scholarly journals The effect of mineral fertilization on the content of phenolic acids and mass of roots of Salvia miltiorrhiza Bunge

2013 ◽  
Vol 57 (1-2) ◽  
pp. 169-173
Author(s):  
Waldemar Buchwald
Keyword(s):  
Phenolic Acids ◽  
Salvia Miltiorrhiza ◽  
Dry Mass ◽  
Pure Component ◽  
Average Content ◽  
Atmospheric Conditions ◽  
Salvia Miltiorrhiza Bunge ◽  
Mineral Fertilization ◽  
Component Content ◽  
One Year

Research on the mineral fertilization of Salvia miltiorrhiza Bunge was carried out in the years 2000 - 2002. It was stated that the potassium fertilization has the strongest effect on the content of phenolic acids and on mass of roots of <i>Salvia miltiorrhiza</i>. The effect of atmospheric conditions in particular years is also essential. The optimal doses of fertilizers (pure component content in kg · ha<sup>-</sup>) were the following: N - 100, P<sub>2</sub>O<sub>5</sub> - 30, K<sub>2</sub>0 - 180. Having used this fertilizing combination the average content of phenolic acids was 4,62% and the average aerial dry mass of roots was 13,21 g per 1 plant after one year of cultivation.

scholarly journals Diterpenoid Tanshinones and Phenolic Acids from Cultured Hairy Roots of Salvia miltiorrhiza Bunge and Their Antimicrobial Activities

Molecules ◽  
2011 ◽  
Vol 16 (3) ◽  
pp. 2259-2267 ◽  
Author(s):  
Jianglin Zhao ◽  
Jingfeng Lou ◽  
Yan Mou ◽  
Peiqin Li ◽  
Jianyong Wu ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Hairy Roots ◽  
Salvia Miltiorrhiza ◽  
Antimicrobial Activities ◽  
Salvia Miltiorrhiza Bunge

Quantitative determination and validation of four phenolic acids in Salvia Miltiorrhiza Bunge using 1H-NMR spectroscopy

2019 ◽  
Vol 16 ◽  
Author(s):  
Zhuoni Hou ◽  
Zongsuo Liang ◽  
Yuanyuan Li ◽  
Feng Su ◽  
Jipeng Chen ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
Phenolic Acids ◽  
Rosmarinic Acid ◽  
1H Nmr Spectroscopy ◽  
Salvia Miltiorrhiza ◽  
Salvianolic Acid B ◽  
Salvia Miltiorrhiza Bunge ◽  
Salvianolic Acid ◽  
Root Extracts

Background: Although chromatography and spectrometry based methods have been used to analyse phenolic acids in Chinese traditional medicine Salvia miltiorrhiza Bunge (SMB), quantitative nuclear magnetic resonance (qNMR) has never previously been used to analyse fresh SMB root extracts. Objective: To establish a fast and simple method of quantitating danshensu, lithospermic acid, rosmarinic acid and salvianolic acid B content in fresh SMB root using 1H-NMR spectroscopy. Method: Fresh SMB root were extracted using a 70% methanol aqueous solution and quantitatively analysed for danshensu, lithospermic acid, rosmarinic acid and salvianolic acid B using 1H-NMR spectroscopy. Different internal standards were compared and the results were validated using high performance liquid chromatography. Results: The established method was accurate and precise with good recovery. The LOD and LOQ indicated the excellent sensitivity of the method. The robustness was testified by modification of four different parameters, and the differences among each parameter were all less than 2%. Conclusion: qNMR offers a fast, reliable and accurate method of identifying and quantifying danshensu, lithospermic acid, rosmarinic acid and salvianolic acid B in fresh SMB root extracts.

Downregulation of Cinnamoyl CoA Reductase Affects Lignin and Phenolic Acids Biosynthesis in Salvia miltiorrhiza Bunge

2012 ◽  
Vol 30 (5) ◽  
pp. 1229-1236 ◽  
Author(s):  
Zhengjun Wang ◽  
Langjun Cui ◽  
Chen Chen ◽  
Xiaojing Liu ◽  
Yaping Yan ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Salvia Miltiorrhiza ◽  
Salvia Miltiorrhiza Bunge ◽  
Cinnamoyl Coa Reductase ◽  
Coa Reductase

scholarly journals Systematic Analysis of Kelch Repeat F-box (KFB) Protein Family and Identification of Phenolic Acid Regulation Members in Salvia miltiorrhiza Bunge

