scholarly journals Molecular Interactions in Natural and Synthetic Self-Assembly Systems

10.5772/35537 ◽  
2012 ◽  
Author(s):  
Liane Gloria Raluca Stan ◽  
Rodica Mirela ◽  
Aurelia Meghe
Keyword(s):  
Molecular Interactions ◽  
Self Assembly ◽  
Assembly Systems ◽  
Natural And Synthetic

scholarly journals Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Luo ◽  
Yujuan Gao ◽  
Zhongyu Duan ◽  
Yu Yi ◽  
Hao Wang
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Recent Progress ◽  
Assembly Systems ◽  
Targeted Cancer Therapy ◽  
Cancer Treatments ◽  
Self Assembling ◽  
Stimuli Response

Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.

Study of stabilization of self-assembly processes in fullerene C60 solution

2021 ◽  
Vol 23 (3) ◽  
pp. 12-14
Author(s):  
U.K. Makhmanov ◽  
A.M. Kokhkharov ◽  
Sh.A. Esanov ◽  
B.A. Aslonov ◽  
B.A. Sindarov ◽  
...  
Keyword(s):  
Refractive Index ◽  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Molecular Interactions ◽  
Self Assembly ◽  
Fullerene C60 ◽  
Self Organization ◽  
Final Size ◽  
Initial Concentration ◽  
Xylene Solution

The dynamics of changes in the values of the refractive index of solutions of C60 in xylene at various concentrations has been studied by the refractometric method. It was found that the deviation from the linear form of the dependence of the refractive index on the C60 concentration occurs at a C60 concentration of 1.8 mg/ml. The deviation is associated with the largest number of molecular interactions between C60−C60 and the formation of large nanoclusters on their basis in solution. It was found by the dynamic light scattering (DLS) that the final size of C60 nanoclusters in solution depends on the initial concentration of the solute. A higher initial concentration of C60 leads to the synthesis of nanoclusters with a larger diameter. Using the method of optical spectroscopy, the processes of self-organization of fullerene C60 molecules in a xylene solution in time are studied. The character of stability of synthesized fullerene nanoclusters in solution is discussed. The results obtained are of particular importance for numerous applications of nanotechnology for understanding self-assembly processes and the development of new nanomaterials.

Recent advances in surface-active ionic liquid assisted self-assembly systems for drug delivery

2021 ◽  
pp. 101515
Author(s):  
Rahman Md Moshikur ◽  
Md. Korban Ali ◽  
Muhammad Moniruzzaman ◽  
Masahiro Goto
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Self Assembly ◽  
Assembly Systems ◽  
Recent Advances ◽  
Surface Active Ionic Liquid ◽  
Surface Active

Constructive Molecular Dynamics Lattice Gases: Three-Dimensional Molecular Self-Assembly

2003 ◽  
Author(s):  
Martin Nilsson ◽  
Steen Rasmussen
Keyword(s):  
Molecular Dynamics ◽  
Self Assembly ◽  
Lattice Gas ◽  
Chemical Properties ◽  
Special Kind ◽  
Lattice Gases ◽  
Living Systems ◽  
Self Organization ◽  
Assembly Systems ◽  
Formal Systems

