Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis: updated meta-analysis

2015 ◽  
Vol 19 (7) ◽  
pp. 841-849 ◽  
Author(s):  
C-P. Li ◽  
Y. Zhou ◽  
X. Xiang ◽  
Y. Zhou ◽  
M. He
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Relationship Of ◽  
I Gene

scholarly journals Association between toll-like receptors 9 (TLR9) gene polymorphism and risk of pulmonary tuberculosis: meta-analysis

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Zhi Chen ◽  
Wei Wang ◽  
Jianqin Liang ◽  
Jinhe Wang ◽  
Shisheng Feng ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Toll Like Receptors ◽  
Tlr9 Gene

scholarly journals Relationship of the p22phox (CYBA) Gene Polymorphism C242T with Risk of Coronary Artery Disease: A Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e70885 ◽  
Author(s):  
Zhijun Wu ◽  
Yuqing Lou ◽  
Wei Jin ◽  
Yan Liu ◽  
Lin Lu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Artery Disease ◽  
Relationship Of ◽  
Cyba Gene

scholarly journals IFN-γ +874 A>T (rs2430561) gene polymorphism and risk of pulmonary tuberculosis: a meta-analysis

2021 ◽  
Vol 17 (1) ◽  
pp. 177-188
Author(s):  
Mohammed Areeshi ◽  
Raju Mandal ◽  
Sajad Dar ◽  
Arshad Jawed ◽  
Mohd Wahid ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Asian Population ◽  
Caucasian Population ◽  
Genetic Models ◽  
Web Databases ◽  
Ifn Γ ◽  
Reduced Risk

IntroductionThe role of interferon gamma (IFN-γ) +874 A>T (rs2430561) gene polymorphism has been evaluated in different ethnicities with pulmonary tuberculosis (PTB) infection, and inconsistent results have been reported. In this study, a meta-analysis was performed to determine the precise association between IFN-γ +874 A>T gene polymorphism and PTB susceptibility.Material and methodsA total of 21 studies comprising 4281 confirmed PTB cases and 5186 healthy controls were included in this meta-analysis by searching the PubMed (Medline), EMBASE, and Google Scholar web-databases.ResultsWe observed reduced risk of PTB in allelic contrast (T vs. A: p = 0.001; OR = 0.818, 95% CI: 0.723–0.926), homozygous (TT vs. AA: p = 0.017; OR = 0.715, 95% CI: 0.543–0.941), heterozygous (AT vs. AA: p = 0.002; OR = 0.782, 95% CI: 0.667–0.917), dominant (TT+AT vs. AA: p = 0.002; OR = 0.768, 95% CI: 0.652–0.906), and recessive (TT vs. AA+AT: p = 0.042; OR = 0.802, 95% CI: 0.649–0.992) genetic models. In ethnicity-wise subgroup analysis, reduced risk of PTB was found in the Caucasian population. However, we did not find an association with any of the genetic models in the Asian population.ConclusionsIn conclusion, the IFN-γ +874 A>T gene polymorphism is significantly associated with reduced risk of PTB, showing a protective effect in the overall and in the Caucasian population. However, this polymorphism is not associated with PTB risk in the Asian population.

scholarly journals TLR2 Arg753Gln Gene Polymorphism Associated with Tuberculosis Susceptibility: An Updated Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Lelin Hu ◽  
Huihui Tao ◽  
Xinrong Tao ◽  
Xiaolong Tang ◽  
Congjing Xu
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Sample Type ◽  
Case Control Studies ◽  
Online Databases ◽  
Toll Like Receptor 2 ◽  
Mixed Populations ◽  
Stratified Analysis

