Time-Dependent Evaluation Of The Antibacterial And Phytochemical Properties Of Vernonia Amygdalina And Gongronema Latifolium

10.5580/2cb2 ◽  
2012 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Time Dependent ◽  
Vernonia Amygdalina ◽  
Gongronema Latifolium

scholarly journals Co-administration of Rauwolfia vomitoria with Gongronema latifolium or Vernonia amygdalina on spatial learning, memory, and some bio-molecules

2015 ◽  
Vol 7 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Moses B Ekong ◽  
Aniekan I Peter ◽  
Ubong U Ekpene
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Psychotic Disorders ◽  
Acute Effect ◽  
Tween 20 ◽  
Spatial Learning And Memory ◽  
Vernonia Amygdalina ◽  
Male Wistar Rats ◽  
Gongronema Latifolium ◽  
Rauwolfia Vomitoria

Background: Rauwolfia vomitoria is a plant with sedative properties found useful in the management of psychotic disorders, with adverse effects being reported on its use in different brain areas.Aims and Objectives: To investigate the acute effect of combination of Rauwolfia vomitoria with either Gongronema latifolium or Vernonia amygdalina on spatial learning and memory, and some bio-molecules in rats.Materials and Methods: 24 adult male Wistar rats weighing between 220 g - 300 g were equally divided into four groups (1-4). Group 1 animals were the control treated with 0.5 ml of Tween 20. Groups 2, 3 and 4 animals were administered respectively; 150 mg/kg of R. vomitoria, a combination of 150 mg/kg of R. vomitoria and 200 mg/kg of G. latifolium, and a combination of 150 mg/kg of R. vomitoria and 200 mg/kg of V. amygdalina for seven days. On days 4-7 concurrent with treatment, spatial learning and memory test was carried out using the Morris water maze, and the animals were sacrificed twelve hours after the last treatment. Their sera were used for enzyme and other bio-molecules analysis.Results: There was no difference in spatial learning and memory. The activities of aspartate aminotrans­ferase, alanine aminotrans­ferase and alkaline phos­phatase, and the serum cholesterol and triglycerides levels were also not different compared to the control group.Conclusion: The dose and duration of administration of the extract of R. vomitoria either alone, or in combination with G. latifolium or V. amygdalina may not affect spatial learning or memory, or alter serum biomolecules.Asian Journal of Medical Sciences Vol.7(1) 2015 82-87

scholarly journals BITTER HERBS OF EASTERN NIGERIA (GONGRONEMA LATIFOLIUM, VERNONIA AMYGDALINA AND VITEX DONIANA): A REVIEW

2018 ◽  
Vol 15 (3) ◽  
pp. 47
Author(s):  
Asuzu Chinwe U.
Keyword(s):  
Key Words ◽  
Traditional Method ◽  
Human Consumption ◽  
Vernonia Amygdalina ◽  
South Eastern ◽  
Electronic Search ◽  
Anti Cancer ◽  
Large Audience ◽  
Vitex Doniana ◽  
Gongronema Latifolium

Background: The article is a review of three bitter vegetables consumed in South-eastern Nigeria (Gongronema latifolium, Vernonia amygdalina and Vitex doniana). These vegetables are not very palatable to taste but are highly famed because of the myriad of illnesses that they are reputed to cure and manage. The different aspects of these vegetables reviewed are their ethnobotany, zoo pharmacology, bioactivity, phytochemistry and toxicity. Materials and method: The literatures consulted were searched using electronic search engines (Google, Google scholar and Pubmed). Substantial amount of literature was consulted but only those directly related to the main review were selected. Result: The review revealed that the three bitter vegetables possessed phytochemicals like saponins, flavonoids, alkaloids among others that justify the claims of curing and managing many of the illnesses that traditional folks attribute to them. From literature, antimicrobial, antinflammatory, antidiabetic, antioxidant and anti cancer activities were attributed to these three bitter herbs. Antinutritional substances like phytate and oxalate reported in these herbs were not regarded as harmful for human consumption because of the traditional method of processing the vegetables by squeeze washing in several changes of water. Conclusion: The three bitter herbs are regarded as beneficial for human consumption and the information should be disseminated to a large audience. Key words: V. amygdalina, V. doniana, G.

scholarly journals Comparative Studies on the Responses of Some Biochemical Markers in Immuno-Suppressed Rats Treated with Gongronema latifolium and Vernonia amygdalina Ethanol Leaf Extract

