scholarly journals Current Evidence on Using Platelet Rich Plasma as a Therapeutic Modality for Veterinary Orthopedic Conditions

2021 ◽  
Vol 11 (1) ◽  
pp. 73-78
Author(s):  
H.M. Suranji Wijekoon ◽  
D.D. Niranjala de Silva
Keyword(s):  
Musculoskeletal Disorders ◽  
Platelet Rich Plasma ◽  
Therapeutic Modality ◽  
Current Evidence ◽  
Evidence Based ◽  
Future Directions ◽  
Factors Influencing ◽  
Clinical Literature ◽  
Promising Treatment ◽  
Available Information

This review evaluates the findings of available clinical literature on the use of platelet-rich plasma (PRP) to develop evidence-based recommendations for treating various musculoskeletal issues that arise in veterinary practice. The use of PRP-based treatments for various orthopedic conditions is rapidly evolving as a promising treatment modality; however, its true effectiveness has yet to be elucidated. Application of PRP has been reported in humans for a variety of orthopedic conditions. Although the majority of the veterinary literature on PRP reports its use in equine patients, there is a dearth of evidence addressing its use in canine patients. Nevertheless, evidence of the efficacy of PRP has appeared to be highly variable depending on its specific indication, particularly in musculoskeletal disorders. This review aims to present the available information on the efficacy of PRP therapy in veterinary orthopedic conditions and describes factors influencing its use, the limitations of PRP therapy, and future directions of PRP research and therapy.

Oxygen therapy in newborns

2009 ◽  
Vol 23 (4) ◽  
pp. 315-319
Author(s):  
Shamsher S. Dalai ◽  
Rajesh Kumar ◽  
Daljit Singh
Keyword(s):  
Present Article ◽  
Critical Field ◽  
Oxygen Therapy ◽  
Current Evidence ◽  
Evidence Based ◽  
Knowledge Gaps ◽  
Available Information ◽  
Evidence Based Care

After more than half a century of use of oxygen in neonates, there are many areas related to oxygen therapy in neonates in which the available information based on current evidence remains inadequate. To address the knowledge gaps that prevent optimal, evidence-based care in this critical field, National Neonatology forum, India is bringing out a set of guidelines on Oxygen therapy in neonates. The present article, which is based on these guidelines, proposes to review oxygen therapy in neonates including what is presently known on this topic, gaps in knowledge and researchable issues.

scholarly journals Cardiac Sarcoidosis: When and How to Treat Inflammation

2021 ◽  
Vol 7 ◽  
Author(s):  
Gerard T Giblin ◽  
Laura Murphy ◽  
Garrick C Stewart ◽  
Akshay S Desai ◽  
Marcelo F Di Carli ◽  
...  
Keyword(s):  
Cardiac Involvement ◽  
Cardiac Sarcoidosis ◽  
Multidisciplinary Treatment ◽  
Current Evidence ◽  
Myocardial Inflammation ◽  
Evidence Based ◽  
Future Directions ◽  
Evidence Based Treatment ◽  
Inflammatory Phase ◽  
Treatment Indications

Sarcoidosis is a complex, multisystem inflammatory disease with a heterogeneous clinical spectrum. Approximately 25% of patients with systemic sarcoidosis will have cardiac involvement that portends a poorer outcome. The diagnosis, particularly of isolated cardiac sarcoidosis, can be challenging. A paucity of randomised data exist on who, when and how to treat myocardial inflammation in cardiac sarcoidosis. Despite this, corticosteroids continue to be the mainstay of therapy for the inflammatory phase, with an evolving role for steroid-sparing and biological agents. This review explores the immunopathogenesis of inflammation in sarcoidosis, current evidence-based treatment indications and commonly used immunosuppression agents. It explores a multidisciplinary treatment and monitoring approach to myocardial inflammation and outlines current gaps in our understanding of this condition, emerging research and future directions in this field.

Intellectual Disability in Autism Spectrum Disorder

2020 ◽  
pp. 176-197
Author(s):  
Benjamin E. Yerys
Keyword(s):  
Autism Spectrum Disorder ◽  
Intellectual Disability ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Current Evidence ◽  
Evidence Based ◽  
Future Directions ◽  
High Degree ◽  
The Relationship ◽  
Degree Of Overlap

Intellectual disability (ID) and autism spectrum disorder (ASD) are two neurodevelopmental disorders noted to have a high degree of overlap and co-occurrence. Historically, symptoms of ID were reported to co-occur in approximately 70% or more of those with ASD; however, the rate of co-occurrence is now believed to be around 30%. As the perceptions and diagnostic conceptualization of each condition by itself have changed over time, our knowledge of the overlap and the relationship between ID and ASD has similarly changed. This chapter provides a brief overview of the relationship between ID and ASD and focuses more on the complexities and nuances pertaining to etiology, diagnosis, and assessment of symptoms that may covary or may differentially occur. Finally, the chapter provides a summary of current evidence-based interventions for use in those who have ASD and co-occurring ID, as well as a look toward future directions for investigation.

scholarly journals The Use of Platelet-Rich Plasma for Conservative Treatment of Partial Ulnar Collateral Ligament Tears in Overhead Athletes: A Critically Appraised Topic

2020 ◽  
Vol 29 (4) ◽  
pp. 509-514
Author(s):  
Bradley J. Conant ◽  
Nicole A. German ◽  
Shannon L. David
Keyword(s):  
Conservative Treatment ◽  
Treatment Program ◽  
Platelet Rich Plasma ◽  
Ulnar Collateral Ligament ◽  
The Body ◽  
Current Evidence ◽  
Evidence Based ◽  
Collateral Ligament ◽  
Overhead Athletes ◽  
Partial Tears

