scholarly journals The role of dapsone in refractory idiopathic granulomatous mastitis

2017 ◽  
Vol 4 (1) ◽  
pp. 72
Author(s):  
Ayla Pelleg ◽  
Kirangowda Pombarahalli Varadaraju ◽  
Swati Datta
Keyword(s):  
Case Report ◽  
Alternative Treatment ◽  
Treatment Guidelines ◽  
Breast Disease ◽  
Breast Mass ◽  
Treatment Modalities ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

Idiopathic Granulomatous Mastitis (IGM) is a benign inflammatory breast disease.  A definite etiology of IGM is still unknown.  IGM classically presents as an unilateral, painful breast mass in women who are 30-40 years of age.  Consensus treatment guidelines do not exist for the management of IGM.  In this case report, we present a patient with IGM who was refractory to Prednisone and started on Dapsone as an alternative treatment. This case report highlights the use of Dapsone and the need for further research of IGM treatment modalities. 

Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

2016 ◽  
Vol 60 (5) ◽  
pp. 438-444 ◽  
Author(s):  
Thanaa El A. Helal ◽  
Lobna S. Shash ◽  
Somaia A. Saad El-Din ◽  
Sally M. Saber
Keyword(s):  
Middle Eastern ◽  
Breast Disease ◽  
Needle Aspiration ◽  
Granulomatous Mastitis ◽  
Aspiration Cytology ◽  
Idiopathic Granulomatous Mastitis ◽  
Tissue Sections ◽  
Egyptian Patients ◽  
Needle Aspiration Cytology

Background: The etiology of idiopathic granulomatous mastitis (IGM) is unknown, and it is commonly misdiagnosed clinically and/or radiologically as breast cancer. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is still a matter of debate. The aim of the current study is to assess the value of FNAC in the diagnosis of IGM, and to search for the presence of bacteria in IGM with cystic vacuoles, which was described recently by a few authors. Materials and Methods: Retrospective study of cytologic smears and histologic tissue sections of 65 Egyptian IGM cases was done along with microbiologic testing. A comparison of the frequency of IGM in Egypt to that of other populations was also made. Results: IGM has typical FNA features which can easily exclude malignancy. Histologically, cystic vacuoles were encountered in 35 out of 65 cases (53.9%), with only 6 (17.14%) of these cases showing Gram-positive bacilli (GPB). The frequency of IGM in Egypt is comparable to those in other Middle Eastern countries but much higher than in Western countries. Conclusion: IGM is a common breast disease in Egypt. FNAC in IGM has a high diagnostic accuracy. This study supports the few recent studies that have detected GPB in IGM with cystic vacuoles. Thus, bacteriologic examination in such cases may affect the treatment strategy.

scholarly journals Low-Dose Methotrexate Use in Idiopathic Granulomatous Mastitis: An Alternative Treatment Method

Breast Care ◽  
2021 ◽  
pp. 1-6
Author(s):  
Mehmet Tolga Kafadar ◽  
Mehmet Veysi Bahadır ◽  
Sadullah Girgin
Keyword(s):  
Side Effects ◽  
Alternative Treatment ◽  
Low Dose ◽  
Treatment Method ◽  
Treatment Modalities ◽  
Unknown Etiology ◽  
Partial Recovery ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Dose Methotrexate

<b><i>Background:</i></b> Idiopathic granulomatous mastitis (IGM) is a rare, recurrent and progressive breast disease with an unknown etiology. Patients with IGM will probably face stressful, time-consuming treatment procedures with side effects due to medications. There are different treatment modalities in clinical use including medical and surgical interventions. <b><i>Objective:</i></b> The aim of this study was to present the results of using the combination therapy of low-dose methotrexate (MTX) and steroid in IGM. <b><i>Methods:</i></b> Seventeen patients diagnosed with IGM and treated with MTX were included into the study. Low-dose MTX at 5 mg/week and 8 mg/day prednisone were given for 2–3 months. <b><i>Results:</i></b> After 2–3 months of treatment, 10 patients exhibited (58.5%) complete, 3 patients (17.6%) partial recovery, and no response to the treatment process was observed in 4 patients (23.5%). No side effects of MTX and recurrent events were noted in any of the patients. <b><i>Conclusion:</i></b> Low-dose MTX and prednisone treatment for IGM patients, who did not respond to steroids alone, should be considered as an alternative treatment method instead of surgical intervention.

