Multidetector Angio-CT and the Use of D-Dimer for the Diagnosis of Acute Mesenteric Ischemia in Geriatric Patients

IntroductionThe aim of this randomized controlled experimental study was to evaluate the efficacy of potassium, pH and D-dimer levels in blood, as well as potassium and pH levels in peritoneal lavage fluid, in the early diagnosis of acute mesenteric ischemia.Material and methodsThis study was conducted at the Istanbul University Center of Experimental Medicine after having received approval from the Istanbul University animal testing ethics committee. Male albino Wistar rats (n = 24; 250 to 350 g) were divided into two control groups and two ischemic groups. Levels of potassium, pH, and D-dimer in blood and levels of potassium and pH in peritoneal lavage fluid were analyzed for 1 h and 2 h after the induced acute mesenteric ischemia procedure. The degree of ischemic injury was determined using the histopathological damage score in tissue samples taken from the terminal ileum.ResultsIschemic groups had statistically significant differences in potassium and pH in blood and peritoneal lavage fluid compared to non-ischemic groups (p < 0.05). There was no significant difference between control and ischemic groups in terms of D-dimer and histologic grading results after 1 h (p = 0.132, p = 0.475 respectively), while there was a significant difference between control and ischemic groups after 2 h (p < 0.05).ConclusionsThe levels of potassium, pH, and D-dimer could be useful in daily practice for the early diagnosis of acute mesenteric ischemia.

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The correlation of the D-dimer test and biphasic computed tomography with mesenteric computed tomography angiography in the diagnosis of acute mesenteric ischemia

The American Journal of Surgery ◽

10.1016/j.amjsurg.2008.02.011 ◽

2009 ◽

Vol 197 (4) ◽

pp. 429-433 ◽

Cited By ~ 27

Author(s):

Hizir Akyildiz ◽

Alper Akcan ◽

Ahmet Oztürk ◽

Erdogan Sozuer ◽

Can Kucuk ◽

...

Keyword(s):

Computed Tomography ◽

Computed Tomography Angiography ◽

Mesenteric Ischemia ◽

Acute Mesenteric Ischemia ◽

D Dimer

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The value of combined elevation of D-dimer and neopterin as a predictive parameter for early stage acute mesenteric ischemia: An experimental study

Vascular ◽

10.1177/1708538116652267 ◽

2016 ◽

Vol 25 (2) ◽

pp. 163-169 ◽

Cited By ~ 3

Author(s):

Ali Kagan Coskun ◽

Zekai Halici ◽

Akgun Oral ◽

Yasin Bayir ◽

Ferhat Deniz ◽

...

Keyword(s):

Experimental Study ◽

Superior Mesenteric Artery ◽

Mesenteric Artery ◽

Mesenteric Ischemia ◽

Early Stage ◽

Acute Mesenteric Ischemia ◽

Artery Occlusion ◽

Control Group ◽

Blood Samples ◽

D Dimer

Background The diagnosis of acute mesenteric ischemia is variable. Early diagnosis is important for reducing the mortality and morbidity rates. Aim This experimental study aims to investigate the diagnostic utility of D-dimer and neopterin as a marker for the early stage of acute mesenteric ischemia caused by occlusion of superior mesenteric artery. Methods The levels of D-dimer and neopterin were measured using an animal acute mesenteric ischemia model in 21 male rabbits. Superior mesenteric artery occlusion (Group 1, n = 14) and control (Group 2, n = 7) groups were identified. Blood samples at different times are collected from each rabbits. Blood samples from superior mesenteric artery occlusion group were taken 30 min after anesthesia but before laparotomy, 1, 2, and 3 h after superior mesenteric artery ligation. Blood samples from control group were taken 1 h before, 1 and 3 h after anesthesia and laparotomy. The D-dimer and neopterin levels of each blood sample were measured. Results The probability of acute mesenteric ischemia was found to be 36 times higher when the D-dimer level was over 0.125 ng/L, whereas the probability was 19.2 times higher when the neopterin level was over 1.25 nmol/L. Conclusions In this experimental study, the combined elevation of two significant markers, D-dimer and neopterin, may be helpful for the early diagnosis of acute mesenteric ischemia.

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The place of D-dimer and L-lactate levels in the early diagnosis of acute mesenteric ischemia

Bratislava Medical Journal ◽

10.4149/bll_2015_094 ◽

2015 ◽

Vol 116 (05) ◽

pp. 343-350

Author(s):

B. Aydin ◽

M. Ozban ◽

M. Serinken ◽

B. Kaptanoglu ◽

N. C. Demirkan ◽

...

Keyword(s):

Early Diagnosis ◽

Mesenteric Ischemia ◽

Acute Mesenteric Ischemia ◽

Lactate Levels ◽

D Dimer

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The Value of D-Dimer in Diagnosis of Acute Mesenteric Ischemia and Differential Diagnosis from Acute Pancreatitis and Acute Cholecystitis

Dicle Medical Journal / Dicle Tip Dergisi ◽

10.5798/diclemedj.0921.2016.01.0644 ◽

2016 ◽

Vol 43 (1) ◽

Author(s):

Semih Hot ◽

Nüvit Duraker ◽

Ayhan Sarı ◽

Kenan Çetin

Keyword(s):

Acute Pancreatitis ◽

Differential Diagnosis ◽

Acute Cholecystitis ◽

Mesenteric Ischemia ◽

Acute Mesenteric Ischemia ◽

D Dimer

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Fibrinopeptide-A and fibrinopeptide-B may help to D-dimer as early diagnosis markers for acute mesenteric ischemia

Turkish Journal of Biochemistry ◽

10.1515/tjb-2018-0301 ◽

2019 ◽

Vol 44 (5) ◽

pp. 654-660

Author(s):

Murat Cikot ◽

Eyup Gemici ◽

Nilgun Isiksacan ◽

Osman Kones ◽

Pinar Kasapoglu ◽

...

Keyword(s):

Early Diagnosis ◽

Mesenteric Ischemia ◽

Acute Mesenteric Ischemia ◽

Control Group ◽

Albino Rats ◽

Fibrinopeptide A ◽

Mortality And Morbidity ◽

Ischemia Group ◽

Wistar Albino Rats ◽

D Dimer

Abstract Background The aim of this study was to investigate the importance of fibrinopeptide-A and fibrinopeptide-B, which occur during the formation of D-dimer, the most commonly used laboratory parameter, in the early diagnosis of acute mesenteric ischemia (AMI). Materials and methods This experimental study was performed in 30 male pathogen-free Wistar albino rats. The experimental animals were divided into 3 equal groups: Control group (n = 10), Sham group (n = 10) and Ischemia group (n = 10). Blood samples were taken 0, 1, 3, and 6 h after the simulation of mesenteric ischemia. Results Fibrinopeptide-A and fibrinopeptide-B levels increased significantly in the first 6 h in the ischemic group, similar to the increase in D-dimer levels. The statistical change between 0, 1, 3 and 6 h was more significant for fibrinopeptide-A and fibrinopeptide-B. Conclusion Fibrinopeptide-A and fibrinopeptide-B may be markers that can be used for early diagnosis of mesenteric ischemia, early diagnosis is highly important for decreasing mortality and morbidity.

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