scholarly journals Comparison between Fluconazole with Oral Protexin Combination and Fluconazole in the Treatment of Vulvovaginal Candidiasis

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
S. Nouraei ◽  
S. Amir Ali Akbari ◽  
M. Jorjani ◽  
H. Alavi Majd ◽  
M. Afrakhteh ◽  
...  
Keyword(s):  
Recovery Time ◽  
Vaginal Discharge ◽  
Therapeutic Response ◽  
Agar Medium ◽  
Treatment Success ◽  
Vulvovaginal Candidiasis ◽  
Double Blind ◽  
Negative Culture ◽  
Double Blind Clinical Trial ◽  
New Treatments

Background. According to the limited studies reporting new treatments for vulvovaginal candidiasis, this study was designed to compare the combination of fluconazole and oral protexin with fluconazole in the treatment of vulvovaginal candidiasis. Methods. A double-blind clinical trial was conducted, involving 90 women who were referred to the gynecology clinic. Vulvovaginal candidiasis was diagnosed with itching, cheesy vaginal discharge, and any one of the following: dysuria, pH < 4.5, dyspareunia, vulvar erythema, or vulvar edema and if branched hyphae and Candida buds were visible after addition of KOH 10% in the culture and the result of cultivation in Sabouraud’s dextrose agar medium was positive. Patients were randomly classified into two groups Absence of discharge, itching, and negative culture results 5–7 days after completion of treatment indicated treatment success. Data in this study were analyzed using the SPSS version 17.0 software. Results. The combinations, fluconazole-oral protexin and fluconazole-placebo, were equally effective in reduction of complaints and symptoms, but fluconazole-oral protexin combination elicited a better therapeutic response (, ). In addition, fluconazole-oral protexin combination treatment demonstrated better recovery time (, ). Conclusion. This study demonstrated that complementary treatment with probiotic Lactobacillus increased the efficacy of fluconazole in treatment of vulvovaginal candidiasis. Further research is recommended.

scholarly journals Therapeutic Effects of Sansevieria Trifasciata Ointment in Callosities of Toes

2016 ◽  
Vol 9 (2) ◽  
pp. 264 ◽  
Author(s):  
Hamidollah Afrasiabian ◽  
Reza Hododi ◽  
Mohammad Hadi Imanieh ◽  
Alireza Salehi
Keyword(s):  
Recovery Time ◽  
Lesion Size ◽  
Therapeutic Effects ◽  
Double Blind ◽  
Dermatology Clinic ◽  
Double Blind Clinical Trial ◽  
Group A ◽  
Spss Software ◽  
Group B ◽  
Methods Of Treatment

<p>Currently study was a double-blind clinical trial in terms of ointments with different contents and the variables such as sex, drug charges, occupation, age, number of lesions, patients, lesions location, time of manifestation, lesion size and methods of treatment and recovery time. In addition, total patients under studied were 100 people in dermatology clinic of Farshchian hospital of Hamadan in Iran that they were divided into two groups. The first group (A) contained of 68 individual who were divided into three groups which used <em>sanseveria</em> extract with different percentage of containing 5, 10, and 20%. Further, the second group (B) included 32 patients who used from other methods of treatment were divided into three groups. In one group12 patients have been treated by using salicylic acid, in the other groups 12 individuals used from electro cautery and 8 patients were used of the corn plasters method. In addition, 116 patients in this study were in the range of 7 to 57 years of age. In fact 100 of them have used the drug correctly while 16 patients were excluded due to wrong usage. Also the plant (<em>Sansevieria Trifasciata</em>) was prepared in Hamedan Research Center from plant by dried extracts method. Finally, the results were analyzed statistically using SPSS software. In conclusion, based on the results of significant impact on the treatment of corns, all patients (100%) in the first group have been treated, additionally all participants in the study were improved within 4 weeks such that the recovery time for the 5% ointment was 25 days, while for 10% and 20% ointment was 15 and 10 days respectively. </p>

scholarly journals Hyoscine versus diazepam for the management of true vertigo in the emergency department

