Application of Local Hypothermia Using Iced Water for the Treatment of Taxane-Group Induced Fingernail Changes

The low temperature phase of Pd5Ce (L-Pd5Ce) has a one-dimensional long period superstructure (1D-LPS) derived from Ll2. The periodic antiphase boundaries (APBs) are parallel to (110) planes and have a shift vector of 1/2[110]. Hereafter, the indices are referred to the basic lattices of Ll2 As insertion of the APB causes a change in composition, such an APB is called “non-conservative”. Then, a domain size M depends upon the Ce concentration in the alloy. It was found that M increases also with temperature. The temperature dependency of M is attributed to a change of the degree of order within the antiphase domains. In this work, morphology of the non-conservative APBs is observed to clarify the formation process of the 1D-LPS.The alloy of Pd-16.7 at%Ce was prepared by arc melting in argon atmosphere. Disc specimens made from the alloy ingot were first held at 985 K for 260 ks and quenched in iced water to obtain the state of M=∞ or Ll2, followed by annealing for various lengths of time. The annealing temperature was 873 K where the equilibrium value for M is about 3 in unit of (110) lattice spacing of Ll2. Observation was carried out using microscopes JEM-2000FX, JEM-4000EX (HVEM Lab., Kyushu Univ.) and JEM-2000EX (Dept. of Mater. Sci. Tech., Kyushu Univ.).

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Relative merits of slow versus rapid rewarming and internal versus external rewarming following acute general and local hypothermia. II

PsycEXTRA Dataset ◽

10.1037/e536492008-001 ◽

1958 ◽

Keyword(s):

Local Hypothermia

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Local Hypothermia with Ice Slush for Kidney Protection During Suprarenal Aortic Cross-Clamping

Vascular Surgery ◽

10.1177/153857449202600614 ◽

1992 ◽

Vol 26 (6) ◽

pp. 515-516 ◽

Cited By ~ 1

Author(s):

Andrew S. Olearchyk

Keyword(s):

Kidney Protection ◽

Local Hypothermia

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Local Hypothermia as a Radioprotector of the Rectal Wall During Prostate Stereotactic Body Radiation Therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2017.01.017 ◽

2017 ◽

Vol 98 (1) ◽

pp. 75-82 ◽

Cited By ~ 2

Author(s):

Brian A. Hrycushko ◽

Rajiv Chopra ◽

James W. Sayre ◽

James A. Richardson ◽

Michael R. Folkert ◽

...

Keyword(s):

Radiation Therapy ◽

Stereotactic Body Radiation Therapy ◽

Rectal Wall ◽

Stereotactic Body Radiation ◽

Local Hypothermia

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Dynamics of intraocular temperature during local hypothermia (experimental study and mathematical modeling)

JOURNAL OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE ◽

10.37621/jnamsu-2019-4-383-388 ◽

2019 ◽

pp. 383-388

Author(s):

Lukyan Anatychuk ◽

Roman Kobyliansky ◽

Nataliya Pasyechnikova ◽

Volodymyr Naumenko ◽

Oleg Zadorozhnyy ◽

...

Keyword(s):

Mathematical Modeling ◽

Mathematical Model ◽

Biological Tissues ◽

Comsol Multiphysics ◽

Rabbit Eye ◽

Local Contact ◽

Group 2 ◽

Local Hypothermia ◽

Group 1

Therapeutic hypothermia currently is successfully in various fields of medicine to protect biological tissues from ischemia. However the issue of changes in intraocular temperature under hypothermia remains poorly understood. Purpose. To study the dynamics of intraocular temperature in conditions of local hypothermia and on the basis of the obtained data to develop a mathematical model of thermophysical processes in the rabbit eye. Materials and methods. An in vivo experiment was performed on 10 rabbits (20 eyes). In group 1 (5 rabbits, 10 eyes), epibulbar and intraocular temperature was measured after local contact hypothermia through closed eyelids, in group 2 (5 rabbits, 10 eyes) after local contact hypothermia directly through the cornea. ока безпосередньо через рогівку. Для гіпотермії застосовувався гелевий акумулятор холоду температурою -10 °С. Для вимірювання температури в різних відділах ока застосовувався термоелектричний пристрій, розроблений Інститутом термоелектрики НАН і МОН України та ДУ «Інститут очних хвороб і тканинної терапії ім. В. П.Філатова НАМН України». Для розробки математичної моделі теплофізичних процесів в оці кролика використано пакет прикладних програм COMSOL Multiphysics. Результати. Температура склоподібного тіла в 1-й і 2-й групі тварин знизилася в порівнянні з вихідними даними відповідно на 2,8 °С і 5,4 °С. Температурний градієнт між зовнішньою поверхнею рогівки і середньою частиною склоподібного тіла ока кролика в 1-й групі становив 7,1 °С, у 2-й групі – 9,2 °С. На підставі отриманих експериментальних даних було розроблено схематичну, математичну та комп’ютерну моделі ока кролика з урахуванням його теплофізичних особливостей, кровообігу, процесів метаболізму і теплообміну. Висновки. У разі локальної контактної гіпотермії очей кролика відбувається зниження епібульбарної температури і температури внутрішньоочних середовищ, як під час охолодження безпосередньо зовнішньої поверхні рогівки, так і під час впливу холоду через закриті повіки. Ключові слова: внутрішньоочна температура, локальна гіпотермія, око кролика, математична модель ока. Для цитування: Анатичук ЛІ, Пасєчнікова НВ, Науменко ВО, Задорожний ОС, Назаретян РЕ, Кобилянський РР, Верешко ЄЮ. Динаміка внутрішньоочної температури в умовах локальної гіпотермії (експериментальне дослідження та математичне моделювання). Журнал Національної академії медичних наук України. 2019;25(4):383–8

