scholarly journals Peroxisome Proliferator Activated Receptor Alpha (PPAR) Agonists: A Potential Tool for a Healthy Aging Brain

Pharmacology ◽  
10.5772/32056 ◽  
2012 ◽  
Author(s):  
Jennifer Tremblay-Mercier
Keyword(s):  
Healthy Aging ◽  
Aging Brain ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha ◽  
Ppar Agonists ◽  
Potential Tool

Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

2014 ◽  
Vol 21 (24) ◽  
pp. 2803-2821 ◽  
Author(s):  
Marco Fidaleo ◽  
Francesca Fanelli ◽  
Maria Ceru ◽  
Sandra Moreno
Keyword(s):  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha

Natural peroxisome proliferator-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis

2010 ◽  
Vol 22 (6) ◽  
pp. 359-365 ◽  
Author(s):  
Clarence De Belilovsky ◽  
Elia Roo-Rodriguez ◽  
Caroline Baudouin ◽  
Franck Menu ◽  
Bernard Chadoutaud ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Therapeutic Response ◽  
Topical Steroids ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha ◽  
Alpha Agonist

scholarly journals Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

2015 ◽  
Vol 6 ◽  
Author(s):  
Maria Thomas ◽  
Stefan Winter ◽  
Britta Klumpp ◽  
Miia Turpeinen ◽  
Kathrin Klein ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha

scholarly journals Agonists of the Peroxisome Proliferator–Activated Receptor Alpha Induce a Fiber-Type–Selective Transcriptional Response in Rat Skeletal Muscle

2006 ◽  
Vol 92 (2) ◽  
pp. 578-586 ◽  
Author(s):  
Angus T. De Souza ◽  
Paul D. Cornwell ◽  
Xudong Dai ◽  
Michelle J. Caguyong ◽  
Roger G. Ulrich
Keyword(s):  
Skeletal Muscle ◽  
Fiber Type ◽  
Transcriptional Response ◽  
Peroxisome Proliferator ◽  
Rat Skeletal Muscle ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha

scholarly journals Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat

2014 ◽  
Vol 78 (9) ◽  
pp. 1550-1559
Author(s):  
Zein Shaban Ibrahim ◽  
Mohamed Mohamed Ahmed ◽  
Samir Ahmed El-Shazly ◽  
Mayumi Ishizuka ◽  
Shoichi Fujita
Keyword(s):  
Constitutive Androstane Receptor ◽  
Clofibric Acid ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha

Abstract 126: Peroxisomal Proliferator Activated Receptor Alpha Overexpression in Hypertrophied Cardiomyocytes Restores Mitochondrial Integrity and Function

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Sagartirtha Sarkar ◽  
Santanu Rana
Keyword(s):  
Energy Demand ◽  
Cardiac Tissue ◽  
Structural Integrity ◽  
Heart Function ◽  
Ros Generation ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Atp Production ◽  
Receptor Alpha ◽  
And Function

Cardiac tissue engineering is an interdisciplinary field that engineers modulation of viable molecular milieu to restore, maintain or improve heart function. Myocardial workload (energy demand) and energy substrate availability (supply) are in continual flux to maintain specialized cellular processes, yet the heart has a limited capacity for substrate storage and utilization during pathophysiological conditions. Damage to heart muscle, acute or chronic, leads to dysregulation of cardiac metabolic processes associated with gradual but progressive decline in mitochondrial respiratory pathways resulting in diminished ATP production. The Peroxisome Proliferator Activated Receptor Alpha ( PPARα ) is known to regulate fatty acid to glucose metabolic balance as well as mitochondrial structural integrity. In this study, a non-canonical pathway of PPARα was analyzed by cardiomyocyte targeted PPARα overexpression during cardiac hypertrophy that showed significant downregulation in p53 acetylation as well as GSK3β activation levels. Targeted PPARα overexpression during hypertrophy resulted in restoration of mitochondrial structure and function along with significantly improved mitochondrial ROS generation and membrane potential. This is the first report of myocyte targeted PPARα overexpression in hypertrophied myocardium that results in an engineered heart with significantly improved function with increased muscle mitochondrial endurance and reduced mitochondrial apoptotic load, thus conferring a greater resistance to pathological stimuli within cardiac microenvironment.

scholarly journals Identification of an extended half-site motif required for the function of peroxisome proliferator-activated receptor alpha

1997 ◽  
Vol 2 (5) ◽  
pp. 315-327 ◽  
Author(s):  
Shiho Osada ◽  
Toshiro Tsukamoto ◽  
Masaki Takiguchi ◽  
Masataka Mori ◽  
Takashi Osumi
Keyword(s):  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha ◽  
Half Site
Sign in / Sign up

Export Citation Format

Share Document