2016 ◽  
Vol 10 (1) ◽  
pp. 8-15
Author(s):  
Ukegbu Chimere Young ◽  
Joshua Parker Elijah ◽  
Eze Chuma ◽  
Akabike Chigozie Adrain ◽  
Igwe Chinagolum Arinzechuk
Keyword(s):  
Comparative Studies ◽  
Biochemical Markers ◽  
Leaf Extract ◽  
Vernonia Amygdalina ◽  
Gongronema Latifolium

scholarly journals Comparative Analysis of Phytochemical Composition of Four Selected Tropical Medicinal Plants Namely: Ocimum gratissimum, Piper guineense, Gongronema latifolium and Vernonia amygdalina

2019 ◽  
pp. 1-11 ◽  
Author(s):  
Bob I. A. Mgbeje ◽  
Ezekiel Udo Umoh ◽  
Christine Emmanuel-Ikpeme
Keyword(s):  
Comparative Analysis ◽  
Quantitative Analysis ◽  
Medicinal Plants ◽  
Qualitative And Quantitative Analysis ◽  
Vernonia Amygdalina ◽  
Piper Guineense ◽  
Qualitative And Quantitative ◽  
Ocimum Gratissimum ◽  
Phytochemical Composition ◽  
Gongronema Latifolium

Aim: The aim of the study was to carry out a comparative analysis of the phytochemical composition of the leaves of four selected tropical medicinal plants namely: Ocimum gratissimum, Piper guineense, Gongronema latifolium and Vernonia amygdalina. Methodology: The phytochemicals in the plant leaves were extracted by cold maceration in ethanol and subjected to both qualitative and quantitative analysis of the phytochemicals. Results: The qualitative and quantitative analysis revealed the presence of the bioactive compounds alkaloids, Saponins, flavonoids, steroids, glycosides, terpenoids, polyphenols, specific cardiac glycosides, tannins, phytates and reducing compound in the leaves of each plant at varying quantities. Resins were only detected in O. gratissimum. From the quantitative analysis, Gongronema latifolium had the highest percentage content of alkaloids, glycosides, saponins, tannins and reducing sugars. Ocimum gratissimum had the highest flavonoid content. Conclusion: Taken together, G. latifolium on balance had a higher phytochemical content than the other three plants and thus should be more versatile in the treatment of a whole range of diseases. This was followed by V. amygdalina, O. gratissimum and P. guineense in that order. The fact that most of these phytochemicals have antioxidant activity may be responsible for their antidiabetic activities and use in treatment of other free radical prone diseases.

scholarly journals Determination of Some Biochemical Parameters in Streptozotocin-Induced Diabetic Albino Rats Pre-Treated and Post-Treated with Vernonia amygdalina and Gongronema latifolium Extracts

2019 ◽  
pp. 1-12
Author(s):  
Ibifiri Bristol ◽  
Ebirien-Agana Samuel Bartimaeus ◽  
Holy Brown
Keyword(s):  
Diabetes Mellitus ◽  
Biochemical Parameters ◽  
Density Lipoprotein ◽  
Treatment Phase ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Albino Rats ◽  
Vernonia Amygdalina ◽  
Atherogenic Index Of Plasma ◽  
Gongronema Latifolium

The use of herbs in the management of diabetes mellitus and its complications have been reported. This study was thus aimed at determining the levels of some biochemical parameters in streptozotocin-induced diabetic albino rats pre-treated and post-treated with Vernonia amygdalina and Gongronema latifolium extracts. Fifty (50) albino rats weighing between 150 – 250 g were used for this study. 25 albino rats were used for each phase of the treatment. The pre-treatment phase involved the treatment of the rats with 400 mg/kg b.w (singly) and 200 mg/kg b.w (combined) extracts for 14 days, after which diabetes mellitus was induced using streptozotocin before the rats were sacrificed. The post-treatment phase involved the inducement of diabetes with streptozotocin after which the rats were treated with 400 mg/kg b.w (singly) and 200 mg/kg b.w (combined) extracts for 28 days before the animals were sacrificed. Blood was collected via cardiac puncture and plasma/serum was collected. Total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined using standard procedures while glucose was measured with a glucometer. Cardiovascular risk ratios such as Castelli risk ratio I and II and atherogenic index of plasma were also calculated. Results showed that extracts of V. amygdalina (only), G. latifolium (only) and V.A+ GL (combined)significantly (p<0.05) reduced the TC, LDL-C , FBS, MDA and TAC levels while HDL-C level significantly (p<0.05) increased. The cardiac risk indices (CRI-I and CRI-II, and Atherogenic index of plasma (AIP) in both the pre-treated and post-treated rats were also reduced when compared to diabetic control. It is thus evident that these plants’ extracts possess hypoglycaemic, hypolipidaemic, and antioxidant properties and thus could be used to reduce cardiovascular risks. Therefore, the tradomedicinal use of these plants in the management of cardiovascular complications is highly recommended.

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