Realistic molecular dynamics and self-assembly is represented in a lattice simulation where water, water-hydrocarbons, and water-amphiphilic systems are investigated. The details of the phase separation dynamics and the constructive self-assembly dynamics are discussed and compared to the corresponding experimental systems. The method used to represent the different molecular types can easily be expended to include additional molecules and thus allow the assembly of more complex structures. This molecular dynamics (MD) lattice gas fills a modeling gap between traditional MD and lattice gas methods. Both molecular objects and force fields are represented by propagating information particles and all microscopic interactions are reversible. Living systems, perhaps the ultimate constructive dynamical systems, is the motivation for this work and our focus is a study of the dynamics of molecular self-assembly and self-organization. In living systems, matter is organized such that it spontaneously constructs intricate functionalities at all levels from the molecules up to the organism and beyond. At the lower levels of description, chemical reactions, molecular selfassembly and self-organization are the drivers of this complexity. We shall, in this chapter, demonstrate how molecular self-assembly and selforganization processes can be represented in formal systems. The formal systems are to be denned as a special kind of lattice gas and they are in a form where an obvious correspondence exists between the observables in the lattice gases and the experimentally observed properties in the molecular self-assembly systems. This has the clear advantage that by using these formal systems, theory, simulation, and experiment can be conducted in concert and can mutually support each other. However, a disadvantage also exists because analytical results are difficult to obtain for these formal systems due to their inherent complexity dictated by their necessary realism. The key to novelt simpler molecules (from lower levels), dynamical hierarchies are formed [2, 3]. Dynamical hierarchies are characterized by distinct observable functionalities at multiple levels of description. Since these higher-order structures are generated spontaneously due to the physico-chemical properties of their building blocks, complexity can come for free in molecular self-assembly systems. Through such processes, matter apparently can program itself into structures that constitute living systems [11, 27, 30].

scholarly journals Molecular interaction balanced one- and two-dimensional hybrid nanoarchitectures for high-performance supercapacitors

2019 ◽  
Vol 21 (40) ◽  
pp. 22283-22292 ◽  
Author(s):  
Mingxia Lu ◽  
Gang Wang ◽  
Bo Li ◽  
Jing Chen ◽  
Jingchao Zhang ◽  
...  
Keyword(s):  
Molecular Interactions ◽  
Self Assembly ◽  
Molecular Interaction ◽  
High Performance ◽  
Charge Storage ◽  
Two Dimensional ◽  
Assembly Process ◽  
Equilibrium Thermodynamic ◽  
Good Separation ◽  
Ratio Dependent

Stepwise ultrasonication and self-assembly process enables good separation between disequilibrium and equilibrium thermodynamic molecular interactions, which allow excellent electrochemical charge storage based on ratio-dependent 1D–2D hybridisation.

Programmed Self-Assembly Systems of Amphiphilic Random Copolymers into Size-Controlled and Thermoresponsive Micelles in Water

2018 ◽  
Vol 51 (2) ◽  
pp. 398-409 ◽  
Author(s):  
Shota Imai ◽  
Yuji Hirai ◽  
Chitose Nagao ◽  
Mitsuo Sawamoto ◽  
Takaya Terashima
Keyword(s):  
Self Assembly ◽  
Random Copolymers ◽  
Assembly Systems ◽  
Size Controlled

scholarly journals Protein assembly systems in natural and synthetic biology

BMC Biology ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Giulio Chiesa ◽  
Szilvia Kiriakov ◽  
Ahmad S. Khalil
Keyword(s):  
Synthetic Biology ◽  
Protein Assembly ◽  
Assembly Systems ◽  
Natural And Synthetic

Conductive porphyrin helix from ternary self-assembly systems

2014 ◽  
Vol 50 (88) ◽  
pp. 13537-13539 ◽  
Author(s):  
Qiang Zhao ◽  
Yao Wang ◽  
Yan Qiao ◽  
Xiaolong Wang ◽  
Xuefeng Guo ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Assembly Systems

The helix with ternary components is easily obtained in aqueous solution. It possesses the characteristic porphyrin fluorescence and conductivity.

Design and Biocatalytic Synthesis of Pluronics-based Nanomicellar Self-assembly Systems for Drug Encapsulation Applications

2010 ◽  
Vol 47 (8) ◽  
pp. 788-793 ◽  
Author(s):  
Mukesh K. Pandey ◽  
Ke Yang ◽  
Cao Pei ◽  
Pramod K. Sharma ◽  
Joana Viola ◽  
...  
Keyword(s):  
Self Assembly ◽  
Assembly Systems ◽  
Drug Encapsulation
Sign in / Sign up

Export Citation Format

Share Document