scholarly journals The Role of Conservative Treatment in Idiopathic Granulomatous Mastitis

2005 ◽  
Vol 11 (6) ◽  
pp. 454-456 ◽  
Author(s):  
Eric C. H. Lai ◽  
Wing Cheong Chan ◽  
Tony K. F. Ma ◽  
Alice P. Y. Tang ◽  
Cycles S. P. Poon ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

scholarly journals Management of Palmo-Plantar Psoriasis by Classical Shodhan and Shaman Chikitsa- A Case Report

2021 ◽  
Vol 12 (1) ◽  
pp. 166-170
Author(s):  
Anagha S Hirapure ◽  
Saurabh Deshmukh ◽  
Trupti Thakre
Keyword(s):  
Mental Health ◽  
Case Report ◽  
Severe Pain ◽  
Functional Disability ◽  
Skin Diseases ◽  
Lifestyle Modification ◽  
Skin Condition ◽  
Treatment Modalities ◽  
Specific Line

Background: Palmo-plantar psoriasis in a non-inflammatory skin condition in which it is capable to produce functional disability. It is the type of psoriasis which occurs in palms and soles together with features like scaling, erythema and itching, pustules cracked & pain, and is limited. Palmo-plantar is the disease which does not have a specific line of treatment, but can be assessed and treated with classical line of Ayurvedic management. This Palmo-plantar not only affects physically but also disturbs the mental health of patient In Ayurveda all the skin diseases are described under single topic; Kushtha (Skin disorders). As Palmo-Plantar psoriasis is compared with Vipadika Kshudra Kushta (cracked bilateral soles & palms) in Ayurveda, the predominant Dosha’s (fundamental bodily bio-elements) are Vata (governs movement of body & mind) & Kapha (controls immune system) in which Vaman Karma (Emesis) is useful. Aim: To evaluate the role of Ayurveda treatment modalities in Vipadika Kshudra Kushta. Materials & Methods: A case report of 56 year old male patient suffering from scaling of both palms and soles with severe pain since 16 years is presented in this article where the patient got satisfactory relief by adopting Shodhan Karma (purification treatment) followed by Shaman Chikitsa (pacifying treatment) with dietary and behavioral lifestyle modification. The symptoms were reduced by Vaman procedure. Result: Patient got about 80% relief after the treatment by which one can say that the palmo-plantar psoriasis can be treated by Ayurveda Medicine.

Breast Mass with Bloody Discharge: A Case of Idiopathic Granulomatous Mastitis

2022 ◽  
Vol 7 (01) ◽  
pp. 58-61
Author(s):  
Lamees AlSulaim
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Nipple Discharge ◽  
Advanced Breast ◽  
Breast Mass ◽  
Breast Diseases ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Skin Changes ◽  
Breast Condition

One of the rare identity of breast diseases is Idiopathic Granulomatous Mastitis (IGM), a chronic inflammatory breast condition that can mimic advanced breast cancer. The case came with nipple discharge and mass with skin changes, which was definitively diagnosed following core-cut biopsy of the mastitis group idiopathic granulomatous.

The therapeutic dilemma of idiopathic granulomatous mastitis

2021 ◽  
Vol 50 (8) ◽  
pp. 598-605 ◽  
Author(s):  
Ee Ling Serene Tang ◽  
Chi Shern Bernard Ho ◽  
Patrick Mun Yew Chan ◽  
Juliana Jia Chuan Chen ◽  
Mui Heng Goh ◽  
...  
Keyword(s):  
Treatment Modality ◽  
Median Number ◽  
Subsequent Treatment ◽  
Treatment Modalities ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Young Females ◽  
Significant Difference ◽  
Breast Condition ◽  
Recurrent Breast

