scholarly journals Antiproliferative Potential of Ethyl acetate Extract of Clerodendrum thomsoniae Balf.f. on DMBA-induced Breast Cancer in Female Sprague-dawley Rats

2021 ◽  
Vol 55 (1) ◽  
pp. 205-214
Author(s):  
VK Muhammed Ashraf ◽  
Kalaichelvan VK Kalaichelvan ◽  
Ragunathan R Ragunathan ◽  
Venkatachalam VV Venkatachalam
Keyword(s):  
Breast Cancer ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Effect of sorghum ethyl-acetate extract on benign prostatic hyperplasia induced by testosterone in Sprague–Dawley rats

2018 ◽  
Vol 82 (12) ◽  
pp. 2101-2108 ◽  
Author(s):  
Jae-Myun Ryu ◽  
Gwi Yeong Jang ◽  
Dongsun Park ◽  
Koan Sik Woo ◽  
Tae Myoung Kim ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Prostatic Hyperplasia ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Anticancer Potential of Ethyl Acetate Extract Fractions of Ipomoea horsfalliae Hook on DMBA- Induced Breast Cancer Model

2021 ◽  
Vol 12 (5) ◽  
pp. 6447-6459
Keyword(s):  
Breast Cancer ◽  
Ethyl Acetate ◽  
Blood Parameters ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Breast Cancer Model ◽  
Antioxidant Characteristics ◽  
Nitrate And Nitrite ◽  
Breast Tissues

The genus Ipomoea is distributed globally and honored as the largest genus of the family Convolvulaceae. Several varieties of this family have been shown to be effective in treating various diseases, including cancer. This research aimed to explore the anticancer activity of ethyl acetate fractions of Ipomoea horsfalliae Hook (EAIH) in female Sprague-Dawley rats. 7, 12-dimethylbenz (a) anthracene (DMBA) was used to produce breast cancer. The Fractions were selected based on the cytotoxicity analysis in vitro, which was reported in our earlier studies. The study employed two dosages of EAIH (25 and 50 mg/kg). Biochemical, hematological, and antioxidant characteristics were investigated. A decrease in mean tumor volume and tumor weight was detected in EAIH treated groups. The blood parameters were seen as normal. In both DMBA and doxorubicin groups, malondialdehyde was increased, and the level was significantly reduced in EAIH-treated groups. The effect of catalase was shown to be diminished in the groups given DMBA and doxorubicin but normal in the EAIH groups. Nitrate and nitrite levels increased in the DMBA control groups but were normal in the others. There was less necrosis and infiltration in breast tissues treated with doxorubicin as well as in EAIH. In animals treated with EAIH, the therapeutic effect was found to be dose-dependent. The therapies helped to repair some of the altered breast patterns. The study concludes that I. horsfolliae may be a potential anticancer candidate and need to explore further.

scholarly journals Correction: Ou-Yang, F. et al. Antiproliferation for Breast Cancer Cells by Ethyl Acetate Extract of Nepenthes thorellii x (ventricosa x maxima). Int. J. Mol. Sci. 2019, 20, 3238

2021 ◽  
Vol 22 (2) ◽  
pp. 668
Author(s):  
Fu Ou-Yang ◽  
I-Hsuan Tsai ◽  
Jen-Yang Tang ◽  
Ching-Yu Yen ◽  
Yuan-Bin Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethyl Acetate ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Ethyl Acetate Extract ◽  
Published Paper

The authors would like to make corrections to their published paper [...]

scholarly journals Exploration of anti-breast cancer effects of Terminalia chebula extract on DMBA-induced mammary carcinoma in Sprague Dawley rats

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Deena Priscilla Henry ◽  
Jasmine Ranjan ◽  
Rajesh Kumar Murugan ◽  
Annapoorani Sivanantham ◽  
Manikandan Alagumuthu
Keyword(s):  
Breast Cancer ◽  
Plant Extract ◽  
Mammary Carcinoma ◽  
Future Perspective ◽  
Terminalia Chebula ◽  
Sprague Dawley ◽  
Analytical Technique ◽  
Isolation And Characterization ◽  
Sprague Dawley Rats ◽  
Mcf 7

