. Results: The ADC values of acute plaques, ADC values of NAWM, number of enhancement in T1w and EDSS values showed a significant difference after treatment compared to before treatment. However, the ADC values of chronic plaques have not shown any significant difference after treatment. There was a significant positive correlation between the difference in EDSS values before and after treatment. Conclusion: The results of study showed that using diffusion technique and ADC values analysis is a proper non-invasive method for MS diagnosis and evaluation of treatment efficacy in these patients.

scholarly journals Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors—A Systematic Review and Meta-Analysis

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 126
Author(s):  
Hans-Jonas Meyer ◽  
Andreas Wienke ◽  
Alexey Surov
Keyword(s):  
Diffusion Weighted Imaging ◽  
Meta Analysis ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
Apparent Diffusion Coefficients ◽  
Diffusion Weighted ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Endothelial Growth Factor ◽  
And Diffusion

To date, only a few studies have investigated relationships between Diffusion-weighted imaging (DWI) and Vascular endothelial growth factor (VEGF) expression in tumors. The reported results are contradictory. The aim of the present analysis was to review the published results and to perform a meta-analysis regarding associations between apparent diffusion coefficients (ADC) derived from DWI and VEGF expression. MEDLINE library was screened for relationships between ADC and VEGF expression up to January 2019. Overall, 14 studies with 578 patients were identified. In 10 studies (71.4%) 3 T scanners were used and in four studies (28.6%) 1.5 T scanners. Furthermore, seven studies (50%) had a prospective design and seven studies (50%) had a retrospective design. Most frequently, prostate cancer, followed by rectal cancer, cervical cancer and esophageal cancer were identified. The pooled correlation coefficient of all tumors was r = −0.02 [95% CI −0.26–0.21]. ADC values derived from routinely acquired DWI do not correlate with VEGF expression in various tumors. Therefore, DWI is not sensitive enough to reflect angiogenesis-related microstructure of tumors.

scholarly journals Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jianxing Qiu ◽  
Jing Liu ◽  
Zhongxu Bi ◽  
Xiaowei Sun ◽  
Xin Wang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Image Quality ◽  
Diffusion Weighted Imaging ◽  
Rectal Tumor ◽  
B Values ◽  
Primary Rectal Cancer ◽  
Diffusion Weighted ◽  
Adc Values ◽  
Group 2 ◽  
Group 1

Abstract Purpose To compare integrated slice-specific dynamic shimming (iShim) diffusion weighted imaging (DWI) and single-shot echo-planar imaging (SS-EPI) DWI in image quality and pathological characterization of rectal cancer. Materials and methods A total of 193 consecutive rectal tumor patients were enrolled for retrospective analysis. Among them, 101 patients underwent iShim-DWI (b = 0, 800, and 1600 s/mm2) and 92 patients underwent SS-EPI-DWI (b = 0, and 1000 s/mm2). Qualitative analyses of both DWI techniques was performed by two independent readers; including adequate fat suppression, the presence of artifacts and image quality. Quantitative analysis was performed by calculating standard deviation (SD) of the gluteus maximus, signal intensity (SI) of lesion and residual normal rectal wall, apparent diffusion coefficient (ADC) values (generated by b values of 0, 800 and 1600 s/mm2 for iShim-DWI, and by b values of 0 and 1000 s/mm2 for SS-EPI-DWI) and image quality parameters, such as signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of primary rectal tumor. For the primary rectal cancer, two pathological groups were divided according to pathological results: Group 1 (well-differentiated) and Group 2 (poorly differentiated). Statistical analyses were performed with p < 0.05 as significant difference. Results Compared with SS-EPI-DWI, significantly higher scores of image quality were obtained in iShim-DWI cases (P < 0.001). The SDbackground was significantly reduced on b = 1600 s/mm2 images and ADC maps of iShim-DWI. Both SNR and CNR of b = 800 s/mm2 and b = 1600 s/mm2 images in iShim-DWI were higher than those of b = 1000 s/mm2 images in SS-EPI-DWI. In primary rectal cancer of iShim-DWI cohort, SIlesion was significantly higher than SIrectum in both b = 800 and 1600 s/mm2 images. ADC values were significantly lower in Group 2 (0.732 ± 0.08) × 10− 3 mm2/s) than those in Group 1 ((0.912 ± 0.21) × 10− 3 mm2/s). ROC analyses showed significance of ADC values and SIlesion between the two groups. Conclusion iShim-DWI with b values of 0, 800 and 1600 s/mm2 is a promising technique of high image quality in rectal tumor imaging, and has potential ability to differentiate rectal cancer from normal wall and predicting pathological characterization.

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