scholarly journals Bioavailability and Dissolution Rate Enhancement of an Anticancer Drug Bicalutamide by Encapsulation into Mesoporous Silica Nanoparticles: Effects of Amine Functionalization and Caco-2 Cell Permeability Study

2020 ◽  
Vol 54 (3) ◽  
pp. 590-601
Author(s):  
Seema Saroj ◽  
Sadhana Rajput
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Dissolution Rate ◽  
Anticancer Drug ◽  
Mesoporous Silica Nanoparticles ◽  
Cell Permeability ◽  
Amine Functionalization ◽  
Rate Enhancement ◽  
Dissolution Rate Enhancement ◽  
Permeability Study

Tailoring the dissolution rate enhancement of aminoglutethimide by functionalization of MCM-41 silica: a hydrogen bonding propensity approach

RSC Advances ◽  
2015 ◽  
Vol 5 (4) ◽  
pp. 2592-2601 ◽  
Author(s):  
Raul-Augustin Mitran ◽  
Silviu Nastase ◽  
Cristian Matei ◽  
Daniela Berger
Keyword(s):  
Hydrogen Bonding ◽  
Mesoporous Silica ◽  
Dissolution Rate ◽  
Rate Enhancement ◽  
Dissolution Rate Enhancement ◽  
Chlorine Ions ◽  
Mcm 41

Chlorine ions can mediate the adsorption and enhance the dissolution release of aminoglutethimide from pristine and functionalized MCM-41 mesoporous silica.

Floating tablets from mesoporous silica nanoparticles

2014 ◽  
Vol 2 (47) ◽  
pp. 8298-8302 ◽  
Author(s):  
Prasanna Lakshmi Abbaraju ◽  
Anand kumar Meka ◽  
Siddharth Jambhrunkar ◽  
Jun Zhang ◽  
Chun Xu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Dissolution Rate ◽  
Mesoporous Silica Nanoparticles ◽  
Floating Tablets

Floating tablets were prepared using hydrophobic (curcumin) and hydrophilic (captopril) drug loaded mesoporous silica nanoparticles respectively, leading to an improved dissolution rate of curcumin and controlled release for captopril.

Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small-molecule anticancer drug co-delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16102-16112 ◽  
Author(s):  
Yang Fei ◽  
Menghuan Li ◽  
Yanan Li ◽  
Xuan Wang ◽  
Chencheng Xue ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
General Purpose

A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for the tumor-targeted delivery of genes and small-molecule anticancer drugs.

In vivo evaluation of an anticancer drug delivery system based on heparinized mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40103-40110 ◽  
Author(s):  
Qiang Wu ◽  
Ruifang Li ◽  
Chao Zhao ◽  
Jiejie Ren ◽  
Keyuan Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
In Vivo Evaluation ◽  
Anticancer Drug Delivery

MSNs-HP loaded with only a low amount of a drug (DOX0.3) achieve a similar antitumor efficacy to that of large doses of the drug (DOX2.0, 7-fold higher in dosage than DOX0.3).

Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 7061-7065 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Jasminka Mrđanović ◽  
Ivana Borišev ◽  
Sanja Milenković ◽  
Đorđe Janaćković ◽  
...  
Keyword(s):  
Folic Acid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drug ◽  
Mesoporous Silica Nanoparticles ◽  
Anticancer Therapy ◽  
Functionalized Mesoporous Silica ◽  
Anticancer Treatment

Fullerenol and anticancer drug loaded pores of folic acid-functionalized mesoporous silica nanoparticles are showcased for targeted anticancer treatment.

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