Primary drug resistance in extra-pulmonary tuberculosis: a hospital-based prospective study from Pakistan

2019 ◽  
Vol 23 (8) ◽  
pp. 900-906 ◽  
Author(s):  
S. Tahseen ◽  
A. Ambreen ◽  
F. Masood ◽  
M. Qadir ◽  
A. Hussain ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Prospective Study ◽  
Extra Pulmonary Tuberculosis ◽  
Primary Drug Resistance ◽  
Extra Pulmonary ◽  
Primary Drug

Primary drug resistance in pulmonary tuberculosis in Great Britain: Second national survey, 1963

Tubercle ◽  
1966 ◽  
Vol 47 (1) ◽  
pp. 92-108 ◽  
Author(s):  
A.B. Miller ◽  
Ruth Tall ◽  
Wallace Fox ◽  
M.J. Lefford ◽  
D.A. Mitchison
Keyword(s):  
Drug Resistance ◽  
Great Britain ◽  
Pulmonary Tuberculosis ◽  
National Survey ◽  
Primary Drug Resistance ◽  
Primary Drug

scholarly journals Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis

2019 ◽  
Vol 7 (9) ◽  
pp. 3532
Author(s):  
Ashok Kumar ◽  
Jawahar Lal Joshi ◽  
Abdurazack Umathoor ◽  
Vishal Chopra ◽  
Komaldeep Kaur ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Early Morning ◽  
Sputum Smear ◽  
Newly Diagnosed ◽  
Primary Drug Resistance ◽  
Smear Positive Pulmonary Tuberculosis ◽  
Probe Assay ◽  
A Prospective Study ◽  
Primary Drug

Background: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients.Method: A prospective study 100 newly diagnosed sputum smear positive pulmonary TB patients was conducted. The patients with an age of ≥15 years and who had either not taken anti TB treatment or who had taken ATT for less than 1 month were enrolled in this study. Two sputum samples (5ml each), including one early morning sample as per the RNTCP guidelines were collected and subjected to line probe assay (LPA).Results: Out of 100 cases 6 were having resistance to both rifampicin and isoniazid, 9 has resistance to INH alone and 1 had resistance to rifampicin alone.Conclusion: The prevalence of primary drug resistance is high. For early and rapid detection of DR-TB newer modality should be used  for the detection of primary drug resistance in sputum smear positive TB patients.

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