Abstract Background Plant extracts are effectively acting as the natural medicinal cocktail, non-side effective, efficacious, and freely available. The present study aimed to unveil the pharmacological and medicinal effects of Terminalia chebula plant extract in 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinoma in Sprague Dawley rats. The plant extract obtained was subjected to in vivo antioxidant and anticancer studies in various concentrations after an analytical technique such as FTIR, GCMS, and HPLC-based chemo-profiling in Sprague Dawley rats. Results Apart from the antiproliferative effect on breast cancer cell line (MCF-7) and normal breast epithelial cells (MCF-10a), we have measured the changes in body weight, along with other tumor parameters such as tumor volume, tumor incidence, tumor weight, tumor burden, serum biochemical parameters, and histopathological findings of breast tissue. As the oxidative stress further enhances the development of cancer, the antioxidant property of the plant extract demonstrates its use against cancer treatment. One hundred fifty milligrams per milliliter (IC50 250 μg/mL) concentration of the ethanolic extract was vital for the proliferation of MCF-7 cell lines (Fig. 7a). Meanwhile, 300 μg/mL (IC50 150 μg/mL) was an effective dose to attain a maximum HDAC inhibition of 78%. Also, the normal liver and kidney functioning revealed the non-toxicity nature of the plant. Conclusion Terminalia chebula could be one of the effective naturally obtained anti-breast cancer medications. Isolation and characterization of individual bioactive compounds of T. chebula would be the future perspective.

Preventive effect of berberine against DMBA-induced breast cancer in female Sprague Dawley rats

2017 ◽  
Vol 92 ◽  
pp. 207-214 ◽  
Author(s):  
Kalyani Chowdary Karnam ◽  
Maheswara Ellutla ◽  
Lakshmi Narendra Bodduluru ◽  
Eshvendar Reddy Kasala ◽  
Shravan Kumar Uppulapu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Preventive Effect ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal Preparation, in 7,12-Dimethylbenz(a)Anthracene-Induced Breast Cancer Rats

2015 ◽  
Vol 20 (4) ◽  
pp. 259-268 ◽  
Author(s):  
Ayyakkannu Purushothaman ◽  
Elumalai Nandhakumar ◽  
Palanivelu Shanthi ◽  
Thiruvaiyaru Panchanatham Sachidanandam
Keyword(s):  
Breast Cancer ◽  
Mammary Carcinoma ◽  
Nuclear Antigen ◽  
Herbal Preparation ◽  
Sprague Dawley ◽  
Protein Levels ◽  
Anticancer Effects ◽  
Sprague Dawley Rats ◽  
Apoptotic Effects ◽  
Proliferating Cell

A herbal preparation, Shemamruthaa (SM), was formulated to investigate the molecular mechanism by which it exhibits anticancer effects in mammary carcinoma bearing rats. Female Sprague-Dawley rats were used for the study, and mammary carcinoma was induced by administration of 7,12-dimethylbenz( a)anthracene, intragastrically. After 3 months of induction period, the rats were treated with SM (400 mg/kg body weight) for 14 days. Our study shows that SM-treated mammary carcinoma rats showed regression in tumor volume with concomitant increase in p53, Bax, caspase-3, and caspase-9 mRNA and protein levels compared with mammary carcinoma–induced rats. Proliferating cell nuclear antigen and anti-apoptotic Bcl-2 were markedly increased in mammary carcinoma–induced rats, whereas the SM treatment significantly decreased the expression of these proteins. The expression pattern of apoptotic signaling molecules analyzed in the present study signifies the therapeutic efficacy of SM against breast cancer.

Effects of Dehydroepiandrosterone on MNU-Induced Breast Cancer in Sprague-Dawley Rats

2006 ◽  
Vol 774 (1) ◽  
pp. 340-341 ◽  
Author(s):  
R. A. LUBET ◽  
D. M. McCORMICK ◽  
G. M. GORDON ◽  
C. GRUBBS ◽  
X-D LEI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Crude ethyl acetate extract of marine microalga,Chaetoceros calcitrans, induces Apoptosis in MDA-MB-231 breast cancer cells

2014 ◽  
Vol 10 (37) ◽  
pp. 1 ◽  
Author(s):  
SuPeng Loh ◽  
Noorjahan BanuMohamed Alitheen ◽  
SuHua Goh ◽  
FatimahMd Yusoff ◽  
SweeKeong Yap
Keyword(s):  
Breast Cancer ◽  
Ethyl Acetate ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Ethyl Acetate Extract ◽  
Marine Microalga ◽  
Chaetoceros Calcitrans

scholarly journals Dietary effect of mead acid on DMBA‑induced breast cancer in female Sprague‑Dawley rats

2020 ◽  
Vol 1 (2) ◽  
pp. 1-1
Author(s):  
Yuichi Kinoshita ◽  
Masahiro Yoshioka ◽  
Yuko Emoto ◽  
Takashi  Yuri ◽  
Michiko Yuki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sprague Dawley ◽  
Mead Acid ◽  
Sprague Dawley Rats
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