2017 ◽  
Vol 12 (2) ◽  
pp. 3
Author(s):  
Hamid Kariman ◽  
Firoozeh Vajihi ◽  
Afshin Amini ◽  
Ali Shahrami ◽  
Ali Arhami-Dolatabadi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Emergency Department ◽  
Treatment Group ◽  
Drug Treatment ◽  
Success Rate ◽  
Treatment Success ◽  
Complete Relief ◽  
Sitting Position ◽  
Double Blind ◽  
Double Blind Clinical Trial

<p class="Abstract">The present study was a double-blind clinical trial to compare the efficiency of hysocine and diazepam in vertigo treatment. Eligible patients (n=69) were randomly divided into 2 groups of 5 mg hyoscine and 10 mg diazepam. Severity of vertigo was measured in supine and sitting position, and while turning the head. Vertigo severity was assessed before, and 1 and 2 hours after administration of the drug. Treatment success rate of diazepam in relieving vertigo in different positions varied between 88.9 and 100%, while this rate was 31.2–73.5% in hyoscine treatment group (p&lt;0.01). Prescription of diazepam led to complete relief of vertigo in 40–63% of the patients, while this rate was only 2.6–12.5% in hyoscine treatment group (p&lt;0.001). It is likely that diazepam is a better option than hyoscine for management of true vertigo in patients presenting to the emergency department.</p>

scholarly journals Epidemiologic Features of Vulvovaginal Candidiasis in Women of Childbearing Age in a Combined Military Hospital

2017 ◽  
Vol 13 (1) ◽  
pp. 13-16
Author(s):  
Syed Nurun Nabi ◽  
Md Rahimgir ◽  
Arif Ahmed Khan ◽  
Kaniz Fatema
Keyword(s):  
Candida Albicans ◽  
Candida Species ◽  
Vaginal Discharge ◽  
Agar Medium ◽  
Vulvovaginal Candidiasis ◽  
Reproductive Age ◽  
Military Hospital ◽  
Age Group ◽  
Childbearing Age ◽  
Reproductive Age Group

Introduction: Vulvovaginal Candidiasis is a reproductive tract infection which remains a common cause of morbidity adversely affecting women’s physical and emotional health. Vaginal discharge in the childbearing age group is the most common complaint encountered every day both by gynaecologists and general practitioners. Among the cases of symptomatic vaginal discharge, Bacterial vaginosis is the commonest cause followed by Candidiasis and Trichomoniasis. It is characterized by curd-like vaginal discharge and itching and is associated with considerable health and economic costs. Objective: To detect the prevalence of Candida species in patients with complaints of vaginal discharge of reproductive age group attending at Child Welfare Centre (CWC), Gynaecology Outpatient Department (GOPD) and Medical Inspection Room (MI Room) of Combined Military Hospital (CMH) Ghatail. Materials and Methods: A cross-sectional descriptive study was conducted at CMH Ghatail during the period of April 2017 to October 2017. A total of 183 patients of reproductive age group with the complaints of vaginal discharge attending CWC, GOPD and MI Room of CMH Ghatail were included in this study. Two specimens of High Vaginal Swabs (HVS) were collected from each patient, one for direct microscopy and another for culture. For every patient, two wet film preparations and two Gram’s staining were done. Specimens were cultured on Blood Agar Medium and Sabourad’s Dextrose Agar Medium. Identification of Candida species was carried out by Wet film, Gram’s staining and culture examination. Results: According to the results of this study, the prevalence of Vulvovaginal Candidiasis (VVC) was found in 57(31.15%) of the cases. The maximum number of patients 126(66.66%) were found between 26 years to 35 years of age group. On the other hand, amongst 57 VVC positive cases, 44(77.19%)were identified as Candida albicans and 13(22.81%) were Candida non-albicans. Conclusion: Candida albicans is the predominant organism amongst candida species identified from VVC in this study. The high prevalence necessitates adequate screening of woman with vaginal discharge in order to give appropriate treatment and to avoid complications associated with it. Journal of Armed Forces Medical College Bangladesh Vol.13(1) 2017: 13-16

scholarly journals Comparison of the Effect of Ketamine, Ketamine-Midazolam and Ketamine-Propofol on Post-Tonsillectomy Agitation in Children