Objective. To date, a series of studies were conducted to investigate the association between TLR2 (Toll-like receptor 2) Arg753Gln gene polymorphism and tuberculosis (TB). However, the results were inconsistent. This meta-analysis was performed to elucidate the roles of TLR2 Arg753Gln gene polymorphism in TB. Methods. All available articles were searched from online databases such as PubMed, Medline, CNKI, and Wanfang. Statistical analyses were performed using the STATA12.0 (Stata Corp LP, College Station, TX, United States) software. Results. 32 case-control studies comprising 5943 cases and 5991 controls were identified in this meta-analysis. Overall, the TLR2 Arg753Gln gene polymorphism was associated with high TB risk in allele model (A vs. G: OR=2.20, 95%CI=1.60-3.04, P≤0.01), dominant model (AA+AG vs. GG: OR=2.70, 95%CI=2.00-3.65, P≤0.01), and heterozygote model (AG vs. GG contrast: OR=2.97, 95%CI=2.39-3.69, P≤0.01). Subgroup analysis by ethnicity indicated that the A allele increased susceptibility to TB in Asian (OR=3.35, 95%CI=2.36-4.74) and Caucasian populations (OR=2.62, 95%CI=1.77-3.87), but not in African (2.08, 95%CI=0.62-2.72) or mixed populations (OR=0.76, 95%CI=0.36-1.14). Stratified analysis by sample type suggested that the A allele associated with high pulmonary tuberculosis (PTB) risks (OR=2.43, 95%CI=1.66-3.54), but not with extra pulmonary tuberculosis (EPTB) (OR=1.84, 95%CI=0.83-4.06). Conclusion. this meta-analysis suggested the following: (1) TLR2 Arg753Gln polymorphism is significantly associated with high TB risk. (2) In subgroup analysis based on ethnicity, TLR2 Arg753Gln polymorphism elevates the risk of TB in Asian and Caucasian populations, but not in African or mixed populations. (3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB.

Meta Analysis: Relationship Of Ventilation And Lighting With The Event Of Pulmonary Tuberculosis

2021 ◽  
Vol 11 (7) ◽  
pp. 108-121
Author(s):  
Rina Haryati ◽  
Mohammad Isa ◽  
Lenie Marlinae ◽  
Husaini . ◽  
Eko Suhartono
Keyword(s):  
Pulmonary Tuberculosis ◽  
Meta Analysis ◽  
Relationship Of

scholarly journals IL-10 -1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis

2017 ◽  
Vol 37 (5) ◽  
Author(s):  
Mohammed Y. Areeshi ◽  
Raju K. Mandal ◽  
Sajad A. Dar ◽  
Arshad Jawed ◽  
Mohd Wahid ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Caucasian Population ◽  
Genetic Models ◽  
African Population ◽  
Web Databases ◽  
Potential Association ◽  
Increased Risk ◽  
Quantitative Synthesis

Background: Earlier studies have shown that interlukin-10 (IL-10) -1082 A>G gene polymorphism is implicated in susceptibility to pulmonary tuberculosis (PTB), but their results are inconsistent and inconclusive. In the present study, a meta-analysis was performed to analyze the potential association between IL-10 -1082 A>G gene polymorphism and PTB susceptibility.Methods: A quantitative synthesis was done using PubMed (Medline), EMBASE, and Google Scholar web databases search and meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models.Results: A total of 22 eligible studies comprising 4956 PTB cases and 6428 healthy controls were included in the analysis. We did not observe any increased or decreased risk of PTB in allelic contrast (G vs. A: P=0.985; OR = 1.001, 95% CI = 0.863–1.162), homozygous (GG vs. AA: P=0.889; OR = 1.029, 95% CI = 0.692–1.529), heterozygous (GA vs. AA: P=0.244; OR = 0.906, 95% CI = 0.767–1.070), dominant (GG + AG vs. AA: P=0.357; OR = 1.196, 95% CI = 0.817–1.752), and recessive (GG vs. AA + AG: P=0.364; OR = 0.921, 95% CI = 0.771–1.100) genetic models. Likewise, no association of IL-10 -1082 A>G polymorphism with PTB risk was observed in Asian and African population for all the genetic models. Interestingly, the dominant model (GG + AG vs. AA: P=0.004; OR = 1.694, 95% CI = 1.183–2.425) demonstrated increased risk of PTB in Caucasian population.Conclusions: This meta-analysis concludes that IL-10 -1082 A>G gene polymorphism is not significantly associated with overall, Asian and African population. However, this polymorphism is associated with Caucasian population.

