The relationship between serum irisin levels with cardiovascular risk factors and insulin resistance parameters in patients with metabolic syndrome

Abstract Objectives The objective of this study is to investigate the cardiovascular risk factors associated with metabolic syndrome (MetS), which is increasingly becoming prevalent in childhood obesity. Methods A total of 113 patients, 76 of whom were between the ages of 10 and 17 (mean age: 14.5 ± 1.8 years) and diagnosed with obesity (30 non-MetS and 46 MetS using IDF) and 37 of whom constituted the control group, participated in the study. Echocardiographic examination and atherogenicity parameters (Atherogenic index of plasma [AIP: logTG/HDL], total cholesterol/HDL, and TG/HDL ratio and non-HDL) were evaluated. Results The most common component accompanying obese MetS was found to be hypertension and low HDL. While obesity duration, body mass index (BMI), blood pressure, fasting insulin, insulin resistance, atherogenicity parameters were determined to be significantly higher in the obese-MetS group. Echocardiography showed that while the thickness, volume, and diameter of LV end-diastolic wall, left ventricular mass (LVM), LVM index (LVMI g/m2) and relative wall thickness (RWT) were significantly high in the MetS group, however, mitral E/A ratio was significantly lower (p<0.05). Change in LV geometry consistent with concentric remodeling (increased RWT, normal LVMI) was visible in obese groups. LVM were positively significantly related to BMI, waist circumference, insulin resistance, blood pressure, LDL level, and negative to mitral E/A ratio. In the obese-MetS group, LVMI was positively correlated to office systolic BP, left atrium end-diastolic volume/index. Conclusions LVMI and atherogenicity parameters that were found to be significantly higher in obese MetS exhibit increased cardiovascular risk in childhood.

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Insulin Resistance in Association with Thyroid Function, Psychoemotional State, and Cardiovascular Risk Factors

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18073388 ◽

2021 ◽

Vol 18 (7) ◽

pp. 3388

Author(s):

Nijole Kazukauskiene ◽

Aurelija Podlipskyte ◽

Giedrius Varoneckas ◽

Narseta Mickuviene

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Thyroid Function ◽

Study Groups ◽

Model Assessment ◽

Psychoemotional State ◽

Study Participants

Background: Individuals with insulin resistance (IR) have a high risk of diabetes or metabolic syndrome, and they are more likely to have depression. Furthermore, IR by itself is a major cardiovascular risk factor in healthy persons. Thus, we aimed to investigate IR in association with thyroid function, psychoemotional state, and cardiovascular risk factors among 45–84-year-old citizens of Palanga. Methods: A randomized epidemiological study was performed with 850 subjects. All participants were evaluated for sociodemographic, clinical, and cardiovascular risk factors and biochemical analysis. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). Results: All study participants were stratified into groups without IR (HOMA-IR ≤ 2.7) and with IR (HOMA-IR > 2.7). The analysis of parameters between the two study groups showed some statistically significant relationships between IR and cardiovascular risk factors. The predictable accuracy was presented using receiver performance characteristic curves for HOMA-IR scores in women and men separately. If the HOMA-IR score is higher than 3.45, individuals are significantly more likely to have type 2 diabetes mellitus (T2DM). Conclusions: An increase of fasting glucose and more frequent incidence of metabolic syndrome, diabetes, and cardiovascular diseases in subjects with IR are associated with the prevalence of cardiovascular risk factors. There was no significant association between thyroid function and HOMA-IR. HOMA-IR cut-offs could predict the presence of T2DM.

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Cardiovascular Risk Factors in Metabolic Syndrome—Impact of Insulin Resistance on Lipids, Hypertension, and the Development of Diabetes and Cardiac Events

US Cardiology Review ◽

10.15420/usc.2005.2.1.35 ◽

2005 ◽

Vol 2 (1) ◽

pp. 35-38

Author(s):

Stuart W Zarich

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Cardiac Events

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Metabolic syndrome, insulin resistance and other cardiovascular risk factors in university students

Ciência & Saúde Coletiva ◽

10.1590/1413-81232015214.10472015 ◽

2016 ◽

Vol 21 (4) ◽

pp. 1123-1136 ◽

Cited By ~ 8

Author(s):