Genes ◽  
2020 ◽  
Vol 11 (5) ◽  
pp. 557
Author(s):  
Haizheng Yu ◽  
Mengdan Jiang ◽  
Bingcong Xing ◽  
Lijun Liang ◽  
Bingxue Zhang ◽  
...  
Keyword(s):  
Secondary Metabolism ◽  
Phenolic Acids ◽  
Salvia Miltiorrhiza ◽  
Chinese Herb ◽  
Cerebrovascular Diseases ◽  
Regulation Mechanism ◽  
Salvia Miltiorrhiza Bunge ◽  
Specific Expression ◽  
Systematic Analysis ◽  
Meja Treatment

S. miltiorrhiza is a well-known Chinese herb for the clinical treatment of cardiovascular and cerebrovascular diseases. Tanshinones and phenolic acids are the major secondary metabolites and significant pharmacological constituents of this plant. Kelch repeat F-box (KFB) proteins play important roles in plant secondary metabolism, but their regulation mechanism in S. miltiorrhiza has not been characterized. In this study, we systematically characterized the S. miltiorrhiza KFB gene family. In total, 31 SmKFB genes were isolated from S. miltiorrhiza. Phylogenetic analysis of those SmKFBs indicated that 31 SmKFBs can be divided into four groups. Thereinto, five SmKFBs (SmKFB1, 2, 3, 5, and 28) shared high homology with other plant KFBs which have been described to be regulators of secondary metabolism. The expression profile of SmKFBs under methyl jasmonate (MeJA) treatment deciphered that six SmKFBs (SmKFB1, 2, 5, 6, 11, and 15) were significantly downregulated, and two SmKFBs (SmKFB22 and 31) were significantly upregulated. Tissue-specific expression analysis found that four SmKFBs (SmKFB4, 11, 16, and 17) were expressed preferentially in aerial tissues, while two SmKFBs (SmKFB5, 25) were predominantly expressed in roots. Through a systematic analysis, we speculated that SmKFB1, 2, and 5 are potentially involved in phenolic acids biosynthesis.

Synthesis and Biological Activity Study of Tanshinone Derivatives: A Literature and Patent Review

2020 ◽  
Vol 20 (28) ◽  
pp. 2520-2534
Author(s):  
He Huang ◽  
Chuanjun Song ◽  
Junbiao Chang
Keyword(s):  
Biological Activity ◽  
Herbal Medicine ◽  
Chemical Synthesis ◽  
Bioactive Compounds ◽  
Chinese Herbal Medicine ◽  
Salvia Miltiorrhiza ◽  
Salvia Miltiorrhiza Bunge ◽  
Chinese Herbal ◽  
Patent Review

: Tanshinones are a class of bioactive compounds present in the Chinese herbal medicine Danshen (Salvia miltiorrhiza Bunge), containing among others, abietane diterpene quinone scaffolds. Chemical synthesis and biological activity studies of natural and unnatural tanshinone derivatives have been reviewed in this article.

scholarly journals Network Biology Approach to Identify the Active Ingredients, Potential Targets, and Signaling Pathways in Phellinus Baumii and Salvia Miltiorrhiza Bunge on Vascular Health (P15-025-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yeni Lim ◽  
Oran Kwon
Keyword(s):  
Clinical Trial ◽  
Signaling Pathways ◽  
Platelet Activation ◽  
Vascular Dysfunction ◽  
Salvia Miltiorrhiza ◽  
Network Biology ◽  
Vascular Health ◽  
Salvia Miltiorrhiza Bunge ◽  
Phellinus Baumii ◽  
Target Molecules

Abstract Objectives Increasing attention has been paid to a range of botanical food supplement that help to maintain vascular health. Multiple components in botanical foods are expected to be working in concert with various targets. In a previous our animal study, Phellinus baumii and Salvia miltiorrhiza Bunge (PS) ameliorated endothelial and vascular dysfunction in a platelet activation rat model. This study aimed to provide the components, target molecules, phenotypes, signaling pathways, and investigate the mechanism of PS on vascular health. Methods Network biology analysis was based on the data from two clinical trials. The first clinical trial was performed in healthy subjects using high-fat-induced vascular dysfunction model. The second clinical trial was performed in healthy smokers. Differential markers obtained from clinical data, Affymetrix microarray, metabolomics, together with ingredient of PS, were mapped onto the network platform termed the context-oriented directed associations. A network of “component-target-phenotype-pathway” was constructed. Results The resulting vascular health network demonstrates that the components of PS are linked various target molecules for adhesion molecule production, platelet activation, endothelial inflammation, vascular dilation, and mitochondrial metabolism and detoxification, implicated with various metabolic pathways. Conclusions Using network biology methods, this study revealed the components and their target molecules, phenotypes, signaling pathways and provided wider information to support the synergistic mechanisms of PS on vascular health. Funding Sources This research was funded by the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science & ICT and the BK21PLUS of the National Research Foundation.

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