Clinical Scenario: Rates of ulnar collateral ligament (UCL) injuries continue to rise in overhead athletes of all ages. Surgical interventions require minimally 6 months and up to 2 years of rehabilitation. Younger athletes and those with partial tears have seen positive results with conservative treatment approaches. Platelet-rich plasma (PRP) continues to be studied with various orthopedic injuries, and its use has the potential to improve return-to-sport rates and reduce recovery time. Focused Clinical Question: Do PRP injections improve conservative treatment outcomes in overhead athletes with partial tears of the UCL compared with conservative treatment alone regarding return to participation? Summary of Search, Best Evidence Appraised, and Key Findings: A literature search was performed to locate all studies investigating outcomes when PRP is included in a conservative treatment program for overhead athletes with partial UCL tears. Three case series qualified and were reviewed. Clinical Bottom Line: Current evidence suggests that including PRP in a conservative treatment program can improve outcomes in overhead athletes with partial UCL tears. Athletes whose treatment included PRP show higher return-to-competition rates and shorter recovery times compared with athletes who used rehabilitation alone. Athletes with grade-1 and proximal-based grade-2 injuries returned to competition at rates comparable with athletes undergoing surgical intervention. For optimal conservative management outcomes, PRP injections should be recommended for treatment of partial UCL tears. Strength of Recommendation: The studies qualifying for inclusion are level 4 evidence based on the 2011 Oxford Centre for Evidence-Based Medicine levels of evidence. The studies are well designed and show consistent results, but higher level studies need to demonstrate similar results to improve the body of evidence. The strength of recommendation is C.

The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders

2021 ◽  
pp. 155335062110148
Author(s):  
Anastasia Prodromidou ◽  
Dimitrios Zacharakis ◽  
Stavros Athanasiou ◽  
Athanasios Protopapas ◽  
Lina Michala ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Platelet Rich Plasma ◽  
Pelvic Organ ◽  
Therapeutic Modality ◽  
Current Evidence ◽  
Considerable Proportion ◽  
Mesh Exposure ◽  
Vaginal Atrophy ◽  
Collagen Concentration ◽  
Feasible Alternative

Background: The regenerative efficacy of platelet-derived products has been recently investigated in the treatment of pelvic floor disorders (PFDs). We aimed to synthesize the current evidence of platelet-rich plasma (PRP) products used in urogynaecological disorders including vaginal atrophy, pelvic organ prolapse (POP), urinary incontinence, vaginal fistulas and vaginal mesh exposure. Methods: A meticulous search of the currently available literature on the use of PRP for the management of PFDs was performed using 3 electronic databases. Results: PRP could be a feasible alternative modality for the management of vaginal atrophy with favourable outcomes in vaginal atrophy parameters and patients’ satisfaction, especially when hormone therapy is contraindicated. In patients with POP, an increase in collagen concentration after PRP application was observed while the use of PRP resulted in improvement of stress urinary incontinence symptoms. A considerable proportion of vesicovaginal fistulas were treated after application of PRP-based injections. Conclusions: There is only limited evidence of the use of PRP for PFDs. Platelet-rich plasma appears to be a promising, easy to apply, cost-effective and feasible alternative therapeutic modality for the management of various urogynaecological disorders. Future randomized trials are needed to confirm the efficacy of PRP in the treatment of urogynaecological disorders.

Meeting the Best Practice for Hearing Aid Verification in Children: Challenges and Future Directions

2019 ◽  
Vol 28 (4) ◽  
pp. 877-894
Author(s):  
Nur Azyani Amri ◽  
Tian Kar Quar ◽  
Foong Yen Chong
Keyword(s):  
Clinical Practice ◽  
Hearing Aids ◽  
Best Practice ◽  
Hearing Aid ◽  
Evidence Based ◽  
Future Directions ◽  
Major Barrier ◽  
Klang Valley ◽  
Age Range ◽  
Fitting Hearing Aids

Purpose This study examined the current pediatric amplification practice with an emphasis on hearing aid verification using probe microphone measurement (PMM), among audiologists in Klang Valley, Malaysia. Frequency of practice, access to PMM system, practiced protocols, barriers, and perception toward the benefits of PMM were identified through a survey. Method A questionnaire was distributed to and filled in by the audiologists who provided pediatric amplification service in Klang Valley, Malaysia. One hundred eight ( N = 108) audiologists, composed of 90.3% women and 9.7% men (age range: 23–48 years), participated in the survey. Results PMM was not a clinical routine practiced by a majority of the audiologists, despite its recognition as the best clinical practice that should be incorporated into protocols for fitting hearing aids in children. Variations in practice existed warranting further steps to improve the current practice for children with hearing impairment. The lack of access to PMM equipment was 1 major barrier for the audiologists to practice real-ear verification. Practitioners' characteristics such as time constraints, low confidence, and knowledge levels were also identified as barriers that impede the uptake of the evidence-based practice. Conclusions The implementation of PMM in clinical practice remains a challenge to the audiology profession. A knowledge-transfer approach that takes into consideration the barriers and involves effective collaboration or engagement between the knowledge providers and potential stakeholders is required to promote the clinical application of evidence-based best practice.

Levosimendan to facilitate weaning from cardiorespiratory support in critically ill patients: current evidence and future directions

2020 ◽  
Vol 86 (6) ◽  
Author(s):  
Fabio Sangalli ◽  
Giacomo Bellani ◽  
Alessandro Affronti ◽  
Francesca Volpi ◽  
Marco Feri ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Current Evidence ◽  
Future Directions
Sign in / Sign up

Export Citation Format

Share Document