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Development of α+β-type biomedical Ti–Nb alloys with high oxygen content

MATEC Web of Conferences ◽

10.1051/matecconf/202032105003 ◽

2020 ◽

Vol 321 ◽

pp. 05003

Author(s):

K. Ueda ◽

M. Omiya ◽

Y. Hirose ◽

T. Narushima

Keyword(s):

Oxygen Content ◽

Low Cost ◽

Total Elongation ◽

Ti Alloy ◽

High Oxygen Content ◽

Β Phase ◽

Α Phase ◽

Heat Treated ◽

Iced Water ◽

Nb Content

Ti-(5–20)Nb-(0.5–1)O alloys (mass%) were investigated for developing low-cost biomedical α+β-type Ti alloy. Ti-(5, 10, 15, 20)Nb-(0.5, 0.75, 1)O alloys (mass%) were arc-melted and forged into bars. The forged alloy bars were heat-treated at 873 to 1373 K for 3.6 ks in an Ar atmosphere and quenched in iced water. β transus (Tβ) of the Ti-Nb-O alloys decreased with increasing Nb content. An increase in the oxygen content led to an increase in Tβ. After quenching, the formation of α′ martensite was observed in Ti-5Nb-yO alloys. An increase in the Nb content to 10 mass% led to the formation of α′ and α″ martensites. A further increase in the Nb content to 15 and 20mass% resulted in the formation of more α″ martensites. The boundary temperature for the formation of α′ and α″ martensite in the Ti-10Nb-yO alloys increased with increasing oxygen content, because oxygen enhances the Nb distribution to the β phase. The ultimate tensile strength of the Ti-xNb-0.75O alloys heattreated to obtain the α-phase fraction (fα) of 0.5 was over 1000 MPa, except for the Ti-15Nb-0.75O alloy. The total elongation decreased with increasing Nb content. The Ti-5Nb-0.75O alloy exhibited excellent strength-ductility balance as a low-cost α+β-type biomedical Ti alloy.

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STUDIES OF DISTAL COLONIC MOTILITY IN CHILDREN

PEDIATRICS ◽

10.1542/peds.17.6.820 ◽

1956 ◽

Vol 17 (6) ◽

pp. 820-833

Author(s):

Murray Davidson ◽

Marvin H. Sleisenger ◽

Thomas P. Almy ◽

Samuel Z. Levine

Keyword(s):

Ulcerative Colitis ◽

Bowel Movement ◽

Colonic Motility ◽

Distal Colon ◽

Wave Form ◽

Spontaneous Bowel Movement ◽

Normal Individuals ◽

Iced Water ◽

Wave Forms

A characteristic propulsive wave, previously reported in adults with ulcerative colitis, has been found in infants with acute diarrhea but not in children with ulcerative colitis. The reasons for this are discussed. The induction of propulsive wave forms in normal individuals by administration of magnesium sulfate orally is described and attention is called to its application to therapeutic studies. The relation of this wave form to propulsion of fecal contents and defecation and its role in the production of abdominal discomfort are considered. Observed variations in the responses of individual children to subcutaneous injection of Mecholyl®, to oral administration of iced water, and to rectal distention may explain innate differences in susceptibility to the development of colonic symptoms in different children. A classification of wave forms from the distal colon based on current concepts of their probable physiologic significance is offered. A tracing from the distal colon in a child having a spontaneous bowel movement is presented and commented on.

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