José Bonifácio Barbosa ◽

Alcione Miranda dos Santos ◽

Marcelo Mesquita Barbosa ◽

Márcio Mesquita Barbosa ◽

Carolina Abreu de Carvalho ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

University Students ◽

Cardiovascular Risk Factors ◽

Hdl Cholesterol ◽

Blood Collection ◽

Cross Sectional ◽

High Blood Glucose

Abstract A cross-sectional population-based study using questionnaire and anthropometric data was conducted on 968 university students of São Luís, Brazil, from which 590 showed up for blood collection. In the statistical analysis the Student t-test, Mann-Whitney and chi-square tests were used. The prevalence of metabolic syndrome by the Joint Interim Statement (JIS) criteria was 20.5%, almost three times more prevalent in men (32.2%) than in women (13.5%) (P < 0.001). The prevalence of insulin resistance was 7.3% and the prevalence of low HDL-cholesterol was high (61.2%), both with no statistically significant differences by sex. Men showed a higher percentage of smoking, overweight, high blood pressure, high blood glucose and increased fasting hypertriglyceridemia. Women were more sedentary. University students of private institutions had higher prevalences of sedentary lifestyle, obesity, abdominal obesity, elevated triglycerides and metabolic syndrome than students from public institutions. High prevalences of metabolic syndrome, insulin resistance and other cardiovascular risk factors were found in this young population. This suggests that the burden of these diseases in the future will be increased.

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We-P11:142 Effects of very low calorie diet (VLCD) on serum leptin, insulin resistance and cardiovascular risk factors in patients with metabolic syndrome

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)81496-0 ◽

2006 ◽

Vol 7 (3) ◽

pp. 377

Author(s):

E. Stokic ◽

D. Tomic ◽

B. Srdic ◽

T. Ivkovic-Lazar

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Very Low Calorie Diet ◽

Serum Leptin ◽

Low Calorie ◽

Low Calorie Diet ◽

Calorie Diet

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Association Between Insulin-like Growth Factor 1 and Insulin Resistance in Obese Prepubertal Boys: A Cross-sectional Study

10.21203/rs.3.rs-97454/v1 ◽

2020 ◽

Author(s):

Jiangying Kuang ◽

Li Zhang ◽

Yueqin Xu ◽

Jiang Xue ◽

Shuang Liang

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Cardiovascular Risk ◽

Growth Factor ◽

Cardiovascular Risk Factors ◽

Whole Body ◽

Sensitivity Index ◽

Insulin Like Growth Factor ◽

Prepubertal Boys ◽

The Relationship

Abstract Background: As one of the most common features of obesity, insulin resistance is central to the pathogenesis of the metabolic syndrome. Low insulin-like growth factor 1(IGF-1) levels have been proven to be associated with many traditional cardiovascular risk factors, but it still remains controversy with the relationship between IGF-1 and insulin resistance. Accordingly, the main purpose of this study is to investigate the relationship between IGF-1 and insulin resistance in obese prepubertal boys.Methods: We used whole body insulin sensitivity index (WBISI) to represent insulin resistance. 70 obese prepubertal boys were included in this study, and the obese subjects were divided into two groups by using 1.285 as a threshold value for WBISI. Clinical examination and laboratory examinations were assessed for all participants.Results: Among obese boys, the group of children with WBISI ≤1.285 had lower IGF-1 standard deviation scores (SDS) (p = 0.021) than WBISI >1.285 group. The results of multivariate stepwise regression analysis show that WBISI was positively correlated with IGF-1 SDS (β =1.726, p = 0.002) after adjusting for traditional cardiovascular risk factors.Conclusion: IGF-1 SDS was negatively associated with insulin resistance in obese prepubertal boys, independent of other traditional cardiovascular disease risk markers.

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Association between insulin-like growth factor 1 and insulin resistance in obese prepubertal boys:a cross-sectional study

10.21203/rs.3.rs-114624/v1 ◽

2020 ◽

Author(s):

Jiangying Kuang ◽

Li Zhang ◽

Yueqin Xu ◽

Jiang Xue ◽

Shuang Liang

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Cardiovascular Risk ◽

Growth Factor ◽

Cardiovascular Risk Factors ◽

Whole Body ◽

Sensitivity Index ◽

Insulin Like Growth Factor ◽

Prepubertal Boys ◽

The Relationship

Abstract Background As one of the most common features of obesity, insulin resistance is central to the pathogenesis of the metabolic syndrome. Low insulin-like growth factor 1(IGF-1) levels have been proven to be associated with many traditional cardiovascular risk factors, but it still remains controversy with the relationship between IGF-1 and insulin resistance. Accordingly, the main purpose of this study is to investigate the relationship between IGF-1 and insulin resistance in obese prepubertal boys.Methods We used whole body insulin sensitivity index (WBISI) to represent insulin resistance. 70 obese prepubertal boys were included in this study, and the obese subjects were divided into two groups by using 1.285 as a threshold value for WBISI. Clinical examination and laboratory examinations were assessed for all participants.Results Among obese boys, the group of children with WBISI ≤ 1.285 had lower IGF-1 standard deviation scores (SDS) (p = 0.021) than WBISI > 1.285 group. The results of multivariate stepwise regression analysis show that WBISI was positively correlated with IGF-1 SDS (β = 1.726, p = 0.002) after adjusting for traditional cardiovascular risk factors.Conclusion IGF-1 SDS was negatively associated with insulin resistance in obese prepubertal boys, independent of other traditional cardiovascular disease risk markers.

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