Relationship Of Patient's Motivation Concerning Prevention Of Transmission With Compliance With The Use Of Mask On Lung Tuberculosis Patients

2018 ◽  
Vol 6 (2) ◽  
pp. 30-35
Author(s):  
Ade Ella Nur Rizky Oktaviyanti
Keyword(s):  
Pulmonary Tuberculosis ◽  
Health Center ◽  
Disease Transmission ◽  
Positive Direction ◽  
Individual Motivation ◽  
Tuberculosis Patients ◽  
Correlation Test ◽  
Patient Motivation ◽  
Relationship Of ◽  
The Relationship

One of the factors that influence compliance is individual motivation. There are still many pulmonary tuberculosis patients who do not wear masks, this can have an impact on disease transmission. Poor individual motivation can affect someone's compliance. The purpose of this research is to determine the relationship of patient motivation regarding prevention of transmission with adherence to the use of masks in patients with pulmonary tuberculosis in Rambipuji Health Center, Jember Regency. This research uses descriptive correlative type of research. In this study using a cross-sectional approach. The sample of this study was taken using simple random sampling, namely pulmonary tuberculosis patients at the Rambipuji Health Center in Jember Regency, totaling 105 patients but only 50 patients were used as samples. This research was conducted by giving a questionnaire to pulmonary tuberculosis patients to find out the patient's motivation about preventing transmission by adhering to the use of masks. The results of the study were analyzed using the Lambda Correlation Test, the results of the analysis found that the motivation of patients was good motivation (22%), patient motivation was sufficient (56%), and patient motivation was less motivation (22%). Whereas adherence to the use of masks in pulmonary tuberculosis patients is compliant (36%), and non-compliant (64%). The Lambda Correlation Test results obtained from the variable compliance with ρ = 0.389 positive direction with a value of ρ count of 0.027 <0.05 which means there is a relationship between patient motivation about prevention of transmission with compliance with the use of masks in patients with pulmonary tuberculosis in Rambipuji Health Center, Jember District. It is recommended that further studies be able to conduct more in-depth research related to the relationship of patient motivation regarding the prevention of transmission with adherence to the use of masks in pulmonary tuberculosis patients

Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis

2020 ◽  
Vol 17 (2) ◽  
pp. 105-111
Author(s):  
Haitao Liu ◽  
Wei Ge ◽  
Wei Chen ◽  
Xue Kong ◽  
Weiming Jian ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Large Scale ◽  
Late Onset ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Positive Trend ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Aldh2 Gene

Objectives: Previous case-control studies have focused on the relationship between ALDH2 gene polymorphism and late-onset Alzheimer's Disease (LOAD), but no definite unified conclusion has been reached. Therefore, the correlation between ALDH2 Glu504Lys polymorphism and LOAD remains controversial. To analyze the correlation between ALDH2 polymorphism and the risk of LOAD, we implemented this up-to-date meta-analysis to assess the probable association. Methods: Studies were searched through China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals, China Biology Medicine, PubMed, Cochrane Library, Clinical- Trials.gov, Embase, and MEDLINE from January 1, 1994 to December 31, 2018, without any restrictions on language and ethnicity. Results: Five studies of 1057 LOAD patients and 1136 healthy controls met our criteria for the analysis. Statistically, the ALDH2 GA/AA genotype was not linked with raising LOAD risk (odds ratio (OR) = 1.48, 95% confidence interval (CI) = 0.96-2.28, p = 0.07). In subgroup analysis, the phenomenon that men with ALDH2*2 had higher risk for LOAD (OR = 1.72, 95%CI = 1.10-2.67, p = 0.02) was observed. Conclusions: This study comprehends only five existing case-control studies and the result is negative. The positive trend might appear when the sample size is enlarged. In the future, more large-scale casecontrol or cohort studies should be done to enhance the association between ALDH2 polymorphism and AD or other neurodegenerative diseases.

Sign in / Sign up

Export Citation Format

Share Document