Evaluation of chronic chlorpyrifos-induced reproductive toxicity in male Wistar rat: protective effects of vitamin C

The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.

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Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis in Wistar rat bone marrow cells

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/s1383-5718(99)00220-x ◽

2000 ◽

Vol 465 (1-2) ◽

pp. 131-137 ◽

Cited By ~ 73

Author(s):

Lusânia M.Greggi Antunes ◽

Maria Cristina P Araújo ◽

Joana D'Arc C Darin ◽

Maria de Lourdes P Bianchi

Keyword(s):

Bone Marrow ◽

Vitamin C ◽

Bone Marrow Cells ◽

Wistar Rat ◽

Rat Bone ◽

Marrow Cells

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PROTECTIVE EFFECTS OF VITAMIN C AGAINST CISPLATIN-INDUCED NEPHROTOXICITY AND LIPID PEROXIDATION IN ADULT RATS: A DOSE-DEPENDENT STUDY

Pharmacological Research ◽

10.1006/phrs.1999.0600 ◽

2000 ◽

Vol 41 (4) ◽

pp. 405-411 ◽

Cited By ~ 143

Author(s):

LUSÂNIA M. GREGGI ANTUNES ◽

JOANA D'ARC C. DARIN ◽

MARIA DE LOURDES P. BIANCHI

Keyword(s):

Lipid Peroxidation ◽

Vitamin C ◽

Protective Effects ◽

Adult Rats ◽

Dose Dependent

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Protective effects of Vitamin C on cisplatin nephrotoxicity

Archives of Pharmacal Research ◽

10.1007/bf02978240 ◽

1994 ◽

Vol 17 (1) ◽

pp. 11-16 ◽

Cited By ~ 1

Author(s):

Se-Young Choung ◽

Jae-Myeong Kong

Keyword(s):

Vitamin C ◽

Protective Effects ◽

Cisplatin Nephrotoxicity

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Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B1 in cultured human lymphocytes

Toxicology and Industrial Health ◽

10.1177/0748233709106068 ◽

2009 ◽

Vol 25 (3) ◽

pp. 183-188 ◽

Cited By ~ 12

Author(s):

L Alpsoy ◽

G Agar ◽

M Ikbal

Keyword(s):

Vitamin A ◽

Vitamin C ◽

Human Lymphocytes ◽

Mutagenic Effect ◽

Treated Group ◽

Protective Role ◽

Effective Concentration ◽

Dependent Manner ◽

Protective Effects ◽

Aflatoxin B

In this study, we aimed to evaluate the effect of vitamins A, C, and E against aflatoxin B1 (AFB1) on blood cultures in relation to induction of sister chromatid exchange (SCE). The results indicated genotoxic and mutagenic damage in cultured human lymphocytes exposed to AFB1. The results showed that 5 μM concentration of AFB1 increased SCE. When vitamins A, C, and E were added to AFB1, the frequency of SCE decreased. These results suggest that vitamins A, C, and E could effectively inhibit AFB1-induced SCE, which may partially responsible for its mutagenic effect of AFB1. Besides, the protective effect of vitamins A, C, and E against AFB1 was increased in a dose-dependent manner (i.e., as the doses increased, their protective effects also increased). There was a significant decrease in the SCE frequency in AFB1-treated group compared with the groups receiving AFB1 and also vitamins A, C, and E. The most effective concentration was 100 microM vitamin C, and the lowest effective concentration was 0.5 microM vitamin A. Vitamin C has the most effective concentration of 100 μM, and vitamin A has the lowest effective concentration of 0.5 μM. The order of the decreasing effect of the SCE frequency of vitamins was as follows: vitamin C > vitamin E > vitamin A.

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Vaspin Alleviates Osteoarthritis by Inhibiting NLRP3-mediated Inflammation

10.21203/rs.3.rs-285169/v1 ◽

2021 ◽

Author(s):

Xianjie Zhu ◽

Shiyou Dai ◽

Baohua Xia ◽

Jianbao Gong ◽

Bingzheng Ma

Keyword(s):

Nlrp3 Inflammasome ◽

Wistar Rat ◽

Cartilage Degradation ◽

Pathological Process ◽

Inflammasome Activation ◽

Protective Effects ◽

Collagen Formation ◽

Nlrp3 Inflammasome Activation

Abstract Background:Osteoarthritis (OA) is a chronic degenerative joint bone disease characterized by cartilage degradation. Visceral adipose tissue-derived serine protease inhibitor (vaspin) is associated with the inflammatory and metabolic responses to OA. However, the underlying mechanisms of the pathological process of OA are not clear. The aim of the present study was to examine the protective effects of vaspin both in vitro and in vivo.Methods:Monosodium iodoacetate (MIA)-induced Wistar rat model of OA was used to assess the in vivo effects of vaspin administered for 12 weeks. The characteristics of OA were evaluated by haematoxylin and eosin (H&E) and safranin O/fast green staining. The anti-inflammatory effect of vaspin was assessed using immunohistochemical, qRT-PCR, and western blotting analysis. Parallel experiments to detect the molecular mechanism through which vaspin prevents OA were performed using LPS-treated chondrocytes.Results:Our results showed that the degeneration of cartilage and upregulated expression of matrix metalloproteinase (MMP)-1 and MMP-13 were ameliorated by vaspin. Additionally, vaspin suppressed the activation of TXNIP/NLRP3 and secretion of tumor necrosis factor ɑ and interleukin-1β in vivo. It was further confirmed that vaspin could also suppress LPS-induced NLRP3 inflammasome activation and reduce collagen formation in chondrocytes. Moreover, vaspin inhibited NLRP3 inflammasome activation by suppressing the ROS/TXNIP pathway.Conclusions: Vaspin inhibited OA by repressing TXNIP/NLRP3 activation in in vitro and in vivo models of OA, thus providing a novel therapeutic strategy for OA.

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Effect of vitamin C supplementation on hematological parameters in smokeless tobacco chewers

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v12i3.4819 ◽

2021 ◽

Vol 12 (3) ◽

pp. 2088-2094

Author(s):

Jaywant S. Thorat ◽

Anand G. Joshi ◽

Kanchan C. Wingkar

Keyword(s):

Platelet Count ◽

Vitamin C ◽

Smokeless Tobacco ◽

Hematological Parameters ◽

Protective Effects ◽

Baseline Study ◽

Vitamin C Supplementation ◽

Baseline Values ◽

Wbc Count ◽

Rbc Count

The present study was aimed to evaluate the effect of Vitamin C (VC) supplementation on hematological parameters in Smokeless Tobacco (ST) chewers. A total of 338 subjects aged between 31 to 60 years (168 ST chewers and 170 ST non-chewers) participated in the present study. ST chewers were further divided into 3 subgroups with respect to ST chewing duration in years. Subjects of both the groups were examined at the baseline study and after 45 days of supplementation of 1 g of Vitamin C (VC) for hematological parameters. WBC count (p=0.04), granulocytes % (p=0.0007), HCT (p=0.01) and MCV (p=0.04) were significantly increased whereas, monocytes % (p=0.002) and platelet count (p<0.0001) were significantly decreased in ST chewers as compared to controls. After supplementation of VC, WBC count (p<0.001) and granulocytes % (p<0.0001) were significantly decreased and lymphocytes % (p=0.008), monocytes % (p<0.0001), RBC count (p=0.01) and Hb content (p=0.006) were significantly increased in ST chewers as compared to their baseline values. In conclusion, the use of ST had deleterious effects on hematological parameters; however, supplementation of 1 g of VC showed protective effects on hematological parameters.

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