ABSTRACT Introduction: Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic breast condition that can cause repeated abscesses or mass formation in bilateral breasts. The condition can severely impact the quality of life of affected women. This study aims to evaluate effective treatment modalities, as well as understand the demographics and clinical presentation of patients with IGM. Methods: An 11-year retrospective review was performed of patients diagnosed with IGM from 1 January 2008 to 31 December 2018 at a tertiary breast unit. Results: A total of 77 patients were included in the study. The median age at presentation was 36 years old. IGM presented most commonly as a breast lump (98.1%). The median number of flares was 2 (1–12). Of the 77 patients, 68.8% (53) were treated with antibiotics, 50.6% (39) with steroids, and 44.2% (34) underwent surgery, in the course of their IGM treatment. Forty-five (59.2%) of the 76 patients with IGM required a multimodal treatment approach to achieve remission. There was no significant difference in the number of flares no matter the initial treatment (P=0.411), or subsequent treatment modality (P=0.343). Smokers had 10 times greater odds of having a “high flare” of IGM compared to those who did not smoke (P=0.031, odds ratio 10.444, 95% confidence interval 1.092–99.859). Conclusion: IGM is a clinical diagnosis. It is a rare, relapsing breast inflammatory condition that affects young females with no superior treatment modality. Smoking is associated with higher number of flares of IGM and should be discouraged in IGM patients Keywords: Breast inflammation, chronic mastitis, idiopathic granulomatous mastitis, recurrent breast abscess

scholarly journals Idiopathic Granulomatous Mastitis Presenting as a Breast Pseudotumor: Case Reports with Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Nour Abdul Halim ◽  
Imad Uthman ◽  
Rayan Rammal ◽  
Hazem I. Assi
Keyword(s):  
Clinical Presentation ◽  
Case Reports ◽  
Radiographic Finding ◽  
Breast Disease ◽  
Granulomatous Mastitis ◽  
Women Of Childbearing Age ◽  
Review Of The Literature ◽  
Childbearing Age ◽  
Idiopathic Granulomatous Mastitis ◽  
History Of

Idiopathic granulomatous mastitis is a rare benign inflammatory breast disease that affects women of childbearing age with a history of breastfeeding. It usually presents as an enlarging breast mass that can greatly mimic breast cancer. Moreover, it does not have a specific radiographic finding, so the only way to reach a definitive diagnosis is by core biopsy and histology. Furthermore, a consensus regarding the best treatment modality has not been reached yet. In this report, we describe the cases of two patients who suffered from this disease, and to our knowledge, such a report is the first of its kind to address this topic in this region. Therefore, because of its uncommon nature and obscure presentation, we hereby report two cases of idiopathic granulomatous mastitis. The clinical presentation, treatment, and pathological findings are described, and a literature review on idiopathic granulomatous mastitis will be reported.

scholarly journals Idiopathic Granulomatous Mastitis: Etiopathogenetic Considerations on a Rare Benign Inflammatory Breast Disease

2020 ◽  
pp. 1-2 ◽  
Author(s):  
Michele Altieri ◽  
Fabio Barra ◽  
Federico Casabona ◽  
Domenico Soriero ◽  
Claudio Gustavino ◽  
...  
Keyword(s):  
Breast Disease ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

scholarly journals Comparison of Conservative versus Surgical Treatment Protocols in Treating Idiopathic Granulomatous Mastitis: A Meta-Analysis

Breast Care ◽  
2019 ◽  
Vol 15 (4) ◽  
pp. 415-420
Author(s):  
Fei Zhou ◽  
Lu Liu ◽  
Liyuan Liu ◽  
Lixiang Yu ◽  
Fei Wang ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Recurrence Rate ◽  
Meta Analysis ◽  
Clinical Effectiveness ◽  
Breast Disease ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Treatment Protocols ◽  
Significant Difference ◽  
Conservative And Surgical Treatment

Background: Idiopathic granulomatous mastitis (IGM) is a rare, benign breast disease without any definitive therapeutic strategy. It is controversial whether to use conservative or surgical treatment of IGM and high-level evidence-based medicine data are lacking. The purpose of this study was to systemically evaluate the clinical effectiveness of the conservative versus surgical treatment for IGM. Methods: In this meta-analysis, we searched PubMed, EMbase, ScienceDirect, and Web of Science for comparative studies about the conservative versus surgical treatment of IGM. Two researchers independently identified reports and extracted data. We used Stata 11 for data analysis. A meta-analysis was performed to investigate the differences in the recurrence rate of conservative and surgical treatment using a random effects model. Results: A total of 10 studies involving 1,101 patients were included. The results demonstrated that there was no significant difference in the recurrence rate among patients who were treated by nonsurgical therapy and surgical treatment. No publication bias was detected. Conclusion: This meta-analysis demonstrates that both the conservative and surgical treatment approaches have appropriate efficacy in IGM treatment and relapse. Further randomized controlled trials with longer follow-up periods are required to confirm the advantages of each approach.

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