2021 ◽  
Vol 28 (5) ◽  
pp. 72-81
Author(s):  
Zeinabsadat Fattahi-Saravi ◽  
◽  
Reza Jouybar ◽  
Rezvan Haghighat ◽  
Naeimehossadat Asmarian ◽  
...  
Keyword(s):  
Recovery Time ◽  
Emergence Agitation ◽  
Sedation Scale ◽  
Richmond Agitation Sedation Scale ◽  
Double Blind ◽  
Post Anaesthesia Care Unit ◽  
Recovery Score ◽  
Haemodynamic Stability ◽  
Double Blind Clinical Trial ◽  
Anaesthesia Care

Background: Emergence agitation (EA) in children is one of the most common complications following anaesthesia. We aimed to compare the effect of ketamine, ketaminemidazolam and ketamine-propofol on EA after tonsillectomy. Methods: This study was a randomised, double-blind clinical trial conducted on 162 children undergoing adenotonsillectomy surgery. The participants were randomly divided into three groups of receiving ketamine (0.5 mg/kg) (N = 54), ketamine (0.5 mg/kg) + propofol (1 mg/kg) (N = 54) and ketamine (0.5 mg/kg) + midazolam (0.01 mg/kg) (N = 54) 10 min before the end of the operation. At the time of the patients’ entry into the post-anaesthesia care unit (PACU) and at intervals of 5 min, 10 min and 20 min after that, consciousness, mobility, breathing, circulation and SpO2 were recorded. Modified Aldrete recovery score (MARS), the objective pain score (OPS) and Richmond agitation-sedation scale (RASS) were also evaluated. Results: At the time of entrance to the PACU and 5 min later, the ketamine-midazolam and ketamine-propofol groups had lower RASS scores than the ketamine group (P < 0.001); after 10 min and 20 min, the ketamine-propofol group showed the lowest RASS score (P < 0.001). Ketamine-propofol group had a significantly lower MARS score at all-time points (P < 0.001). Recovery time was the longest for the ketamine-propofol group (P = 0.008). Conclusion: The ketamine-midazolam group had lower RASS, greater haemodynamic stability and MARS values without delayed awakening.

Laboratory evaluation of the etiology of pathological vaginal dischurge

2019 ◽  
pp. 64-68
Author(s):  
O.A. Burka ◽  
◽  
T.M. Tutchenko ◽  
Keyword(s):  
Bacterial Vaginosis ◽  
Crucial Role ◽  
Inflammatory Process ◽  
Vaginal Discharge ◽  
Vulvovaginal Candidiasis ◽  
Diagnostic Methods ◽  
Laboratory Evaluation ◽  
Aerobic Vaginitis ◽  
Laboratory Confirmation ◽  
Vaginal Secretions

Pathological vaginal discharge is one of the most common complaints in women of all ages. Today, gynecologists are increasingly faced with a problem when, in the absence of laboratory confirmation of vulvovaginal candidiasis, bacterial vaginosis and STIs, women complain of discomfort caused by vaginal secretions. Causes of pathological vaginal discharge can be infectious and non-infectious processes and their combinations. The article analyzes the causes of the difficulties of diagnosing the of pathological vaginal discharge ethiology, demonstrates how the application of adequate volume of modern laboratory diagnostic methods in combination with understanding the multifaceted components of the inflammatory process plays crucial role in finding out the etiology of pathological vaginal secretions and the choice of optimal therapeutic tactics. Key words: pathological vaginal dischurge, vaginal microbiota, vulvovaginal candidiasis, bacterial vaginosis, aerobic vaginitis, cytolytic vaginosis.

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